Article
Neurosciences
Amanda E. Selwood, Vibeke S. Catts, Katya Numbers, Teresa Lee, Anbupalam Thalamuthu, Margaret J. Wright, Perminder S. Sachdev
Summary: This study aimed to examine the heritability of subjective cognitive complaints (SCCs) and their correlations with memory ability, personality, and mood. The results showed that SCCs had moderate heritability and were genetically, environmentally, and phenotypically correlated with memory performance, personality, and mood. Specifically, mood was environmentally related to SCCs, while memory performance had a genetic correlation with SCCs. The link between personality and SCCs was mediated by mood. These findings suggest that SCCs are influenced by both mood and memory performance, and these determinants are not mutually exclusive.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Astrid Lugtenburg, Marij Zuidersma, Klaas J. Wardenaar, Ivan Aprahamian, Didi Rhebergen, Robert A. Schoevers, Richard C. Oude Voshaar
Summary: This study aimed to identify late-life-related subtypes of depression based on measures of depressive symptom dimensions, cognitive performance, and physical frailty. The results showed that patients could be subtyped by specific combinations of age-related clinical features, which may have prospective relevance. Subtyping according to cognitive profile and physical frailty could be relevant for treatment studies on the effectiveness of antidepressants, psychotherapy, and geriatric rehabilitation.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Pankaja Desai, Kristin R. Krueger, Carlos Mendes de Leon, Robert S. Wilson, Denis A. Evans, Kumar B. Rajan
Summary: This study investigates the impact of depressive symptoms and glial fibrillary acid protein (GFAP) concentrations on cognitive functioning. The results show that depressive symptoms and high GFAP concentrations contribute to cognitive decline, while depressive symptoms and low GFAP concentrations have a smaller effect.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Cell Biology
Myung-Hoon Han, Eun-Hye Lee, Hyun-Hee Park, Seong Hye Choi, Seong-Ho Koh
Summary: This study found that early subjective depressive symptoms and cognitive complaints are associated with relatively shorter telomere length in relatively healthy elderly individuals. The study also found that interleukin-6 plays an important role in the relationship between telomere shortening and early subjective depressive symptoms and cognitive complaints.
Article
Clinical Neurology
Cristina Delgado-Alonso, Maria Diez-Cirarda, Josue Pagan, Carlos Perez-Izquierdo, Silvia Oliver-Mas, Lucia Fernandez-Romero, Alvaro Martinez-Petit, Maria Valles-Salgado, Maria Jose Gil-Moreno, Miguel Yus, Jorge Matias-Guiu, Jose Luis Ayala, Jordi A. Matias-Guiu
Summary: Brain fog associated with COVID-19 is characterized by attention and episodic memory symptoms, and fatigue serves as the main mediator between objective and subjective cognition. Our findings contribute to understanding the pathophysiology of brain fog and underline the importance of unraveling the main mechanisms underlying brain fog, taking into account multiple aspects.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Wentian Lu, Manacy Pai, Shaun Scholes, Baowen Xue
Summary: This study found that chronic diseases such as stroke, high blood pressure, diabetes, heart problems, and comorbidity, were associated with lower levels of cognition in older adults, with depressive symptoms mediating a significant portion of this association. The findings highlight the importance of considering the psychological factors in addition to the direct symptoms of chronic diseases in addressing cognitive challenges in older adults.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Madia Lozupone, Francesca D'Urso, Massimiliano Copetti, Rodolfo Sardone, Simona Arcuti, Fabio Castellana, Ilaria Galizia, Lucia Lofano, Federica Veneziani, Carla Piccininni, Maria Rosaria Barulli, Alessandra Grasso, Petronilla Battista, Rosanna Tortelli, Rosa Capozzo, Chiara Griseta, Fabrizio Doricchi, Nicola Quaranta, Emanuela Resta, Antonio Daniele, Davide Seripa, Vincenzo Solfrizzi, Antonello Bellomo, Giancarlo Logroscino, Francesco Panza
Summary: The prevalence of late-life depression varies depending on the sample and diagnostic methods used. The 30-item Geriatric Depression Scale (GDS-30) showed moderate accuracy in diagnosing late-life depression, with performance affected by educational level. Adjustments may be needed for more accurate diagnosis.
PSYCHIATRY RESEARCH
(2022)
Article
Health Care Sciences & Services
Sunhae Kim, Kounseok Lee
Summary: This study examined depressive symptoms among elderly individuals with subjective memory complaints (SMCs) through network analysis. The results showed that depressed mood and anhedonia were the most important factors in the subjective cognitive decline group.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Geriatrics & Gerontology
Lucia Perez-Blanco, Dolores Rodriguez-Salgado
Summary: A systematic review of intervention programs targeting subjective cognitive complaints (SCCs) in cognitively unimpaired older people reveals that interventions including cognitive stimulation combined with psychoeducation, physical exercise, and group sessions and discussions are effective in reducing SCCs.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Psychology, Clinical
Sarah M. Goldberg, Oscar L. Lopez, Ann D. Cohen, William E. Klunk, Howard A. Aizenstein, Akiko Mizuno, Beth E. Snitz
Summary: This study examined subjective memory complaints in older adults and the roles of setting, response bias, and personality. Findings showed that volunteers exhibited higher levels of under-reporting response bias, Neuroticism was associated with over-reporting, and Agreeableness and Conscientiousness were associated with under-reporting bias in volunteers.
INTERNATIONAL PSYCHOGERIATRICS
(2021)
Article
Psychiatry
Lee Smith, Jae Il Shin, Tae-Jin Song, Benjamin R. Underwood, Louis Jacob, Guillermo F. Lopez Sanchez, Felipe Schuch, Hans Oh, Nicola Veronese, Pinar Soysal, Laurie Butler, Yvonne Barnett, Ai Koyanagi
Summary: People with depression and subjective cognitive complaints may have a higher risk of developing dementia, and this study aimed to investigate their association in low- and middle-income countries. The results showed that different types of depression were significantly associated with worse subjective cognitive complaints. This association was consistent across different age groups and genders.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Article
Psychology, Clinical
Gabrielle N. Pfund, Isaiah Spears, Sara A. Norton, Ryan Bogdan, Thomas F. Oltmanns, Patrick L. Hill
Summary: Purposeful adults may experience greater cognitive resilience as a result of the buffering effects of a sense of purpose against the effects of depressive symptoms and loneliness. This study found that a higher sense of purpose attenuates the association between loneliness and subjective cognitive decline. The buffering effects of a sense of purpose on subjective cognitive decline were stronger for Black adults.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Nutrition & Dietetics
David Vauzour, Andrew Scholey, David J. White, Neal J. Cohen, Aedin Cassidy, Rachel Gillings, Michael A. Irvine, Colin D. Kay, Min Kim, Rebecca King, Cristina Legido-Quigley, John F. Potter, Hilary Schwarb, Anne-Marie Minihane
Summary: This study investigated the combined effect of omega-3 long-chain polyunsaturated fatty acids (EPA and DHA) and cocoa flavanols on cognitive performance and brain structures in older adults with memory complaints. The results showed that this intervention did not improve cognitive outcomes but led to negative effects, such as increased reaction time variability, decreased alertness and executive function, and a decrease in cortical volume.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2023)
Article
Psychology, Biological
Joanna Szyszkowska, Aleksandra Bala
Summary: This study investigated the relationship between rumination, depression, and subjective cognitive impairment in 168 healthy individuals and 93 patients with depression. The results showed that the depression group had higher levels of depression symptoms, rumination, and subjective cognitive deficits compared to the control group. Hierarchical regression analysis revealed that depression and rumination were significant predictors of subjective cognitive impairment, while objective memory performance was not. Exploratory analyses further found that rumination mediated the association between depression and subjective cognitive complaints.
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Vaughn E. Bryant, Robert A. Fieo, Andrew J. Fiore, Veronica L. Richards, Eric C. Porges, Renessa Williams, Huiyin Lu, Zhi Zhou, Robert L. Cook
Summary: Research on subjective cognitive complaints in people living with HIV is limited, with age, hazardous alcohol consumption, frequent marijuana use, and psychiatric symptoms being significant predictors. Subjective cognitive complaints were associated with lower adherence to antiretroviral therapy, but this relationship was no longer significant after controlling for other factors. Further investigation into the relationship between depression and subjective cognitive complaints may offer new intervention strategies.
Review
Neurosciences
Mabel Seto, Rebecca L. Weiner, Logan Dumitrescu, Timothy J. Hohman
Summary: Alzheimer's disease is a complex neurodegenerative disorder with both genetic and environmental factors contributing to its etiology. Recent focus has shifted towards individuals who show resistance or resilience to the pathology of the disease, offering potential insights into new biological mechanisms and therapeutic targets. This review highlights some genes and variants that provide protection from AD and suggests avenues for developing precision interventions leveraging the ideas of protection and resilience.
MOLECULAR NEURODEGENERATION
(2021)
Article
Genetics & Heredity
Alex G. Nackenoff, Timothy J. Hohman, Sarah M. Neuner, Carolyn S. Akers, Nicole C. Weitzel, Alena Shostak, Shawn M. Ferguson, Bret Mobley, David A. Bennett, Julie A. Schneider, Angela L. Jefferson, Catherine C. Kaczorowski, Matthew S. Schrag
Summary: PLD3 is a lysosomal phospholipase D that plays a role in AD and cognition. PLD3 expression levels are associated with beta-amyloid plaque density and cognitive decline.
Article
Clinical Neurology
Elizabeth E. Moore, Dandan Liu, Judy Li, Samantha J. Schimmel, Francis E. Cambronero, James G. Terry, Sangeeta Nair, Kimberly R. Pechman, Marissa E. Moore, Susan P. Bell, Joshua A. Beckman, Katherine A. Gifford, Timothy J. Hohman, Kaj Blennow, Henrik Zetterberg, John Jeffrey Carr, Angela L. Jefferson
Summary: With increasing age, greater aortic stiffening is associated with in vivo biomarker evidence of neuroinflammation, tau phosphorylation, synaptic dysfunction, and neurodegeneration, but not amyloidosis. Central arterial stiffening may lead to cumulative cerebral microcirculatory damage and reduced blood flow delivery to tissue, resulting in neuroinflammation and neurodegeneration in more advanced age.
Article
Neurosciences
Adam J. Dugan, Peter T. Nelson, Yuriko Katsumata, Lincoln M. P. Shade, Kevin L. Boehme, Merilee A. Teylan, Matthew D. Cykowski, Shubhabrata Mukherjee, John S. K. Kauwe, Timothy J. Hohman, Julie A. Schneider, David W. Fardo
Summary: Limbic-predominant age-related TDP-43 encephalopathy neuropathologic change (LATE-NC) is one of the most common subtypes of TDP-43 proteinopathy, often co-occurring with hippocampal sclerosis (HS) pathology, and showing associations with specific genetic variants. Through analyzing the genetic associations with HS, LATE-NC, and Alzheimer's pathologies, significant gene-based associations were found, offering new insights into the differential effects of risk alleles on LATE-NC and HS.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Hematology
Corey W. Bown, Omair A. Khan, Elizabeth E. Moore, Dandan Liu, Kimberly R. Pechman, Francis E. Cambronero, James G. Terry, Sangeeta Nair, L. Taylor Davis, Katherine A. Gifford, Bennett A. Landman, Timothy J. Hohman, John Jeffrey Carr, Angela L. Jefferson
Summary: The study revealed that higher baseline aortic stiffness is associated with greater decrease in gray matter volume and greater increase in white matter hyperintensity over time in older adults, potentially due to the impact of arterial stiffening on highly active brain regions.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Endocrinology & Metabolism
W. Hudson Robb, Omair A. Khan, Humza A. Ahmed, Judy Li, Elizabeth E. Moore, Francis E. Cambronero, Kimberly R. Pechman, Dandan Liu, Katherine A. Gifford, Bennett A. Landman, Manus J. Donahue, Timothy J. Hohman, Angela L. Jefferson
Summary: The study found interactions between CMRO2 and APOE-ε4 status in cognitive performance and neuroimaging variables among older adults, suggesting that low oxygen metabolism is associated with certain cognitive impairments, particularly in APOE-ε4 carriers.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Clinical Neurology
Mabel Seto, Emily R. Mahoney, Logan Dumitrescu, Vijay K. Ramanan, Corinne D. Engelman, Yuetiva Deming, Marilyn Albert, Sterling C. Johnson, Henrik Zetterberg, Kaj Blennow, Prashanthi Vemuri, Angela L. Jefferson, Timothy J. Hohman
Summary: This study identifies the interaction between APOE-e4 gene and rs62263260 gene on the protein levels related to Alzheimer's disease and hippocampal atrophy. The functional annotation suggests the involvement of SEMA5B gene in synaptic pruning and neurodevelopment.
