Review
Immunology
Zhending Gan, Meiyu Zhang, Donghui Xie, Xiaoyan Wu, Changming Hong, Jian Fu, Lijuan Fan, Shengyi Wang, Sufang Han
Summary: Glycine, acting as an inhibitory neurotransmitter, not only affects the functions of macrophages but also shapes their polarization through cellular signaling pathways and microRNAs. Additionally, glycine has beneficial effects in preventing and treating macrophage-associated diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Fisheries
Yeojin Hong, Jiae Lee, Thi Hao Vu, Sooyeon Lee, Hyun S. Lillehoj, Yeong Ho Hong
Summary: This study demonstrates the immunoregulatory functions of LPS-activated exosomes in chicken immune systems, enhancing gene expression of cytokines and chemokines and inducing the MyD88/NF-kappa B signaling pathway to regulate immune responses. In the future, LPS-stimulated exosomes may be utilized as an immune stimulator.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
LiNa Wang, Ming Dong, DongMei Shi, CaiHui Yang, Shuo Liu, Lu Gao, WeiDong Niu
Summary: In chronic apical periodontitis, PI3K plays a role in bone destruction by regulating the proliferation and differentiation of osteoclasts and osteoblasts.
Article
Biochemistry & Molecular Biology
Shih-Ming Ou, Yin-Chieh Hsu, Shu-Ling Fu, Lie-Chwen Lin, Chao-Hsiung Lin
Summary: Galgravin has anti-inflammatory effects, it can suppress NF-kappa B activation and reduce the expression of proinflammatory molecules, suggesting its potential application in inflammation diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Yong Zhang, Jingshu Tang, Yujun Zhou, Qiong Xiao, Qiuyu Chen, Hongyue Wang, Jiaqi Lan, Lei Wu, Ying Peng
Summary: The pharmacological activity of dimethyl fumarate (DMF) in treating psoriasis and multiple sclerosis (MS) is not fully understood. DMF is hydrolysed to monomethyl fumarate (MMF) in vivo, which is believed to account for the therapeutic effects of DMF. However, previous studies have provided evidence that DMF also enters the circulation. Given that DMF is short-lived in the blood, whether DMF has a therapeutic impact is still unclear.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Food Science & Technology
Guohua Zhang, Xianghui Yan, Jiaheng Xia, Zhihong Zhang, Dongsheng Wang, Ping Sheng, Ping Yu, Zheling Zeng
Summary: This study aimed to investigate the anti-inflammatory activity of ethanol extracts (EE) of C. camphora seed and the changes after digestion and hydrolysis. The results showed that EE, digested ethanol extracts (dEE), and hydrolysed ethanol extracts (hEE) exhibited cell protection function and significantly reduced pro-inflammatory mediators and cytokines secretion and expression. Although the anti-inflammatory activity of EE was decreased, most of it was retained after digestion and hydrolysis. The findings suggest that the anti-inflammatory activity of EE is relatively stable and may facilitate the processing and consumption of related products.
Article
Plant Sciences
Mengran Zhao, Chen Qiao, Zilu Cui, Wen Zhang, Shuyue Yang, Congmin Zhu, Feng Du, Tingting Ning, Sian Xie, Si Liu, Peng Li, Junxuan Xu, Shengtao Zhu
Summary: This study demonstrates that Moluodan (MLD) has an obvious hemostatic effect but exacerbates the severity of inflammation in a mouse model of colitis by promoting macrophage polarization towards the M1 phenotype.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Stamatia Papoutsopoulou, Lorna Morris, Andrew Bayliff, Thomas Mair, Hazel England, Massimiliano Stagi, Francois Bergey, Mohammad Tauqeer Alam, Raheleh Sheibani-Tezerji, Philip Rosenstiel, Werner Muller, Vitor A. P. Martins Dos Santos, Barry J. Campbell
Summary: The NF kappa B transcription factors play a crucial role in innate immune responses and their dysregulation is associated with inflammatory diseases. In this study, the introduction of human RelA protein into mouse cells was shown to impact murine gene transcription, affecting both NF kappa B and non-NF kappa B target genes, and interfering with interferon and cytokine signaling pathways.
