Article
Immunology
Yaxian Ma, Peiling Zhang, Yuhan Bao, Hui Luo, Jiachen Wang, Liang Huang, Miao Zheng
Summary: Chronic active Epstein-Barr virus (CAEBV) disease is a high-mortality disease characterized by persistent infectious mononucleosis-like symptoms. This study analyzed the outcomes of PD-1 inhibitors treatment for CAEBV patients and found that the treatment had a high response rate and tolerable toxicity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Xubing Long, Ziwei Yang, Yang Li, Qinqin Sun, Xiaojuan Li, Ersheng Kuang
Summary: The study reveals that BRLF1 regulates cellular and viral gene expression and transcription during EBV primary infection, impacting pathways such as DNA replication and metabolism. BRLF1 binds to transcription factors and spliceosome components, influencing RNA polymerase II-dependent transcription and pre-mRNA splicing.
Article
Biochemistry & Molecular Biology
Isak Holmqvist, Alan Backerholm, Yarong Tian, Guojiang Xie, Kaisa Thorell, Ka-Wei Tang
Summary: FLAME is a Python-based bioinformatics pipeline for comprehensive analysis of alternative splicing of gene-specific or transcriptome-wide long-read sequencing data. By combining nanopore sequencing reads with short-read sequencing data, FLAME can effectively resolve the spliceome of RPMS1. The study identified 32 novel exons, including two intron retentions and a cassette exon, within the RPMS1 gene.
Article
Multidisciplinary Sciences
Yoshimi Enose-Akahata, Limin Wang, Fahad Almsned, Kory R. Johnson, Yair Mina, Joan Ohayon, Xin Wei Wang, Steven Jacobson
Summary: Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS), and the cause of MS remains unknown. This study investigated the antibody responses against various viruses in the cerebrospinal fluid (CSF) and serum of MS patients, and found significant differences compared to healthy volunteers, as well as a pattern of antibody responses against multiple viruses, including Epstein-Barr virus. These findings indicate that virus-specific antibody signatures might reflect the disease-associated inflammatory milieu in the CSF of patients with neuroinflammatory diseases.
Article
Immunology
Joelle R. Madi, Amani Al Outa, Mirna Ghannam, Hadi M. Hussein, Marwa Shehab, Zeinab Al Kobra Haj Hasan, Antoine Abou Fayad, Margret Shirinian, Elias A. Rahal
Summary: The study suggests that EBV DNA may worsen intestinal inflammation by enhancing the IMD pathway and increasing cellular inflammatory responses, potentially perpetuating proinflammatory processes in an inflamed digestive system. D. melanogaster can serve as a model to further understand EBV-associated gastroinflammatory pathologies and further studies in mammalian models may validate these findings.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Plant Sciences
Zhen Wang, Yechun Hong, Juanjuan Yao, Huan Huang, Bilian Qian, Xue Liu, Yunjuan Chen, Jia Pang, Xiangqiang Zhan, Jian-Kang Zhu, Jianhua Zhu
Summary: Cold stress inhibits plant growth and crop production, but the molecular mechanisms of chilling stress responses in plants are not well understood. This study identified alleles mutants in the SmEb gene that are defective in development and responses to chilling stress. The SmEb gene controls the splicing of pre-mRNAs under chilling stress, which is critical for proper plant development and chilling stress responses.
PLANT CELL AND ENVIRONMENT
(2022)
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Hematology
Hannes Vietzen, Philippe L. Furlano, Jan J. Cornelissen, Georg A. Boehmig, Peter Jaksch, Elisabeth Puchhammer-Stoeckl
Summary: This study found that nonclassic human leukocyte antigen E (HLA-E)-restricted immune responses have a significant impact on the development of Epstein-Barr virus (EBV) diseases in the individual host. The highly expressed HLA-E*0103/0103 genotype is protective against infectious mononucleosis (IM) by inducing potent EBV BZLF1-specific HLA-E-restricted CD8(+) T-cell responses. Variations in the inhibitory NKG2A/LMP-1/HLA-E axis are associated with the risk of symptomatic EBV reactivations in both immunocompetent individuals and immunocompromised transplant recipients.
Article
Immunology
Nina Vindegaard, Liselotte Petersen, Bodil Ingrid Lyng-Rasmussen, Soren Dalsgaard, Michael Eriksen Benros
Summary: Infectious mononucleosis is associated with a 40% increased risk of subsequent depression, especially in the periods one to four years and five years after diagnosis, with no differences according to age or sex.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Multidisciplinary Sciences
Munetoshi Hinata, Tetsuo Ushiku
Summary: A histology-based deep learning model was constructed to efficiently screen EBV and MSI/dMMR subtypes in gastric cancers, showing high accuracy in detecting the subgroup and highlighting intraepithelial lymphocytosis as a discriminative characteristic shared by EBV and MSI/dMMR tumors. This model offers a potential economical and less time-consuming alternative for stratifying patients who respond to ICIs.
SCIENTIFIC REPORTS
(2021)
Review
Medicine, Research & Experimental
Prankur Awasthi, Manish Dwivedi, Dhruv Kumar, Saba Hasan
Summary: Epstein-Barr Virus (EBV) infection is associated with various lymphomas, carcinomas, and disorders. The carcinogenic potential of EBV is related to latent membrane protein 1 (LMP1), which plays an essential role in the transformation of fibroblasts and primary lymphocytes. LMP1, a constitutively active transmembrane protein of the tumour necrosis factor receptor (TNFR) superfamily, interferes with and influences numerous host cellular activities and functions, contributing to the pathogenesis of EBV-associated malignancies.
Review
Oncology
Ramon Yarza, Mateo Bover, Maria Teresa Agullo-Ortuno, Lara Carmen Iglesias-Docampo
Summary: Nasopharyngeal carcinoma (NPC) is a molecularly paradigmatic tumor with complex environmental and host dependent factors, where Epstein Barr Virus (EBV) plays a key role in malignant transformation. The dysregulation of proteasome signaling is central in NPC pathogenesis and could be a potential therapeutic target. Studies have shown the efficacy of immunotherapy in NPC, with novel strategies aiming to reverse immune resistance and favor tumor recognition.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Microbiology
Francesco Baccianti, Charlene Masson, Susanne Delecluse, Zhe Li, Remy Poirey, Henri-Jacques Delecluse
Summary: EBV efficiently infects and transforms B lymphocytes by activating viral gene expression and manipulating cellular pathways to limit the immune response, according to this study. The viral particle components sequentially activate proinflammatory B lymphocyte signaling pathways, leading to viral gene expression and cytokine release. However, infection also triggers the expression of ZFP36L1, a stress protein that limits the cytokine response. This study highlights the complex interactions between EBV and host cells during infection and transformation.
Article
Biochemical Research Methods
Hansaim Lim, Chung-Jung Tsai, Ozlem Keskin, Ruth Nussinov, Attila Gursoy
Summary: HMI-PRED 2.0 is a publicly available web service that predicts host-microbe protein-protein interaction using interface mimicry. It aims to be user-friendly without requiring extensive computational experience.
Article
Multidisciplinary Sciences
Tobias Lanz, R. Camille Brewer, Peggy P. Ho, Jae-Seung Moon, Kevin M. Jude, Daniel Fernandez, Ricardo A. Fernandes, Alejandro M. Gomez, Gabriel-Stefan Nadj, Christopher M. Bartley, Ryan D. Schubert, Isobel A. Hawes, Sara E. Vazquez, Manasi Iyer, J. Bradley Zuchero, Bianca Teegen, Jeffrey E. Dunn, Christopher B. Lock, Lucas B. Kipp, Victoria C. Cotham, Beatrix M. Ueberheide, Blake T. Aftab, Mark S. Anderson, Joseph L. DeRisi, Michael R. Wilson, Rachael J. M. Bashford-Rogers, Michael Platten, K. Christopher Garcia, Lawrence Steinman, William H. Robinson
Summary: Multiple sclerosis (MS) is an autoimmune disease where autoreactive lymphocytes attack the central nervous system. Epstein-Barr virus (EBV) infection has been linked to MS, with molecular mimicry between EBV nuclear antigen 1 (EBNA1) and central nervous system protein GlialCAM. EBNA1 immunization exacerbates disease in MS mouse models and anti-EBNA1 and anti-GlialCAM antibodies are prevalent in MS patients, providing a mechanistic link between MS and EBV and guiding the development of new MS therapies.