BRAIN COMMUNICATIONS
(2022)
Meeting Abstract
Behavioral Sciences
Daniel E. Gustavson, Chandra A. Reynolds, Timothy J. Hohman, Angela L. Jefferson, Matthew S. Panizzon, Michael C. Neale, Carol E. Franz, William S. Kremen
Article
Neuroimaging
Derek B. Archer, Elizabeth E. Moore, Ujwala Pamidimukkala, Niranjana Shashikumar, Kimberly R. Pechman, Kaj Blennow, Henrik Zetterberg, Bennett A. Landman, Timothy J. Hohman, Angela L. Jefferson, Katherine A. Gifford
Summary: The study investigated the association between white matter microstructure and subjective cognitive decline, suggesting that white matter microstructure may serve as an early marker of cognitive decline. The results indicated that in addition to amyloid deposition, the microstructure of frontal and temporal white matter tracts also plays an important role in subjective cognitive decline scores.
NEUROIMAGE-CLINICAL
(2021)
Meeting Abstract
Psychology, Clinical
Marilyn J. Steinbach, Omair A. Khan, Dandan Liu, Camdyn Gilbert, Natalie Thwaites, Francis E. Cambronero, Elizabeth E. Moore, Corey W. Bown, Lealani Mae Y. Acosta, Katie Osborn Spirko, Kimberly R. Pechman, Kaj Blennow, Henrik Zetterberg, Timothy J. Hohman, Angela L. Jefferson, Katherine A. Gifford
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2021)
Meeting Abstract
Psychology, Clinical
Natalie A. Thwaites, Omair A. Khan, Dandan Liu, Marilyn Steinbach, Camdyn Gilbert, Francis E. Cambronero, Elizabeth E. Moore, Corey W. Bown, Lealani Acosta, Katie Osborn Spirko, Kimberly R. Pechman, Timothy J. Hohman, Kaj Blennow, Henrik Zetterberg, Angela L. Jefferson, Katherine A. Gifford
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2021)
Meeting Abstract
Psychology, Clinical
Camdyn Gilbert, Marilyn Steinbach, Omair Kahn, Dandan Liu, Natalie Thwaites, Francis E. Cambronero, Elizabeth E. Moore, Corey W. Bown, Lealani Acosta, Katie Osborn Spirko, Kimberly R. Pechman, Timothy J. Hohman, Kaj Blennow, Henrik Zetterberg, Angela Jefferson, Katherine A. Gifford
ARCHIVES OF CLINICAL NEUROPSYCHOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Zijie Zhao, Yanyao Yi, Jie Song, Yuchang Wu, Xiaoyuan Zhong, Yupei Lin, Timothy J. Hohman, Jason Fletcher, Qiongshi Lu
Summary: PUMAS is a novel method to fine-tune PRS models using summary statistics from GWASs, which significantly improves statistical power in downstream association analysis.
Article
Clinical Neurology
Evan Fletcher, Brandon Gavett, Paul Crane, Anja Soldan, Timothy Hohman, Sarah Farias, Keith Widaman, Colin Groot, Miguel Arce Renteria, Laura Zahodne, Charles DeCarli, Dan Mungas
Summary: The brain signature concept aims to characterize brain regions most strongly associated with an outcome of interest. Recent work has used exploratory voxel-wise or atlas-based searches, with some using machine learning techniques to define salient features. Findings suggest that the cross-validated signature region model may easily and robustly applied for modelling and hypothesis testing in mixed cognition cohorts.
Article
Clinical Neurology
Kacie D. Deters, Valerio Napolioni, Reisa A. Sperling, Michael D. Greicius, Richard Mayeux, Timothy Hohman, Elizabeth C. Mormino
Summary: This study found differences in amyloid PET between non-Hispanic White and Black participants who passed initial screening for the A4 study, with lower amyloid levels observed in Black participants. The effect of race on amyloid was strongest in the APOE epsilon 4 group, and within Black participants, those with lower percentage of African ancestry had higher amyloid levels.