Article
Pharmacology & Pharmacy
Ziyang Sun, Juehong Li, Gang Luo, Weixuan Liu, Yunwei He, Feiyan Wang, Yun Qian, Cunyi Fan
Summary: This study reveals that metformin can effectively attenuate trauma-induced heterotopic ossification by mitigating macrophage inflammatory responses through inhibiting NF-kappa B signaling via SIRT1-dependent mechanisms. These findings provide novel insights for future therapeutic investigations in trauma-related diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Limin Yin, Chaohong Shi, Zhongchen Zhang, Wensheng Wang, Ming Li
Summary: This study found that FC can inhibit the production of inflammatory mediators, such as nitric oxide and prostaglandin, while also suppressing the expression of iNOS and COX-2. FC was able to block the LPS-induced expression and release of TNF-α, IL-1β, and IL-6 by downregulating the IκB kinase, IκB, and p65/NF-κB pathway. These results suggest that FC has anti-inflammatory properties and may be a potential agent for treating inflammation-associated disorders.
KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY
(2021)
Article
Cell Biology
Aihong Gao, Yu Wang, Xiao Gao, Wei Tian
Summary: LCZ696 attenuates LPS-induced endothelial dysfunction by reducing oxidative stress and inhibiting pro-inflammatory cytokines. It also prevents cell adhesion and nuclear translocation of inflammatory factors.
Article
Biochemistry & Molecular Biology
Ji Cao, Qian Li, Xuehuai Shen, Yao Yao, Longlong Li, Haitian Ma
Summary: DHEA suppresses inflammatory responses through the activation of Nrf2 and inhibition of NF-kappa B in LPS-stimulated macrophages.
MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Yun Tang, Chan Wang, Shasha Chen, Li Li, Xiang Zhong, Jiong Zhang, Yunlin Feng, Lin Wang, Jie Chen, Meidie Yu, Fang Wang, Li Wang, Guisen Li, Yarong He, Yi Li
Summary: This study elucidated the immunomodulatory role of dimethyl fumarate (DMF) in lipopolysaccharide (LPS)-induced septic acute kidney injury (AKI). DMF attenuated renal dysfunction and murine pathological kidney injury by suppressing macrophage activation and phosphorylation of NF-kappa B p65. The findings suggest the potential therapeutic role of DMF for patients in ICU threatened by septic AKI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Immunology
Jingjing Wang, Zhikai Wu, Xingyi Zhu, Peixuan Li, Yiwu Fu, Xia Wang, Youpeng Sun, Ershun Zhou, Zhengtao Yang
Summary: The study demonstrates the important regulatory roles of LSD1 in LPS-induced mastitis and the inhibitory effects of GSK-LSD1 on LSD1 activity, leading to reduced inflammatory response and tissue damage. The inhibition of LSD1 results in increased histone H3K4me2 and H3K9me2 levels, and suppression of NF-kappa B signaling and cytokine production in mammary gland. These findings suggest LSD1 as a potential regulator of inflammation and provide insights into epigenetic control mechanisms in inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
He Fang, Xingtong Wang, Mahendra Damarla, Rongju Sun, Qingli He, Ruojing Li, Pengfei Luo, Jun O. Liu, Zhaofan Xia
Summary: Sepsis is a severe complication with no effective treatment, but this study found that dimethyl fumarate (DMF) can inhibit sepsis, improve survival rate, and reduce inflammation, suggesting that DMF has the potential to be repurposed as a new treatment for sepsis.
MEDIATORS OF INFLAMMATION
(2023)
Article
Chemistry, Applied
M. J. Germano, M. D. Munoz, M. C. Della-Vedova, G. E. Feresin, M. Rinaldi-Tosi, R. D. Enriz, D. C. Ramirez, F. A. Giannini
Summary: The study evaluated the antioxidant and anti-inflammatory activity of waste product from wine production, finding that extracts from Syrah grape had high levels of total phenols and flavonoids, as well as strong antioxidant and anti-inflammatory effects.