Editorial Material
Immunology
Alexander J. Sundermann, Cornelius J. Clancy, A. William Pasculle, Guojun Liu, Richard B. Cumbie, Eileen Driscoll, Ashley Ayres, Lisa Donahue, Steven A. Pergam, Lilian Abbo, David R. Andes, Pranatharthi Chandrasekar, Alison L. Galdys, Kimberly E. Hanson, Kieren A. Marr, Jeanmarie Mayer, Seema Mehta, Michele I. Morris, John Perfect, Sanjay G. Revankar, Becky Smith, Sankar Swaminathan, George R. Thompson, Merin Varghese, Jose Vazquez, Estella Whimbey, John R. Wingard, M. Hong Nguyen
CLINICAL INFECTIOUS DISEASES
(2019)
Article
Virology
Wenmin Fu, Dinesh Verma, Ashlee Burton, Sankar Swaminathan
JOURNAL OF VIROLOGY
(2019)
Article
Microbiology
Dajiang Li, Sankar Swaminathan
Meeting Abstract
Endocrinology & Metabolism
Rahul Agrawal, Michael G. Montgomery, Dinesh Verma, Griffin T. Durupt, Adriana Vieira de Abreu, Sankar Swaminathan, Simon Fisher
Article
Virology
Dajiang Li, Tim Mosbruger, Dinesh Verma, Sankar Swaminathan
JOURNAL OF VIROLOGY
(2020)
Editorial Material
Immunology
Priya Swaminathan, Sankar Swaminathan
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Multidisciplinary Sciences
Dinesh Verma, Trenton Mel Church, Sankar Swaminathan
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Immunology
Rebekah M. Martin, Kristina Burke, Dinesh Verma, Heng Xie, Janine Langer, Robert Schlaberg, Sankar Swaminathan, Kimberly E. Hanson
OPEN FORUM INFECTIOUS DISEASES
(2020)
Article
Sport Sciences
Kimberly G. Harmon, Paul S. Pottinger, Aaron L. Baggish, Jonathan A. Drezner, Andrew M. Luks, Alexis A. Thompson, Sankar Swaminathan
SPORTS HEALTH-A MULTIDISCIPLINARY APPROACH
(2020)
Article
Virology
Dinesh Verma, Trenton Mel Church, Sankar Swaminathan
Summary: Understanding the factors that affect the infectivity of SARS-CoV-2 is crucial in combating COVID-19. This study showed that Epstein-Barr virus (EBV) infection induced ACE2 expression in epithelial cells, increasing susceptibility to SARS-CoV-2. The EBV transcriptional activator Zta directly activated the ACE2 promoter, and inhibiting EBV replication may reduce susceptibility to SARS-CoV-2.
JOURNAL OF VIROLOGY
(2021)
Article
Immunology
Elena G. Gibson, Melissa Pender, Michael Angerbauer, Craig Cook, Barbara Jones, Adam M. Spivak, Emily S. Spivak, Sankar Swaminathan
Summary: This case highlights the potential risk of persistent SARS-CoV-2 infection in patients treated with anti-CD-20 monoclonal antibodies, and the potential effectiveness of convalescent plasma and antiviral therapy in resolving symptoms. It suggests a significant role for humoral immunity in disease resolution.
OPEN FORUM INFECTIOUS DISEASES
(2021)
Article
Immunology
Melissa Pender, Ninad Mehta, Blake D. Hamilton, Sankar Swaminathan
Summary: We describe the case of a poorly controlled type 2 diabetes mellitus patient who presented with left-sided abdominal pain and was found to have a left adrenal abscess caused by Nocardia beijingensis. We review the published literature on this uncommonly identified Nocardia species among immunocompetent patients and summarize the diagnosis and management of N beijingensis isolated from an adrenal abscess.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Sport Sciences
Kimberly Harmon, Anabelle M. de St Maurice, Adam C. Brady, Sankar Swaminathan, Doug F. Aukerman, Miguel A. Rueda, Kim Terrell, Randall P. Cohen, Seth C. Gamradt, Sunday D. Henry, Lindsay M. Huston, David R. McAllister, Kenneth M. McCarty, Anthony N. Pass, Stephen R. Paul, David J. Petron, Stephanie A. Kliethermes
Summary: This study evaluated the diagnostic accuracy of antigen testing compared with RT-PCR in an asymptomatic athlete screening program, finding that antigen testing has high specificity but lower sensitivity than RT-PCR. Daily antigen testing or RT-PCR testing two to three times a week showed similar effectiveness in identifying infections, with benefits and drawbacks to each approach.
BMJ OPEN SPORT & EXERCISE MEDICINE
(2021)
Article
Medicine, Research & Experimental
Rahul Agrawal, Griffin Durupt, Dinesh Verma, Michael Montgomery, Adriana Vieira-de Abreu, Casey Taylor, Sankar Swaminathan, Simon J. Fisher
Meeting Abstract
Infectious Diseases
M. Hong Nguyen, Cornelius Clancy, William Pasculle, Merin Varghese, Becky Smith, John Perfect, Kirk Huslage, L. Abbo, Kieran Marr, Seema Mehta, Jose Vazquez, Stephen Pergam, George R. Thompson, Peter Pappas, John Wingard, Michelle Morris, Allison Galdys, Kimberly Hanson, Jeanmarie Mayer, Sankar Swaminathan, Estella Whimbey, David Andes, Pranathar Chandrasekar, Sanjay Revankar, M. Hong Nguyen