Belimumab restores Treg/Th17 balance in patients with refractory systemic lupus erythematosus

Sirolimus in patients with clinically active systemic lupus erythematosus resistant to, or intolerant of, conventional medications: a single-arm, open-label, phase 1/2 trial

(2018) Zhi-Wei Lai et al.   LANCET

Blockade of Treg Cell Differentiation and Function by the Interleukin-21-Mechanistic Target of Rapamycin Axis Via Suppression of Autophagy in Patients With Systemic Lupus Erythematosus

(2018) Hiroshi Kato et al.   Arthritis & Rheumatology

Belimumab use, clinical outcomes and glucocorticoid reduction in patients with systemic lupus erythematosus receiving belimumab in clinical practice settings: results from the OBSErve Canada Study

(2017) Zahi Touma et al.   RHEUMATOLOGY INTERNATIONAL

mTORC1 and mTORC2 Kinase Signaling and Glucose Metabolism Drive Follicular Helper T Cell Differentiation

(2016) Hu Zeng et al.   IMMUNITY

Success and failure of biological treatment in systemic lupus erythematosus: A critical analysis

(2016) Mariele Gatto et al.   JOURNAL OF AUTOIMMUNITY

Effects of Belimumab on Flare Rate and Expected Damage Progression in Patients With Active Systemic Lupus Erythematosus

(2016) Luca Iaccarino et al.   ARTHRITIS CARE & RESEARCH

In vivoregulation of gene expression and T helper type 17 differentiation by RORγt inverse agonists

(2015) Jill Skepner et al.   IMMUNOLOGY

Editorial: The BAFFling Immunology of Systemic Lupus Erythematosus: Beyond B Cells

(2015) William Stohl   Arthritis & Rheumatology

Th17 cells in autoimmune diseases

(2015) Lei Han et al.   Frontiers of Medicine

Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation

(2014) Seung-ye Baek et al.   ACTA PHARMACOLOGICA SINICA

Mechanistic Target of Rapamycin Complex 1 Expands Th17 and IL-4+ CD4-CD8- Double-Negative T Cells and Contracts Regulatory T Cells in Systemic Lupus Erythematosus

(2014) H. Kato et al.   JOURNAL OF IMMUNOLOGY

The BAFF/APRIL system: Emerging functions beyond B cell biology and autoimmunity

(2013) Fabien B. Vincent et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Th17 Cells

(2012) Mohan S. Maddur et al.   AMERICAN JOURNAL OF PATHOLOGY

Belimumab in the treatment of systemic lupus erythematosus: high disease activity predictors of response

(2012) Ronald F van Vollenhoven et al.   ANNALS OF THE RHEUMATIC DISEASES

Derivation and validation of the Systemic Lupus International Collaborating Clinics classification criteria for systemic lupus erythematosus

(2012) Michelle Petri et al.   ARTHRITIS AND RHEUMATISM

N-acetylcysteine reduces disease activity by blocking mammalian target of rapamycin in T cells from systemic lupus erythematosus patients: A randomized, double-blind, placebo-controlled trial

(2012) Zhi-Wei Lai et al.   ARTHRITIS AND RHEUMATISM

Balance between Regulatory T and Th17 Cells in Systemic Lupus Erythematosus: The Old and the New

(2012) Alessia Alunno et al.   Clinical & Developmental Immunology

Imbalance between Th17 and regulatory T-cells in systemic lupus erythematosus

(2012) Weronika Kleczynska et al.   FOLIA HISTOCHEMICA ET CYTOBIOLOGICA

A phase III, randomized, placebo-controlled study of belimumab, a monoclonal antibody that inhibits B lymphocyte stimulator, in patients with systemic lupus erythematosus

(2011) Richard Furie et al.   ARTHRITIS AND RHEUMATISM

Disturbed Th1, Th2, Th17 and Treg balance in patients with systemic lupus erythematosus

(2011) Sebastian Dolff et al.   CLINICAL IMMUNOLOGY

Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial

(2011) Sandra V Navarra et al.   LANCET

Elevated Th17 cells are accompanied by FoxP3+ Treg cells decrease in patients with lupus nephritis

(2011) Qian Xing et al.   RHEUMATOLOGY INTERNATIONAL

The cytokine milieu in the interplay of pathogenic Th1/Th17 cells and regulatory T cells in autoimmune disease

(2010) Stewart Leung et al.   Cellular & Molecular Immunology

The imbalance between regulatory and IL-17-secreting CD4+ T cells in lupus patients

(2010) Jilin Ma et al.   CLINICAL RHEUMATOLOGY

Plasma IL-17A Is Increased in New-Onset SLE Patients and Associated with Disease Activity

(2010) Xiao Qi Chen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus

(2010) Kamini Shah et al.   ARTHRITIS RESEARCH & THERAPY

Frequency and determinants of flare and persistently active disease in systemic lupus erythematosus

(2009) Mandana Nikpour et al.   ARTHRITIS AND RHEUMATISM

Th17 and natural Treg cell population dynamics in systemic lupus erythematosus

(2009) Ji Yang et al.   ARTHRITIS AND RHEUMATISM

IL-21 and T follicular helper cells

(2009) R. Spolski et al.   INTERNATIONAL IMMUNOLOGY

Dysfunctional CD4+,CD25+ regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-α–producing antigen-presenting cells

(2008) Bing Yan et al.   ARTHRITIS AND RHEUMATISM

Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: Implications for Th17-mediated inflammation in auto-immunity

(2008) Chun Kwok Wong et al.   CLINICAL IMMUNOLOGY

Quantitative and qualitative deficiencies of regulatory T cells in patients with systemic lupus erythematosus (SLE)

(2008) M. Bonelli et al.   INTERNATIONAL IMMUNOLOGY

Changing Patterns in Mortality and Disease Outcomes for Patients with Systemic Lupus Erythematosus

(2008) Murray B. Urowitz et al.   JOURNAL OF RHEUMATOLOGY

Altered frequency and migration capacity of CD4+CD25+ regulatory T cells in systemic lupus erythematosus

(2008) H.-Y. Lee et al.   RHEUMATOLOGY