Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups

C‐reactive protein levels and risk of dementia—Observational and genetic studies of 111,242 individuals from the general population

(2022) Sharif H. Hegazy et al.   Alzheimers & Dementia

Avoiding collider bias in Mendelian randomization when performing stratified analyses

(2022) Claudia Coscia et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile

(2021) Marios K. Georgakis et al.   CIRCULATION

Interleukin-6 Signaling and Anti-Interleukin-6 Therapeutics in Cardiovascular Disease

(2021) Paul M Ridker et al.   CIRCULATION RESEARCH

IL-6 inhibition with ziltivekimab in patients at high atherosclerotic risk (RESCUE): a double-blind, randomised, placebo-controlled, phase 2 trial

(2021) Paul M Ridker et al.   LANCET

Targeting inflammation in atherosclerosis — from experimental insights to the clinic

(2021) Oliver Soehnlein et al.   NATURE REVIEWS DRUG DISCOVERY

A Missense Variant in the IL-6 Receptor and Protection from Peripheral Artery Disease

(2021) Michael G Levin et al.   CIRCULATION RESEARCH

Mendelian Randomization Studies in Stroke: Exploration of Risk Factors and Drug Targets With Human Genetic Data

(2021) Marios K. Georgakis et al.   STROKE

Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization

(2021) Veronika W. Skrivankova et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Circulating Interleukin-6 Levels and Incident Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Studies

(2021) Andreas Papadopoulos et al.   NEUROLOGY

Additive Effects of Genetic Interleukin‐6 Signaling Downregulation and Low‐Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis

(2021) Marios K. Georgakis et al.   Journal of the American Heart Association

Interleukin-6 Signaling Effects on Ischemic Stroke and other Cardiovascular Outcomes: A Mendelian Randomization Study

(2020) Marios K. Georgakis et al.   Circulation-Genomic and Precision Medicine

Cellular Mechanisms of Aortic Aneurysm Formation

(2019) Raymundo Alain Quintana et al.   CIRCULATION RESEARCH

Interleukin-6 promotes a sustained loss of endothelial barrier function via Janus kinase-mediated STAT3 phosphorylation and de novo protein synthesis

(2018) Hiba Alsaffar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Relationship of C-reactive protein reduction to cardiovascular event reduction following treatment with canakinumab: a secondary analysis from the CANTOS randomised controlled trial

(2018) Paul M Ridker et al.   LANCET

Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders

(2018) Symen Ligthart et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Semiparametric methods for estimation of a nonlinear exposure-outcome relationship using instrumental variables with application to Mendelian randomization

(2017) James R. Staley et al.   GENETIC EPIDEMIOLOGY

From C-Reactive Protein to Interleukin-6 to Interleukin-1

(2016) Paul M Ridker   CIRCULATION RESEARCH

Bias due to participant overlap in two-sample Mendelian randomization

(2016) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

A review of instrumental variable estimators for Mendelian randomization

(2015) Stephen Burgess et al.   STATISTICAL METHODS IN MEDICAL RESEARCH

Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis

(2013) S. Kaptoge et al.   EUROPEAN HEART JOURNAL

Use of allele scores as instrumental variables for Mendelian randomization

(2013) Stephen Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis

(2009)   LANCET