Stable IgG-like Bispecific Antibodies Directed toward the Type I Insulin-like Growth Factor Receptor Demonstrate Enhanced Ligand Blockade and Anti-tumor Activity
Published 2010 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Stable IgG-like Bispecific Antibodies Directed toward the Type I Insulin-like Growth Factor Receptor Demonstrate Enhanced Ligand Blockade and Anti-tumor Activity
Authors
Keywords
-
Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 286, Issue 6, Pages 4703-4717
Publisher
American Society for Biochemistry & Molecular Biology (ASBMB)
Online
2010-12-02
DOI
10.1074/jbc.m110.184317
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Discovery of Fully Human Anti-MET Monoclonal Antibodies with Antitumor Activity against Colon Cancer Tumor Models In Vivo
- (2015) Edward Htun van der Horst et al. NEOPLASIA
- Sym004: A Novel Synergistic Anti-Epidermal Growth Factor Receptor Antibody Mixture with Superior Anticancer Efficacy
- (2010) M. W. Pedersen et al. CANCER RESEARCH
- The trifunctional antibody catumaxomab for the treatment of malignant ascites due to epithelial cancer: Results of a prospective randomized phase II/III trial
- (2010) Markus M. Heiss et al. INTERNATIONAL JOURNAL OF CANCER
- Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTβR
- (2010) Jennifer S. Michaelson et al. mAbs
- Neutralization ofClostridium difficiletoxin A using antibody combinations
- (2010) Stephen J. Demarest et al. mAbs
- Combination of Two Insulin-Like Growth Factor-I Receptor Inhibitory Antibodies Targeting Distinct Epitopes Leads to an Enhanced Antitumor Response
- (2010) J. Dong et al. MOLECULAR CANCER THERAPEUTICS
- Stability engineering of scFvs for the development of bispecific and multivalent antibodies
- (2010) Brian R. Miller et al. PROTEIN ENGINEERING DESIGN & SELECTION
- Strongly Enhanced Antitumor Activity of Trastuzumab and Pertuzumab Combination Treatment on HER2-Positive Human Xenograft Tumor Models
- (2009) W. Scheuer et al. CANCER RESEARCH
- Antibody Protection against Botulinum Neurotoxin Intoxication in Mice
- (2009) L. W. Cheng et al. INFECTION AND IMMUNITY
- Characterization of Inhibitory Anti-insulin-like Growth Factor Receptor Antibodies with Different Epitope Specificity and Ligand-blocking Properties
- (2009) Adam Doern et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Design and Characterization of Oligospecific Antibodies for Simultaneous Targeting of Multiple Disease Mediators
- (2009) Nazzareno Dimasi et al. JOURNAL OF MOLECULAR BIOLOGY
- Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules
- (2009) Jacob L. Jordan et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Insulin-Like Growth Factor 1 Receptor Targeted Therapeutics: Novel Compounds and Novel Treatment Strategies for Cancer Medicine
- (2009) Madeleine Hewish et al. Recent Patents on Anti-Cancer Drug Discovery
- Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site
- (2009) J. Bostrom et al. SCIENCE
- Enhancement of transient gene expression and culture viability using Chinese hamster ovary cells overexpressing Bcl-xL
- (2008) Brian S. Majors et al. BIOTECHNOLOGY AND BIOENGINEERING
- Targeting ErbB2 and ErbB3 with a bispecific single-chain Fv enhances targeting selectivity and induces a therapeutic effect in vitro
- (2008) M K Robinson et al. BRITISH JOURNAL OF CANCER
- Targeting insulin and insulin-like growth factor signalling in oncology
- (2008) Michael Pollak CURRENT OPINION IN PHARMACOLOGY
- E2F-1 overexpression increases viable cell density in batch cultures of Chinese hamster ovary cells
- (2008) Brian S. Majors et al. JOURNAL OF BIOTECHNOLOGY
- Thermodynamically Stable Aggregation-Resistant Antibody Domains through Directed Evolution
- (2008) Kristoffer Famm et al. JOURNAL OF MOLECULAR BIOLOGY
- Conserved amino acid networks involved in antibody variable domain interactions
- (2008) Norman Wang et al. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
- Tumor Regression in Cancer Patients by Very Low Doses of a T Cell-Engaging Antibody
- (2008) R. Bargou et al. SCIENCE
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started