Article
Gastroenterology & Hepatology
Caroline Voskens, Diane Stoica, Marita Rosenberg, Francesco Vitali, Sebastian Zundler, Marion Ganslmayer, Heike Knott, Manuel Wiesinger, Jutta Wunder, Mirko Kummer, Britta Siegmund, Elisabeth Schnoy, Timo Rath, Arndt Hartmann, Holger Hackstein, Beatrice Schuler-Thurner, Carola Berking, Gerold Schuler, Raja Atreya, Markus F. Neurath
Summary: This study reports a successful case of adoptive transfer of ex vivo expanded Tregs in a patient with refractory UC, showing positive responses. These findings suggest that adoptive Treg therapy might be effective in refractory UC.
Article
Immunology
Ramon Cortez, Luana N. Moreira, Marina Padilha, Mariana D. Bibas, Ricardo K. Toma, Gilda Porta, Carla R. Taddei
Summary: Studies have shown that the composition of intestinal microbiome in pediatric patients with primary sclerosing cholangitis (PSC) is influenced by disease, age, and disease activity status, highlighting significant differences in microbiome between PSC patients. Specific genera Veillonella and Megasphaera have increased relative abundance depending on age at diagnosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Gastroenterology & Hepatology
Teresa Da Cunha, Haleh Vaziri, George Y. Wu
Summary: Primary sclerosing cholangitis is a rare disease often associated with inflammatory bowel disease. The pathogenesis may involve changes in cholangiocyte function, gut microbiome, human leukocyte antigen haplotypes, and immune system dysregulation, but these fail to explain the association with inflammatory bowel disease.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Article
Multidisciplinary Sciences
Younghun Y. Han, Jinyoung J. Byun, Catherine Zhu, Ryan R. Sun, Julia Y. Roh, Heather Cordell, Hyun-Sung A. Lee, Vikram R. Shaw, Sung Wook Kang, Javad Razjouyan, Matthew A. Cooley, Manal M. Hassan, Katherine A. Siminovitch, Trine Folseraas, David Ellinghaus, Annika Bergquist, Simon M. Rushbrook, Andre Franke, Tom H. Karlsen, Konstantinos N. Lazaridis, Katherine A. McGlynn, Lewis R. Roberts, Christopher Amos, Christoph Schramm, David Shapiro, Elizabeth Goode
Summary: This study used multitrait joint analyses to explore the genetic contribution and correlations between various clinical and epidemiological traits associated with PSC. Several new risk loci and potential susceptibility genes such as MANBA and IRF5 were identified, and in silico drug screening provided candidate agents for further investigation of pharmacological effects in PSC.
NATURE COMMUNICATIONS
(2023)
Review
Immunology
Xinhe Zhang, Xuyong Lin, Xuedan Li, Lin Guan, Yiling Li, Ningning Wang
Summary: This case report describes a patient with ulcerative colitis, primary biliary cholangitis, and autoimmune hepatitis, ultimately diagnosed with overlap syndrome. The accurate diagnosis of overlap syndrome requires multiple laboratory tests and pathological examinations.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Gastroenterology & Hepatology
In Sub Han, Dong Hoon Baek, Seung Min Hong, Bong Eun Lee, Moon Won Lee, Gwang Ha Kim, Geun Am Song
Summary: The purpose of this study was to estimate the incidence of primary sclerosing cholangitis in patients with ulcerative colitis (UC-PSC) and investigate adverse clinical events associated with UC-PSC. The results showed that patients with UC-PSC had higher healthcare utilization, medication use, surgery rate, and risk of colorectal cancer, biliary tract cancer, and death compared to patients with UC-alone.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2023)
Article
Immunology
Manon de Krijger, Ishtu L. Hageman, Andrew Y. F. Li Yim, Jan Verhoeff, Juan J. Garcia Vallejo, Patricia H. P. van Hamersveld, Evgeni Levin, Theodorus B. M. Hakvoort, Manon E. Wildenberg, Peter Henneman, Cyriel Y. Ponsioen, Wouter J. de Jonge
Summary: Distinguishing patients with PSC-UC from those with UC alone is possible through peripheral blood DNA methylation, indicating a potential for biomarker development.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
G. S. Sica, B. Sensi, L. Siragusa, F. Blasi, B. Crispino, B. Pirozzi, R. Angelico, L. Biancone, J. Khan
Summary: Colon cancer in ulcerative colitis patients with liver transplant (UCCOLT) due to primary sclerosing cholangitis poses significant treatment challenges. Proctocolectomy and end-ileostomy (PC) and restorative ileal pouch-anal anastomosis (IPAA) have shown good results in these patients, but ileo-rectal anastomosis (IRA) may also be considered in selected cases.
