PDE4: A Novel Target in the Treatment of Chronic Obstructive Pulmonary Disease

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

(2011) Kirsty F. MacKenzie et al.   BIOCHEMICAL JOURNAL

Budesonide/formoterol vs. salmeterol/fluticasone in COPD: a systematic review and adjusted indirect comparison of pneumonia in randomised controlled trials

(2011) D. M. G. Halpin et al.   INTERNATIONAL JOURNAL OF CLINICAL PRACTICE

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function

(2011) H. Murdoch et al.   JOURNAL OF CELL SCIENCE

In Vivo Characterization of GSK256066, a High-Affinity Inhaled Phosphodiesterase 4 Inhibitor

(2011) A. T. Nials et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C

(2010) Rebecca J. Bird et al.   BIOCHEMICAL JOURNAL

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK

(2010) Xiang Li et al.   BIOCHEMICAL JOURNAL

Silence of the Limbs: Pharmacological Symptomatic Treatment of Intermittent Claudication

(2010) Tine De Backer et al.   Current Vascular Pharmacology

Association of serotonin transporter gene variation with smoking, chronic obstructive pulmonary disease and its depressive symptoms

(2010) Takeo Ishii et al.   JOURNAL OF HUMAN GENETICS

Role of emphysema and airway obstruction in prognosis of lung cancer

(2010) J.A. Gullón et al.   LUNG CANCER

Roflumilast

(2010) Leonardo M. Fabbri et al.   NATURE REVIEWS DRUG DISCOVERY

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

(2010) C. M. Adamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Bone Mineral Density in Patients With Chronic Obstructive Pulmonary Disease Who Are Candidates for Lung Transplant

(2010) J.M. Vaquero-Barrios et al.   TRANSPLANTATION PROCEEDINGS

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

(2009) Katharine H Banner et al.   BRITISH JOURNAL OF PHARMACOLOGY

A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD

(2009) J. Vestbo et al.   EUROPEAN RESPIRATORY JOURNAL

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

(2009) Leonardo M Fabbri et al.   LANCET

Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials

(2009) Peter MA Calverley et al.   LANCET

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10)

(2008) Angela McCahill et al.   CELLULAR SIGNALLING

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA)

(2008) Daniel M. Collins et al.   CELLULAR SIGNALLING

Subtype Selectivity in Phosphodiesterase 4 (PDE4): A Bottleneck in Rational Drug Design

(2008) P. Srivani et al.   CURRENT PHARMACEUTICAL DESIGN

Trends in Kidney Transplantation over the Past Decade

(2008) Greg Knoll   DRUGS

Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4

(2008) Wito Richter et al.   EMBO JOURNAL

Differential Effects of PDE4 Inhibitors on Cortical Neurons and T-Lymphocytes

(2008) Ryo Hirose et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES