Article
Psychiatry
Fangxiang Mao, Yaoyao Sun, Juan Wang, Yongqi Huang, Yane Lu, Fenglin Cao
Summary: The study found that the EPDS is sensitive in detecting changes in maternal depressive symptoms during pregnancy. An average MCID value of 4 points for improvement and 3 points for worsening are recommended for EPDS.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Orthopedics
Sze-Ee Soh, Ian A. Harris, Kara Cashman, Emma Heath, Michelle Lorimer, Stephen E. Graves, Ilana N. Ackerman
Summary: This study aimed to estimate the minimal clinically important changes (MCICs) for the HOOS-12 and KOOS-12 assessments among patients undergoing joint replacement for osteoarthritis. Multiple methods were used to calculate MCICs, and the estimates obtained from predictive modeling were found to be the most clinically applicable.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Medicine, General & Internal
Carlos Roncero, Joselin Perez, Jesus Molina, Jose Antonio Quintano, Ana Isabel Campuzano, Javier Perez, Marc Miravitlles
Summary: This study aims to investigate the prevalence of suicidal ideation in patients with chronic obstructive pulmonary disease (COPD) and its association with demographic and clinical variables. The study found that suicidal ideation is common in COPD patients, especially in women. Severe depression is significantly associated with the occurrence of suicidal ideation.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Tsuyoshi Hara, Eisuke Kogure, Shinno Iijima, Yasuhisa Fukawa, Akira Kubo, Wataru Kakuda
Summary: The study aimed to estimate the minimal clinically important difference (MCID) for postoperative recovery metrics in gastrointestinal cancer patients. Results showed cutoff values for clinically relevant decline on the 6-minute walk test and SF-36 role-physical subscale. The study suggests that MCIDs can aid in interpreting clinical trial results and observing postoperative clinical courses.
SUPPORTIVE CARE IN CANCER
(2022)
Article
Medicine, General & Internal
Chien-Chia Huang, Pei-Wen Wu, Chi-Che Huang, Po-Hung Chang, Chia-Hsiang Fu, Ta-Jen Lee
Summary: This study aimed to investigate depression- and anxiety-associated psychological symptoms in patients with empty nose syndrome (ENS) before and after surgical reconstruction, and to compare them with those of control subjects. The results showed that patients with ENS experienced significant improvement in nasal and psychological evaluations after surgery, but both were still significantly greater than those in the control group. Preoperative BDI-II and BAI scores were significant predictors of postoperative residual psychological symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Francisco Javier Ruiz-Sanchez, Maria do Rosario Martins, Salete Soares, Carlos Romero-Morales, Daniel Lopez-Lopez, Juan Gomez-Salgado, Ana Maria Jimenez-Cebrian
Summary: This study examined the level of depression in patients with multiple sclerosis (MS) compared to a healthy population. The findings showed that MS patients had higher levels of depression, indicating a negative impact on their quality of life.
Article
Medicine, General & Internal
Hsiang -An Hsueh, Ta-Jen Lee, Chi-Che Huang, Po -Huang Chang, Chia-Hsiang Fu
Summary: This study aimed to evaluate the role of serum interleukin-6 (IL-6) levels in the mental status of patients with Empty Nose Syndrome (ENS). The results showed that ENS patients with higher preoperative serum IL-6 levels were more likely to have severe depressive burden. Therefore, timely treatment plan and psychotherapy may be considered for patients with high levels of serum IL-6 after surgical treatment.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Clinical Neurology
Michael Cronquist Christensen, Andrea Fagiolini, Ioana Florea, Henrik Loft, Alessandro Cuomo, Guy M. Goodwin
Summary: The study validates the clinical utility of the Oxford Depression Questionnaire (ODQ) in assessing emotional blunting in patients with MDD. After 8 weeks of vortioxetine treatment, there was a significant improvement in patients' ODQ scores, indicating a reduction in emotional blunting symptoms. The minimal clinically important difference in terms of change in ODQ-20 and ODQ-26 scores is suggested to be 16 and 20 points, respectively.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Review
Medicine, General & Internal
Berthold Langguth, Dirk De Ridder
Summary: Tinnitus assessment and outcome measurement are complex due to the subjective nature of tinnitus. Various instruments are used for outcome measurement, including self-report questionnaires, visual analogue or numeric rating scales, and psychoacoustic measurements. The concept of minimal clinically important difference (MCID) is introduced for evaluating therapeutic interventions. MCID calculations have been performed for most tinnitus outcome instruments, but the values vary across studies. Psychoacoustic assessments have not shown sufficient reliability and validity for outcome measurement. Future research should confirm these estimates in larger samples with different interventions and consider time intervals and baseline values.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Thomas M. Zervos, Karam Asmaro, Ellen L. Air
Summary: MCID varies depending on population characteristics and calculation methods. In the context of pain, MCID is influenced by pain quality, chronicity, and treatment options. Using MCID in outcome evaluation helps avoid misinterpreting statistically significant but clinically insignificant results.