Article
Gastroenterology & Hepatology
Aiva Lundberg Bave, Annika Bergquist, Matteo Bottai, Anna Warnqvist, Erik von Seth, Caroline Nordenvall
Summary: The study found that PSC patients have a four times overall increased risk of developing cancer compared to the general population, with a particularly higher risk of developing hepatobiliary, colorectal, and pancreatic cancer.
HEPATOLOGY INTERNATIONAL
(2021)
Article
Gastroenterology & Hepatology
Timur Liwinski, Sina Huebener, Lara Henze, Peter Huebener, Melina Heinemann, Marcus Tetzlaff, Marie Hiller, Bettina Jagemann, Rambabu Surabattula, Diana Leeming, Morten Karsdal, Erika Monguzzi, Guido Schachschal, Thomas Roesch, Corinna Bang, Andre Franke, Ansgar W. Lohse, Detlef Schuppan, Christoph Schramm
Summary: This study suggests that a short-term gluten/ATI-free diet may not lead to clinical improvement in patients with PSC-IBD, but it can improve biomarkers of intestinal inflammation and barrier function, as well as affect changes in the enteric microbiota.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Gastroenterology & Hepatology
Aiva Lundberg Bave, Ola Olen, Jonas Soederling, Jonas F. Ludvigsson, Annika Bergquist, Caroline Nordenvall
Summary: Colectomy in UC patients was not associated with a decreased risk of subsequent PSC. The observed differences in the risk of PSC development over calendar periods are likely due to changes in PSC-diagnosis and UC-treatment.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2023)
Review
Gastroenterology & Hepatology
Johannes R. Hov, Tom H. Karlsen
Summary: This Review explores the links between Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD), and the mechanisms related to the gut-liver axis. It is found that the gut microbiota in people with PSC differs from that of healthy individuals, but the specific microbial factors that differentiate PSC from IBD without PSC are poorly understood. The potential existence of a specific unknown factor related to the gut-liver axis as a cause of PSC is postulated.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Cell Biology
Xiaojun Jiang, Annika Bergquist, Britt-Sabina Loscher, Geetha Venkatesh, Jeff E. Mold, Kristian Holm, Jon K. Laerdahl, Sigrid S. Skanland, Kimia T. Maleki, Martin Cornillet, Kjetil Tasken, Andre Franke, Tom H. Karlsen, Niklas K. Bjorkstrom, Espen Melum
Summary: A heterozygous germline missense mutation in the CD100 gene was found in a family with PSC, leading to T cell functional defects and increased proliferation as well as impaired interferon-gamma production. Mice with homologous mutation showed a higher susceptibility to develop severe cholangitis, which could be attenuated by transferring wild-type T cells. The study suggests a potential therapeutic role for T cells in protecting against PSC.
SCIENCE TRANSLATIONAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Henry E. Pratt, Tong Wu, Shaimae Elhajjajy, Jeffrey Zhou, Kate Fitzgerald, Tom Fazzio, Zhiping Weng, Daniel S. Pratt
Summary: Noncoding PSC-risk variants are enriched within immune-specific enhancers, particularly ones involved in T-cell response to antigenic stimulation. Regulatory elements play a key role in the pathophysiology of PSC.
HEPATOLOGY COMMUNICATIONS
(2023)
Article
Gastroenterology & Hepatology
Federica Del Chierico, Sabrina Cardile, Valerio Baldelli, Tommaso Alterio, Sofia Reddel, Matteo Bramuzzo, Daniela Knafelz, Sara Lega, Fiammetta Bracci, Giuliano Torre, Giuseppe Maggiore, Lorenza Putignani
Summary: This study reveals the dysbiosis of gut microbiota and mycobiota in pediatric patients with PSC-UC, showing an increase in pro-inflammatory pathobionts and a reduction in anti-inflammatory commensals.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Chemistry, Multidisciplinary
Jhih-Guang Wu, Shu-Chen Wei, Shyh-Chyang Luo
ADVANCED MATERIALS INTERFACES
(2020)
Article
Gastroenterology & Hepatology
Yu-Chen Pai, Li-Ting Weng, Shu-Chen Wei, Li-Ling Wu, David Q. Shih, Stephen R. Targan, Jerrold R. Turner, Linda Chia-Hui Yu
Summary: This study demonstrated the upregulation of TL1A, IFN gamma, and two MLCK variants in human IBD biopsy specimens. TL1A was found to induce MLCK-dependent changes in gut barrier function and bacterial internalization. Different MLCK isoforms were shown to orchestrate divergent pathways of bacterial infiltration in IBD, suggesting a potential mechanism for symptom flares in the disease.
