Article
Food Science & Technology
Chucen Liu, Chengcheng Zhao, Hujun Liu, Wen Du, Jing Sun, Wenhua Zhou, Changpo Sun
Summary: In this study, two novel strains of Brevibacillus sp., ALJ01 and ALJ02, were isolated from wheat samples and found to have the ability to degrade OTA. The degradation products of OTA were identified as ochratoxin and phenylalanine. These strains could completely degrade OTA within 12 hours and efficiently reduce OTA in wheat products. Strain ALJ02 also showed antagonistic activity against certain OTA-producing fungal species. This study discovered two new strains of Brevibacillus genus with good OTA degradation ability and revealed their potential prospects for biodegradation and biocontrol of OTA.
Article
Food Science & Technology
Flavio Fonseca Veras, Rafaela Diogo Silveira, Juliane Elisa Welke
Summary: Fungal diseases impact agricultural productivity and quality, and some fungi produce mycotoxins that are harmful to human health. The use of synthetic fungicides is concerning due to their toxicity, leading to the emergence of biological control strategies. Bacillus spp. is identified as a promising alternative for sustainable and safe fungal and mycotoxin control.
CURRENT OPINION IN FOOD SCIENCE
(2023)
Article
Food Science & Technology
Mengxue Peng, Zitong Zhao, Zhihong Liang
Summary: The strain Brevundimonas naejangsanensis ML17 can simultaneously degrade OTA and OTB, with a degradation rate of 100%. Its extracellular enzyme has a degradation rate of OTA above 90% within the temperature range of 25-55 degrees Celsius, making it a potential detoxifier for ochratoxins.
Article
Chemistry, Applied
Mengxue Peng, Zhenzhen Zhang, Xinge Xu, Haoxiang Zhang, Zitong Zhao, Zhihong Liang
Summary: In this study, four novel OTA and OTB degrading enzymes, BnOTase1, BnOTase2, BnOTase3, and BnOTase4, were purified from the metabolites of Brevundimonas naejangsanensis ML17 strain. These enzymes hydrolyzed OTA into OT alpha and OTB into OT beta. They showed no significant cytotoxicity to HEK293 cells, suggesting their potential in mitigating the toxicity of OTA and OTB.
Article
Biochemistry & Molecular Biology
Jelena Loncar, Barbara Bellich, Alessia Parroni, Massimo Reverberi, Roberto Rizzo, Slaven Zjalic, Paola Cescutti
Summary: The study evaluated oligosaccharides extracted from Trametes versicolor for controlling two mycotoxins, with heptasaccharides showing up to 90% inhibitory activity. These results suggest that these oligosaccharides could be natural alternatives for controlling mycotoxins.
Review
Food Science & Technology
Qiya Yang, Solairaj Dhanasekaran, Guillaume Legrand Ngolong Ngea, Shiping Tian, Boqiang Li, Hongyin Zhang
Summary: This review discusses the issue of ochratoxin A (OTA) contamination in foodstuff and the latest developments in OTA control and bio-decontamination strategies. Biological control and bio-decontamination are considered the most promising strategies, but further research is needed to improve their efficiency and cost-effectiveness.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Environmental Sciences
Dun Jiang, Shuai Wu, Mingtao Tan, Hong Jiang, Shanchun Yan
Summary: This study found that exposure to cadmium increased the susceptibility of gypsy moth larvae to Beauveria bassiana, with an additive effect between cadmium exposure and B. bassiana infection on larval mortality. The immunotoxic effects induced by cadmium exposure increased at the transcription level in a negative dose-response manner, while a potentially suppressed or stimulated trend was revealed in the Toll and Imd signaling pathways at the protein level.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Ana Lucia Leitao, Francisco J. Enguita
Summary: Through structure-based methods and proteome mining, potential enzymatic activity capable of degrading ochratoxins has been identified in filamentous fungi, offering a promising solution for detoxification of various food commodities.