Article
Medicine, General & Internal
Fatimah A. AlGhofaili
Summary: This study aimed to estimate the prevalence of depression among acne patients in Riyadh, Saudi Arabia, before and after treatment with isotretinoin. Results showed a significant reduction in depression scores after three and six months of isotretinoin treatment, suggesting that isotretinoin therapy for acne does not increase the risk of depression in the Saudi population. Further studies are needed to confirm these findings.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Health Care Sciences & Services
Michael M. Ward, Maria Alba
Summary: The study found that in samples with higher responsiveness, the minimal clinically important improvements (MCII) were also larger. Results showed that with increasing treatment impact, MCIIs also increased, with a wider range of MCIIs in samples with higher responsiveness.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2022)
Article
Critical Care Medicine
Jude Moutchia, Robyn L. McClelland, Nadine Al-Naamani, Dina H. Appleby, Kristina Blank, Dan Grinnan, John H. Holmes, Stephen C. Mathai, Jasleen Minhas, Corey E. Ventetuolo, Roham T. Zamanian, Steven M. Kawut
Summary: The 6-minute-walk distance (6MWD) is a significant metric in pulmonary arterial hypertension (PAH), but there is no consensus on the clinically significant minimal change in 6MWD. This study aimed to determine the minimal clinically important difference in 6MWD and found it to be approximately 33 meters for adults with PAH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Health Care Sciences & Services
Clarissa Bauer-Staeb, Daphne-Zacharenia Kounali, Nicky J. Welton, Emma Griffith, Nicola J. Wiles, Glyn Lewis, Julian J. Faraway, Katherine S. Button
Summary: This study aimed to determine the minimal clinically important difference (MCID) across baseline severity spectrum, with results showing MCID estimates varied depending on severity, ranging from no change to significant changes on PHQ-9 and GAD-7. The ED50 method provided greater precision but with increased complexity for tailoring MCID to specific populations based on baseline severities.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2021)
Article
Orthopedics
Lisa Su, Ignacio Garcia-Mansilla, Benjamin Kelley, Armin Arshi, Peter Fabricant, Seth L. Sherman, Kristofer J. Jones
Summary: This study systematically reviewed clinical outcome studies of patients undergoing MAT and found that postoperative improvements exceeded MCID thresholds, indicating a significant effect of MAT on functional improvement.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Psychology, Clinical
J. E. J. Buckman, Z. D. Cohen, C. O'Driscoll, E. Fried, R. Saunders, G. Ambler, R. J. DeRubeis, S. Gilbody, S. D. Hollon, T. Kendrick, E. Watkins, T. C. Eley, A. J. Peel, C. Rayner, D. Kessler, N. Wiles, G. Lewis, S. Pilling
Summary: This study developed models based on pre-treatment data to predict post-treatment outcomes for depressed adults. The models showed some effectiveness in predicting the severity of depressive symptoms post-treatment, but a significant amount of variance in prognosis remained unexplained. To improve predictive accuracy and clinical utility, it may be necessary to consider a broader range of variables.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Catherine Hobbs, Jie Sui, David Kessler, Marcus R. Munafo, Katherine S. Button
Summary: This study examined the cognitive differences in self-reference, emotion, and reward processing among individuals with depression. The results showed that there was little association between self-reference and depression when measured independently. However, when self-reference was combined with emotion and reward processing, depression was associated with an increased positive bias towards others.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Jonathan P. Rogers, Thomas A. Pollak, Nazifa Begum, Anna Griffin, Ben Carter, Megan Pritchard, Matthew Broadbent, Anna Kolliakou, Jessie Ke, Robert Stewart, Rashmi Patel, Adrian Bomford, Ali Amad, Michael S. Zandi, Glyn Lewis, Timothy R. Nicholson, Anthony S. David
Summary: Catatonia occurred in approximately 1 per 10,000 person-years in this study. Patients with catatonia had longer duration of hospitalisation, but there was no increase in mortality after adjustment.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychology, Clinical
Zachary D. Cohen, Robert J. DeRubeis, Rachel Hayes, Edward R. Watkins, Glyn Lewis, Richard Byng, Sarah Byford, Catherine Crane, Willem Kuyken, Tim Dalgleish, Susanne Schweizer
Summary: Clinical prediction models can help adults with recurrent depression choose between antidepressant medication (ADM) maintenance or switching to mindfulness-based cognitive therapy (MBCT). The study found that individuals with the poorest ADM prognoses who switched to MBCT had better outcomes compared to those who continued with ADM. For individuals with moderate to good ADM prognoses, both treatments resulted in similar likelihood of relapse.
CLINICAL PSYCHOLOGICAL SCIENCE
(2023)
Article
Psychology, Clinical
Clarissa Bauer-Staeb, Emma Griffith, Julian J. Faraway, Katherine S. Button
Summary: The study found that cognitive-behavioural therapy (CBT) has a positive effect on improving symptoms of depression and generalised anxiety. Symptoms such as low mood/hopelessness and guilt/worthlessness showed the fastest improvement in depression, while symptoms like sleeping problems, appetite changes, and psychomotor retardation/agitation improved relatively slower. For anxiety, uncontrollable worry and too much worry improved the fastest, while irritability and restlessness improved the slowest.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Clinical Neurology
Catherine Hobbs, Milly Beck, Faye Denham, Laura Pettitt, Julian Faraway, Marcus R. Munafo, Jie Sui, David Kessler, Katherine S. Button
Summary: This study investigated the association between changes in biased learning of social evaluations and mood during early antidepressant treatment. The results suggest that increased positive learning about oneself and friends is associated with a reduction in anxiety symptoms, but not depression.
JOURNAL OF PSYCHOPHARMACOLOGY
(2023)
Article
Pediatrics
Hannah B. Edwards, Maria Theresa Redaniel, Carlos Sillero-Rejon, Ruta Margelyte, Tim J. Peters, Kate Tilling, William Hollingworth, Hugh McLeod, Pippa Craggs, Elizabeth Hill, Sabi Redwood, Jenny Donovan, Emma Treloar, Ellie Wetz, Natasha Swinscoe, Gary A. Ford, John Macleod, Karen Luyt
Summary: This study evaluated the effectiveness and cost-effectiveness of the National PReCePT Programme in increasing the use of magnesium sulfate in preterm births. The results showed that the implementation of the NPP significantly increased the uptake of magnesium sulfate in preterm births in 137 maternity units in England. From a societal and lifetime perspective, the NPP generated health gains and cost savings, making it a cost-effective intervention.
ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION
(2023)
Article
Respiratory System
Matthew Evison, Ross Maconachie, Toby Mercer, Caitlin H. Daly, Nicky J. Welton, Shahzeena Aslam, Doug West, Neal Navani
Summary: Chemoradiotherapy followed by surgery (CRS) provides an extended disease-free survival and improved cost-effectiveness compared to chemotherapy plus surgery (CS) and chemotherapy plus radiotherapy (CR) in potentially resectable stage III-N2 NSCLC patients.
Article
Medicine, General & Internal
F. C. C. Hamdy, J. L. L. Donovan, J. A. Lane, C. Metcalfe, M. Davis, E. L. L. Turner, R. M. M. Martin, G. J. J. Young, E. I. I. Walsh, R. J. J. Bryant, P. Bollina, A. Doble, A. Doherty, D. Gillatt, V Gnanapragasam, O. Hughes, R. Kockelbergh, H. Kynaston, A. Paul, E. Paez, P. Powell, D. J. J. Rosario, E. Rowe, M. Mason, J. W. F. Catto, T. J. J. Peters, J. Oxley, N. J. J. Williams, J. Staffurth, D. E. E. Neal
Summary: A study in the UK showed that after 15 years of follow-up, the mortality rate of prostate cancer was low regardless of the treatment assigned. Therefore, the choice of therapy for localized prostate cancer involves considering the trade-offs between benefits and harms.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Debbie Tallon, Laura Thomas, Sally Brabyn, Brian Chi Fung Ching, Jane Sungmin Hahn, Berry Jude, Mekeda Logan, Alex Burrage, Fiona Fox, Simon Gilbody, Paul Lanham, Glyn Lewis, Jinshuo Li, Stephanie J. MacNeill, Irwin Nazareth, Steve Parrott, Tim J. Peters, Roz Shafran, Katrina Turner, Chris Williams, David Kessler, Nicola Wiles
Summary: The INTERACT trial will evaluate the clinical and cost-effectiveness, as well as the acceptability to therapists and clients, of the integration of online CBT materials and high-intensity therapist-led CBT delivered remotely. If successful, this model could increase access to and equity of CBT provision.
Article
Obstetrics & Gynecology
Hannah B. Edwards, Maria Theresa Redaniel, Carlos Sillero-Rejon, Christalla Pithara-McKeown, Ruta Margelyte, Tracey Stone, Tim J. Peters, William Hollingworth, Hugh Mcleod, Pippa Craggs, Elizabeth M. Hill, Sabi Redwood, Emma Treloar, Jenny L. Donovan, Brent C. Opmeer, Karen Luyt
Summary: This study compared two quality improvement interventions to improve the uptake of antenatal magnesium sulphate (MgSO4) in preterm births for the prevention of cerebral palsy. The results showed that enhanced support did not further improve MgSO4 uptake but may improve teamwork. Therefore, further research is needed to explore targeted enhanced support, sustainability of improvements, and the possible indirect benefits of stronger teamwork associated with enhanced support.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2023)
Review
Sport Sciences
Brad S. Currier, Jonathan C. Mcleod, Laura Banfield, Joseph Beyene, Nicky J. Welton, Alysha C. D'Souza, Joshua A. J. Keogh, Lydia Lin, Giulia Coletta, Antony Yang, Lauren Colenso-Semple, Kyle J. Lau, Alexandria Verboom, Stuart M. Phillips
Summary: This study aimed to determine the effects of distinct combinations of resistance training prescription variables (load, sets, and frequency) on muscle strength and hypertrophy. A systematic review and Bayesian network meta-analysis were conducted, and it was found that higher-load, multiset, thrice-weekly training was the most effective for strength gains, while higher-load, multiset, twice-weekly training was the best for hypertrophy.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Medicine, Research & Experimental
Karen Morgan, Mei-See Man, Rachael Bloomer, Madeleine Cochrane, Melissa Cole, Sandi Dheensa, Nathan Eisenstadt, Gene Feder, Daisy M. Gaunt, Rwth Leach, Rebecca Kandiyali, Sian Noble, Tim J. Peters, Beverly A. Shirkey, Helen Cramer
Summary: This study aims to estimate the effectiveness and cost-effectiveness of a perpetrator programme for men.
Article
Psychiatry
Darragh Glavin, Eoin Martino Grua, Carina Akemi Nakamura, Marcia Scazufca, Edinilza Ribeiro dos Santos, Gloria H. Y. Wong, William Hollingworth, Tim J. Peters, Ricardo Araya, Pepijn Van de Ven
Summary: This study used machine learning and PHQ-9 items to identify the most predictive ultrabrief questionnaire for depressive symptomatology and validated its use with external data sets. The study found that alternative PHQ-9 item pairings were more effective than the PHQ-2 for prescreening depressive symptomatology.
JMIR MENTAL HEALTH
(2023)
Review
Medicine, General & Internal
Anair Beverly, Giok Ong, Catherine Kimber, Josie Sandercock, Carolyn Doree, Nicky J. Welton, Peter Wicks, Lise J. Estcourt
Summary: The study aimed to assess the effectiveness and safety of antifibrinolytic and hemostatic drugs in reducing bleeding and the need for blood transfusion in people undergoing major vascular surgery. However, due to limited data, a network meta-analysis could not be performed. Further research in this field is needed.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2023)