JOURNAL OF CROHNS & COLITIS
(2021)
Article
Medicine, General & Internal
Chih-Kai Chang, Tiffany Ting-Fang Shih, Yu-Wen Tien, Ming-Chu Chang, Yu-Ting Chang, Shih-Hung Yang, Mei-Fang Cheng, Bang-Bin Chen
Summary: The study compared metabolites in pancreatic cancer and normal pancreas, finding significantly decreased Glx, NAA, and lipid levels in pancreatic cancer. These metabolites correlated with PET parameters and clinical stages, with lower lipid levels seen in patients with T4 stage.
Article
Gastroenterology & Hepatology
Ji Min Lee, Shu-Chen Wei, Kang-Moon Lee, Byong Duk Ye, Ren Mao, Hyun-Soo Kim, Soo Jung Park, Sang Hyoung Park, Eun Hye Oh, Jong Pil Im, Byung Ik Jang, Dae Bum Kim, Ken Takeuchi
Summary: This study investigated the clinical course and liver dysfunction risks in HBV-infected IBD patients undergoing anti-TNF-alpha therapy. The results showed that liver dysfunction due to HBV reactivation was more common in patients with chronic HBV infection. Antiviral prophylaxis significantly reduced the risk of liver dysfunction in patients with chronic HBV infection.
Article
Biochemistry & Molecular Biology
Michael X. Chen, Ho-Hsuan Su, Ching-Ya Shiao, Yu-Ting Chang, Ming-Chu Chang, Chih-Chin Kao, San-Yuan Wang, Hsi-Chang Shih, I-Lin Tsai
Summary: The study developed an analytical workflow for dissecting IgG4 glycosylation profiles for autoimmune pancreatitis. Comparisons revealed specific features of IgG4 glycosylation in the AIP group, which could serve as potential biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Meng-Tzu Weng, I-Lun Shih, Chien-Chih Tung, Yew-Loong Leong, Ming-Jium Shieh, Cheng-Yi Wang, Jau-Min Wong, Yen-Hsuan Ni, Shu-Chen Wei
Summary: This study aimed to evaluate the prevalence, clinical manifestation, and outcomes of primary sclerosing cholangitis (PSC) in Taiwanese patients with inflammatory bowel disease (IBD). The results showed a prevalence rate of 1.57% for PSC in Taiwanese IBD patients. The majority of patients with IBD and PSC were men and were diagnosed at a younger age. Routine evaluation of biliary enzymes and liver imaging is recommended in young male patients with IBD.
INTESTINAL RESEARCH
(2022)
Review
Gastroenterology & Hepatology
Michael J. Buie, Joshua Quan, Joseph W. Windsor, Stephanie Coward, Tawnya M. Hansen, James A. King, Paulo G. Kotze, Richard B. Gearry, Siew C. Ng, Joyce W. Y. Mak, Maria T. Abreu, David T. Rubin, Charles N. Bernstein, Rupa Banerjee, Jesus K. Yamamoto-Furusho, Remo Panaccione, Cynthia H. Seow, Christopher Ma, Fox E. Underwood, Vineet Ajuja, Nicola Panaccione, Abdel-Azi Shaheen, Jayna Holroyd-Leduc, Gilaad G. Kaplan, Domingo Balderramo, Vui Heng Chong, Fabian Juliao-Banos, Usha Dutta, Marcellus Simadibrata, Jamilya Kaibullayeva, Yang Sun, Ida Hilmi, Raja Affendi Raja Ali, Mukesh Sharma Paudel, Mansour Altuwaijri, Juanda Leo Hartono, Shu Chen Wei, Julajak Limsrivilai, Sara El Ouali, Beatriz Iade Vergara, Viet Hang Dao, Paul Kelly, Phoebe Hodges, Yinglei Miao, Maojuan Li
Summary: This study investigates the hospitalization rates of inflammatory bowel disease (IBD) in different regions of the world and finds that while the rates are stabilizing in developed countries, they are rapidly increasing in newly industrialized countries, leading to a growing burden on global healthcare systems.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Nutrition & Dietetics
Cheng-Tzu Hsieh, Meng-Tzu Weng, Chien-Chih Tung, Nai-Chia Chen, Hui-Chuen Chen, Kuo-Liong Chien, Shu-Chen Wei
Summary: This survey focused on the dietary beliefs, practices, and information resources of Taiwanese UC patients in clinical remission. It found that a majority of patients believed diet could trigger UC and avoided specific foods to prevent relapses, with spicy foods being the most commonly avoided. Information resources mainly came from patients' own experiences.
