Novel LRRK2 GTP-binding inhibitors reduced degeneration in Parkinson's disease cell and mouse models

Parkinson disease-associated mutation R1441H in LRRK2 prolongs the "active state" of its GTPase domain

(2014) J. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rationally Designed Multi-Targeted Agents Against Neurodegenerative Diseases

(2013) W. J. Geldenhuys et al.   CURRENT MEDICINAL CHEMISTRY

Leucine-rich repeat kinase 2 inhibitors: a patent review (2006 – 2011)

(2012) Xianming Deng et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

(2012) A. Biosa et al.   HUMAN MOLECULAR GENETICS

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin

(2012) Dejun Yang et al.   NEUROBIOLOGY OF DISEASE

The IkappaB Kinase Family Phosphorylates the Parkinson’s Disease Kinase LRRK2 at Ser935 and Ser910 during Toll-Like Receptor Signaling

(2012) Nicolas Dzamko et al.   PLoS One

Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease

(2012) Byoung Dae Lee et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Leprosy susceptibility: genetic variations regulate innate and adaptive immunity, and disease outcome

(2011) Cynthia Chester Cardoso et al.   Future Microbiology

Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

(2011) Zhaohui Liu et al.   HUMAN MOLECULAR GENETICS

Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities

(2011) Philip J. Webber et al.   JOURNAL OF MOLECULAR BIOLOGY

Parkinson’s disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures

(2011) Mansoureh Hakimi et al.   JOURNAL OF NEURAL TRANSMISSION

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

(2011) Xianming Deng et al.   Nature Chemical Biology

The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease

(2011) Zhihua Liu et al.   NATURE IMMUNOLOGY

Phosphorylation-Dependent 14-3-3 Binding to LRRK2 Is Impaired by Common Mutations of Familial Parkinson's Disease

(2011) Xianting Li et al.   PLoS One

Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2—Discovery of LRRK2 inhibitors

(2010) Min Liu et al.   ANALYTICAL BIOCHEMISTRY

Kinetic Mechanistic Studies of Wild-Type Leucine-Rich Repeat Kinase2: Characterization of the Kinase and GTPase Activities

(2010) Min Liu et al.   BIOCHEMISTRY

Synphilin-1 attenuates neuronal degeneration in the A53T  -synuclein transgenic mouse model

(2010) W. W. Smith et al.   HUMAN MOLECULAR GENETICS

Reevaluation of Phosphorylation Sites in the Parkinson Disease-associated Leucine-rich Repeat Kinase 2

(2010) Xiaojie Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LRRK2 Is Involved in the IFN-  Response and Host Response to Pathogens

(2010) A. Gardet et al.   JOURNAL OF IMMUNOLOGY

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

(2010) Byoung Dae Lee et al.   NATURE MEDICINE

The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

(2010) Mark R. Cookson   NATURE REVIEWS NEUROSCIENCE

GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

(2010) Yulan Xiong et al.   PLoS Genetics

Development of Extracellular Signal-Regulated Kinase Inhibitors

(2009) Kimberly Burkhard et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

LRRK2 in Parkinson’s disease: genetic and clinical studies from patients

(2009) Udhaya Kumari et al.   FEBS Journal

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease

(2008) Saskia Biskup et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Identification and Validation of Human DNA Ligase Inhibitors Using Computer-Aided Drug Design

(2008) Shijun Zhong et al.   JOURNAL OF MEDICINAL CHEMISTRY

Leucine-rich repeat kinase 2 (LRRK2): A key player in the pathogenesis of Parkinson's disease

(2008) Payal N. Gandhi et al.   JOURNAL OF NEUROSCIENCE RESEARCH

The biology and pathobiology of LRRK2: Implications for Parkinson's disease

(2008) Darren J. Moore   PARKINSONISM & RELATED DISORDERS

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase

(2008) J. Deng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA