Article
Biotechnology & Applied Microbiology
Likun Wei, Meiniang Wang, Haitao Xiang, Yuan Jiang, Jinhua Gong, Dan Su, M. A. R. Al Azad, Hongming Dong, Limin Feng, Jiajun Wu, Leo Lai Chan, Naibo Yang, Jiahai Shi
Summary: The white-spotted bamboo shark has been demonstrated as a promising small animal model for the production of shark single domain antibodies (sdAbs), offering a cost-effective and easy-to-operate alternative to large-scale shark farming. Research has shown that bamboo sharks exhibit effective immune responses and can produce high-affinity IgNAR, paving the way for the discovery and development of sdAbs for the biomedical industry.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Behnaz Eshaghi, Alex Schudel, Ilin Sadeghi, Ziqi Chen, Amy H. Lee, Maria Kanelli, Flora Tierney, Jooli Han, Bailey Ingalls, David M. Francis, Gary Li, Ulrich von Andrian, Robert Langer, Ana Jaklenec
Summary: Mucosal vaccines play a critical role in combating mucosal pathogens by directly neutralizing the invading pathogens. This review examines the role of material design in addressing the challenges associated with mucosal vaccine delivery and discusses different classes of materials currently being used.
NATURE REVIEWS MATERIALS
(2023)
Article
Medicine, Research & Experimental
Lingzhou Zhao, Changcun Liu, Yan Xing, Jin He, Jim O'Doherty, Wenhua Huang, Jinhua Zhao
Summary: Accurate determination of HER2 expression is crucial for HER2-targeted therapy. A novel Tc-99m-labeled anti-HER2 single-domain antibody was developed for noninvasive detection, showing safety, favorable biodistribution, and reasonable radiation doses in breast cancer patients. Tc-99m-NM-02 SPECT imaging may offer an accurate and noninvasive method for detecting HER2 status.
MOLECULAR PHARMACEUTICS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Betuel Altunay, Andreas Goedicke, Oliver H. H. Winz, Fabian Hertel, Dirk von Mallek, Levente K. K. Meszaros, Gitasha Chand, Hans-Juergen Biersack, Elmar Stickeler, Katja Krauss, Felix M. M. Mottaghy
Summary: The accurate determination of HER2 status is crucial for cancer patients receiving HER2-targeted therapy. Noninvasive techniques in molecular imaging, such as the use of RAD201, have shown promise in accurately determining HER2 status in metastatic (breast) cancer.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Pharmacology & Pharmacy
Chi-Hsun Chen, Chung-Chu Chen, Wei-Bo Wang, Vania Lionel, Chia-Chyi Liu, Li-Min Huang, Suh-Chin Wu
Summary: In this study, a recombinant ZIKV envelope DIII protein genetically fused with Salmonella typhimurium flagellin was developed as a mucosal antigen. Intranasal immunization with this antigen elicited strong protective immunity against ZIKV challenges, demonstrating its potential for developing mucosal vaccines.
Article
Immunology
Ahmad Najafi, Reza Valadan, Hossein Asgarian-Omran, Alireza Rafiei, Mohsen Tehrani
Summary: In this study, a recombinant phage was generated using the phage display method to select monoclonal phages that can react with the dimerization domain of HER2 receptor. Functional tests confirmed their specificity and anti-tumor properties.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Abhay P. S. Rathore, Ashley L. St. John
Summary: COVID-19 is caused by SARS-CoV-2 and current vaccines offer effective protection against severe disease and death. However, vaccine-induced immunity wanes quickly and does not effectively block virus transmission. Mucosal vaccines are being developed to induce long-lasting protective immune responses at the sites of SARS-CoV-2 infection. This article discusses mucosal immune responses, advances in understanding mucosal responses to SARS-CoV-2 infection and current COVID-19 vaccines, as well as challenges in mucosal vaccination.
