Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

(2012) Tengchuan Jin et al.   IMMUNITY

Targeting Toll-like Receptor (TLR) Signaling by Toll/Interleukin-1 Receptor (TIR) Domain-containing Adapter Protein/MyD88 Adapter-like (TIRAP/Mal)-derived Decoy Peptides

(2012) Leah A. Couture et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Molecular analysis of the binding mode of Toll/interleukin-1 receptor (TIR) domain proteins during TLR2 signaling

(2012) Masatoshi Nada et al.   MOLECULAR IMMUNOLOGY

Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling

(2012) Zhijie Lin et al.   PLoS One

The Brucella TIR-like protein TcpB interacts with the death domain of MyD88

(2011) Anu Chaudhary et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Structural Basis for the Activation of Innate Immune Pattern-Recognition Receptor RIG-I by Viral RNA

(2011) Eva Kowalinski et al.   CELL

Structural and Functional Analysis of a Plant Resistance Protein TIR Domain Reveals Interfaces for Self-Association, Signaling, and Autoregulation

(2011) Maud Bernoux et al.   Cell Host & Microbe

Identification of Interaction Sites for Dimerization and Adapter Recruitment in Toll/Interleukin-1 Receptor (TIR) Domain of Toll-like Receptor 4

(2011) Celia Bovijn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeting TLR4 Signaling by TLR4 Toll/IL-1 Receptor Domain-Derived Decoy Peptides: Identification of the TLR4 Toll/IL-1 Receptor Domain Dimerization Interface

(2011) V. Y. Toshchakov et al.   JOURNAL OF IMMUNOLOGY

Yersinia pestis TIR-domain protein forms dimers that interact with the human adaptor protein MyD88

(2011) Rohini R. Rana et al.   MICROBIAL PATHOGENESIS

Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection

(2011) E. Valkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Microbial Toll/interleukin 1 receptor proteins: A new class of virulence factors

(2010) Christine Cirl et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Subversion of Innate Immune Signaling Through Molecular Mimicry

(2010) Tsan Sam Xiao   JOURNAL OF CLINICAL IMMUNOLOGY

Oncogenically active MYD88 mutations in human lymphoma

(2010) Vu N. Ngo et al.   NATURE

Helical assembly in the MyD88–IRAK4–IRAK2 complex in TLR/IL-1R signalling

(2010) Su-Chang Lin et al.   NATURE

Inhibition of TIR Domain Signaling by TcpC: MyD88-Dependent and Independent Effects on Escherichia coli Virulence

(2010) Manisha Yadav et al.   PLoS Pathogens

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk

(2009) M. S. D. Kormann et al.   ALLERGY

Molecular Mimicry in Innate Immunity

(2009) Siew Leong Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

BrucellaTIR Domain-containing Protein Mimics Properties of the Toll-like Receptor Adaptor Protein TIRAP

(2009) Girish K. Radhakrishnan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for the multiple interactions of the MyD88 TIR domain in TLR4 signaling

(2009) H. Ohnishi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Crystal Structure of the Human Toll-like Receptor 10 Cytoplasmic Domain Reveals a Putative Signaling Dimer

(2008) Tomas Nyman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GROMACS 4:  Algorithms for Highly Efficient, Load-Balanced, and Scalable Molecular Simulation

(2008) Berk Hess et al.   Journal of Chemical Theory and Computation

Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain–containing proteins

(2008) Christine Cirl et al.   NATURE MEDICINE

Brucella Control of Dendritic Cell Maturation Is Dependent on the TIR-Containing Protein Btp1

(2008) Suzana P. Salcedo et al.   PLoS Pathogens

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE