Dictyostelium discoideumhas a highly Q/N-rich proteome and shows an unusual resilience to protein aggregation

Nucleocytoplasmic protein translocation during mitosis in the social amoebozoanDictyostelium discoideum

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Sorting out the trash: the spatial nature of eukaryotic protein quality control

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Amyloids and Yeast Prion Biology

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Protein disorder, prion propensities, and self-organizing macromolecular collectives

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PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone

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Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

Chaperone machines for protein folding, unfolding and disaggregation

(2013) Helen Saibil   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Spreading of a Prion Domain from Cell-to-Cell by Vesicular Transport in Caenorhabditis elegans

(2013) Carmen I. Nussbaum-Krammer et al.   PLoS Genetics

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

(2012) Oliver D. King et al.   BRAIN RESEARCH

Operational Plasticity Enables Hsp104 to Disaggregate Diverse Amyloid and Nonamyloid Clients

(2012) Morgan E. DeSantis et al.   CELL

Chaperone networks in protein disaggregation and prion propagation

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Molecular chaperones and stress-inducible protein-sorting factors coordinate the spatiotemporal distribution of protein aggregates

(2012) Liliana Malinovska et al.   MOLECULAR BIOLOGY OF THE CELL

Prions are a common mechanism for phenotypic inheritance in wild yeasts

(2012) Randal Halfmann et al.   NATURE

dictyBase 2013: integrating multiple Dictyostelid species

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Amino Acid Repeats Cause Extraordinary Coding Sequence Variation in the Social Amoeba Dictyostelium discoideum

(2012) Clea Scala et al.   PLoS One

Strategies for identifying new prions in yeast

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Sex, prions, and plasmids in yeast

(2012) A. C. Kelly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Plasmodium falciparum  heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers

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Polyglutamine Toxicity Is Controlled by Prion Composition and Gene Dosage in Yeast

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Nucleolar aggresomes as counterparts of cytoplasmic aggresomes in proteotoxic stress

(2011) Leena Latonen   BIOESSAYS

Regulatory Circuits of the AAA+ Disaggregase Hsp104

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Opposing Effects of Glutamine and Asparagine Govern Prion Formation by Intrinsically Disordered Proteins

(2011) Randal Halfmann et al.   MOLECULAR CELL

Molecular chaperones in protein folding and proteostasis

(2011) F. Ulrich Hartl et al.   NATURE

RNA-binding proteins with prion-like domains in ALS and FTLD-U

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Cellular Strategies of Protein Quality Control

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Comparative genomics of the social amoebae Dictyostelium discoideum and Dictyostelium purpureum

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Applying Hsp104 to protein-misfolding disordersThis paper is one of a selection of papers published in this special issue entitled 8th International Conference on AAA Proteins and has undergone the Journal's usual peer review process.

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Chaperone-assisted degradation: multiple paths to destruction

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Polyglutamine toxicity in non-neuronal cells

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A Nucleus-based Quality Control Mechanism for Cytosolic Proteins

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Protein Quality Control in the Cytosol and the Endoplasmic Reticulum: Brothers in Arms

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Cellular strategies for controlling protein aggregation

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Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability

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Prions, protein homeostasis, and phenotypic diversity

(2010) Randal Halfmann et al.   TRENDS IN CELL BIOLOGY

The ubiquitin proteasome system in neuropathology

(2009) Norman L. Lehman   ACTA NEUROPATHOLOGICA

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

Characterization of a REG/PA28 Proteasome Activator Homolog inDictyostelium discoideumIndicates that the Ubiquitin- and ATP-Independent REGγ Proteasome Is an Ancient Nuclear Protease

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Quality Control Against Misfolded Proteins in the Cytosol: A Network for Cell Survival

(2009) H. Kubota   JOURNAL OF BIOCHEMISTRY

Mimicking proteasomal release of polyglutamine peptides initiates aggregation and toxicity

(2009) M. Raspe et al.   JOURNAL OF CELL SCIENCE

Compositional Determinants of Prion Formation in Yeast

(2009) J. A. Toombs et al.   MOLECULAR AND CELLULAR BIOLOGY

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Proteasomes Cleave at Multiple Sites within Polyglutamine Tracts

(2008) Gregory Pratt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 is localized to a sub-nucleolar compartment after proteasomal inhibition in an energy-dependent manner

(2008) O. Karni-Schmidt et al.   JOURNAL OF CELL SCIENCE

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

(2008) Da Wei Huang et al.   NUCLEIC ACIDS RESEARCH

A new set of small, extrachromosomal expression vectors for Dictyostelium discoideum

(2008) Douwe M. Veltman et al.   PLASMID

The yeast Sup35NM domain propagates as a prion in mammalian cells

(2008) C. Krammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adapting Proteostasis for Disease Intervention

(2008) William E. Balch et al.   SCIENCE

Polyglutamine neurodegeneration: protein misfolding revisited

(2008) Aislinn J. Williams et al.   TRENDS IN NEUROSCIENCES