Article
Microbiology
Becky H. Lee, Giulia Tebaldi, Suzanne M. Pritchard, Anthony Nicola
Summary: This study demonstrates the importance of the NEDD8 cascade in the internalization of HSV-1 and HSV-2, while having minimal effect on the entry of veterinary viruses. The results provide new insights into the cellular processes involved in HSV internalization.
MICROBIOLOGY SPECTRUM
(2022)
Article
Microbiology
Ye Liu, Qiao You, Fang Zhang, Deyan Chen, Zhenping Huang, Zhiwei Wu
Summary: Harringtonine (HT) significantly inhibited HSV-1 infection and two ACV-resistant strains by mainly targeting HVEM and reducing the early stage of HSV-1 infection. The study demonstrated that HT could be a promising therapeutic candidate for mitigating HSV-1-induced pathogenesis.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Multidisciplinary Sciences
Katherine Kaugars, Joseph Dardick, Anna Paula de Oliveira, Kayla A. Weiss, Regy Lukose, John Kim, Lawrence Leung, Saranathan Rajagopalan, Sydney Wolin, Leor Akabas, David M. Knipe, Goran Bajic, William R. Jacobs Jr
Summary: Despite annual vaccination efforts, influenza continues to cause significant morbidity and mortality worldwide. To improve vaccine efficacy, researchers are exploring the use of antibodies that can activate immune cell effector functions, such as ADCC. Evidence suggests that ADCC is crucial for protection against influenza and other infectious diseases, leading to the development of innovative vaccine strategies such as using Delta gD-2 as a vector for a broadly protective influenza vaccine.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Virology
Nithya Jambunathan, Carolyn M. Clark, Farhana Musarrat, Vladimir N. Chouljenko, Jared Rudd, Konstantin G. Kousoulas
Summary: HSV-1 and HSV-2 are prototypical alphaherpesviruses that infect neurons and establish lifelong latent infections. They cause orofacial and ocular infections, genital and neonatal infections respectively. The viral glycoproteins bind to cellular receptors to enter cells and mediate cell-to-cell fusion for virus spread. The complex of viral glycoproteins and cellular receptors play a critical role in virus entry and spread.
Article
Virology
Xiao Yuan, Xiaoman Zhang, Huan Wang, Xiang Mao, Yingjie Sun, Lei Tan, Cuiping Song, Xusheng Qiu, Chan Ding, Ying Liao
Summary: This study reveals the important role of the ubiquitin-proteasome system (UPS) in coronavirus entry. Inhibition of UPS severely impairs the infectivity of infectious bronchitis virus (IBV) and porcine epidemic diarrhea virus (PEDV). UPS inhibition prevents the membrane fusion of IBV and PEDV with late endosomes or lysosomes, blocking virus uncoating, initial translation, and replication events.
