Potential Therapeutic Value of a Novel FAAH Inhibitor for the Treatment of Anxiety

Cannabinoids & Stress: Impact of HU-210 on behavioral tests of anxiety in acutely stressed mice

(2015) Renee Kinden et al.   BEHAVIOURAL BRAIN RESEARCH

Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context

(2015) Patricia Rivera et al.   Frontiers in Cellular Neuroscience

Effects of the fatty acid amide hydrolase inhibitor URB597 on pain-stimulated and pain-depressed behavior in rats

(2014) Andrew J. Kwilasz et al.   BEHAVIOURAL PHARMACOLOGY

Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

(2014) Mauro Maccarrone et al.   NATURE REVIEWS NEUROSCIENCE

Animal models of anxiety disorders and stress

(2014) Alline C. Campos et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Effects of the fatty acid amide hydrolase inhibitor URB597 on coping behavior under challenging conditions in mice

(2013) Jozsef Haller et al.   PSYCHOPHARMACOLOGY

The age of anxiety: role of animal models of anxiolytic action in drug discovery

(2011) John F Cryan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Endocannabinoid system and psychiatry: in search of a neurobiological basis for detrimental and potential therapeutic effects

(2011) Eva Marco   Frontiers in Behavioral Neuroscience

A new group of oxime carbamates as reversible inhibitors of fatty acid amide hydrolase

(2010) Sonia Gattinoni et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System

(2010) Sonia Gattinoni et al.   ChemMedChem

Palmitoylethanolamide and other anandamide congeners. Proposed role in the diseased brain

(2010) Harald S. Hansen   EXPERIMENTAL NEUROLOGY

Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo

(2010) Gabriel M. Simon et al.   Molecular BioSystems

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

Inhibition of endocannabinoid catabolic enzymes elicits anxiolytic-like effects in the marble burying assay

(2010) Steven G. Kinsey et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Emerging strategies for exploiting cannabinoid receptor agonists as medicines

(2009) Roger G Pertwee   BRITISH JOURNAL OF PHARMACOLOGY

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

(2009) Kay Ahn et al.   CHEMISTRY & BIOLOGY

Characterization of the Endocannabinoid System in Human Spermatozoa and Involvement of Transient Receptor Potential Vanilloid 1 Receptor in Their Fertilizing Ability

(2009) F. Francavilla et al.   ENDOCRINOLOGY

Fatty acid amide hydrolase as a potential therapeutic target for the treatment of pain and CNS disorders

(2009) Kay Ahn et al.   Expert Opinion on Drug Discovery

Cannabis and anxiety: a critical review of the evidence

(2009) José Alexandre Crippa et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

The endocannabinoid system: emotion, learning and addiction

(2008) Fabrício A. Moreira et al.   ADDICTION BIOLOGY

Thiadiazolopiperazinyl ureas as inhibitors of fatty acid amide hydrolase

(2008) John M. Keith et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Anxiolytic Effects in Mice of a Dual Blocker of Fatty Acid Amide Hydrolase and Transient Receptor Potential Vanilloid Type-1 Channels

(2008) Vincenzo Micale et al.   NEUROPSYCHOPHARMACOLOGY

An endocannabinoid signaling system modulates anxiety-like behavior in male Syrian hamsters

(2008) Anna M. Moise et al.   PSYCHOPHARMACOLOGY

The endogenous cannabinoid anandamide has effects on motivation and anxiety that are revealed by fatty acid amide hydrolase (FAAH) inhibition

(2007) Maria Scherma et al.   NEUROPHARMACOLOGY

Reduced anxiety-like behaviour induced by genetic and pharmacological inhibition of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) is mediated by CB1 receptors

(2007) Fabricio A. Moreira et al.   NEUROPHARMACOLOGY