Structural insights and biomedical potential of IgNAR scaffolds from sharks

A Chemoenzymatic Approach to Protein Immobilization onto Crystalline Cellulose Nanoscaffolds

(2014) Christina Uth et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Shark variable new antigen receptor biologics – a novel technology platform for therapeutic drug development

(2014) Marina Kovaleva et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

What the shark immune system can and cannot provide for the expanding design landscape of immunotherapy

(2014) Michael F Criscitiello   Expert Opinion on Drug Discovery

Shark Attack: High affinity binding proteins derived from shark vNAR domains by stepwise in vitro affinity maturation

(2014) Stefan Zielonka et al.   JOURNAL OF BIOTECHNOLOGY

From target discovery to clinical trials with armed antibody products

(2014) Giuliano Elia et al.   Journal of Proteomics

What's fueling the biotech engine—2012 to 2013

(2014) Saurabh (Rob) Aggarwal   NATURE BIOTECHNOLOGY

The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins

(2014) M. J. Feige et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanobodies: Natural Single-Domain Antibodies

(2013) Serge Muyldermans   Annual Review of Biochemistry

Replacing Antibodies: Engineering New Binding Proteins

(2013) Scott Banta et al.   Annual Review of Biomedical Engineering

Anti-tumor necrosis factor VNAR single domains reduce lethality and regulate underlying inflammatory response in a murine model of endotoxic shock

(2013) Rafael Bojalil et al.   BMC IMMUNOLOGY

Therapeutic antibody engineering by high efficiency cell screening

(2013) Achim Doerner et al.   FEBS LETTERS

Humoral immune response of the small-spotted catshark, Scyliorhinus canicula

(2013) Kathryn Crouch et al.   FISH & SHELLFISH IMMUNOLOGY

Atypical Antigen Recognition Mode of a Shark Immunoglobulin New Antigen Receptor (IgNAR) Variable Domain Characterized by Humanization and Structural Analysis

(2013) Oleg V. Kovalenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Which are the antibodies to watch in 2013?

(2013) Janice M. Reichert   mAbs

Human TNF cytokine neutralization with a vNAR fromHeterodontus franciscishark: A potential therapeutic use

(2013) Tanya Camacho-Villegas et al.   mAbs

The African coelacanth genome provides insights into tetrapod evolution

(2013) Chris T. Amemiya et al.   NATURE

The Shape of the Lymphocyte Receptor Repertoire: Lessons from the B Cell Receptor

(2013) Katherine J. L. Jackson et al.   Frontiers in Immunology

Drug-conjugated antibodies for the treatment of cancer

(2012) John M. Lambert   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Monoclonal antibody therapeutics: history and future

(2012) Nicholas APS Buss et al.   CURRENT OPINION IN PHARMACOLOGY

Natural and Engineered Cystine Knot Miniproteins for Diagnostic and Therapeutic Applications

(2012) Harald Kolmar   CURRENT PHARMACEUTICAL DESIGN

Variable domain antibodies specific for viral hemorrhagic septicemia virus (VHSV) selected from a randomized IgNAR phage display library

(2012) Maki Ohtani et al.   FISH & SHELLFISH IMMUNOLOGY

Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain

(2012) Mischa R. Müller et al.   mAbs

Marketed therapeutic antibodies compendium

(2012) Janice M. Reichert   mAbs

Construction of an Artificially Randomized IgNAR Phage Display Library: Screening of Variable Regions that Bind to Hen Egg White Lysozyme

(2012) Maki Ohtani et al.   MARINE BIOTECHNOLOGY

What's fueling the biotech engine—2011 to 2012

(2012) Saurabh Aggarwal   NATURE BIOTECHNOLOGY

The TITAN trial – Assessing the efficacy and safety of an anti-von Willebrand factor Nanobody in patients with acquired thrombotic thrombocytopenic purpura

(2012) Josefin-Beate Holz   TRANSFUSION AND APHERESIS SCIENCE

Immuno-imaging using nanobodies

(2011) Ilse Vaneycken et al.   CURRENT OPINION IN BIOTECHNOLOGY

Non-immunoglobulin based protein scaffolds

(2011) John Löfblom et al.   CURRENT OPINION IN BIOTECHNOLOGY

Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias)

(2011) Lauren E. Smith et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Crystal Structure of the Amyloid-  p3 Fragment Provides a Model for Oligomer Formation in Alzheimer's Disease

(2011) V. A. Streltsov et al.   JOURNAL OF NEUROSCIENCE

Isolation and characterisation of Ebolavirus-specific recombinant antibody fragments from murine and shark immune libraries

(2011) Sarah A. Goodchild et al.   MOLECULAR IMMUNOLOGY

Targeting the hepatitis B virus precore antigen with a novel IgNAR single variable domain intrabody

(2011) Renae Walsh et al.   VIROLOGY

A Case Of Convergence: Why Did a Simple Alternative to Canonical Antibodies Arise in Sharks and Camels?

(2011) Martin F. Flajnik et al.   PLOS BIOLOGY

Bispecific Antibodies for Cancer Immunotherapy

(2010) Dafne Müller et al.   BIODRUGS

Antibody fragments

(2010) Aaron L. Nelson   mAbs

Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties

(2010) G. Wozniak-Knopp et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Stability engineering of scFvs for the development of bispecific and multivalent antibodies

(2010) Brian R. Miller et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Next generation immunotherapeutics—honing the magic bullet

(2009) Carrie Enever et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineered protein scaffolds as next-generation antibody therapeutics

(2009) Michaela Gebauer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

(2009) Janusz Wesolowski et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies

(2009) Matthias J. Feige et al.   MOLECULAR CELL

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8

(2009) Elmar Krieger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Display scaffolds: protein engineering for novel therapeutics

(2008) S NUTTALL et al.   CURRENT OPINION IN PHARMACOLOGY

SPECT Imaging with 99mTc-Labeled EGFR-Specific Nanobody for In Vivo Monitoring of EGFR Expression

(2008) Lieven Huang et al.   MOLECULAR IMAGING AND BIOLOGY

Shark IgNAR antibody mimotopes target a murine immunoglobulin through extended CDR3 loop structures

(2007) David P. Simmons et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS