Article
Clinical Neurology
Emily Rosenich, Lisa Bransby, Nawaf Yassi, Jurgen Fripp, Simon M. Laws, Ralph N. Martins, Christopher Fowler, Stephanie R. Rainey-Smith, Christopher C. Rowe, Colin L. Masters, Paul Maruff, Yen Ying Lim
Summary: This study aimed to determine the association of modifiable/nonmodifiable components in the CAIDE risk score with hippocampal volume loss and episodic memory decline. The results showed that age and APOE epsilon 4 were associated with these declines. Interventions to reduce modifiable cardiovascular risk factors may be beneficial in reducing the hippocampal volume loss and episodic memory decline in cognitively normal older adults.
Article
Behavioral Sciences
Joan Jimenez-Balado, Alexandra Ycaza Herrera, Kay Igwe, Lynda Klem, Korhan Buyukturkoglu, Andrei Irimia, Liu Chen, Jia Guo, Adam M. Brickman, Teal S. Eich
Summary: This study found that sex, rather than the ApoE epsilon 4 genotype, moderates the relationship between hippocampal GABA+ and episodic memory, with women showing worse memory performance when having lower GABA+ concentration.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hui Zhang, Pui W. Chiu, Isaac Ip, Tianyin Liu, Gloria H. Y. Wong, You-Qiang Song, Savio W. H. Wong, Karl Herrup, Henry K. F. Mak
Summary: The ApoE4 allele is the most common gene polymorphism related to Alzheimer's disease, and it remains unclear whether ApoE4 status affects hippocampal neuromodulation and brain network topology. This study found that healthy ApoE4 carriers exhibit poorer local interconnectivity and a close relationship between glutamate and small-world network properties in these carriers may reflect a compensatory response to impaired network efficiency.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Dong Cui, Dianyu Wang, Jingna Jin, Xu Liu, Yuheng Wang, Weifang Cao, Zhipeng Liu, Tao Yin
Summary: This study investigated the age and sex differences in cortical morphology among middle-aged and older adults and their relationship with cognitive decline. The results showed that both males and females exhibited age-related decreases in cortical thickness, fractal dimension, and gyrification index. Moreover, significant sex differences in fractal dimension and gyrification index were observed among middle-aged and older adult participants. There were also significant correlations between cortical morphology differences and test scores for processing speed and working memory.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Geriatrics & Gerontology
Yaara Orland, Michal Schnaider Beeri, Sigal Levy, Ariel Israel, Ramit Ravona-Springer, Shlomo Segev, Odelia Elkana
Summary: The study shows that physical fitness plays an important protective role in healthy aging, slowing down cognitive decline in older adults. Better physical fitness is associated with faster cognitive processing speed among the elderly, and the relationship between age and processing speed is fully mediated by physical fitness.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Clinical Neurology
Simon Schmitt, Kai G. Ringwald, Tina Meller, Frederike Stein, Katharina Brosch, Julia-Katharina Pfarr, Tim Hahn, Hannah Lemke, Susanne Meinert, Jonathan Repple, Katharina Thiel, Lena Waltemate, Alexandra Winter, Dominik Grotegerd, Astrid Dempfle, Andreas Jansen, Axel Krug, Udo Dannlowski, Igor Nenadic, Tilo Kircher
Summary: Epidemiological studies have shown that gestational age and birth weight are associated with cognitive performance in adults. This study examined the relationships between gestational age, cortical gyrification, and specific neuropsychological factors in healthy adults. The findings suggest that gestational age is positively associated with cortical folding in certain brain regions, and these associations are moderated by gestational age. Additionally, gyrification is related to specific neuropsychological abilities. These results have important implications for understanding the cortical neurodevelopment of cognitive domains and mental health.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Bethany M. Coad, Parisa A. Ghomroudi, Rebecca Sims, John P. Aggleton, Seralynne D. Vann, Claudia Metzler-Baddeley
Summary: This study investigated the impact of three risk factors (APOE-64, family history of dementia, and central obesity) on different subfields of the hippocampal formation in cognitively healthy adults. The results showed that aging and central obesity affected the myelin/neurite packing, and APOE 64 carriers exhibited lower size/complexity in individuals with a healthy waist-hip ratio.