NATURAL PRODUCT RESEARCH
(2021)
Article
Cell Biology
Hala Chaaban, Kathryn Burge, Jeffrey Eckert, Ravi S. Keshari, Robert Silasi, Cristina Lupu, Barbara Warner, Marilyn Escobedo, Michael Caplan, Florea Lupu
Summary: Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease primarily affecting premature infants, and NETs play a critical role in the innate immune defense against NEC. However, treatment with the NET inhibitor chloramidine in a murine NEC model resulted in increased systemic inflammation, bacterial load, organ injury, and mortality.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Microbiology
Narcis Popescu, Ravi S. Keshari, Jackie Cochran, K. Mark Coggeshall, Florea Lupu
Review
Cell Biology
Florea Lupu, Gary Kinasewitz, Kenneth Dormer
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2020)
Article
Hematology
Ravi S. Keshari, Robert Silasi, Narcis Popescu, Girija Regmi, Hala Chaaban, John D. Lambris, Cristina Lupu, Tom E. Mollnes, Florea Lupu
Summary: The study explored the effect of CD14 blockade on sepsis-induced coagulopathy, inflammation, organ dysfunction, and mortality. The results showed that anti-CD14 treatment reduced coagulation activation, enhanced fibrinolysis, decreased pro-inflammatory cytokines, and significantly improved survival outcomes in the baboon model of lethal E. coli sepsis.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Chemistry, Medicinal
Zili Zhai, Prasanna K. Vaddi, Jenny Mae Samson, Tomoya Takegami, Mayumi Fujita
Summary: The NLRP1 protein is a downstream effector of the MAPK/ERK signaling pathway in metastatic melanoma cells, regulated by ATF4. While in parental cells, regulation of NLRP1 by MAPK/ERK pathway is through RSK2, drug-resistant cells use the cAMP/PKA pathway to redirect ATF4/NLRP1. Targeting NLRP1 may improve the therapeutic efficacy of targeted therapy in melanoma, as demonstrated by reduced cell growth and colony formation in drug-resistant cells upon NLRP1 silencing.
Article
Biochemistry & Molecular Biology
Yizhi Jiang, Yaqiong Tang, Christopher Hoover, Yuji Kondo, Dongping Huang, Damien Restagno, Bojing Shao, Liang Gao, J. Michael McDaniel, Meixiang Zhou, Robert Silasi-Mansat, Samuel McGee, Miao Jiang, Xia Bai, Florea Lupu, Changgeng Ruan, Jamey D. Marth, Depei Wu, Yue Han, Lijun Xia
Summary: The study found that CLEC4F is a key receptor on Kupffer cells in the liver that mediates the phagocytosis of desialylated platelets. This discovery provides new insights into the pathogenesis of thrombocytopenia in disease conditions like sepsis.
CELL DEATH AND DIFFERENTIATION
(2021)
Review
Biochemistry & Molecular Biology
Cristina Lupu, Maulin M. Patel, Florea Lupu
Summary: ADTRP is an androgen-inducible protein that regulates the expression and activity of inhibitors in the coagulation pathway, associated with cardiovascular diseases and thrombosis, and plays a role in artery protection. Additionally, ADTRP maintains vascular integrity and function through regulation of matrix metalloproteinase-9.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Cristina Puy, Jiaqing Pang, Stephanie E. Reitsma, Christina U. Lorentz, Erik Tucker, David Gailani, Andras Gruber, Florea Lupu, Owen J. T. McCarty
Summary: The study found that FXIa directly interacts with CFH and neutralizes CFH by cleaving the R341/R342 bonds, reducing its function and enhancing the activity of the complement system. Additionally, the generation of FXIa promotes the cleavage of CFH in plasma. These results reveal a novel link between the contact pathway of coagulation and the complement system.
