Improving the pharmacokinetic properties of biologics by fusion to an anti-HSA shark VNAR domain

Glomerular endothelium: A porous sieve and formidable barrier

(2012) Marya Obeidat et al.   EXPERIMENTAL CELL RESEARCH

Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor

(2012) Jan Terje Andersen et al.   Nature Communications

Strategies for extended serum half-life of protein therapeutics

(2011) Roland E Kontermann   CURRENT OPINION IN BIOTECHNOLOGY

Characterization of the immunoglobulin repertoire of the spiny dogfish (Squalus acanthias)

(2011) Lauren E. Smith et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

PEGylation of therapeutic proteins

(2010) Simona Jevševar et al.   Biotechnology Journal

Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR

(2010) Jennifer S. Michaelson et al.   mAbs

Multivalent antibodies: when design surpasses evolution

(2010) Ángel M. Cuesta et al.   TRENDS IN BIOTECHNOLOGY

Engineered therapeutic antibodies with improved effector functions

(2009) Tsuguo Kubota et al.   CANCER SCIENCE

Engineering Human IgG1 Affinity to Human Neonatal Fc Receptor: Impact of Affinity Improvement on Pharmacokinetics in Primates

(2009) Y. A. Yeung et al.   JOURNAL OF IMMUNOLOGY

Affinity Maturation of a Humanized Rat Antibody for Anti-RAGE Therapy: Comprehensive Mutagenesis Reveals a High Level of Mutational Plasticity Both Inside and Outside the Complementarity-Determining Regions

(2009) William J. Finlay et al.   JOURNAL OF MOLECULAR BIOLOGY

Biodistribution of [125I]-labeled therapeutic proteins: Application in protein drug development beyond oncology**All authors are current or former employees of Wyeth, Inc.

(2009) Yulia Vugmeyster et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Molecular engineering and design of therapeutic antibodies

(2008) Leonard G Presta   CURRENT OPINION IN IMMUNOLOGY

DARPins: A new generation of protein therapeutics

(2008) Michael T. Stumpp et al.   DRUG DISCOVERY TODAY

Alternative binding proteins: Anticalins - harnessing the structural plasticity of the lipocalin ligand pocket to engineer novel binding activities

(2008) Arne Skerra   FEBS Journal

Alternative binding proteins: Affibody binding proteins developed from a small three-helix bundle scaffold

(2008) Per-Åke Nygren   FEBS Journal

N-Glycosylation as Novel Strategy to Improve Pharmacokinetic Properties of Bispecific Single-chain Diabodies

(2008) Roland Stork et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A simple high-throughput purification method for hit identification in protein screening

(2008) Emma Cummins et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Improved tumor targeting of anti-epidermal growth factor receptor Nanobodies through albumin binding: taking advantage of modular Nanobody technology

(2008) B. M. Tijink et al.   MOLECULAR CANCER THERAPEUTICS

Anti-serum albumin domain antibodies for extending the half-lives of short lived drugs

(2008) L. J. Holt et al.   PROTEIN ENGINEERING DESIGN & SELECTION