NEUROBIOLOGY OF AGING
(2022)
Article
Medicine, General & Internal
Jianping Jia, Tan Zhao, Zhaojun Liu, Yumei Liang, Fangyu Li, Yan Li, Wenying Liu, Fang Li, Shengliang Shi, Chunkui Zhou, Heyun Yang, Zhengluan Liao, Yang Li, Huiying Zhao, Jintao Zhang, Kunnan Zhang, Minchen Kan, Shanshan Yang, Hao Li, Zhongling Liu, Rong Ma, Jihui Lv, Yue Wang, Xin Yan, Furu Liang, Xiaoling Yuan, Jinbiao Zhang, Serge Gauthier, Jeffrey Cummings
Summary: This study aimed to identify an optimal lifestyle profile for protecting older individuals from memory loss. The findings revealed that a healthy lifestyle is associated with slower memory decline, even in the presence of the APOE epsilon 4 allele. This study offers important information to protect older adults against memory decline.
BMJ-BRITISH MEDICAL JOURNAL
(2023)
Article
Multidisciplinary Sciences
Chris B. Martin, Bryan Hong, Rachel N. Newsome, Katarina Savel, Melissa E. Meade, Andrew Xia, Christopher J. Honey, Morgan D. Barense
Summary: The act of remembering everyday experiences affects our perception of the world, future thinking, and self-perception. However, the ability to recall specific details and relive the past tends to decline with age. To address this, a smartphone application called HippoCamera was developed to help older adults enhance their episodic memory. By repeatedly reactivating memories of real-world events, participants experienced improved recollection and more positive emotions. These benefits were observed shortly after the intervention and even after a 3-month delay.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Geriatrics & Gerontology
Cristina Sole-Padulles, Didac Macia, Micael Andersson, Mikael Stiernstedt, Sara Pudas, Sandra Duezel, Eniko Zsoldos, Klaus P. Ebmeier, Julia Binnewies, Christian A. Drevon, Andreas M. Brandmaier, Athanasia M. Mowinckel, Anders M. Fjell, Kathrine Skak Madsen, William F. C. Baare, Ulman Lindenberger, Lars Nyberg, Kristine B. Walhovd, David Bartres-Faz
Summary: Loneliness is associated with worsening of verbal episodic memory in older adults, especially in individuals experiencing progressive cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Eelco van Duinkerken, Richard G. IJzerman, Frederik Barkhof, Annette C. Moll, Michaela Diamant, Frank J. Snoek, Martin Klein
Summary: The study revealed an interaction between ApoE-epsilon 4 and T1DM in affecting cognitive performance and hippocampal connectivity, particularly in domains of attention and information processing speed. Patients with T1DM showed worse cognitive performance and increased connectivity with ApoE-epsilon 4 presence, while control subjects with ApoE-epsilon 4 had decreased connectivity without cognitive effects.
Article
Geriatrics & Gerontology
Jinshil Hyun, Mindy J. Katz, Carol A. Derby, Nelson Roque, Elizabeth Munoz, Martin J. Sliwinski, Gina S. Lovasi, Richard B. Lipton
Summary: This study examined the association between healthy food availability and cognitive performance among urban older adults. It found that subjective availability of healthy foods, but not objective food environments, was associated with better processing speed and memory binding performance. Furthermore, a portion of this association was mediated through fruit and vegetable consumption.
Article
Cell Biology
Haoyang Li, Li Xu, Wei Jiang, Xiusheng Qiu, Huiming Xu, Fan Zhu, Yu Hu, Shuzhen Liang, Chengcheng Cai, Wei Qiu, Zhengqi Lu, Yaxiong Cui, Changyong Tang
Summary: This study reveals that cognitive impairment is associated with a decline in adult hippocampal neurogenesis (AHN). Pleiotrophin (PTN) expression decreases with aging, leading to impaired AHN and poor learning and memory. The study shows that PTN interacts with protein tyrosine phosphatase receptor type Z1 (PTPRZ1) to promote neural stem and progenitor cell (NSPC) proliferation and differentiation through AKT signaling. Overexpression of PTN or pharmacological activation of AKT signaling in aging mice restores AHN and improves memory deficits.
Article
Psychology, Multidisciplinary
George Samrani, Anders Lundquist, Sara Pudas
Summary: Declarative memory abilities change across adulthood. Semantic memory and autobiographic episodic knowledge can remain stable or even increase from mid- to late adulthood, while episodic memory abilities decline in later adulthood. An increased reliance on memory integration may be an adaptive mechanism to handle increased interference from accumulating memory traces and knowledge across adulthood. Middle-aged adults show age-equivalent performance on integration and discrimination measures, along with higher verbal knowledge and slower perceptual speed compared to younger adults.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Geriatrics & Gerontology
Kendra L. Pizzonia, Julie A. Suhr, Leatha A. Clark, Brian C. Clark
Summary: This study examined the relationship between ApoE and COMT genes and their interaction on cognitive and motor performance in community-dwelling older adults. Results showed that COMT genotypes were associated with worse cognitive performance in older adults with at least one ApoE ε4 allele, while women scored higher than men in cognitive tasks. There were no significant effects on motor function.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Giorgio Pigato, Stella Rosson, Nicola Bresolin, Tommaso Toffanin, Fabio Sambataro, Daniele Olivo, Giulia Perini, Francesco Causin, Luca Denaro, Andrea Landi, Domenico D'Avella
Summary: This study conducted a long-term follow-up on 5 patients with treatment-resistant depression (TRD) who received vagus nerve stimulation (VNS) implant. The results showed that VNS had long-lasting effectiveness in improving symptoms and functioning in patients with severe and chronic depression. The study supports VNS as a viable treatment option for TRD due to its sustained efficacy and good tolerability.
Article
Biochemistry & Molecular Biology
Nicolo Trevisan, Fabio Di Camillo, Niccolo Ghiotto, Giulia Cattarinussi, Maddalena Sala, Fabio Sambataro
Summary: In this study, the complexity of cortical folding (CCF) was compared between patients with cocaine addiction and controls. Patients with cocaine addiction showed reduced CCF in the left insula, the supramarginal gyrus, and the left medial orbitofrontal cortex. The reduction in cortical folding in the left medial orbitofrontal cortex was associated with the age of onset of cocaine addiction and attentional impulsivity.
Article
Psychiatry
Brita Elvevag
Summary: Thought disorder is an important part of the clinical presentation in schizophrenia, and traditional measurement approaches have limitations. Utilizing speech technologies can automate traditional clinical rating tasks and enhance assessment. However, translating thought disorder measurement into a clinically implementable tool still faces many challenges.
PSYCHIATRY RESEARCH
(2023)
Article
Substance Abuse
Gudrun M. Henemann, Mike M. Schmitgen, Nadine D. Wolf, Dusan Hirjak, Katharina M. Kubera, Fabio Sambataro, Tagrid Lemenager, Julian Koenig, Robert Christian Wolf
Summary: This study found a correlation between excessive smartphone use and the endogenous mu-opioid receptor (MOR) system using cross-modal correlations. The MOR system is closely linked to reward and withdrawal, suggesting its potential as a biological marker for technology-related addictive behaviors.
EUROPEAN ADDICTION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Ramachandran Prakasam, Angela Bonadiman, Roberta Andreotti, Emanuela Zuccaro, Davide Dalfovo, Caterina Marchioretti, Debasmita Tripathy, Gianluca Petris, Eric N. Anderson, Alice Migazzi, Laura Tosatto, Anna Cereseto, Elena Battaglioli, Gianni Soraru, Wooi Fang Lim, Carlo Rinaldi, Fabio Sambataro, Naemeh Pourshafie, Christopher Grunseich, Alessandro Romanel, Udai Bhan Pandey, Andrea Contestabile, Giuseppe Ronzitti, Manuela Basso, Maria Pennuto
Summary: Prakasam and colleagues demonstrate that targeting overexpressed co-activators Lsd1 and Prmt6 with artificial miRNAs can attenuate polyQ-expanded androgen receptor toxicity, ameliorating spinal-bulbar muscular atrophy phenotypes in flies and mice. This study suggests that targeting these co-regulators could be a potential therapeutic strategy for patients with SBMA, as it helps mitigate toxic gain-of-function without exacerbating loss-of-function mechanisms.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Diana Piol, Laura Tosatto, Emanuela Zuccaro, Eric N. Anderson, Antonella Falconieri, Maria J. Polanco, Caterina Marchioretti, Federica Lia, Joseph White, Elisa Bregolin, Giovanni Minervini, Sara Parodi, Xavier Salvatella, Giorgio Arrigoni, Andrea Ballabio, Albert R. La Spada, Silvio C. E. Tosatto, Fabio Sambataro, Diego L. Medina, Udai B. Pandey, Manuela Basso, Maria Plennuto
Summary: Spinal and bulbar muscular atrophy is caused by polyglutamine expansions in androgen receptor, leading to gain-of-function toxicity. This study investigates the phosphorylation of polyglutamine-expanded receptor and its role in neurodegeneration. The researchers find that certain kinases and phosphatases can modify the function and toxicity of the receptor, and targeting these enzymes can potentially be used as a therapeutic approach.
Article
Neurosciences
Mario Luciano, Gaia Sampogna, Bianca Della Rocca, Alessio Simonetti, Pasquale De Fazio, Marco Di Nicola, Giorgio Di Lorenzo, Maria Pepe, Fabio Sambataro, Maria Salvina Signorelli, Alexia Emilia Koukopoulos, Roberto Delle Chiaie, Gabriele Sani, Andrea Fiorillo
Summary: This study investigated the relationship between affective temperaments and suicidality. It found that certain affective dispositions were associated with the onset and intensity of suicidal ideation and behaviors. Therefore, evaluating affective dispositions in clinical settings can help identify individuals at risk of suicide and develop effective preventive interventions.
Article
Psychiatry
Hugo Corona Hernandez, Cheryl Corcoran, Amelie M. Achim, Janna N. de Boer, Tessel Boerma, Sanne G. Brederoo, Guillermo A. Cecchi, Silvia Ciampelli, Brita Elvevag, Riccardo Fusaroli, Silvia Giordano, Mathias Hauglid, Arjan van Hessen, Wolfram Hinzen, Philipp Homan, Sybren F. de Kloet, Sanne Koops, Gina R. Kuperberg, Kritika Maheshwari, Natalia B. Mota, Alberto Parola, Roberta Rocca, Iris E. C. Sommer, Khiet Truong, Alban E. Voppel, Marieke van Vugt, Frank Wijnen, Lena Palaniyappan
Summary: This workshop summary discusses the application of natural language processing (NLP) markers in psychosis and other psychiatric disorders. It highlights the importance of understanding the underlying mechanisms of these disorders for the optimal development of NLP markers. The challenges of implementing NLP marker-based Clinical Decision Support Systems (CDSSs) in psychiatric practice, particularly in relation to psychosis, are also identified.