Article
Biochemistry & Molecular Biology
Jose Louzinho Lopes, Vinicius Seiki Takemura Quinteiro, Jessica Wouk, Maria Laura Darido, Robert F. H. Dekker, Aneli M. Barbosa-Dekker, Vaclav Vetvicka, Mario A. A. Cunha, Ligia Carla Faccin-Galhardi, Alexandre Orsato
Summary: By introducing carboxyl and sulfonate groups into β-D-glucan, researchers attempted to improve its antiviral activity against enveloped viruses. The results showed that sulfonated-carboxymethylated derivatives could inhibit herpes virus, while their inhibition of dengue virus was weaker, indicating varying resistance of different viruses to anionic β-D-glucans. Comparing with a previous study, the presence of carboxymethyl groups might have a negative impact on antiviral activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Microbiology
Xiaowei Song, Yiliang Wang, Feng Li, Wenyan Cao, Qiongzhen Zeng, Shurong Qin, Zhaoyang Wang, Jiaoyan Jia, Ji Xiao, Xiao Hu, Kaisheng Liu, Yifei Wang, Zhe Ren
Summary: This study found that inhibitors of heat shock protein 90 (Hsp90) have antiviral activity against HSV-1 infection in neuronal cells. The results suggest that Hsp90 inhibitors promote viral adsorption but inhibit subsequent penetration, providing further insights into the molecular mechanism of Hsp90 in HSV-1 infection.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Zhaoqi Wang, Han Yan, Fujie He, Jie Wang, Yang Zhang, Lishan Sun, Cui Hao, Wei Wang
Summary: The natural compound wedelolactone (WDL) exhibits strong inhibitory effects against both HSV-1 and HSV-2 in vitro and in vivo, with mechanisms distinct from acyclovir and involving interference with host genes and signaling pathways. WDL treatment improves survival, attenuates inflammatory symptoms, and reduces viral titres in infected mice.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Microbiology
Kevin Danastas, Gerry Guo, Jessica Merjane, Nathan Hong, Ava Larsen, Monica Miranda-Saksena, Anthony L. Cunningham
Summary: This study explores the effects of interferons (IFNs) on herpes simplex virus-1 (HSV-1) and reveals that IFNs have the potential to block virus release from nerve endings, thereby preventing transmission into the skin. The study also highlights the potential wider antiviral effects of IFN-γ in neurons, suggesting its role in HSV-1 reactivation. These findings identify new targets for the development of immunotherapies to impede HSV-1 spread from nerves to the skin.
Article
Chemistry, Multidisciplinary
Pradeep Chopra, Tejabhiram Yadavalli, Francesco Palmieri, Seino A. K. Jongkees, Luca Unione, Deepak Shukla, Geert-Jan Boons
Summary: Inhibition of human heparanase (Hpse) has been found to be a promising therapeutic strategy for preventing the spread of herpes simplex virus (HSV-1). The synthesis of hexa- and octasaccharide inhibitors of Hpse showed potent enzyme inhibition and the presence of 2-O-sulfation on iduronic acid was tolerated. These inhibitors not only blocked viral-induced shedding of cell-surface heparan sulfate (HS) but also inhibited cell migration and proliferation in corneal epithelial cells infected with HSV-1.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Virology
Qing Fan, Richard Longnecker, Sarah A. Connolly
Summary: The viral fusion protein glycoprotein B (gB) is essential for virus entry in all herpesviruses. By introducing structure-based mutations, researchers identified mutations that counteracted a slow-entry phenotype in the virus and found that these mutations were located in different regions of the gB protein.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Malgorzata Krzyzowska, Anders Jarneborn, Karolina Thorn, Kristina Eriksson, Tao Jin
Summary: This study provides evidence that treatment with tofacitinib may increase the risk of disease aggravation and severe encephalitis in primary herpes simplex infection by impairing antiviral response induced by monocytes and microglia.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Cooper K. Hayes, Christopher K. Villota, Fiona B. McEnany, Stacey Ceron, Sita Awasthi, Moriah L. Szpara, Harvey M. Friedman, David A. Leib, Richard Longnecker, Matthew D. Weitzman, Lisa N. Akhtar
Summary: Clinical HSV-2 isolates collected from neonates with encephalitis are more neurovirulent in human neuronal cell culture and murine models as compared to isolates from neonates with skin-limited disease, suggesting that viral factors contribute to neurologic outcome following human neonatal infection.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Virology
Katrina A. Gianopulos, Tri Komala Sari, Darin J. Weed, Suzanne M. Pritchard, Anthony Nicola
Summary: Low endosomal pH facilitates herpesvirus entry in a cell-specific manner. The gC protein of HSV-1 plays a critical role in low-pH entry pathway by regulating the conformational changes of viral envelope glycoprotein B (gB). This study reveals that low pH triggers conformational changes in gC itself, and a specific gC epitope is important for low-pH entry inhibition.
JOURNAL OF VIROLOGY
(2022)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)