Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences

Prediction of the Biological Activity Spectra of Organic Compounds Using the Pass Online Web Resource

(2014) D. A. Filimonov et al.   Chemistry of Heterocyclic Compounds

Anti-Inflammatory Effects of IKK Inhibitor XII, Thymulin, and Fat-Soluble Antioxidants in LPS-Treated Mice

(2014) E. G. Novoselova et al.   MEDIATORS OF INFLAMMATION

Chemo- and bioinformatics resources for in silico drug discovery from medicinal plants beyond their traditional use: a critical review

(2014) Alexey A. Lagunin et al.   NATURAL PRODUCT REPORTS

Anti-inflammatory effect of tricin 4′-O-(threo-β-guaiacylglyceryl) ether, a novel flavonolignan compound isolated from Njavara on in RAW264.7 cells and in ear mice edema

(2014) Young-Suk Jung et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

α-Dihydroxychalcone-glycoside (α-DHC) isolated from the heartwood of Pterocarpus marsupium inhibits LPS induced MAPK activation and up regulates HO-1 expression in murine RAW 264.7 macrophage

(2014) Prarthana Chakraborty et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Novel IKKβ inhibitors discovery based on the co-crystal structure by using binding-conformation-based and ligand-based method

(2013) Jing-Jie Huang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Desoxyrhapontigenin, a potent anti-inflammatory phytochemical, inhibits LPS-induced inflammatory responses via suppressing NF-κB and MAPK pathways in RAW 264.7 cells

(2013) Ran Joo Choi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Silver-based nanoparticles induce apoptosis in human colon cancer cells mediated through p53

(2013) Shakti Ranjan Satapathy et al.   Nanomedicine

Regulation of nuclear factor-κB in autoimmunity

(2013) Shao-Cong Sun et al.   TRENDS IN IMMUNOLOGY

Neurotensin Modulates the Migratory and Inflammatory Response of Macrophages under Hyperglycemic Conditions

(2013) Liane I. F. Moura et al.   Biomed Research International

Hit identification of IKKβ natural product inhibitor

(2013) Chung-Hang Leung et al.   BMC Pharmacology & Toxicology

Computational Drug Discovery Approach Based on Nuclear Factor-κB Pathway Dynamics

(2012) Ky-Youb Nam et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Corosolic Acid Ameliorates Atherosclerosis in Apolipoprotein E-Deficient Mice by Regulating the Nuclear Factor-κB Signaling Pathway and Inhibiting Monocyte Chemoattractant Protein-1 Expression

(2012) Hong Chen et al.   CIRCULATION JOURNAL

Stevioside Suppressed Inflammatory Cytokine Secretion by Downregulation of NF-κB and MAPK Signaling Pathways in LPS-Stimulated RAW264.7 Cells

(2012) Li Fengyang et al.   INFLAMMATION

Euscaphic acid isolated from roots of Rosa rugosa inhibits LPS-induced inflammatory responses via TLR4-mediated NF-κB inactivation in RAW 264.7 macrophages

(2012) In-Tae Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nootropic action of some antihypertensive drugs: computer predicting and experimental testing

(2012) S. A. Kryzhanovskii et al.   PHARMACEUTICAL CHEMISTRY JOURNAL

Oleanolic acid

(2012) Jacob Pollier et al.   PHYTOCHEMISTRY

Potent Anti-Inflammatory Activity of Ursolic Acid, a Triterpenoid Antioxidant, Is Mediated through Suppression of NF-κB, AP-1 and NF-AT

(2012) Rahul Checker et al.   PLoS One

Prediction of Molecular Targets of Cancer Preventing Flavonoid Compounds Using Computational Methods

(2012) Hanyong Chen et al.   PLoS One

Cornuside Suppresses Lipopolysaccharide-Induced Inflammatory Mediators by Inhibiting Nuclear Factor-Kappa B Activation in RAW 264.7 Macrophages

(2011) Yun Ho Choi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Softening the Rule of Five—where to draw the line?

(2011) Joachim Petit et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Ursolic acid improves high fat diet-induced cognitive impairments by blocking endoplasmic reticulum stress and IκB kinase β/nuclear factor-κB-mediated inflammatory pathways in mice

(2011) Jun Lu et al.   BRAIN BEHAVIOR AND IMMUNITY

Tormentic acid, a triterpenoid saponin, isolated from Rosa rugosa, inhibited LPS-induced iNOS, COX-2, and TNF-α expression through inactivation of the nuclear factor-κb pathway in RAW 264.7 macrophages

(2011) Hyo-Jin An et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Quinacrine has anticancer activity in breast cancer cells through inhibition of topoisomerase activity

(2011) Ranjan Preet et al.   INTERNATIONAL JOURNAL OF CANCER

Crystal structure of inhibitor of κB kinase β

(2011) Guozhou Xu et al.   NATURE

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+-ATPase

(2010) Ronald JY Chen et al.   ACTA PHARMACOLOGICA SINICA

Celastrol: Molecular targets of Thunder God Vine

(2010) Antero Salminen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibiting NF-κB activation by small molecules as a therapeutic strategy

(2010) Subash C. Gupta et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Virtual screening against nuclear factor κB (NF-κB) of a focus library: Identification of bioactive furocoumarin derivatives inhibiting NF-κB dependent biological functions involved in cystic fibrosis

(2010) Laura Piccagli et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibition of the NEMO/IKKβ association complex formation, a novel mechanism associated with the NF-κB activation suppression by Withania somnifera’s key metabolite withaferin A

(2010) Abhinav Grover et al.   BMC GENOMICS

Multi-Targeted Natural Products Evaluation Based on Biological Activity Prediction with PASS

(2010) Alexey Lagunin et al.   CURRENT PHARMACEUTICAL DESIGN

Madecassoside suppresses LPS-induced TNF-α production in cardiomyocytes through inhibition of ERK, p38, and NF-κB activity

(2010) Wei Cao et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

SIRT2 regulates NF- B-dependent gene expression through deacetylation of p65 Lys310

(2010) K. M. Rothgiesser et al.   JOURNAL OF CELL SCIENCE

Anti-inflammatory effects of methanol extracts of the root of Lilium lancifolium on LPS-stimulated Raw264.7 cells

(2010) Ok-Kyoung Kwon et al.   JOURNAL OF ETHNOPHARMACOLOGY

Effects of triterpenes on the immune system

(2010) José-Luis Ríos   JOURNAL OF ETHNOPHARMACOLOGY

Anti-inflammatory and antinociceptive properties of the leaves of Eriobotrya japonica

(2010) Dong Seok Cha et al.   JOURNAL OF ETHNOPHARMACOLOGY

PASS-assisted exploration of new therapeutic potential of natural products

(2010) Rajesh Kumar Goel et al.   MEDICINAL CHEMISTRY RESEARCH

Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer

(2010) Vivek R. Yadav et al.   Toxins

Roles of NF-κB in health and disease: mechanisms and therapeutic potential

(2009) Ee Tsin Wong et al.   CLINICAL SCIENCE

Progress Towards the Development of Anti-Inflammatory Inhibitors of IKKβ

(2009) Paul Bamborough et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

A Novel, Highly Selective, Tight Binding I B Kinase-2 (IKK-2) Inhibitor: A Tool to Correlate IKK-2 Activity to the Fate and Functions of the Components of the Nuclear Factor- B Pathway in Arthritis-Relevant Cells and Animal Models

(2009) G. Mbalaviele et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Recent developments in anti-inflammatory natural products

(2009) Raju Gautam et al.   MEDICINAL RESEARCH REVIEWS

Pentacyclic Triterpene Distribution in Various Plants – Rich Sources for a New Group of Multi-Potent Plant Extracts

(2009) Sebastian Jäger et al.   MOLECULES

Pentacyclic Triterpenes of the Lupane, Oleanane and Ursane Group as Tools in Cancer Therapy

(2009) Melanie Laszczyk   PLANTA MEDICA

Computer-Aided Prediction of Rodent Carcinogenicity by PASS and CISOC-PSCT

(2009) Alexey Lagunin et al.   Quantitative structure-activity relationships & combinatorial science

Terpenoids: natural inhibitors of NF-κB signaling with anti-inflammatory and anticancer potential

(2008) A. Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Desmethylanhydroicaritin inhibits NF-κB-regulated inflammatory gene expression by modulating the redox-sensitive PI3K/PTEN/Akt pathway

(2008) Ji-Hee Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Boswellic acids: a group of medicinally important compounds

(2008) Bhahwal Ali Shah et al.   NATURAL PRODUCT REPORTS

Computer-aided prediction of QT-prolongation1

(2008) O. Filz et al.   SAR AND QSAR IN ENVIRONMENTAL RESEARCH