Human Immunodeficiency Virus Reverse Transcriptase: 25 Years of Research, Drug Discovery, and Promise

Reverse Transcriptase Inhibitors as Microbicides

(2012) Paul Lewi et al.   CURRENT HIV RESEARCH

Structural and Binding Analysis of Pyrimidinol Carboxylic Acid andN-Hydroxy Quinazolinedione HIV-1 RNase H Inhibitors

(2011) Eric B. Lansdon et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Mutagenesis of Human Immunodeficiency Virus Reverse Transcriptase p51 Subunit Defines Residues Contributing to Vinylogous Urea Inhibition of Ribonuclease H Activity

(2011) Suhman Chung et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis, Activity, and Structural Analysis of Novel α-Hydroxytropolone Inhibitors of Human Immunodeficiency Virus Reverse Transcriptase-Associated Ribonuclease H

(2011) Suhman Chung et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H

(2010) S. Chung et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

HIV-1 RT-Associated RNase H Function Inhibitors: Recent Advances in Drug Development

(2010) E. Tramontano et al.   CURRENT MEDICINAL CHEMISTRY

Structural Basis for the Inhibition of RNase H Activity of HIV-1 Reverse Transcriptase by RNase H Active Site-Directed Inhibitors

(2010) H.-P. Su et al.   JOURNAL OF VIROLOGY

Initiation complex dynamics direct the transitions between distinct phases of early HIV reverse transcription

(2010) Shixin Liu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Twenty-Six Years of Anti-HIV Drug Discovery: Where Do We Stand and Where Do We Go?

(2009) Youcef Mehellou et al.   JOURNAL OF MEDICINAL CHEMISTRY

HIV-1 Reverse Transcriptase Can Simultaneously Engage Its DNA/RNA Substrate at Both DNA Polymerase and RNase H Active Sites: Implications for RNase H Inhibition

(2009) Greg L. Beilhartz et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure of HIV-1 Reverse Transcriptase with the Inhibitor β-Thujaplicinol Bound at the RNase H Active Site

(2009) Daniel M. Himmel et al.   STRUCTURE

Vinylogous Ureas as a Novel Class of Inhibitors of Reverse Transcriptase-Associated Ribonuclease H Activity

(2008) Michaela Wendeler et al.   ACS Chemical Biology

Mutations M184V and Y115F in HIV-1 Reverse Transcriptase Discriminate against “Nucleotide-competing Reverse Transcriptase Inhibitors”

(2008) Maryam Ehteshami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dynamic binding orientations direct activity of HIV reverse transcriptase

(2008) Elio A. Abbondanzieri et al.   NATURE

Slide into Action: Dynamic Shuttling of HIV Reverse Transcriptase on Nucleic Acid Substrates

(2008) S. Liu et al.   SCIENCE