SCHIZOPHRENIA BULLETIN
(2023)
Review
Neurosciences
Ahmad Shamabadi, Hanie Karimi, Giulia Cattarinussi, Hossein Sanjari Moghaddam, Shahin Akhondzadeh, Fabio Sambataro, Giandomenico Schiena, Giuseppe Delvecchio
Summary: Transcranial magnetic stimulation (TMS) has shown promise as a treatment for bipolar disorder (BD). This study reviewed neuroimaging findings of functional, structural, and metabolic brain changes associated with TMS in BD. Eleven studies were included, revealing that increased connectivity of emotion regulation and executive control regions, lower ventromedial prefrontal cortex connectivity, and changes in blood perfusion were important predictors of response to TMS.
Article
Neurosciences
Nicolo Trevisan, Giulia Cattarinussi, Daniele Olivo, Andrea Di Ciano, Lucia Giudetti, Alan Pampallona, Katharina M. M. Kubera, Dusan Hirjak, Robert Christian Wolf, Fabio Sambataro
Summary: This study investigated the neural bases of social victimization using functional magnetic resonance imaging. The results showed increased activation in certain brain areas during social victimization, as well as correlations with personality traits such as neuroticism and irritability.
Article
Clinical Neurology
Alessandro Miola, Nicolo Trevisan, Margherita Salvucci, Matteo Minerva, Silvia Valeggia, Renzo Manara, Fabio Sambataro
Summary: Facial emotion recognition, especially for sadness, is impaired in bipolar disorder. The association between this impairment and brain structure, clinical variables, and subtypes of bipolar disorder remains unclear.
EUROPEAN ARCHIVES OF PSYCHIATRY AND CLINICAL NEUROSCIENCE
(2023)
Review
Clinical Neurology
Mahan Shafie, Elnaz Shahmohamadi, Giulia Cattarinussi, Hossein Sanjari Moghaddam, Shahin Akhondzadeh, Fabio Sambataro, Chiara Moltrasio, Giuseppe Delvecchio
Summary: This review summarizes the findings of resting-state functional magnetic resonance imaging (rsfMRI) studies in individuals with borderline personality disorder (BPD). The results indicate aberrant functional connectivity within and between several brain networks, including the default mode network (DMN), salience network (SN), and central executive network (CEN), as well as selective functional impairments in specific brain regions. However, the generalizability of these results is limited by the observational design, small sample size, and heterogeneity across imaging methodologies.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Alessio Simonetti, Mario Luciano, Gaia Sampogna, Bianca Della Rocca, Emiliana Mancuso, Pasquale De Fazio, Marco Di Nicola, Giorgio Di Lorenzo, Maria Pepe, Fabio Sambataro, Maria Salvina Signorelli, Alexia Emilia Koukopoulos, Roberto Delle Chiaie, Andrea Fiorillo, Gabriele Sani
Summary: This multicentric observational study aimed to investigate the relationship between affective temperaments and bipolar disorder (BD) or major depressive disorder (MDD), as well as their influence on the severity and course of the diseases. The results revealed that specific affective temperaments were associated with certain disease characteristics. Evaluating affective temperaments may contribute to a better understanding of mood disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Meeting Abstract
Psychiatry
N. Trevisan, F. Di Camillo, G. Cattarinussi, N. Ghiotto, M. Sala, F. Sambataro
EUROPEAN PSYCHIATRY
(2023)
Review
Biochemistry & Molecular Biology
Michele Fornaro, Claudio Caiazza, Niccolo Solini, Michele De Prisco, Martina Billeci, Martina Vannini, Risa Shorr, Stefano Caiolo, Marialaura Lussignoli, Dan Siskind, Giorgio Pigato, Annarita Barone, Fabio Sambataro, Andrea de Bartolomeis, Christoph U. Correll, Marco Solmi
Summary: This study conducted a network meta-analysis on antipsychotic-induced sialorrhea. The results showed that dopamine receptor antagonists, metoclopramide, and sulpiride were effective in treating sialorrhea, while antihistamines and atropine showed no significant effect on nocturnal sialorrhea. This study provides some guidance for the treatment of antipsychotic-related sialorrhea.
MOLECULAR PSYCHIATRY
(2023)