Antibody light chain variable domains and their biophysically improved versions for human immunotherapy

Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor

(2013) Xiaolei Ma et al.   JOURNAL OF MOLECULAR BIOLOGY

Anthrax drug first antibacterial mAb to win approval

(2013) Jeffrey L Fox   NATURE BIOTECHNOLOGY

Targeting high affinity and epitope-distinct oligoclonal nanobodies to HER2 over-expressing tumor cells

(2012) Fatemeh Rahimi Jamnani et al.   EXPERIMENTAL CELL RESEARCH

Straightforward Selection of Broadly Neutralizing Single-Domain Antibodies Targeting the Conserved CD4 and Coreceptor Binding Sites of HIV-1 gp120

(2012) J. Matz et al.   JOURNAL OF VIROLOGY

A Novel Strategy for Development of Recombinant Antitoxin Therapeutics Tested in a Mouse Botulism Model

(2012) Jean Mukherjee et al.   PLoS One

Crystal Structure of a Human Single Domain Antibody Dimer Formed through VH-VH Non-Covalent Interactions

(2012) Toya Nath Baral et al.   PLoS One

General strategy for the generation of human antibody variable domains with increased aggregation resistance

(2012) K. Dudgeon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Disulfide linkage engineering for improving biophysical properties of human VH domains

(2012) D. Y. Kim et al.   PROTEIN ENGINEERING DESIGN & SELECTION

A VL single-domain antibody library shows a high-propensity to yield non-aggregating binders

(2012) G. Hussack et al.   PROTEIN ENGINEERING DESIGN & SELECTION

An integrated approach to extreme thermostabilization and affinity maturation of an antibody

(2012) A. D. McConnell et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Diagnostic evaluation of a nanobody with picomolar affinity toward the protease RgpB from Porphyromonas gingivalis

(2011) Peter Durand Skottrup et al.   ANALYTICAL BIOCHEMISTRY

A Disulfide-Free Single-Domain VL Intrabody with Blocking Activity towards Huntingtin Reveals a Novel Mode of Epitope Recognition

(2011) André Schiefner et al.   JOURNAL OF MOLECULAR BIOLOGY

Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability

(2011) Greg Hussack et al.   PLoS One

Potent Neutralization of Influenza A Virus by a Single-Domain Antibody Blocking M2 Ion Channel Protein

(2011) Guowei Wei et al.   PLoS One

Enhancement of Polymeric Immunoglobulin Receptor Transcytosis by Biparatopic VHH

(2011) Chris D. Emmerson et al.   PLoS One

A Broad Set of Different Llama Antibodies Specific for a 16 kDa Heat Shock Protein of Mycobacterium tuberculosis

(2011) Anke K. Trilling et al.   PLoS One

Antibody engineering reveals the important role of J segments in the production efficiency of llama single-domain antibodies in Saccharomyces cerevisiae

(2011) A. Gorlani et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Llama-Derived Single Domain Antibodies Specific for Abrus Agglutinin

(2011) Ellen R. Goldman et al.   Toxins

A bispecific nanobody to provide full protection against lethal scorpion envenoming

(2010) Issam Hmila et al.   FASEB JOURNAL

Antibody fragments

(2010) Aaron L. Nelson   mAbs

Identification of potent nanobodies to neutralize the most poisonous polypeptide from scorpion venom

(2009) Rahma Ben Abderrazek et al.   BIOCHEMICAL JOURNAL

Pentabody-mediated antigen delivery induces antigen-specific mucosal immune response

(2009) Shenghua Li et al.   MOLECULAR IMMUNOLOGY

Development trends for therapeutic antibody fragments

(2009) Aaron L Nelson et al.   NATURE BIOTECHNOLOGY

Gene silencing by cell-penetrating, sequence-selective and nucleic-acid hydrolyzing antibodies

(2009) Woo-Ram Lee et al.   NUCLEIC ACIDS RESEARCH

Immunological applications of single-domain llama recombinant antibodies isolated from a naïve library

(2009) Ana Monegal et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Mass Spectrometric Determination of Disulfide Linkages in Recombinant Therapeutic Proteins Using Online LC−MS with Electron-Transfer Dissociation

(2008) Shiaw-Lin Wu et al.   ANALYTICAL CHEMISTRY

Engineering a Camelid Antibody Fragment That Binds to the Active Site of Human Lysozyme and Inhibits Its Conversion into Amyloid Fibrils†

(2008) Pak-Ho Chan et al.   BIOCHEMISTRY

Nanobodies, a promising tool for species-specific diagnosis of Taenia solium cysticercosis

(2008) N. Deckers et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Thermodynamically Stable Aggregation-Resistant Antibody Domains through Directed Evolution

(2008) Kristoffer Famm et al.   JOURNAL OF MOLECULAR BIOLOGY

Disulfide Bond Introduction for General Stabilization of Immunoglobulin Heavy-Chain Variable Domains

(2008) Dirk Saerens et al.   JOURNAL OF MOLECULAR BIOLOGY

Aggregation-resistant VHs selected by in vitro evolution tend to have disulfide-bonded loops and acidic isoelectric points

(2008) M. Arbabi-Ghahroudi et al.   PROTEIN ENGINEERING DESIGN & SELECTION