Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Immunology
Qiyu Yang, Jing Ouyang, Damao Pi, Li Feng, Jiadan Yang
Summary: There is accumulating evidence that patients with inflammatory bowel disease (IBD) have a higher risk of developing different cancers, and the presence of Malassezia fungus may worsen the inflammatory response and promote tumorigenesis in these patients. Surveillance and intervention should be taken to minimize the cancer risk in individuals with IBD.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Engineering, Biomedical
Jingbo Zhao, Donghua Liao, Rune Wilkens, Klaus Krogh, Henning Glerup, Hans Gregersen
Summary: This study aimed to quantify the mechanical properties of intestinal stenosis in CD patients and found that the changes in mechanical properties were mainly associated with chronic inflammation, fibrosis, and collagen fraction.
ACTA BIOMATERIALIA
(2021)
Review
Biochemistry & Molecular Biology
Yuri Haneishi, Yuma Furuya, Mayu Hasegawa, Antonio Picarelli, Mauro Rossi, Junki Miyamoto
Summary: Inflammatory bowel disease (IBD) is a rapidly increasing inflammatory disease of the gastrointestinal tract worldwide. Recent research suggests that factors such as genetics, environment, microbiota, and immune responses are involved in its development, but the underlying causes are unclear. Dysbiosis of gut microbiota, particularly a decrease in specific genera, has been identified as a possible trigger for IBD. Improving gut microbiota and identifying specific bacterial species are crucial for understanding and treating IBD and autoimmune diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Martin Maronek, Irene Marafini, Roman Gardlik, Rene Link, Edoardo Troncone, Giovanni Monteleone
Summary: Inflammatory bowel diseases (IBD) refer to chronic inflammatory conditions of the gastrointestinal tract, including Crohn's disease (CD) and ulcerative colitis (UC). Excessive production of matrix metalloproteinases (MMPs) without sufficient inhibition by tissue inhibitors of metalloproteinases (TIMPs) in inflamed tissue of IBD patients contributes significantly to mucosal degradation in IBD-related pathologies.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Chao Liu, Yuhong Jiang, Ganglei Liu, Zhushu Guo, Qianqian Jin, Dongju Long, Weihan Zhou, Ke Qian, Hua Zhao, Kuijie Liu
Summary: This study found that PPARGC1A was downregulated in DSS-induced colitis and DSS-stimulated colonic epithelial cells, and PDT treatment could upregulate PPARGC1A expression. Knockdown of PPARGC1A could attenuate the therapeutic effects of PDT on DSS-induced colitis and DSS-stimulated colonic epithelial cells.
BIOCHEMICAL PHARMACOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Ting Zhang, Xinghui Ji, Gaochen Lu, Faming Zhang
Summary: Akkermansia muciniphila is a promising next-generation probiotic with recognized potential applications in metabolic diseases and tumor immunotherapy. Its safety and therapeutic value in human metabolic diseases have been confirmed in recent clinical trials. Additionally, A. muciniphila shows promise in the treatment of intestinal inflammatory diseases, particularly inflammatory bowel disease (IBD).
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Yang Zheng, Yang Yu, Xu-Feng Chen, Sheng-Lan Yang, Xiao-Long Tang, Zheng-Guo Xiang
Summary: Inflammatory bowel disease (IBD) is a group of chronic inflammatory disorders, with unclear mechanisms and lack of ideal treatments. Intestinal macrophage autophagy plays an important role in IBD, with potential implications for treatment by regulating inflammation and immune responses.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Timon E. Adolph, Jingwan Zhang
Summary: The diet and gut microbiota play a crucial role in gut inflammation in IBD. Specific nutrients in a Western diet can trigger or worsen experimental gut inflammation in genetically susceptible individuals. Nutritional trials provide common grounds for dietary advice in pediatric and adult IBD, with exclusive enteral nutrition showing effectiveness in treating pediatric Crohn's disease.
Review
Nutrition & Dietetics
Lewis Steell, Stuart R. Gray, Richard K. Russell, Jonathan MacDonald, John Paul Seenan, Sze Choong Wong, Daniel R. Gaya
Summary: Musculoskeletal deficits are commonly reported in patients with inflammatory bowel disease (IBD), particularly Crohn's disease. The adverse effects on bone and muscle are multifactorial, including inflammation, nutritional deficits, and therapies, leading to increased risk of osteoporosis and sarcopenia. Ib children with IBD, these factors may impact optimal bone and muscle accrual.
Article
Nutrition & Dietetics
Marlijne C. G. de Graaf, Corinne E. G. M. Spooren, Evelien M. B. Hendrix, Martine A. M. Hesselink, Edith J. M. Feskens, Agnieszka Smolinska, Daniel Keszthelyi, Marieke J. Pierik, Zlatan Mujagic, Daisy M. A. E. Jonkers
Summary: The study found that diet quality was lower in patients with IBD and IBS, and was associated with intestinal inflammation and gastrointestinal symptoms to varying degrees.
Article
Gastroenterology & Hepatology
Katsuyoshi Ando, Mikihiro Fujiya, Kenji Watanabe, Sakiko Hiraoka, Hisashi Shiga, Shinji Tanaka, Hideki Iijima, Tsunekazu Mizushima, Taku Kobayashi, Masakazu Nagahori, Hiroki Ikeuchi, Shingo Kato, Takehiro Torisu, Kiyonori Kobayashi, Masaaki Higashiyama, Toshiro Fukui, Takashi Kagaya, Motohiro Esaki, Shunichi Yanai, Daiki Abukawa, Makoto Naganuma, Satoshi Motoya, Masayuki Saruta, Shigeki Bamba, Makoto Sasaki, Kazuhiko Uchiyama, Katsuyuki Fukuda, Hideo Suzuki, Hiroshi Nakase, Toshiaki Shimizu, Masahiro Iizuka, Mamoru Watanabe, Yasuo Suzuki, Tadakazu Hisamatsu
Summary: The study investigated the mortality and risk factors of TE in IBD patients in Japan. The incidence of TE among 31,940 IBD patients was 1.89%, with 10.7% developing severe TE and 1.0% TE-associated mortality. Ischemic heart disease was the only risk factor for severe ATE and ATE-associated death, while age, VTE location, and disease severity were independent risk factors for severe VTE and VTE-associated death.
JOURNAL OF GASTROENTEROLOGY
(2021)
Review
Immunology
Xiaowen Zheng, Yi Zhu, Zihan Zhao, Ying Chu, Wenjing Yang
Summary: Inflammation is a characteristic symptom of many diseases, and this review summarizes the changes and mechanisms of amino acids in inflammatory bowel disease and other inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Joana Franco Lacerda, Ana Catarina Lagos, Elisabete Carolino, Ana Santos Silva-Herdade, Manuel Silva, Catarina Sousa Guerreiro
Summary: The study aimed to evaluate the effect of food components on intestinal permeability and inflammatory markers in individuals with IBD. While the specific impact of food components was inconclusive, there was a trend observed in the reduction of inflammatory parameters and gastrointestinal symptom prevalence. More controlled intervention studies with diet plans including potentially beneficial food components for intestinal barrier integrity are warranted.
Review
Immunology
Hoyul Lee, Jae-Han Jeon, Eun Soo Kim
Summary: Mitochondria play a critical role in regulating immune responses and metabolic reprogramming in inflammation. The metabolic pathways of glycolysis, pyruvate oxidation, and glutaminolysis have been shown to be crucial for the metabolic reprogramming of colitogenic T cells. In addition, mitochondrial dysfunction is implicated in the pathogenesis of inflammatory bowel disease (IBD).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Paul Reidler, Alex Brehm, Peter B. Sporns, Vanessa Granja Burbano, Lena Stueckelschweiger, Gabriel Broocks, Thomas Liebig, Marios-Nikos Psychogios, Jens Ricke, Konstantinos Dimitriadis, Martin Dichgans, Wolfgang G. Kunz, Steffen Tiedt
Summary: The study found that human stroke progression varies across the 24-hour cycle, with patients who have nocturnal stroke onset showing larger infarct core volumes and faster core growth. These findings have implications for the design and interpretation of neuroprotection trials.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Marios K. Georgakis, Rainer Malik, Stephen Burgess, Martin Dichgans
Summary: Genetically downregulated IL-6 signaling and genetically lowered LDL-C are associated with additively lower lifetime risk of cardiovascular disease. Future trials should explore combined IL-6 inhibition and LDL-C lowering treatments for cardiovascular prevention.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Clinical Neurology
Kristiina Rannikmae, Konrad Rawlik, Amy C. Ferguson, Nikos Avramidis, Muchen Jiang, Nicola Pirastu, Xia Shen, Emma Davidson, Rebecca Woodfield, Rainer Malik, Martin Dichgans, Albert Tenesa, Cathie Sudlow
Summary: The accuracy of stroke codes in UK Biobank was studied using genetic validation. The results showed that stroke case numbers varied depending on the code source and type used. All stroke definitions were significantly genetically correlated with the largest stroke GWAS to date, but some results had limited precision.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Andreas Zellner, Stephan A. Mueller, Barbara Lindner, Nathalie Beaufort, Annemieke J. M. Rozemuller, Thomas Arzberger, Nils C. Gassen, Stefan F. Lichtenthaler, Bernhard Kuster, Christof Haffner, Martin Dichgans
Summary: Cerebral amyloid angiopathy (CAA) is an age-related condition that is closely associated with Alzheimer's disease (AD). This study identified a specific proteomic profile associated with CAA type 1, involving the accumulation of high-temperature requirement protein A1 (HTRA1) and its substrates. Interestingly, this signature was not present in AD cases, highlighting a molecular difference between the two conditions.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Clinical Neurology
Frank Jessen, Steffen Wolfsgruber, Luca Kleineindam, Annika Spottke, Slawek Altenstein, Claudia Bartels, Moritz Berger, Frederic Brosseron, Marcel Daamen, Martin Dichgans, Laura Dobisch, Michael Ewers, Friederike Fenski, Klaus Fliessbach, Silka D. Freiesleben, Wenzel Glanz, Doreen Goerss, Selim Guersel, Daniel Janowitz, Ingo Kilimann, Xenia Kobeleva, Andrea Lohse, Franziska Maier, Coraline Metzger, Matthias Munk, Lukas Preis, Carolin Sanzenbacher, Eike Spruth, Boris Rauchmann, Ruth Vukovich, Renat Yakupov, Anne-Sophie Weyrauch, Gabriel Ziegler, Matthias Schmid, Christoph Laske, Robert Perneczky, Anja Schneider, Jens Wiltfang, Stefan Teipel, Katharina Buerger, Josef Priller, Oliver Peters, Alfredo Ramirez, Henning Boecker, Michael T. Heneka, Michael Wagner, Emrah Duezel
Summary: Research finds that subjective cognitive decline (SCD) in individuals who seek medical help may serve as an initial symptomatic stage 2 of the Alzheimer's disease (AD) continuum. The SCD group shows slightly worse cognition, as well as more subtle functional and behavioral symptoms compared to the control group (CO). It is also discovered that SCD-A+ cases (39.3% of all SCD) exhibit greater hippocampal atrophy, lower cognitive and functional performance, and more behavioral symptoms.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Marios K. Georgakis, Rong Fang, Marco Duering, Frank A. Wollenweber, Felix J. Bode, Sebastian Stoesser, Christine Kindlein, Peter Hermann, Thomas G. Liman, Christian H. Nolte, Lucia Kerti, Benno Ikenberg, Kathleen Bernkopf, Holger Poppert, Wenzel Glanz, Valentina Perosa, Daniel Janowitz, Michael Wagner, Katja Neumann, Oliver Speck, Laura Dobisch, Emrah Duezel, Benno Gesierich, Anna Dewenter, Annika Spottke, Karin Waegemann, Michael Goertler, Silke Wunderlich, Matthias Endres, Inga Zerr, Gabor Petzold, Martin Dichgans
Summary: The global burden of small vessel disease (SVD) predicts cognitive and functional outcomes in stroke patients, but the current score used for assessment does not improve prediction capability. Assessing the severity of SVD lesions adds value in predicting outcomes beyond known predictors.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Marios K. Georgakis, Rainer Malik, Tom G. Richardson, Joanna M. M. Howson, Christopher D. Anderson, Stephen Burgess, G. Kees Hovingh, Martin Dichgans, Dipender Gill
Summary: The study found that genetically predicted IL-6 signaling is positively associated with CVD risk, and the increase in CVD risk is linearly related to baseline hsCRP levels. There is no heterogeneity in the association of genetically predicted IL-6 signaling with CVD risk when stratifying the population by sex, age, body mass index, estimated glomerular filtration rate, or systolic blood pressure, but there is evidence of greater associations in individuals with low-density lipoprotein cholesterol >= 160 mg/dL.
