Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging

In Vivo Bacterial Imaging without Engineering; A Novel Probe-Based Strategy Facilitated by Endogenous Nitroreductase Enzymes

(2015) Michael Stanton et al.   CURRENT GENE THERAPY

Bioluminescence of Beetle Luciferases with 6′-Amino-d-luciferin Analogues Reveals Excited Keto-oxyluciferin as the Emitter and Phenolate/Luciferin Binding Site Interactions Modulate Bioluminescence Colors

(2014) Vadim R. Viviani et al.   BIOCHEMISTRY

Bacterial-Mediated Knockdown of Tumor Resistance to an Oncolytic Virus Enhances Therapy

(2014) Michelle Cronin et al.   MOLECULAR THERAPY

The gut microbiota, bacterial metabolites and colorectal cancer

(2014) Petra Louis et al.   NATURE REVIEWS MICROBIOLOGY

Nitro drugs for the treatment of trypanosomatid diseases: past, present, and future prospects

(2014) Stephen Patterson et al.   TRENDS IN PARASITOLOGY

Noninvasive Theranostic Imaging of HSV1-sr39TK-NTR/GCV-CB1954 Dual-Prodrug Therapy in Metastatic Lung Lesions of MDA-MB-231 Triple Negative Breast Cancer in Mice

(2014) Thillai V. Sekar et al.   Theranostics

A Biocompatible in Vivo Ligation Reaction and Its Application for Noninvasive Bioluminescent Imaging of Protease Activity in Living Mice

(2013) Aurélien Godinat et al.   ACS Chemical Biology

A novel near-infrared fluorescent probe for selectively sensing nitroreductase (NTR) in an aqueous medium

(2013) Youmin Shi et al.   ANALYST

Nitroreductase Detection and Hypoxic Tumor Cell Imaging by a Designed Sensitive and Selective Fluorescent Probe, 7-[(5-Nitrofuran-2-yl)methoxy]-3H-phenoxazin-3-one

(2013) Zhao Li et al.   ANALYTICAL CHEMISTRY

7-((5-Nitrothiophen-2-yl)methoxy)-3H-phenoxazin-3-one as a spectroscopic off–on probe for highly sensitive and selective detection of nitroreductase

(2013) Zhao Li et al.   CHEMICAL COMMUNICATIONS

Enhanced detection of myeloperoxidase activity in deep tissues through luminescent excitation of near-infrared nanoparticles

(2013) Ning Zhang et al.   NATURE MEDICINE

Visualizing cellular interactions with a generalized proximity reporter

(2013) M. A. Sellmyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lessons Learned from the Clinical Development and Market Authorization of Glybera

(2013) Laura M. Bryant et al.   Human Gene Therapy Clinical Development

Real-Time Noninvasive Imaging of Fatty Acid Uptake in Vivo

(2012) Amy H. Henkin et al.   ACS Chemical Biology

Bacterial vectors for imaging and cancer gene therapy: a review

(2012) M Cronin et al.   CANCER GENE THERAPY

Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer

(2012) E. McCormack et al.   CANCER RESEARCH

High Resolution In Vivo Bioluminescent Imaging for the Study of Bacterial Tumour Targeting

(2012) Michelle Cronin et al.   PLoS One

Structure of Ddn, the Deazaflavin-Dependent Nitroreductase from Mycobacterium tuberculosis Involved in Bioreductive Activation of PA-824

(2012) Susan E. Cellitti et al.   STRUCTURE

Strategies for in vivo imaging of enzyme activity: an overview and recent advances

(2011) Andrew Razgulin et al.   CHEMICAL SOCIETY REVIEWS

Noninvasive optical imaging of nitroreductase gene-directed enzyme prodrug therapy system in living animals

(2011) S Bhaumik et al.   GENE THERAPY

A New Prodrug-Derived Ratiometric Fluorescent Probe for Hypoxia: High Selectivity of Nitroreductase and Imaging in Tumor Cell

(2011) Lei Cui et al.   ORGANIC LETTERS

In vivo imaging of early stage apoptosis by measuring real-time caspase-3/7 activation

(2010) Matteo Scabini et al.   APOPTOSIS

Noninvasive molecular imaging of apoptosis in vivo using a modified firefly luciferase substrate, Z-DEVD-aminoluciferin

(2010) J Hickson et al.   CELL DEATH AND DIFFERENTIATION

Real-Time Bioluminescence Imaging of Glycans on Live Cells

(2010) Allison S. Cohen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Imaging β-Galactosidase Activity in Human Tumor Xenografts and Transgenic Mice Using a Chemiluminescent Substrate

(2010) Li Liu et al.   PLoS One

In vivo imaging of hydrogen peroxide production in a murine tumor model with a chemoselective bioluminescent reporter

(2010) G. C. Van de Bittner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery and evaluation of Escherichia coli nitroreductases that activate the anti-cancer prodrug CB1954

(2009) G.A. Prosser et al.   BIOCHEMICAL PHARMACOLOGY

In Vivo Bioluminescence Imaging of Furin Activity in Breast Cancer Cells Using Bioluminogenic Substrates

(2009) Anca Dragulescu-Andrasi et al.   BIOCONJUGATE CHEMISTRY

Guided by the light: visualizing biomolecular processes in living animals with bioluminescence

(2009) Jennifer A Prescher et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Pre-clinical whole-body fluorescence imaging: Review of instruments, methods and applications

(2009) Frederic Leblond et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

A Phase I/II Clinical Trial in Localized Prostate Cancer of an Adenovirus Expressing Nitroreductase with CB1984

(2009) Prashant Patel et al.   MOLECULAR THERAPY

Bioluminescence imaging of myeloperoxidase activity in vivo

(2009) Shimon Gross et al.   NATURE MEDICINE

Giardia, Entamoeba, and Trichomonas Enzymes Activate Metronidazole (Nitroreductases) and Inactivate Metronidazole (Nitroimidazole Reductases)

(2008) D. Pal et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular Imaging of Hypoxia

(2008) K. A. Krohn et al.   JOURNAL OF NUCLEAR MEDICINE