CLINICAL NUTRITION ESPEN
(2022)
Review
Gastroenterology & Hepatology
Chun-Chi Lin, Hung-Hsin Lin, Hui-Chuen Chen, Nai-Chia Chen, I-Lun Shih, Ji-Shiang Hung, Te-Cheng Yueh, Feng-Fan Chiang, Ping-Wei Lin, Yuan-Yao Tsai, Shu-Chen Wei
Summary: Crohn's disease is a chronic inflammatory disease that primarily affects the gastrointestinal tract. Both medical treatment and surgical intervention may be necessary for its management. Nutritional optimization and ERAS implementation are crucial in reducing postoperative complications, while the risks and strategies related to medication and surgery should be individualized based on each case.
ANNALS OF GASTROENTEROLOGICAL SURGERY
(2023)
Article
Medicine, General & Internal
Po -Yen Hsiao, Meng-Tzu Weng, Chin-Hao Chang, Ling-Yun Huang, Chien-Chih Tung, Yew-Loong Leong, Ming-Jium Shieh, Jau-Min Wong, Shu-Chen Wei
Summary: This study found that the screening rate for anemia in inflammatory bowel disease (IBD) patients in Taiwan has increased over the years. Anemia is associated with worse outcomes, and early investigation and treatment of anemia in IBD patients are recommended.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Medicine, General & Internal
Yen-Ling Peng, Chung-Hsin Chang, Shu-Chen Wei, Tien-Yu Huang, Wei-Chen Tai, Wen-Hung Hsu, Deng-Chyang Wu, Hsu-Heng Yen, Chi-Ming Tai, Chen-Wang Chang, Wei-Chen Lin, Horng-Yuan Wang, Chun-Chi Lin, Chia-Jung Kuo, Cheng-Tang Chiu, Ching-Pin Lin, Hsi-Chang Lee, Jia-Feng Wu, Chen-Shuan Chung
Summary: This study evaluated the impact of the COVID-19 pandemic on the perceptions of patients with inflammatory bowel disease (IBD). The results showed that patients were concerned about adverse events from vaccination, higher risks of developing severe COVID-19, and COVID-19 infection compared to the general population. Some patients self discontinued IBD medication during the pandemic, leading to worse symptoms. However, after receiving education, the anxiety levels of the patients were mitigated.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Oncology
Yu-Ting Chang, Hsuan-Yu Peng, Chun-Mei Hu, Sui-Chih Tien, Yi-Ing Chen, Yung-Ming Jeng, Ming-Chu Chang
Summary: Cancer-associated fibroblasts (CAFs), a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC), play an important role in tumorigenesis, metastasis, and chemoresistance. Tumor-derived small extracellular vesicles (sEVs), which mediate cell-to-cell communication between cancer cells and fibroblasts, are also critical for cancer progression and metastasis. In this study, we found that ezrin (EZR) in PDAC cell-derived sEVs can activate fibroblasts and promote PDAC cell proliferation, invasion, and liver metastasis through the STAT3 and YAP-1 signaling pathways.
MOLECULAR ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Su Bum Park, Kyeong Ok Kim, Hong Sub Lee, Chang Hwan Choi, Shu Chen Wei, Min Hu Chen, Katsuyoshi Matsuoka
Summary: This study investigated the current approaches and practices of physicians regarding vaccinations for inflammatory bowel disease (IBD) patients in different Asian countries/regions. The results showed similarities among countries/regions in terms of recognizing the importance of vaccination, but there were differences in the selection and recommendation of certain vaccines, reflecting each country's vaccination guidelines and health insurance. Therefore, more communication among doctors and a consensus regarding IBD vaccination differences in the Asian region are needed.
INTESTINAL RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Meng-Tzu Weng, Kuan-Lin Lin, Ya-Ling Huang, Chitra Karki, Jin-Liern Hong, Dimitri Bennett, K. Arnold Chan, Shu-Chen Wei
Summary: The prevalence of pCD in Taiwanese CD patients is 14.8%, with half of them being diagnosed before CD and one-third experiencing recurrence. Although pCD patients have higher healthcare utilization, their 15-year mortality rate is lower than those without pCD.
CROHNS & COLITIS 360
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Wei-En Lee, Meng-Tzu Weng, Shu-Chen Wei, I-Lun Shih
Summary: This study compared the diagnostic accuracy of three different scoring methods for assessing Crohn's disease activity and found that the sMaRIA and Nancy scores are comparable to the MaRIA score. These alternative scoring methods could be used in clinical practice, especially for disease monitoring.
ABDOMINAL RADIOLOGY
(2023)