5th European Antibody Congress 2009

Development of Biosimilars—Pharmacokinetic and Pharmacodynamic Considerations

(2010) Yow-Ming C. Wang et al.   Journal of Biopharmaceutical Statistics

4th European Antibody Congress 2008: December 1-3, 2008, Geneva, Switzerland

(2010) Alain Beck et al.   mAbs

Patenting antibodies in Europe

(2010) Louise Holliday   mAbs

Guardians at the gate

(2010) Kevin W. McCabe   mAbs

Non-human primate immune libraries combined with germline humanization

(2010) Thibaut Pelat et al.   mAbs

Ustekinumab

(2010) Oya Cingoz   mAbs

Evolution of anti- CD20 monoclonal antibody therapeutics in oncology

(2010) Ezogelin Oflazoglu et al.   mAbs

Antibodies to watch in 2010

(2010) Janice M. Reichert   mAbs

Catumaxomab

(2010) Rolf Linke et al.   mAbs

Bioanalysis of recombinant proteins and antibodies by mass spectrometry

(2009) Eric Ezan et al.   ANALYST

Identification and characterization of asparagine deamidation in the light chain CDR1 of a humanized IgG1 antibody

(2009) Josef Vlasak et al.   ANALYTICAL BIOCHEMISTRY

Extending Mass Spectrometry Contribution to Therapeutic Monoclonal Antibody Lead Optimization: Characterization of Immune Complexes Using Noncovalent ESI-MS

(2009) Cédric Atmanene et al.   ANALYTICAL CHEMISTRY

Hyperalgesia, synovitis and multiple biomarkers of inflammation are suppressed by interleukin 1 inhibition in a novel animal model of gouty arthritis

(2009) R Torres et al.   ANNALS OF THE RHEUMATIC DISEASES

Safety Assessment and Dose Selection for First-in-Human Clinical Trials With Immunomodulatory Monoclonal Antibodies

(2009) PY Muller et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The minimum anticipated biological effect level (MABEL) for selection of first human dose in clinical trials with monoclonal antibodies

(2009) Patrick Y Muller et al.   CURRENT OPINION IN BIOTECHNOLOGY

Optimization of Fc-mediated effector functions of monoclonal antibodies

(2009) William R Strohl   CURRENT OPINION IN BIOTECHNOLOGY

GlycoFi's technology to control the glycosylation of recombinant therapeutic proteins

(2009) Alain Beck et al.   Expert Opinion on Drug Discovery

Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties

(2009) Adam Doern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Use of biofluorescence imaging to compare the distribution of certolizumab pegol, adalimumab, and infliximab in the inflamed paws of mice with collagen-induced arthritis

(2009) Roger Palframan et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Pre‐ and Postexposure Use of Human Monoclonal Antibody against H5N1 and H1N1 Influenza Virus in Mice: Viable Alternative to Oseltamivir

(2009) Wouter Koudstaal et al.   JOURNAL OF INFECTIOUS DISEASES

Structural characterization of a human Fc fragment engineered for extended serum half-life

(2009) Vaheh Oganesyan et al.   MOLECULAR IMMUNOLOGY

Development trends for therapeutic antibody fragments

(2009) Aaron L Nelson et al.   NATURE BIOTECHNOLOGY

Therapeutic IgG4 antibodies engage in Fab-arm exchange with endogenous human IgG4 in vivo

(2009) Aran F Labrijn et al.   NATURE BIOTECHNOLOGY

Gearing up for follow-on biologics

(2009) Bethan Hughes   NATURE REVIEWS DRUG DISCOVERY

Immunogenicity of biologically-derived therapeutics: Assessment and interpretation of nonclinical safety studies

(2009) Rafael Ponce et al.   REGULATORY TOXICOLOGY AND PHARMACOLOGY

Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site

(2009) J. Bostrom et al.   SCIENCE

Antibody Recognition of a Highly Conserved Influenza Virus Epitope

(2009) D. C. Ekiert et al.   SCIENCE

Absolute Quantification of Monoclonal Antibodies in Biofluids by Liquid Chromatography−Tandem Mass Spectrometry

(2008) Charlotte Hagman et al.   ANALYTICAL CHEMISTRY

Towards Absolute Quantification of Therapeutic Monoclonal Antibody in Serum by LC−MS/MS Using Isotope-Labeled Antibody Standard and Protein Cleavage Isotope Dilution Mass Spectrometry

(2008) Olivier Heudi et al.   ANALYTICAL CHEMISTRY

Immunopurification and Mass Spectrometric Quantification of the Active Form of a Chimeric Therapeutic Antibody in Human Serum

