Article
Multidisciplinary Sciences
Cezanne Miete, Gonzalo P. Solis, Alexey Koval, Martina Bruckner, Vladimir L. Katanaev, Jurgen Behrens, Dominic B. Bernkopf
Summary: This study finds that G alpha i2 can induce the condensation of conductin, leading to the degradation of β-catenin and inhibition of Wnt signaling, thus suppressing the growth of colorectal cancer. Colorectal cancer evades this inhibition by decreasing the expression of G alpha i2 and inactivating mutations, but the G alpha i2-activating drug guanabenz can reduce colorectal cancer growth.
NATURE COMMUNICATIONS
(2022)
Article
Cell & Tissue Engineering
Yi Xiao, Qin Liu, Nanyin Peng, Yuzhang Li, Danyang Qiu, Tianlun Yang, Richard Kang, Ahsan Usmani, Efosa Amadasu, Cesario Borlongan, Guolong Yu
Summary: Statins, commonly used drugs for controlling lipid levels, have shown the potential to lower colorectal cancer incidence and improve patient survival through inhibiting Wnt/β-catenin and YAP/TAZ signaling pathways. This study provides evidence supporting the clinical use of statins in non-cardiovascular contexts and identifies novel targets for anticancer treatments.
CELL TRANSPLANTATION
(2022)
Article
Plant Sciences
Sonal Srivastava, Jayant Dewangan, Sakshi Mishra, Aman Divakar, Swati Chaturvedi, Muhammad Wahajuddin, Sadan Kumar, Srikanta Kumar Rath
Summary: The study demonstrates that the combination of CXB and PIP offers a novel approach for the treatment of colon cancer, with significant anti-proliferative effects and modulation of apoptotic and Wnt/beta-catenin signaling pathways observed in HT-29 cells.
Article
Cell & Tissue Engineering
Yuhui Xu, Jiali Hu, Qiaoying Lv, Chenyi Shi, Mengdi Qiu, Liying Xie, Wei Liu, Bingyi Yang, Weiwei Shan, Yali Cheng, Bing Zhao, Xiaojun Chen
Summary: This study aimed to investigate the potential therapeutic effects and underlying mechanisms of mesenchymal stem cells (MSCs) on well-differentiated endometrial cancer (EC). The results demonstrated that endometrium-derived MSCs (eMSCs) had the highest inhibitory effect on EC cell viability and xenograft tumor growth compared to adipose-derived MSCs (AD-MSCs) and umbilical-cord-derived MSCs (UC-MSCs). The study also revealed that eMSCs inhibited EC cell proliferation and stemness through the DKK1-Wnt/beta-catenin signaling pathway. Furthermore, the combination of eMSCs and medroxyprogesterone acetate (MPA) showed enhanced inhibition of EC growth. These findings suggest that eMSCs may be a promising therapeutic strategy for young EC patients desiring fertility preservation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Irina Giralt, Gabriel Gallo-Oller, Natalia Navarro, Patricia Zarzosa, Guillem Pons, Ainara Magdaleno, Miguel F. Segura, Constantino Sabado, Raquel Hladun, Diego Arango, Jose Sanchez de Toledo, Lucas Moreno, Soledad Gallego, Josep Roma
Summary: The study demonstrates the therapeutic potential of DKK-1 pharmaceutical inhibition in rhabdomyosarcoma, resulting in beta-catenin activation and modulation of focal adhesion kinase, with positive effects on myogenic marker expression and a reduction in proliferation and invasion. In addition, the chemical inhibitor WAY-262611 was able to impair tumor cell survival in vivo, suggesting DKK-1 as a potential molecular target for novel therapeutic strategies in RMS patients, especially those with high DKK-1 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Qihong Nie, Wei Wei Peng, Yuli Wang, Liting Zhong, Xuebing Zhang, Ling Zeng
Summary: This study revealed that berberine can inhibit the proliferation of colon cancer cells by regulating the β-catenin signaling pathway. The expression level of CTNNB1, the active component of berberine, was found to be higher in colon cancer patients compared to normal controls. This suggests that CTNNB1 may have potential clinical diagnostic and therapeutic value in colon cancer.
