Article
Biotechnology & Applied Microbiology
Pin Lv, Yuan Xue
Summary: The study identified the expression level of LINC01638 in papillary thyroid carcinoma (PTC) and its role in PTC progression. It was found that LINC01638 regulates PTC progression by inhibiting the Wnt/beta-catenin pathway and activating Axin2.
Article
Oncology
Jiaxue Hao, Xufen Dai, Juan Gao, Yuexuan Li, Zhaoling Hou, Zhongman Chang, Yuxin Wang
Summary: Curcumin has been extensively studied for its efficacy in treating colorectal cancer, demonstrating suppression of tumorigenesis by inhibiting pro-inflammatory cytokine expression and downregulating Axin2 in the Wnt/beta-catenin signaling pathway in the AOM-DSS induced CRC mouse model. These results highlight Axin2 as a potential therapeutic target for CRC.
Article
Cell & Tissue Engineering
Yuhui Xu, Jiali Hu, Qiaoying Lv, Chenyi Shi, Mengdi Qiu, Liying Xie, Wei Liu, Bingyi Yang, Weiwei Shan, Yali Cheng, Bing Zhao, Xiaojun Chen
Summary: This study aimed to investigate the potential therapeutic effects and underlying mechanisms of mesenchymal stem cells (MSCs) on well-differentiated endometrial cancer (EC). The results demonstrated that endometrium-derived MSCs (eMSCs) had the highest inhibitory effect on EC cell viability and xenograft tumor growth compared to adipose-derived MSCs (AD-MSCs) and umbilical-cord-derived MSCs (UC-MSCs). The study also revealed that eMSCs inhibited EC cell proliferation and stemness through the DKK1-Wnt/beta-catenin signaling pathway. Furthermore, the combination of eMSCs and medroxyprogesterone acetate (MPA) showed enhanced inhibition of EC growth. These findings suggest that eMSCs may be a promising therapeutic strategy for young EC patients desiring fertility preservation.
STEM CELL RESEARCH & THERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Haitao Gu, Zhiquan Xu, Jianbo Zhang, Yanbing Wei, Ling Cheng, Jijian Wang
Summary: circ_0038718 is highly expressed in colon cancer and can sponge miR-195-5p in the cytoplasm, facilitating malignant progression of colon cancer cells through the miR-195-5p/Axin2 axis.
Article
Oncology
Yan-Long Han, Dan Luo, Kakeng Habaxi, Julaiti Tayierjiang, Wei Zhao, Wei Wang, Wumaierjiang Aikebaier, Li Wang
Summary: In this study, we identified COL5A2 as a prognostic gene for osteosarcoma through bioinformatics analysis, and showed that COL5A2 inhibits invasion and metastasis of osteosarcoma by suppressing the TGF-beta and Wnt/β-Catenin signaling pathways.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Yuxuan Li, Lutian Yao, Jing Lu
Summary: IL-35 inhibits adipogenesis by regulating the proliferation, cytotoxicity, and differentiation of adipocytes. It suppresses the expression of PPAR gamma and C/EBP alpha, and also influences the Wnt/beta-actin pathway through the regulation of Axin2 expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Peilei Shi, Xudong Xie, Chunmei Xu, Yafei Wu, Jun Wang
Summary: In this study, the regulatory mechanisms of Wnt/beta-catenin signaling on Axin2(+) cells in tooth development were investigated using the mouse incisor model. The results showed that Wnt signaling plays a key role in the differentiation and maturation of Axin2(+) cells in mouse incisors.
Article
Multidisciplinary Sciences
Abhishek Sinha, Vinson B. Fan, Aravinda-Bharathi Ramakrishnan, Nicole Engelhardt, Jennifer Kennell, Ken M. Cadigan
Summary: SOX9 promotes turnover of β-catenin independently of the destruction complex and proteasome in mammalian cell culture. This requires the activation of MAML2, which acts as a coactivator for SOX9 in antagonizing the Wnt/β-catenin pathway. This newly identified pathway provides a parallel mechanism for restricting Wnt/β-catenin signaling.
Article
Cell Biology
Hang Tian, Lei Hou, Yumei Xiong, Qiuju Cheng
Summary: The study showed that DEX can inhibit OC development by upregulating miR-185 expression and deactivating the SOX9/Wnt/beta-catenin signaling pathway. MiR-185 targeted SOX9, and interfering with miR-185 expression affected HO-8910 cell proliferation, invasion, migration, and apoptosis. SOX9 knockdown repressed OC development and the Wnt/beta-catenin pathway.
Article
Biochemistry & Molecular Biology
Min Gyu Lee, Hwamok Oh, Jong Woo Park, Jueng Soo You, Jeung-Whan Han
Summary: Nuclear S6K1 functions in the regulation of Wnt target gene expression and has an impact on cell proliferation and invasion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Yi Xiao, Qin Liu, Nanyin Peng, Yuzhang Li, Danyang Qiu, Tianlun Yang, Richard Kang, Ahsan Usmani, Efosa Amadasu, Cesario Borlongan, Guolong Yu
Summary: Statins, commonly used drugs for controlling lipid levels, have shown the potential to lower colorectal cancer incidence and improve patient survival through inhibiting Wnt/β-catenin and YAP/TAZ signaling pathways. This study provides evidence supporting the clinical use of statins in non-cardiovascular contexts and identifies novel targets for anticancer treatments.
CELL TRANSPLANTATION
(2022)
Article
Biochemistry & Molecular Biology
Jing Cai, Song-Yun Shi, Fan Cheng, Min Wei, Kun Zou, Xiao-Qin Yu, Jian-Feng Chen
Summary: (E)-7-Phenyl-2-hepten-4,6-diyn-1-ol (1) and (Z)-7-Phenyl-2-hepten-4,6-diyn-1-ol (2) are isomeric natural polyacetylenes isolated from Bidens pilosa L., a Chinese medicinal plant. These polyacetylenes showed excellent anti-metastasis potential on HGC-27 cells, inhibiting their migration, invasion, and adhesion in a dose-dependent manner. The mechanism underlying the activities involved the reversal of the EMT process and the suppression of the Wnt/beta-catenin and Hippo/YAP signaling pathways.
Article
Biochemistry & Molecular Biology
Mingliang He, Xiaoyang Lv, Xiukai Cao, Zehu Yuan, Tesfaye Getachew, Yutao Li, Shanhe Wang, Wei Sun
Summary: SRY-box transcription factor 18 (SOX18) is expressed in dermal papilla cells (DPCs) of sheep hair follicles and plays a crucial role in promoting DPC proliferation through activating the Wnt/β-Catenin signaling pathway. Inhibition of the Wnt/β-Catenin signaling pathway can be rescued by SOX18, suggesting the essential role of SOX18 in governing DPC proliferation and hair growth.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Junghoon Kim, Kyeng-Won Choi, Jungwoon Lee, Jaeyoung Lee, Seonock Lee, Ruijing Sun, Jungho Kim
Summary: The CD44(+)CD133(+) subpopulation from Caco-2 cells is highly enriched in tumorigenic cells with unusual proliferative capacity and tumor-forming potential. These cells exhibit faster tumor growth in secondary xenografts, and the over-activation of the Wnt/beta-catenin pathway is closely associated with their nature.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell Biology
Yangyang Guo, Hengyue Zhu, Yanyi Xiao, Hangcheng Guo, Miaomiao Lin, Ziwei Yuan, Xuejia Yang, Youze Huang, Qiyu Zhang, Yongheng Bai
Summary: This study found that Niclosamide inhibits the progression of pancreatic cancer by targeting beta-catenin degradation, enhances the effects of chemotherapy drugs, and reduces immune evasion ability. This suggests that Niclosamide may be a potential therapeutic candidate for pancreatic cancer.
CELL DEATH & DISEASE
(2022)
Article
Plant Sciences
Robin Huber, Laurence Marcourt, Alexey Koval, Sylvain Schnee, Davide Righi, Emilie Michellod, Vladimir L. Katanaev, Jean-Luc Wolfender, Katia Gindro, Emerson Ferreira Queiroz
Summary: A series of complex phenylpropanoid derivatives were obtained by chemoenzymatic biotransformation. These compounds showed anti-Wnt activity and have potential applications.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Neurosciences
Denis Silachev, Alexey Koval, Mikhail Savitsky, Guru Padmasola, Charles Quairiaux, Fabrizio Thorel, Vladimir L. Katanaev
Summary: This study establishes two mouse models of GNAO1 encephalopathy, which simulate different clinical manifestations of the disease and reveal it as a neurodevelopmental disorder. These models contribute to understanding the disease mechanism and developing future treatment approaches.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Antonina Klimenko, Elvira E. Rodina, Denis Silachev, Maria Begun, Valentina A. Babenko, Anton S. Benditkis, Anton S. Kozlov, Alexander A. Krasnovsky, Yuri S. Khotimchenko, Vladimir L. Katanaev
Summary: Photodynamic therapy (PDT) is a powerful anticancer treatment that relies on the use of photosensitizers. This study identifies ETPA as a major metabolite of the North Pacific brittle stars and demonstrates its strong phototoxicity against cancer cell lines in vitro. In a mouse model of glioblastoma, ETPA injection combined with red laser irradiation induces necrotic ablation of the brain tumor.
Article
Chemistry, Multidisciplinary
Mikhail Kryuchkov, Jozef Adamcik, Vladimir L. Katanaev
Summary: Researchers have expanded the versatility of bionic nanocoatings by using different Retinin-like proteins and metallization methods, and have identified the best protocols for constructing anti-infective metalized bionic nanocoatings.
Article
Chemistry, Multidisciplinary
Robin Huber, Alexey Koval, Laurence Marcourt, Margaux Heritier, Sylvain Schnee, Emilie Michellod, Leonardo Scapozza, Vladimir L. Katanaev, Jean-Luc Wolfender, Katia Gindro, Emerson Ferreira Queiroz
Summary: The study obtained a library of complex stilbene derivatives through biotransformation, and comprehensively quantified their inhibitory activity against the oncogenic Wnt pathway. The structure-activity relationships and mechanistic details of these compounds were revealed, providing insights for potential therapeutically relevant compounds targeting this pathway.
FRONTIERS IN CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Antonina Klimenko, Robin Huber, Laurence Marcourt, Dmitry Tabakaev, Alexey Koval, Salim Sh. Dautov, Tatyana N. N. Dautova, Jean-Luc Wolfender, Rob Thew, Yuri Khotimchenko, Emerson Ferreira Queiroz, Vladimir L. L. Katanaev
Summary: Through metabolite analysis, we have identified five new chlorin compounds from Ophiura sarsii and O. ooplax, demonstrating their potential applications in photodynamic therapy.
Review
Biochemistry & Molecular Biology
Vladimir L. Katanaev, Alexey Baldin, Tatiana V. Denisenko, Denis N. Silachev, Anna E. Ivanova, Gennadiy T. Sukhikh, Lee Jia, Lev A. Ashrafyan
Summary: Wnt signaling plays multiple important roles in cancer, including primary transformation, tumor growth, and metastasis. It is not only crucial for cancer cell-intrinsic functions but also for cross-communication among different cell types in the tumor microenvironment. Various cell types, such as fibroblasts, macrophages, endothelial cells, and lymphocytes, use the Wnt language to communicate with cancer cells and each other, and these messages are essential for tumor progression and fate. Decoding this language will provide valuable insights into tumor biology and lead to novel therapeutic strategies.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Vladimir L. Katanaev
Summary: Neuroscience and neurology research heavily relies on experimentation with rodents, but non-vertebrate models such as fruit flies have not been able to fully replace mice and rats in these studies. One reason is that existing methodologies for creating fruit fly models of neurological diseases do not accurately reflect the genetic conditions of the diseases. Therefore, the author argues for a systematic humanization approach, where the fruit fly orthologs of human disease genes are replaced with the human sequences. This approach would improve disease modeling and drug discovery in fruit flies.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Alexey Koval, Yonika A. Larasati, Mikhail Savitsky, Gonzalo P. Solis, Jean-Marc Good, Mathieu Quinodoz, Carlo Rivolta, Andrea Superti-Furga, Vladimir L. Katanaev
Summary: A study found a mutation in the GNAO1 gene associated with pediatric encephalopathies. A precision medicine workflow combining NGS diagnostics, molecular etiology analysis, and personalized drug discovery was used to study this mutation. The mutation was found to cause structural changes in the Gao protein, leading to aberrant biochemical functions and providing insights into the molecular etiology of this pathology.
Article
Microbiology
Alexey Koval, Jiabin Xu, Nathalia Williams, Mirco Schmolke, Karl-Heinz Krause, Vladimir L. Katanaev
Summary: Despite previous indications, pharmacological modulation of the Wnt pathway is not a promising strategy to control SARS-CoV-2 infection in lung epithelia.
MICROBIOLOGY SPECTRUM
(2023)
Article
Multidisciplinary Sciences
Alexey Koval, Xin Zhang, Vladimir L. Katanaev
Summary: Intracellular signaling plays crucial roles in an organism's development and functioning, and dysregulation of signaling pathways can lead to various pathologies, including cancer. A key characteristic of cell signaling is channel capacity, which measures how much information can be reliably transmitted by a signaling system. In this study, we present improved methods to quantify the channel capacity of GPCR signaling in single cells, and we analyze the channel capacity of cancer cells for the first time. We find that different types of cancer cells exhibit decreased channel capacity in their GPCR signaling, supporting the hypothesis that cancer is an information disease. These findings have important implications for understanding cancer biology and discovering new anticancer drugs.