Article
Immunology
Jenny Lorena Molina Estupinan, Audur Anna Aradottir Pind, Poorya Foroutan Pajoohian, Ingileif Jonsdottir, Stefania P. Bjarnarson
Summary: Immaturity of the neonatal immune system leads to increased susceptibility to diseases and poor vaccine responses. The use of adjuvants, such as dmLT and mmCT, can enhance the immune response in neonates. This study evaluated the effects of these adjuvants and different immunization routes on the immune response to a pneumococcal conjugate vaccine in neonatal mice. The results showed that adjuvants enhanced antibody responses and influenced the route of immunization. Additionally, adjuvants promoted inflammation and immune cell formation. These findings suggest that dmLT and mmCT are promising adjuvants for early life vaccination strategies.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Ruth I. Connor, Elizabeth B. Brickley, Wendy F. Wieland-Alter, Margaret E. Ackerman, Joshua A. Weiner, John F. Modlin, Ananda S. Bandyopadhyay, Peter F. Wright
Summary: The global initiative to eradicate polio focuses on inducing mucosal immunity to limit virus replication in the intestine and restrict virus shedding through the widespread use of live and inactivated poliovirus vaccines. Recent clinical trials have shown clear differences in the ability of new combined vaccine regimens to limit virus shedding after oral challenge with live virus, with enteric neutralizing IgA playing a critical role in this process. This review summarizes key findings in vaccine-induced intestinal immunity and discusses the impact of immunization on global polio eradication efforts.
MUCOSAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aziz Gauhar, Cyril Privezentzev, Mykhaylo Demydchuk, Tanja Gerlza, Julia Rieger, Andreas J. Kungl, Frank S. Walsh, J. Lynn Rutkowski, Pawel Stocki
Summary: Single domain shark variable domain of new antigen receptor (VNAR) antibodies identified using phage display show high affinity and specificity against SARS-CoV-2 spike protein, with potential to treat COVID-19. These antibodies can block viral entry and neutralize the virus, making them a promising adjunct in the fight against COVID-19.
Article
Biochemistry & Molecular Biology
Letian Li, Maopeng Wang, Jiayi Hao, Jicheng Han, Tingting Fu, Jieying Bai, Mingyao Tian, Ningyi Jin, Guangze Zhu, Chang Li
Summary: A recombinant L. plantarum expressing RBD of SARS-CoV-2 spike protein induced mucosal IgA antibodies and T cell immune response in mice, suggesting a promising mucosal vaccine candidate for preventing COVID-19.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Brittany L. Hartwell, Mariane B. Melo, Peng Xiao, Ashley A. Lemnios, Na Li, Jason Y. H. Chang, Jingyou Yu, Makda S. Gebre, Aiquan Chang, Laura Maiorino, Crystal Carter, Tyson J. Moyer, Neil C. Dalvie, Sergio A. Rodriguez-Aponte, Kristen A. Rodrigues, Murillo Silva, Heikyung Suh, Josetta Adams, Jane Fontenot, J. Christopher Love, Dan H. Barouch, Francois Villinger, Ruth M. Ruprecht, Darrell J. Irvine
Summary: Using a protein vaccine modified with an albumin-binding polymer-lipid tail as an intranasal vaccine can effectively promote mucosal immunity and generate higher antibody titers in mice and nonhuman primates.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Qian Qin, Hao Liu, Wenbo He, Yucheng Guo, Jiaxin Zhang, Junjun She, Fang Zheng, Sicai Zhang, Serge Muyldermans, Yurong Wen
Summary: Increasing antibiotic resistance poses a serious threat to human health. Nanobodies, a new type of antibodies with small size, high stability, and strong antigen-binding affinity, have emerged as a desirable alternative to conventional antibodies and have shown progress in the diagnosis and neutralization of bacterial infections.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Sarah A. Brendle, Jingwei Li, Nancy M. Cladel, Karla K. Balogh, Jennifer Booth, Debra A. Shearer, Vonn Walter, Song Lu, Neil D. Christensen, Danielle Covington, Jake DeBroff, Janice Milici, Yusheng Zhu, Raphael Viscidi, Jiafen Hu
Summary: We established a mouse papillomavirus (MmuPV1) model and tested passive immunization using a single neutralizing monoclonal antibody to protect both cutaneous and mucosal infections in mice. Results showed that MPV.A4 antibody provided protection against MmuPV1 infections at both skin and mucosal sites, with partial protection observed at 6 hours post-viral inoculation in female mice. The study also demonstrated the presence of MPV.A4 antibody in the blood for up to 8 weeks postadministration.
JOURNAL OF VIROLOGY
(2022)
Article
Medicine, General & Internal
Erin E. Congdon, Ruimin Pan, Yixiang Jiang, Leslie A. Sandusky-Beltran, Andie Dodge, Yan Lin, Mengyu Liu, Min-Hao Kuo, Xiang-Peng Kong, Einar M. Sigurdsson
Summary: The study suggests that tau antibodies with effector function are safer and more effective in clearing pathological tau. Tau antibodies can provide valuable insights into tau pathogenesis, but some may worsen the condition.