Article
Oncology
Jiong Ning, Qi Sun, Zijie Su, Lifeng Tan, Yun Tang, Sapna Sayed, Huan Li, Vivian Weiwen Xue, Shanshan Liu, Xianxiong Chen, Desheng Lu
Summary: CK1 delta/epsilon enhance beta-catenin-mediated transcription by regulating beta-catenin acetylation. CK1 delta/epsilon interact with Tip60 and facilitate its recruitment to the beta-catenin complex, leading to increased beta-catenin acetylation at K49. Furthermore, this study discovers that a complex consisting of CK1 delta/CK1 epsilon/beta-catenin/Tip60 is present in colon cancer cells, and this complex plays an important role in beta-catenin acetylation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yan-Long Han, Dan Luo, Kakeng Habaxi, Julaiti Tayierjiang, Wei Zhao, Wei Wang, Wumaierjiang Aikebaier, Li Wang
Summary: In this study, we identified COL5A2 as a prognostic gene for osteosarcoma through bioinformatics analysis, and showed that COL5A2 inhibits invasion and metastasis of osteosarcoma by suppressing the TGF-beta and Wnt/β-Catenin signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Yangyang Guo, Hengyue Zhu, Yanyi Xiao, Hangcheng Guo, Miaomiao Lin, Ziwei Yuan, Xuejia Yang, Youze Huang, Qiyu Zhang, Yongheng Bai
Summary: This study found that Niclosamide inhibits the progression of pancreatic cancer by targeting beta-catenin degradation, enhances the effects of chemotherapy drugs, and reduces immune evasion ability. This suggests that Niclosamide may be a potential therapeutic candidate for pancreatic cancer.
CELL DEATH & DISEASE
(2022)
Article
Cell Biology
Shengliang Gu, Fahui Liu, Xueheng Xie, Meng Ding, Zhen Wang, Xiaoyan Xing, Tianbao Xiao, Xiaobo Sun
Summary: The study aimed to investigate the biological functions and prognostic value of the LEF-1-mediated Wnt/β-catenin pathway in colon cancer (CC). Beta-sitosterol was found to effectively suppress CC cell growth and migration by down-regulating LEF-1 and disrupting the Wnt/β-catenin pathway. These results suggest that beta-sitosterol can be used as a potential treatment for CC by targeting LEF-1.
CELLULAR SIGNALLING
(2023)
Article
Biotechnology & Applied Microbiology
Haitao Gu, Zhiquan Xu, Jianbo Zhang, Yanbing Wei, Ling Cheng, Jijian Wang
Summary: circ_0038718 is highly expressed in colon cancer and can sponge miR-195-5p in the cytoplasm, facilitating malignant progression of colon cancer cells through the miR-195-5p/Axin2 axis.
Article
Multidisciplinary Sciences
David Buechel, Nami Sugiyama, Natalia Rubinstein, Meera Saxena, Ravi K. R. Kalathur, Fabiana Luond, Vida Vafaizadeh, Tomas Valenta, George Hausmann, Claudio Cantu, Konrad Basler, Gerhard Christofori
Summary: The transcriptional activity of beta-catenin plays a crucial role in the malignant progression of breast cancer, affecting tumor growth, invasion, and metastasis formation. This contrasts its adhesion function, highlighting the importance of Wnt/beta-catenin-dependent transcription in cancer progression.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Young-Eun Cho, Jeong-Hee Kim, Young-Hyun Che, Yong-Jun Kim, Ji-Youn Sung, Yoon-Wha Kim, Bong-Geun Choe, Sun Lee, Jae-Hoon Park
Summary: ZKSCAN3 acts as an oncogenic transcription factor in human malignant tumors, and it has been identified as a downstream effector of the Wnt/β-catenin signaling pathway. It upregulates chromosomal instability in colon cancer cells by suppressing MAD2L2 expression. Moreover, the upregulation of ZKSCAN3 is an early event in the adenoma-carcinoma sequence during colon cancer development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Xiao-Feng Luan, Lei Wang, Xue-Feng Gai
Summary: CAMTA2 is highly expressed in colon cancer and correlated with poor survival. miR-28-5p regulates CAMTA2 expression in colon cancer. The miR-28-5p/CAMTA2 axis plays a critical role in human colon cancer development and may be a potential target for diagnosis and treatment.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Jiawei He, Anhui Yang, Xuyu Zhao, Yang Liu, Shuyan Liu, Di Wang
Summary: Gloeostereum incarnatum polysaccharides (GIPS) exhibit anti-colon cancer effects by regulating cytokines and the Wnt/β-catenin signaling pathway, demonstrating anti-inflammatory and tumor growth inhibition properties.
FOOD SCIENCE AND HUMAN WELLNESS
(2021)
Article
Cell Biology
Fernanda S. O. Campos, Felipe M. Pina-Rodrigues, Alice Reis, Georgia C. Atella, Claudia S. Mermelstein, Silvana Allodi, Leny A. Cavalcante
Summary: OEC migration is sensitive to ganglioside blockage through specific antibodies, indicating the involvement of gangliosides in cell migration. The lipid rafts of OECs are enriched in cholesterol, sphingolipids, specific proteins, and gangliosides, suggesting a role for membrane lipid rafts in OEC migration and providing new insights into the molecular composition of OEC membrane microdomains.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Andrew Clugston, Andrew Bodnar, Debora Malta Cerqueira, Yu Leng Phua, Alyssa Lawler, Kristy Boggs, Andreas R. Pfenning, Jacqueline Ho, Dennis Kostka
Summary: The study identified 1104 miRNAs and 46374 chromatin accessible regions in mammalian nephron progenitor cells, with changes in expression playing crucial roles in processes like cellular differentiation, migration, extracellular matrix interactions, and developmental signaling pathways. New candidate cis-regulatory elements for genes like Eya1 and Pax8 were highlighted, with expression-changing miRNAs such as let-7-5p, miR-125b-5p, miR-181a-2-3p, and miR-9-3p associated with candidate cis-regulatory elements and target genes. These analyses emphasize the discovery of new putative cis-regulatory loci for miRNA in nephron progenitors.
Review
Oncology
Luiz F. S. Oliveira, Danilo Predes, Helena L. Borges, Jose G. Abreu
Summary: Colorectal cancer (CRC) is the second leading cause of death worldwide, and its treatment is limited due to late diagnoses and resistance to available treatments. The use of naturally occurring small molecules that inhibit the Wnt/beta-catenin pathway in experimental CRC models has shown promise in overcoming these challenges. However, moving these small molecules from the laboratory to the clinical platform presents its own set of progress and challenges. This review discusses the importance of understanding the role of the Wnt/beta-catenin pathway in CRC and highlights the potential of naturally occurring small molecules as therapeutic agents.
Article
Biochemistry & Molecular Biology
Ingrid Del Castilo, Arthur S. Neumann, Felipe S. Lemos, Marco A. De Bastiani, Felipe L. Oliveira, Eduardo R. Zimmer, Amanda M. Rego, Cristiane C. P. Hardoim, Luis Caetano M. Antunes, Flavio A. Lara, Claudia P. Figueiredo, Julia R. Clarke
Summary: This study investigated the effects of long-term exposure to GBH-RUp on the gut environment in mice and found that it caused morphological and functional changes in the gut, which correlated with behavioral changes similar to those observed in patients with neurodevelopmental disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Debora Malta Cerqueira, Maliha Tayeb, Jacqueline Ho
Summary: MicroRNAs play a significant role in kidney development and diseases, and can be used as biomarkers and therapeutic agents.
Editorial Material
Cell Biology
Barbara F. Fonseca, Lisa A. Chakrabarti
JOURNAL OF CELL BIOLOGY
(2022)
Review
Cell Biology
Miaoci Zhang, Alice H. Reis, Mijo Simunovic
Summary: The molecular mechanisms of early human embryonic events have become a major focus of developmental biology research, as they have the potential to impact the treatment of pregnancy disorders and infertility. Recent progress in 3D culture of human embryonic stem cells has provided a new opportunity to study these critical events. In this review, we discuss the development of 3D models of the human embryo, known as embryoids, and their potential in studying various aspects of early human development.
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Danilo Predes, Lorena A. Maia, Isadora Matias, Hannah Paola Mota Araujo, Carolina Soares, Fernanda G. Q. Barros-Aragao, Luiz F. S. Oliveira, Renata R. Reis, Nathalia G. Amado, Alessandro B. C. Simas, Fabio A. Mendes, Flavia C. A. Gomes, Claudia P. Figueiredo, Jose G. Abreu
Summary: This study identifies quercitrin as a novel Wnt signaling potentiator through various experimental models and approaches. Quercitrin enhances the signaling pathway and has positive effects on neuronal function. Moreover, it rescues memory impairment caused by Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Kayo Moreira Bagri, Luiz Fernando Oliveira, Miria Gomes Pereira, Jose Garcia Abreu, Claudia Mermelstein
Summary: During chick myogenesis, lysosomes exhibit differences in size and distribution in muscle and non-muscle cells, which are modulated by the Wnt/beta-catenin pathway, impacting the positioning, size, and function of lysosomes.
Letter
Genetics & Heredity
Piranit Kantaputra, Peeranat Jatooratthawichot, Naomi Kottege, Robert P. P. Anthonappa, Massupa Kaewgahya, Sissades Tongsima, Chumpol Ngamphiw, James R. Ketudat R. Cairns, Danilo Predes, Xi He
Article
Multidisciplinary Sciences
Mirian Romitti, Adrien Tourneur, Barbara de Faria da Fonseca, Gilles Doumont, Pierre Gillotay, Xiao-Hui Liao, Sema Elif Eski, Gaetan Van Simaeys, Laura Chomette, Helene Lasolle, Olivier Monestier, Dominika Figini Kasprzyk, Vincent Detours, Sumeet Pal Singh, Serge Goldman, Samuel Refetoff, Sabine Costagliola
Summary: The study reports the generation of transplantable thyroid organoids derived from human embryonic stem cells, which can restore thyroid hormone levels in athyreotic mice. Thyroid hormones are essential for the normal functioning and growth of tissues, and hypothyroidism is a common disorder that is difficult to treat effectively. This research provides proof of concept for future therapeutic development.
NATURE COMMUNICATIONS
(2022)
Article
Chemistry, Medicinal
Jessica Raquel Borges Monteiro, Ricardo Pereira Rodrigues, Ana Carolina Mazzuco, Rita de Cassia Ribeiro Goncalves, Angelo Fraga Bernardino, Ricardo Machado Kuster, Rodrigo Rezende Kitagawa
Summary: It is estimated that there will be nearly 2 million new cases of gastric cancer worldwide in the next two decades, leading to an increased demand for new treatments. Marine algae, such as Laurencia genus, have been found to contain cytotoxic compounds like terpenes and acetogenins. This study identified and tested the cytotoxicity of compounds from Laurencia obtusa, demonstrating their potential for treating gastric adenocarcinoma.
Article
Chemistry, Applied
Larissa Silva de Souza, Cristina Luz Tosta, Jessica Rodrigues Pereira de Oliveira Borlot, Marcia C. B. N. Varricchio, Rodrigo Rezende Kitagawa, Paulo Roberto Filgueiras, Ricardo Machado Kuster
Summary: The ethanol extract from Euphorbia tirucalli L. and its latex suspended in water are used in Brazil for the treatment of various diseases, including cancer. This study aimed to determine the cytotoxic effects of the ethanol extract on gastric adenocarcinoma cells (AGS) and analyze its chemical composition. Hexane and aqueous fractions of the extract showed higher cytotoxicity on AGS cells. Analysis revealed the presence of triterpene compounds in the hexane fraction and ellagic acid as the main phenolic compound in the aqueous extract, suggesting that these components contribute to the greater cytotoxic activity of the ethanol extract compared to latex.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Nataly Senna Gerhardt Barraqui, Jose Aires Ventura, Fabiana Gomes Ruas, Rodrigo Borges de Araujo Gomes, Betina Pires Oliveira Lovatti, Samantha Ribeiro Campos da Silva, Paulo Roberto Filgueiras, Ricardo Machado Kuster
Summary: This study evaluated the quality of Brazilian peppertree fruits at different maturation stages and found that the red fruits had the highest yield of essential oil. The analysis of physical and chemical characteristics of each stage showed distinct profiles, with the pinkish-green and pinkish stages displaying a transition in characteristics. The chromatography data were suitable for chemometric analysis and can contribute to optimizing the harvest time for aroeira fruits.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2023)
Article
Multidisciplinary Sciences
Monique B. Elias, Anderson J. Teodoro, Felipe S. Lemos, Emerson S. Bernardes, Sofia N. Santos, Sidney Pacheco, Felipe L. de Oliveira
Summary: Lycopene promotes B lymphocyte differentiation and plasma cell generation, and is involved in humoral and mucosal immunity.
ANAIS DA ACADEMIA BRASILEIRA DE CIENCIAS
(2022)