JOURNAL OF IMMUNOLOGY
(2021)
Article
Nutrition & Dietetics
Hala Chaaban, Kathryn Burge, Jeffrey Eckert, MaJoi Trammell, David Dyer, Ravi S. Keshari, Robert Silasi, Girija Regmi, Cristina Lupu, Misty Good, Steven J. McElroy, Florea Lupu
Summary: In this study, it was found that oral supplementation of HA 35 KDa to mouse pups led to increased intestinal epithelial cell proliferation, as well as the development of Paneth cells and goblet cell subsets. Additionally, HA 35 KDa impacted the composition of the intestinal microbiota, suggesting potential implications for further research.
Article
Chemistry, Medicinal
Dinoop Ravindran Menon, Yang Li, Takeshi Yamauchi, Douglas Grant Osborne, Prasanna Kumar Vaddi, Michael F. Wempe, Zili Zhai, Mayumi Fujita
Summary: This study demonstrates that EGCG enhances anti-tumor immune responses by inhibiting JAK-STAT signaling in melanoma. It could be used as an alternative treatment strategy to target the PD-L1/PD-L2-PD-1 axis in cancers.
Review
Oncology
Takeshi Yamauchi, Sarah Shangraw, Zili Zhai, Dinoop Ravindran Menon, Nisha Batta, Robert P. Dellavalle, Mayumi Fujita
Summary: Studying social-environmental risk factors associated with melanoma is crucial for improving public health initiatives and patient outreach and education methods.
Article
Cell Biology
C. Hemakumar, B. S. Ravindranath, G. A. Ravishankar, D. C. Ramirez, S. V. Kiran
Summary: Through computational analysis, marmesin and marmelosin were found to be potential inhibitors in bael fruit extract, which interact with human heparan sulfatase-2 (HSULF-2) overexpressed on the surface of cancer cells, inhibiting its activity and killing breast tumor cells.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2023)
Article
Immunology
Prasanna Kumar Vaddi, Douglas Grant Osborne, Andrew Nicklawsky, Nazanin K. Williams, Dinoop Ravindran Menon, Derek Smith, Jonathan Mayer, Anna Reid, Joanne Domenico, Giang Huong Nguyen, William A. Robinson, Melanie Ziman, Dexiang Gao, Zili Zhai, Mayumi Fujita
Summary: CTLA-4 expression is downregulated in metastatic melanoma, leading to worse prognosis and patient survival. Treg cells are responsible for the decreased CTLA-4 expression, which is confirmed by lower CTLA-4 surface protein expression in Treg cells of metastatic melanoma patients. Mechanistically, miRNA-155 downregulates CTLA4 mRNA post-transcriptionally and upregulates FOXP3 expression in Treg cells. Targeting miRNA-155 or other factors involved in CTLA4 regulation in Treg cells could improve the efficacy of immunotherapy in melanoma.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Oncology
Zili Zhai, Takeshi Yamauchi, Sarah Shangraw, Vincent Hou, Akiko Matsumoto, Mayumi Fujita
Summary: Acetaldehyde (AcAH), a carcinogenic byproduct of ethanol metabolism, has been linked to the development of malignancies in the upper gastrointestinal tract as well as cutaneous melanoma. This review examines the sources of ethanol and AcAH in the skin, their metabolic pathways, and the role of dysfunctional ethanol and AcAH metabolizing enzymes in melanoma development and progression. Data analysis also shows reduced activity of alcohol and AcAH metabolizing enzymes in melanoma tissues.
Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Yujia Xue, Anqi Zhou, Ying Chen, Yifei Chen, Xiulian Miao, Fangqiao Lv
Summary: BRG1 plays an important role in HSC-myofibroblast transition and targeting it could be a reasonable strategy for liver fibrosis intervention.
Article
Medicine, Research & Experimental
Liu Ye, Beibei Liu, Jingling Huang, Xiaolin Zhao, Yuan Wang, Yungen Xu, Shuping Wang
Summary: Doublecortin-like kinase 1 (DCLK1) is a significant prooncogenic factor that is strongly associated with the malignant progression and clinical prognosis of various cancers. DCLK1 plays important roles in stem cell marker regulation, tumor cell reprogramming, and immune evasion. However, the exact biological functions of DCLK1, especially the disparities between its alpha- and beta-form transcripts in cancer progression, remain ambiguous.