(2008) Mathieu Dubois et al.   ANALYTICAL CHEMISTRY

Novel human antibody therapeutics: The age of the Umabs

(2008) Sigrid R. Ruuls et al.   Biotechnology Journal

Specificity and affinity of human Fc  receptors and their polymorphic variants for human IgG subclasses

(2008) P. Bruhns et al.   BLOOD

A human anti-D monoclonal antibody selected for enhanced FcγRIII engagement clears RhD+autologous red cells in human volunteers as efficiently as polyclonal anti-D antibodies

(2008) Roland Beliard et al.   BRITISH JOURNAL OF HAEMATOLOGY

Chronic lymphocytic leukaemia cells are efficiently killed by an anti-CD20 monoclonal antibody selected for improved engagement of FcγRIIIA/CD16

(2008) Christophe de Romeuf et al.   BRITISH JOURNAL OF HAEMATOLOGY

Engineered Antibodies of IgG1/IgG3 Mixed Isotype with Enhanced Cytotoxic Activities

(2008) A. Natsume et al.   CANCER RESEARCH

When binding is enough: nonactivating antibody formats

(2008) Aran F Labrijn et al.   CURRENT OPINION IN IMMUNOLOGY

Terminal sugars of Fc glycans influence antibody effector functions of IgGs

(2008) T Shantha Raju   CURRENT OPINION IN IMMUNOLOGY

Considerations for the development of therapeutic monoclonal antibodies

(2008) Patrick G Swann et al.   CURRENT OPINION IN IMMUNOLOGY

Editorial [Hot Topic: Therapeutic Antibodies and Derivatives: From the Bench to the Clinic(Guest Editor: Alain Beck)]

(2008) A. Beck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Development of Novel Protein Scaffolds as Alternatives to Whole Antibodies for Imaging and Therapy: Status on Discovery Research and Clinical Validation

(2008) T. Wurch et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Monoclonal Antibodies - Regulatory Challenges

(2008) Christian Schneider   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Development and Production of Commercial Therapeutic Monoclonal Antibodies in Mammalian Cell Expression Systems: An Overview of the Current Upstream Technologies

(2008) Michel Chartrain et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Monoclonal Antibodies as Innovative Therapeutics

(2008) Janice Reichert   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Trends in Glycosylation, Glycoanalysis and Glycoengineering of Therapeutic Antibodies and Fc-Fusion Proteins

(2008) Alain Beck et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

(2008) J. Vlasak et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

DARPins: A new generation of protein therapeutics

(2008) Michael T. Stumpp et al.   DRUG DISCOVERY TODAY

The effect of Fc glycan forms on human IgG2 antibody clearance in humans

(2008) X. Chen et al.   GLYCOBIOLOGY

Human IgG2 Antibodies Display Disulfide-mediated Structural Isoforms

(2008) Jette Wypych et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural and Functional Characterization of Disulfide Isoforms of the Human IgG2 Subclass

(2008) Thomas M. Dillon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The way forward, enhanced characterization of therapeutic antibody glycosylation: Comparison of three level mass spectrometry-based strategies

(2008) Elsa Wagner-Rousset et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Germline Humanization of a Non-human Primate Antibody that Neutralizes the Anthrax Toxin, by in Vitro and in Silico Engineering

(2008) Thibaut Pelat et al.   JOURNAL OF MOLECULAR BIOLOGY

Early drug development of inhibitors of the insulin-like growth factor-I receptor pathway: Lessons from the first clinical trials

(2008) J. Rodon et al.   MOLECULAR CANCER THERAPEUTICS

Toward biosimilar monoclonal antibodies

(2008) Christian K Schneider et al.   NATURE BIOTECHNOLOGY

Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index

(2008) Jagath R Junutula et al.   NATURE BIOTECHNOLOGY

Economic issues with follow-on protein products

(2008) Michael Lanthier et al.   NATURE REVIEWS DRUG DISCOVERY

Cetuximab-Induced Anaphylaxis and IgE Specific for Galactose-α-1,3-Galactose

(2008) Christine H. Chung et al.   NEW ENGLAND JOURNAL OF MEDICINE

IMGT(R), the international ImMunoGeneTics information system(R)

(2008) M.-P. Lefranc et al.   NUCLEIC ACIDS RESEARCH

Heterosubtypic Neutralizing Monoclonal Antibodies Cross-Protective against H5N1 and H1N1 Recovered from Human IgM+ Memory B Cells

(2008) Mark Throsby et al.   PLoS One