The STAT3 inhibitor S3I-201 suppresses fibrogenesis and angiogenesis in liver fibrosis

Transforming Growth Factor-β (TGF-β) Directly Activates the JAK1-STAT3 Axis to Induce Hepatic Fibrosis in Coordination with the SMAD Pathway

(2017) Liu-Ya Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TGF-β signalling and liver disease

(2016) Isabel Fabregat et al.   FEBS Journal

Pathobiology of liver fibrosis: a translational success story

(2015) Youngmin A Lee et al.   GUT

Hepatic fibrosis: Concept to treatment

(2015) Christian Trautwein et al.   JOURNAL OF HEPATOLOGY

STAT3 selectively interacts with Smad3 to antagonize TGF-β

(2015) G Wang et al.   ONCOGENE

Correction: Brivanib Attenuates Hepatic Fibrosis In Vivo and Stellate Cell Activation In Vitro by Inhibition of FGF, VEGF and PDGF Signaling

(2015) Ikuo Nakamura et al.   PLoS One

Sorafenib and its derivative SC-1 exhibit antifibrotic effects through signal transducer and activator of transcription 3 inhibition

(2015) Tung-Hung Su et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stat3 signaling activation crosslinking of TGF-β1 in hepatic stellate cell exacerbates liver injury and fibrosis

(2014) Ming-Yi Xu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Vascular Endothelial Growth Factor Promotes Fibrosis Resolution and Repair in Mice

(2014) Liu Yang et al.   GASTROENTEROLOGY

Effects of AG490 and S3I-201 on regulation of the JAK/STAT3 signaling pathway in relation to angiogenesis in TRAIL-resistant prostate cancer cells in vitro

(2014) VENHAR GURBUZ et al.   Oncology Letters

STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib

(2013) Yan-Ru Deng et al.   JOURNAL OF AUTOIMMUNITY

Erratum to “Clinical evidence for the regression of liver fibrosis” [J Hepatol 2012;56:1171–1180]

(2013) Elizabeth L. Ellis et al.   JOURNAL OF HEPATOLOGY

Probiotic Yeast Inhibits VEGFR Signaling and Angiogenesis in Intestinal Inflammation

(2013) Xinhua Chen et al.   PLoS One

Signal Transducer and Activator of Transcription 3 in Liver Diseases: A Novel Therapeutic Target

(2012) Hua Wang et al.   International Journal of Biological Sciences

A histone deacetylase inhibitor, largazole, decreases liver fibrosis and angiogenesis by inhibiting transforming growth factor-β and vascular endothelial growth factor signalling

(2012) Yuqing Liu et al.   LIVER INTERNATIONAL

Inhibition of PDGF, TGF-β, and Abl signaling and reduction of liver fibrosis by the small molecule Bcr-Abl tyrosine kinase antagonist Nilotinib

(2011) Yuqing Liu et al.   JOURNAL OF HEPATOLOGY

Lack of Glycoprotein 130/Signal Transducer and Activator of Transcription 3-Mediated Signaling in Hepatocytes Enhances Chronic Liver Injury and Fibrosis Progression in a Model of Sclerosing Cholangitis

(2010) Werner Plum et al.   AMERICAN JOURNAL OF PATHOLOGY

Drug Combination Studies and Their Synergy Quantification Using the Chou-Talalay Method

(2010) T.-C. Chou   CANCER RESEARCH

Signal Transducer and Activator of Transcription 3 Protects From Liver Injury and Fibrosis in a Mouse Model of Sclerosing Cholangitis

(2010) Markus Mair et al.   GASTROENTEROLOGY

Dissociation between liver inflammation and hepatocellular damage induced by carbon tetrachloride in myeloid cell-specific signal transducer and activator of transcription 3 gene knockout mice

(2010) Norio Horiguchi et al.   HEPATOLOGY

New insights into the antifibrotic effects of sorafenib on hepatic stellate cells and liver fibrosis

(2010) Yan Wang et al.   JOURNAL OF HEPATOLOGY

A novel STAT3 inhibitor, S3I-201, attenuates renal interstitial fibroblast activation and interstitial fibrosis in obstructive nephropathy

(2010) Maoyin Pang et al.   KIDNEY INTERNATIONAL

Chemokines in Liver Inflammation and Fibrosis

(2010) Hermann Wasmuth et al.   SEMINARS IN LIVER DISEASE

Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways

(2009) Joy X. Jiang et al.   JOURNAL OF HEPATOLOGY

Therapeutic targeting of the PDGF and TGF-β-signaling pathways in hepatic stellate cells by PTK787/ZK22258

(2009) Yuqing Liu et al.   LABORATORY INVESTIGATION

The STAT3 inhibitor NSC 74859 is effective in hepatocellular cancers with disrupted TGF-β signaling

(2009) L Lin et al.   ONCOGENE