Article
Clinical Neurology
Brittany L. Mitchell, Santiago Diaz-Torres, Svetlana Bivol, Gabriel Cuellar-Partida, Zachary F. Gerring, Nicholas G. Martin, Sarah E. Medland, Katrina L. Grasby, Dale R. Nyholt, Miguel E. Renteria
Summary: This study explores the genetic relationship between migraine risk and brain morphometry using genome-wide association studies. The researchers found a negative genetic correlation between migraine risk and intracranial volume, and identified shared genomic regions between migraine and various brain structures. Additionally, evidence of a causal relationship between smaller brain volumes and increased migraine risk was discovered. These findings contribute to the understanding of the genetic basis for migraine and potential therapeutic targets.
Article
Clinical Neurology
Anna Dewenter, Mina A. Jacob, Mengfei Cai, Benno Gesierich, Paul Hager, Anna Kopczak, Davina Biel, Michael Ewers, Anil M. Tuladhar, Frank-Erik De Leeuw, Martin Dichgans, Nicolai Franzmeier, Marco Duering
Summary: Fixel-based analysis of diffusion MRI can identify changes in white matter integrity. Neurodegeneration in Alzheimer's disease affects white matter macrostructure, while cerebral small vessel disease affects white matter microstructure. Fiber density reflects the impact of cerebral small vessel disease, while fiber-bundle cross-section is primarily determined by neurodegeneration.
Article
Clinical Neurology
Andreas Charidimou, Gregoire Boulouis, Matthew P. Frosch, Jean-Claude Baron, Marco Pasi, Jean Francois Albucher, Gargi Banerjee, Carmen Barbato, Fabrice Bonneville, Sebastian Brandner, Lionel Calviere, Francois Caparros, Barbara Casolla, Charlotte Cordonnier, Marie-Bernadette Delisle, Vincent Deramecourt, Martin Dichgans, Elif Gokcal, Jochen Herms, Mar Hernandez-Guillamon, Hans Rolf Jager, Zane Jaunmuktane, Jennifer Linn, Sergi Martinez-Ramirez, Elena Martinez-Saez, Christian Mawrin, Joan Montaner, Solene Moulin, Jean-Marc Olivot, Fabrizio Piazza, Laurent Puy, Nicolas Raposo, Mark A. Rodrigues, Sigrun Roeber, Jose Rafael Romero, Neshika Samarasekera, Julie A. Schneider, Stefanie Schreiber, Frank Schreiber, Corentin Schwall, Colin Smith, Levente Szalardy, Pascale Varlet, Alain Viguier, Joanna M. Wardlaw, Andrew Warren, Frank A. Wollenweber, Marialuisa Zedde, Mark A. van Buchem, M. Edip Gurol, Anand Viswanathan, Rustam Al-Shahi Salman, Eric E. Smith, David J. Werring, Steven M. Greenberg
Summary: This study aimed to update and validate the Boston criteria for the diagnosis of cerebral amyloid angiopathy (CAA). The results showed that the Boston criteria version 2.0 had superior accuracy in terms of sensitivity and specificity, and incorporated new MRI markers.
Editorial Material
Cardiac & Cardiovascular Systems
Martin Dichgans, Frank M. Faraci, Christer Betsholtz, Elizabeth Hillman, Anne Joutel, Mark Nelson, Dominik Paquet, BRENDA Network
EUROPEAN HEART JOURNAL
(2023)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
A. Zatcepin, A. Kopczak, A. Holzgreve, A. Schindler, M. Duering, L. Kaiser, M. Schidlowski, T. Stoecker, P. Bartenstein, M. Dichgans, N. Albert, M. Brendel, S. Ziegler
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
J. Kamtchum Tatuene, L. Saba, M. R. Heldner, M. H. F. Poorthuis, G. J. De Borst, T. Rundek, S. Kakkos, M. Dichgans, S. Chaturvedi, R. Topakian, J. Polak, G. C. Jickling
Meeting Abstract
Biochemistry & Molecular Biology
Amy C. Ferguson, Konrad Rawlik, Rainer Malik, Sophie Thrippleton, David Henshall, Martin Dichgans, Albert Tenesa, Cathie Sudlow, Kristiina Rannikmae
EUROPEAN JOURNAL OF HUMAN GENETICS
(2022)
Correction
Cardiac & Cardiovascular Systems
Marios K. Georgakis, Jurgen Bernhagen, Laura H. Heitman, Christian Weber, Martin Dichgans
EUROPEAN HEART JOURNAL
(2022)
