Succinate dehydrogenase deficiency is associated with decreased 5-hydroxymethylcytosine production in gastrointestinal stromal tumors: implications for mechanisms of tumorigenesis

Immunohistochemical Loss of Succinate Dehydrogenase Subunit A (SDHA) in Gastrointestinal Stromal Tumors (GISTs) Signals SDHA Germline Mutation

(2013) Markku Miettinen et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Succinate Dehydrogenase-deficient Tumors

(2012) Justine A. Barletta et al.   ADVANCES IN ANATOMIC PATHOLOGY

Loss of SDHA Expression Identifies SDHA Mutations in Succinate Dehydrogenase–deficient Gastrointestinal Stromal Tumors

(2012) Trisha Dwight et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Predictors of Response to Targeted Therapies for Gastrointestinal Stromal Tumors

(2012) Andrea Marrari et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

SDHA loss of function mutations in a subset of young adult wild-type gastrointestinal stromal tumors

(2012) Antoine Italiano et al.   BMC CANCER

Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma

(2012) Christine Guo Lian et al.   CELL

Tet family proteins and 5-hydroxymethylcytosine in development and disease

(2012) L. Tan et al.   DEVELOPMENT

IDHmutations: new genetic signatures in cholangiocarcinoma and therapeutic implications

(2012) Darrell R Borger et al.   Expert Review of Anticancer Therapy

Inhibition of  -KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors

(2012) M. Xiao et al.   GENES & DEVELOPMENT

Loss of succinate dehydrogenase subunit B (SDHB) expression is limited to a distinctive subset of gastric wild-type gastrointestinal stromal tumours: a comprehensive genotype-phenotype correlation study

(2012) Leona A Doyle et al.   HISTOPATHOLOGY

C-KIT mutations were closely associated with the response to Imatinib in Chinese advanced gastrointestinal stromal tumor patients

(2012) Jing Gao et al.   MEDICAL ONCOLOGY

Loss of expression of SDHA predicts SDHA mutations in gastrointestinal stromal tumors

(2012) Andrew J Wagner et al.   MODERN PATHOLOGY

SDHA mutations in adult and pediatric wild-type gastrointestinal stromal tumors

(2012) Lindsey Oudijk et al.   MODERN PATHOLOGY

Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation

(2012) H Yang et al.   ONCOGENE

Alterations of metabolic genes and metabolites in cancer

(2012) Eric K. Oermann et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Succinate Dehydrogenase Subunit B (SDHB) Is Expressed in Neurofibromatosis 1-Associated Gastrointestinal Stromal Tumors (Gists): Implications for the SDHB Expression Based Classification of Gists

(2012) Jeanny H. Wang et al.   Journal of Cancer

A Distinct Pediatric-type Gastrointestinal Stromal Tumor in Adults

(2011) Maria A. Pantaleo et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

IDH1 and IDH2 mutations are frequent events in central chondrosarcoma and central and periosteal chondromas but not in other mesenchymal tumours

(2011) M Fernanda Amary et al.   JOURNAL OF PATHOLOGY

SDHA Loss-of-Function Mutations in KIT-PDGFRA Wild-Type Gastrointestinal Stromal Tumors Identified by Massively Parallel Sequencing

(2011) M. A. Pantaleo et al.   JNCI-Journal of the National Cancer Institute

Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome

(2011) Twinkal C Pansuriya et al.   NATURE GENETICS

The Common Feature of Leukemia-Associated IDH1 and IDH2 Mutations Is a Neomorphic Enzyme Activity Converting α-Ketoglutarate to 2-Hydroxyglutarate

(2010) Patrick S. Ward et al.   CANCER CELL

Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma

(2010) Houtan Noushmehr et al.   CANCER CELL

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2

(2010) Myunggon Ko et al.   NATURE

Defects in succinate dehydrogenase in gastrointestinal stromal tumors lacking KIT and PDGFRA mutations

(2010) K. A. Janeway et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gastrointestinal stromal tumors

(2010) Bernadette Liegl-Atzwanger et al.   VIRCHOWS ARCHIV

BRAFMutation Status in Gastrointestinal Stromal Tumors

(2009) Isabelle Hostein et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

V600E BRAF mutations are alternative early molecular events in a subset of KIT/PDGFRA wild-type gastrointestinal stromal tumours

(2009) A Agaimy et al.   JOURNAL OF CLINICAL PATHOLOGY

Inhibition of succinate dehydrogenase dysregulates histone modification in mammalian cells

(2009) Ana M Cervera et al.   Molecular Cancer

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Molecular Characterization of Pediatric Gastrointestinal Stromal Tumors

(2008) N. P. Agaram et al.   CLINICAL CANCER RESEARCH

Novel V600E BRAF mutations in imatinib-naive and imatinib-resistant gastrointestinal stromal tumors

(2008) Narasimhan P. Agaram et al.   GENES CHROMOSOMES & CANCER