A novel acetylcholinesterase inhibitor and calcium channel blocker SCR-1693 improves Aβ25–35-impaired mouse cognitive function

Simvastatin prevents β-amyloid25–35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate

(2015) Conghui Wang et al.   NEUROPHARMACOLOGY

Behavioral assays with mouse models of Alzheimer's disease: Practical considerations and guidelines

(2014) Daniela Puzzo et al.   BIOCHEMICAL PHARMACOLOGY

Biomarker-Driven Therapeutic Management of Alzheimer’s Disease: Establishing the Foundations

(2013) J Cummings et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Simvastatin Exerts Antiamnesic Effect in Aβ25-35-Injected Mice

(2013) Wen-Hong Zhi et al.   CNS Neuroscience & Therapeutics

Acetylcholinesterase Inhibitors: Pharmacology and Toxicology

(2013) Mirjana B. Colovic et al.   Current Neuropharmacology

Protective effect of xanthoceraside against β-amyloid-induced neurotoxicity in neuroblastoma SH-SY5Y cells

(2013) Tian-Yan Chi et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH

Memantine Rescues Transient Cognitive Impairment Caused by High-Molecular-Weight A  Oligomers But Not the Persistent Impairment Induced by Low-Molecular-Weight Oligomers

(2013) C. P. Figueiredo et al.   JOURNAL OF NEUROSCIENCE

Therapeutics of Alzheimer's disease: Past, present and future

(2013) R. Anand et al.   NEUROPHARMACOLOGY

Blockade of Tau Hyperphosphorylation and Aβ1–42 Generation by the Aminotetrahydrofuran Derivative ANAVEX2-73, a Mixed Muscarinic and σ1 Receptor Agonist, in a Nontransgenic Mouse Model of Alzheimer’s Disease

(2013) Valentine Lahmy et al.   NEUROPSYCHOPHARMACOLOGY

Expression and Pharmacology of Endogenous Cav Channels in SH-SY5Y Human Neuroblastoma Cells

(2013) Silmara R. Sousa et al.   PLoS One

The interactions of azure B, a metabolite of methylene blue, with acetylcholinesterase and butyrylcholinesterase

(2013) Anél Petzer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Neuroprotective effects of donepezil against cholinergic depletion

(2013) Debora Cutuli et al.   Alzheimers Research & Therapy

Comparative Impact of Voltage-Gated Calcium Channels and NMDA Receptors on Mitochondria-Mediated Neuronal Injury

(2012) R. I. Stanika et al.   JOURNAL OF NEUROSCIENCE

Anti-amnesic effect of neurosteroid PREGS in Aβ25–35-injected mice through σ1 receptor- and α7nAChR-mediated neuroprotection

(2012) Rong Yang et al.   NEUROPHARMACOLOGY

Time-Course and Regional Analyses of the Physiopathological Changes Induced after Cerebral Injection of an Amyloid β Fragment in Rats

(2011) Charleine Zussy et al.   AMERICAN JOURNAL OF PATHOLOGY

Calcium channel blocking as a therapeutic strategy for Alzheimer's disease: The case for isradipine

(2011) Thimmappa S. Anekonda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Dysregulated phosphorylation of Ca2+/calmodulin-dependent protein kinase II-α in the hippocampus of subjects with mild cognitive impairment and Alzheimer’s disease

(2011) Lindsay C. Reese et al.   JOURNAL OF NEUROCHEMISTRY

Acute effects of donepezil in healthy young adults underline the fractionation of executive functioning

(2011) GE Ginani et al.   JOURNAL OF PSYCHOPHARMACOLOGY

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(2011) Daniel Paris et al.   MOLECULAR MEDICINE

Neuroprotection of paliperidone on SH-SY5Y cells against β-amyloid peptide25-35, N-methyl-4-phenylpyridinium ion, and hydrogen peroxide-induced cell death

(2011) Ming-Chang Yang et al.   PSYCHOPHARMACOLOGY

Xanthoceraside attenuates amyloid β peptide25–35-induced learning and memory impairments in mice

(2011) Ping Lu et al.   PSYCHOPHARMACOLOGY

Pharmacokinetic and Pharmacodynamic Properties of Cholinesterase Inhibitors Donepezil, Tacrine, and Galantamine in Aged and Young Lister Hooded Rats

(2010) C. W. Goh et al.   DRUG METABOLISM AND DISPOSITION

Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25–35 in rats

(2010) Juan Deng et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease

(2010) Thimmappa S. Anekonda et al.   NEUROBIOLOGY OF DISEASE

Neuroprotective effects of Eucommia ulmoides Oliv. Bark on amyloid beta25–35-induced learning and memory impairments in mice

(2010) Seung-Hwan Kwon et al.   NEUROSCIENCE LETTERS

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Daidzein induces MCF-7 breast cancer cell apoptosis via the mitochondrial pathway

(2009) S. Jin et al.   ANNALS OF ONCOLOGY

Cholinesterase Inhibitors and Beyond

(2009) Giancarlo Pepeu et al.   Current Alzheimer Research

Tacripyrines, the First Tacrine−Dihydropyridine Hybrids, as Multitarget-Directed Ligands for the Treatment of Alzheimer’s Disease

(2009) José Marco-Contelles et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphorylation Changes of CaMKII, ERK1/2, PKB/Akt Kinases and CREB Activation During Early Long-Term Potentiation at Schaffer Collateral-CA1 Mouse Hippocampal Synapses

(2009) Mauro Racaniello et al.   NEUROCHEMICAL RESEARCH

Protective effect of stilbenes containing extract-fraction from Cajanus cajan L. on Aβ25–35-induced cognitive deficits in mice

(2009) Can-Jun Ruan et al.   NEUROSCIENCE LETTERS

Calcium dysregulation in Alzheimer's disease: From mechanisms to therapeutic opportunities

(2009) Jin-Tai Yu et al.   PROGRESS IN NEUROBIOLOGY

Donepezil: potential neuroprotective and disease-modifying effects

(2008) Sandra A Jacobson et al.   Expert Opinion on Drug Metabolism & Toxicology

Multi-target-Directed Ligands To Combat Neurodegenerative Diseases

(2008) Andrea Cavalli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Linking Calcium to Aβ and Alzheimer's Disease

(2008) Kim N. Green et al.   NEURON

Neuronal calcium mishandling and the pathogenesis of Alzheimer's disease

(2008) Ilya Bezprozvanny et al.   TRENDS IN NEUROSCIENCES

The anti-amnesic and neuroprotective effects of donepezil against amyloid β25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor

(2006) J Meunier et al.   BRITISH JOURNAL OF PHARMACOLOGY