Article
Pharmacology & Pharmacy
Lan Wang, Xia Hua, Jie Shi, Ninghao Jing, Ting Ji, Bing Lv, Lijun Liu, Yun Chen
Summary: This paper reviews the source, occurrence, and latest achievements in the removal and detoxification of Ochratoxin A (OTA) in food and agricultural products. The influencing factors and mechanisms related to the biodetoxification of OTA are discussed, as well as the advantages, disadvantages, and potential application prospects of these methods.
Article
Food Science & Technology
Eva Cebrian, Felix Nunez, Micaela Alvarez, Elia Roncero, Mar Rodriguez
Summary: This study evaluated the effect of two microorganisms isolated from dry-cured meat products, Debaryomyces hansenii and Staphylococcus xylosus, as biocontrol agents (BCAs) against the ochratoxin A (OTA) producing mould Penicillium nordicum during the ripening of dry-cured fermented sausages. The BCAs were able to colonise and develop throughout the processing, and although they did not reduce the growth of P. nordicum, a decrease in OTA was observed in sausages inoculated with D. hansenii individually or combined with S. xylosus.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xinge Xu, Min Pang, Jiawei Liu, Yuping Wang, Xiaoyan Wu, KunLun Huang, Zhihong Liang
Summary: Bacillus subtilis CW14, isolated from fresh elk droppings in Beijing Zoo, is a GRAS bacterium capable of detoxifying ochratoxin A (OTA). The genome sequence of CW14 revealed putative enzymes involved in degrading mycotoxins, with particular focus on carboxypeptidases for OTA detoxification. This bacterium and its carboxypeptidases show promise as OTA detoxification agents in food and feed industry production.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Environmental Sciences
Ponnuswamy Vijayaraghavan, A. Amala Lourthuraj, Mariadhas Valan Arasu, Naif AbdullahAl-Dhabi, Balasubramani Ravindran, Soon WoongChang
Summary: This study focused on screening antibiotics-degrading bacteria from enriched sewage sludge and analyzing their degradation efficiency and optimal conditions in a moving bed bioreactor for the removal of antibiotics and nutrients from wastewater. Selected bacterial strains showed high antibiotic tolerance and efficient degradation rates, indicating the potential of indigenous bacterial communities for survival in challenging environments. The moving bed bioreactor proved to be useful for the simultaneous removal of nutrients and antibiotics from wastewater.
ENVIRONMENTAL RESEARCH
(2021)
Article
Food Science & Technology
Micaela Alvarez, Josue Delgado, Felix Nunez, Eva Cebrian, Maria J. Andrade
Summary: The study evaluated the efficiency of biocontrol agents against ochratoxigenic P. nordicum on dry-cured fermented sausages. Rosemary essential oil and the combination of rosemary leaves with D. hansenii were found to significantly inhibit OTA production. Proteomic analysis revealed that rosemary essential oil reduced proteins involved in OTA production, while the combination of rosemary leaves with D. hansenii showed inter-strain differences in protein abundance related to OTA reduction.
Article
Food Science & Technology
Izabela Podgorska-Kryszczuk, Urszula Pankiewicz, Lidia Sas-Paszt
Summary: The results of this study demonstrate the potential of two wild yeast strains, Aureobasidium pullulans PP3 and Saitozyma podzolicus D10, in the biological control of A. parasiticus and A. ochraceus and the reduction of OTA and AFs production. The yeast strains exhibited enzyme activity and the ability to grow under a wide range of conditions. Adding the yeast to bread dough resulted in a decrease in OTA and AFs levels.
Article
Food Science & Technology
Eva Cebrian, Elia Roncero, Josue Delgado, Felix Nunez, Mar Rodriguez
Summary: The aim of this study was to investigate the antifungal mode of action of Staphylococcus xylosus Sx8 and Staphylococcus equorum Se31 against Penicillium nordicum. The results showed that live cells of both cocci effectively inhibited the growth of P. nordicum at 15 or 20°C, while dead cells and extracellular extracts had no effect. Furthermore, S. xylosus and S. equorum were able to decrease the production of ochratoxin A (OTA) by P. nordicum, and this was associated with alterations in OTA biosynthesis, cell wall integrity, and carbohydrate metabolism.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Wentao Xu, Wanchong He, Zaihui Du, Liye Zhu, Kunlun Huang, Yi Lu, Yunbo Luo
Summary: Functional nucleic acid (FNA) nanotechnology focuses on studying the interactions between FNAs and nanomaterials, aiming to create advanced biomaterials with unique properties for various applications in bioimaging, biosensing, biomedicine, and other important fields.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Cell Biology
Junyu Liu, Chuanhai Zhang, Boyang Zhang, Yao Sheng, Wentao Xu, Yunbo Luo, Xiaoyun He, Kunlun Huang
Article
Cell Biology
Boyang Zhang, Hongyu Li, Liye Zhu, Xiaoyun He, Haoshu Luo, Kunlun Huang, Wentao Xu
CELL BIOLOGY AND TOXICOLOGY
(2021)
Article
Chemistry, Applied
Xuetong Li, Yuan Su, Huashuo Chu, Shuxia Lyu, Jingjing Tian, Wentao Xu
Article
Chemistry, Applied
Ying Shang, Boyang Zhang, Liye Zhu, Kunlun Huang, Wentao Xu
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2020)
Article
Chemistry, Analytical
Kai Li, Yunbo Luo, Kunlun Huang, Zhansen Yang, Yusong Wan, Wentao Xu
ANALYTICA CHIMICA ACTA
(2020)
Article
Cell Biology
Boyang Zhang, Yaqi Dai, Liye Zhu, Xiaoyun He, Kunlun Huang, Wentao Xu
CELL BIOLOGY AND TOXICOLOGY
(2020)
Article
Environmental Sciences
Liye Zhu, Chuchu Huang, Xuan Yang, Boyang Zhang, Xiaoyun He, Wentao Xu, Kunlun Huang
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2020)
Article
Biochemistry & Molecular Biology
Chuanhai Zhang, Xiaoyun He, Yao Sheng, Cui Yang, Jia Xu, Shujuan Zheng, Junyu Liu, Wentao Xu, Yunbo Luo, Kunlun Huang
Article
Chemistry, Applied
Ying Shang, Yuancong Xu, Kunlun Huang, Yunbo Luo, Wentao Xu
Article
Agriculture, Multidisciplinary
Xiaoyun He, Shujuan Zheng, Yao Sheng, Tong Miao, Jia Xu, Wentao Xu, Kunlun Huang, Changhui Zhao
Summary: Supplementation with chlorogenic acid can improve high-fat diet-induced obesity and associated glucose intolerance mainly through regulating food intake and energy expenditure.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2021)
Article
Multidisciplinary Sciences
Chuanhai Zhang, Xiaoyun He, Yao Sheng, Jia Xu, Cui Yang, Shujuan Zheng, Junyu Liu, Haoyu Li, Jianbing Ge, Minglan Yang, Baiqiang Zhai, Wentao Xu, Yunbo Luo, Kunlun Huang
Article
Agriculture, Multidisciplinary
Xu Chen, Hongyu Li, Wentao Xu, Kunlun Huang, Baiqiang Zhai, Xiaoyun He
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Nanoscience & Nanotechnology
Lirong Zheng, Boyang Zhang, Huashuo Chu, Ping Cheng, Hongyu Li, Kunlun Huang, Xiaoyun He, Wentao Xu
Article
Forestry
Hao Sun, Tiantao Li, Xiangjun Pei, Jian Guo, Jingjing Tian, Shoudao Wang, Mingfang Pu
Summary: The Nandongzi landslide in North China was studied, and it was found that the structure of the soft and hard interbedded rock and the proximity of the fault are the main factors causing slope deformation. Monitoring data show that rainfall is the direct cause of slope deformation.