Aging and HIV/AIDS: pathogenetic role of therapeutic side effects

Sarcopenia, obesity, and natural killer cell immune senescence in aging: Altered cytokine levels as a common mechanism

(2016) Charles T. Lutz et al.   Aging-US

Blocking protein farnesylation improves nuclear shape abnormalities in keratinocytes of mice expressing the prelamin A variant in Hutchinson-Gilford progeria syndrome

(2014) Yuexia Wang et al.   Nucleus

Inhibition of Telomerase Activity by Human Immunodeficiency Virus (HIV) Nucleos(t)ide Reverse Transcriptase Inhibitors: A Potential Factor Contributing to HIV-Associated Accelerated Aging

(2013) Edwin Leeansyah et al.   JOURNAL OF INFECTIOUS DISEASES

Telomerase inhibition may contribute to accelerated mitochondrial aging induced by anti-retroviral HIV treatment

(2013) F.M. Bollmann   MEDICAL HYPOTHESES

Age-Associated Changes in Monocyte and Innate Immune Activation Markers Occur More Rapidly in HIV Infected Women

(2013) Genevieve E. Martin et al.   PLoS One

Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice

(2012) Kati J. Ahlqvist et al.   Cell Metabolism

Life expectancy living with HIV

(2012) Fumiyo Nakagawa et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Human Immunodeficiency Virus Reverse Transcriptase: 25 Years of Research, Drug Discovery, and Promise

(2012) Stuart F. J. Le Grice   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of telomere length and homeostasis by telomerase enzyme processivity

(2012) Y. D'Souza et al.   JOURNAL OF CELL SCIENCE

HIV-1 Induces Telomerase Activity in Monocyte-Derived Macrophages, Possibly Safeguarding One of Its Reservoirs

(2012) R. Reynoso et al.   JOURNAL OF VIROLOGY

Antiviral Therapy Can Reverse the Development of Immune Senescence in Elderly Mice with Latent Cytomegalovirus Infection

(2012) M. Beswick et al.   JOURNAL OF VIROLOGY

In Vitro and Ex Vivo Inhibition of Human Telomerase by Anti-HIV Nucleoside Reverse Transcriptase Inhibitors (NRTIs) but Not by Non-NRTIs

(2012) Kyle R. Hukezalie et al.   PLoS One

Tolerability of HIV integrase inhibitors

(2012) Frederick J. Lee et al.   Current Opinion in HIV and AIDS

The use of HIV-1 integrase inhibitors in antiretroviral naive patients

(2012) Jeffrey L. Lennox   Current Opinion in HIV and AIDS

Sensitivity of Mitochondrial Transcription and Resistance of RNA Polymerase II Dependent Nuclear Transcription to Antiviral Ribonucleosides

(2012) Jamie J. Arnold et al.   PLoS Pathogens

Blocking farnesylation of the prelamin A variant in Hutchinson-Gilford progeria syndrome alters the distribution of A-type lamins

(2012) Yuexia Wang et al.   Nucleus

Editorial overview

(2011) Beatrix Grubeck-Loebenstein et al.   CURRENT OPINION IN IMMUNOLOGY

Ageing theories unified

(2011) Daniel P. Kelly   NATURE

Telomere dysfunction induces metabolic and mitochondrial compromise

(2011) Ergün Sahin et al.   NATURE

Epigenetic regulation of telomerase expression in HIV-1-specific CD8+ T cells

(2010) Katie Williams et al.   AIDS

Inhibition of telomerase activity alters tight junction protein expression and induces transendothelial migration of HIV-1-infected cells

(2010) Wen Huang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Immune senescence

(2010) Richard Aspinall et al.   CURRENT OPINION IN IMMUNOLOGY

Nucleoside reverse transcriptase inhibitor toxicity and mitochondrial DNA

(2010) Christopher A Koczor et al.   Expert Opinion on Drug Metabolism & Toxicology

Side effects of long-term oral antiviral therapy for hepatitis B

(2010) Robert J. Fontana   HEPATOLOGY

Treatment Outcomes of Clevudine versus Lamivudine at Week 48 in Naïve Patients with HBeAg Positive Chronic Hepatitis B

(2010) In Hee Kim et al.   JOURNAL OF KOREAN MEDICAL SCIENCE

Expression of NES-hTERT in Cancer Cells Delays Cell Cycle Progression and Increases Sensitivity to Genotoxic Stress

(2010) Olga A. Kovalenko et al.   PLoS One

Mitochondrial Telomerase Reverse Transcriptase Binds to and Protects Mitochondrial DNA and Function From Damage

(2009) Judith Haendeler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

(2009) Dao-Fu Dai et al.   CIRCULATION

Long-term therapy with clevudine for chronic hepatitis B can be associated with myopathy characterized by depletion of mitochondrial DNA

(2009) Jung Im Seok et al.   HEPATOLOGY

Clevudine Demonstrates Potent Antiviral Activity in Naïve Chronic Hepatitis B Patients

(2009) June Sung Lee et al.   INTERVIROLOGY

In VivoStoichiometry of Shelterin Components

(2009) Kaori K. Takai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy

(2009) James J Kohler et al.   LABORATORY INVESTIGATION

How Telomeres Solve the End-Protection Problem

(2009) T. de Lange   SCIENCE

Radical-free biology of oxidative stress

(2008) Dean P. Jones   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The many faces of telomerase: emerging extratelomeric effects

(2008) F. Mathias Bollmann   BIOESSAYS

Antiretroviral Treatment of Adult HIV Infection

(2008) Scott M. Hammer et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Distinct Mechanisms for Mitochondrial DNA Loss in T and B Lymphocytes from HIV‐Infected Patients Exposed to Nucleoside Reverse‐Transcriptase Inhibitors and Those Naive to Antiretroviral Treatment

(2008) Anne Maagaard et al.   JOURNAL OF INFECTIOUS DISEASES

Murine cardiac mtDNA: effects of transgenic manipulation of nucleoside phosphorylation

(2008) James J Kohler et al.   LABORATORY INVESTIGATION

Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging

(2008) Ignacio Varela et al.   NATURE MEDICINE

Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase   replication fidelity

(2008) Z. F. Pursell et al.   NUCLEIC ACIDS RESEARCH

The Impact of Purinergic Signaling on Renal Ischemia-Reperfusion Injury

(2008) Bo Lu et al.   TRANSPLANTATION