Resolving self-association of a therapeutic antibody by formulation optimization and molecular approaches

Identification of a Human Monoclonal Antibody To Replace Equine Diphtheria Antitoxin for Treatment of Diphtheria Intoxication

(2013) Leila M. Sevigny et al.   INFECTION AND IMMUNITY

Thermodynamic and structural characterization of an antibody gel

(2013) Osigwe Esue et al.   mAbs

Proximity energies: a framework for understanding concentrated solutions

(2012) Tom Laue   JOURNAL OF MOLECULAR RECOGNITION

Pathological crystallization of human immunoglobulins

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aggregation-resistant domain antibodies engineered with charged mutations near the edges of the complementarity-determining regions

(2012) J. M. Perchiacca et al.   PROTEIN ENGINEERING DESIGN & SELECTION

In VivoCrystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells

(2011) Haruki Hasegawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies

(2011) Sandeep Yadav et al.   PHARMACEUTICAL RESEARCH

Factors Affecting the Viscosity in High Concentration Solutions of Different Monoclonal Antibodies

(2010) Sandeep Yadav et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Phase Separation of an IgG1 Antibody Solution under a Low Ionic Strength Condition

(2010) Hirotaka Nishi et al.   PHARMACEUTICAL RESEARCH

Structure-based engineering of a monoclonal antibody for improved solubility

(2010) S.-J. Wu et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Understanding and Modulating Opalescence and Viscosity in a Monoclonal Antibody Formulation

(2009) Branden A. Salinas et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen

(2009) Kenneth Smith et al.   Nature Protocols

Carboxylate-Dependent Gelation of a Monoclonal Antibody

(2009) Osigwe Esue et al.   PHARMACEUTICAL RESEARCH

Design of therapeutic proteins with enhanced stability

(2009) N. Chennamsetty et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reversible Self-Association of a Concentrated Monoclonal Antibody Solution Mediated by Fab–Fab Interaction That Impacts Solution Viscosity

(2008) Sonoko Kanai et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Protein Phase Behavior in Aqueous Solutions: Crystallization, Liquid-Liquid Phase Separation, Gels, and Aggregates

(2007) André C. Dumetz et al.   BIOPHYSICAL JOURNAL