Article
Medicine, Research & Experimental
Jiahui Yang, Xiaoyu Chen, Tianjing Liu, Yongyan Shi
Summary: This article reviews the role of bile acids in necrotizing enterocolitis (NEC) and their potential therapeutic value. The dysregulation of bile acids is associated with intestinal injury, and inflammatory factors in the liver also play a crucial role in regulating bile acid transport. The bile acid metabolic pathway is important for regulating intestinal microbiota, cell proliferation, and barrier protection.
Review
Medicine, Research & Experimental
Zhenzheng Zhu, Yuemiao Xu, Yuwei Xia, Xinru Jia, Yixin Chen, Yuyue Liu, Leyin Zhang, Hui Chai, Leitao Sun
Summary: Bile acid, as the final product of cholesterol breakdown, plays a complex regulatory and signaling role in human metabolism. Research suggests that it has the potential to enhance metabolism and regulate chronic metabolic diseases through various pathways. The interaction between bile acid and gut microbiota is also of great significance.
Article
Medicine, Research & Experimental
Xin He, Hong-Xu Zhou, Xian Fu, Kai-Di Ni, Ai-Zhi Lin, Ling-Tong Zhang, Hou-Hua Yin, Qing Jiang, Xue Zhou, Yi-Wen Meng, Jun-Yan Liu
Summary: DON exposure causes an increase in deoxycholic acid (DCA), which contributes to intestinal injury. DCA may be a potential therapeutic target for DON enterotoxicity.
Article
Medicine, Research & Experimental
Zhitao Wang, Heng Ma, Abdul Nasir, Sufang Liu, Zhisong Li, Feng Tao, Qian Bai
Summary: This study reveals the involvement of TET1-mediated epigenetic regulation in chronic TMJ pain through trigeminal TNF alpha signaling.
Article
Medicine, Research & Experimental
Lu Yu, Hao Ran, Yaru Lu, Qian Ma, Huan Huang, Weibin Liu
Summary: This study found that the HIF-1 alpha inhibitor BAY 87-2243 can alleviate the symptoms of the Experimental Autoimmune Myasthenia Gravis (EAMG) inflammation model. BAY 87-2243 can restore the balance of CD4(+)T cell subsets, reduce the production of pro-inflammatory cytokines, and act as both an immune imbalance regulator and anti-inflammatory.
Article
Medicine, Research & Experimental
Alex Peralvarez-Marin, Montse Sole, Judith Serrano, Alice Taddeucci, Belen Perez, Clara Penas, Gemma Manich, Marcel Jimenez, Pilar D'Ocon, Francesc Jimenez-Altayo
Summary: This study provides the first evidence that TRPV2 channels may modulate vascular tone by balancing opposing inputs from the endothelium and smooth muscle, leading to net vasodilation. The amplification of TRPV2 channel-induced activity by NO emphasizes the pathophysiological relevance of these findings.
Article
Medicine, Research & Experimental
Amin Ullah, Jing Zhao, Jiakun Li, Rajeev K. Singla, Bairong Shen
Summary: Gastric cancer is the fifth-most prevalent and second-most deadly cancer worldwide. Late onset of symptoms makes early detection important. CXC chemokines play an important role in the pathological process of gastric cancer, but their exact role in diagnosis and prognosis is not fully understood. Inhibiting CXC chemokines shows promise as a targeted therapy.
Article
Medicine, Research & Experimental
Menna S. Zeyada, Salma M. Eraky, Mamdouh M. El-Shishtawy
Summary: The current study demonstrates the prophylactic and antifibrotic effects of Trig against BLM-induced PF by targeting multiple signaling pathways. The combination of Trig and Pirf may be a promising approach to enhance Pirf's anti-fibrotic effect.