Proteins with Intrinsically Disordered Domains Are Preferentially Recruited to Polyglutamine Aggregates

Intrinsically disordered proteins and their (disordered) proteomes in neurodegenerative disorders

(2015) Vladimir N. Uversky   Frontiers in Aging Neuroscience

Introducing Protein Intrinsic Disorder

(2014) Johnny Habchi et al.   CHEMICAL REVIEWS

SUCLG2 identified as both a determinator of CSF Aβ1–42 levels and an attenuator of cognitive decline in Alzheimer's disease

(2014) Alfredo Ramirez et al.   HUMAN MOLECULAR GENETICS

Dysfunction of Endocytic Kinase AAK1 in ALS

(2014) Bingxing Shi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Large Scale Huntingtin Protein Interaction Network Implicates Rho GTPase Signaling Pathways in Huntington Disease

(2014) Cendrine Tourette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Huntingtin is associated with cytomatrix proteins at the presynaptic terminal

(2014) Jia Yao et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

(2014) Janel O Johnson et al.   NATURE NEUROSCIENCE

Large-Scale RNA Interference Screening in Mammalian Cells Identifies Novel Regulators of Mutant Huntingtin Aggregation

(2014) Tomoyuki Yamanaka et al.   PLoS One

SUMO3 Modification Accelerates the Aggregation of ALS-Linked SOD1 Mutants

(2014) Takako Niikura et al.   PLoS One

Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: Implication in a loss-of-function pathology

(2014) Hui Yang et al.   Scientific Reports

hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations

(2013) Kohji Mori et al.   ACTA NEUROPATHOLOGICA

Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions

(2013) Nicola J. Rutherford et al.   BRAIN RESEARCH

The Rat Genome Database 2013--data, tools and users

(2013) S. J. F. Laulederkind et al.   BRIEFINGS IN BIOINFORMATICS

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

(2013) Mani Ramaswami et al.   CELL

PolyQ Proteins Interfere with Nuclear Degradation of Cytosolic Proteins by Sequestering the Sis1p Chaperone

(2013) Sae-Hun Park et al.   CELL

Compromised paraspeckle formation as a pathogenic factor in FUSopathies

(2013) Tatyana A. Shelkovnikova et al.   HUMAN MOLECULAR GENETICS

Non-targeted Identification of Prions and Amyloid-forming Proteins from Yeast and Mammalian Cells

(2013) Dmitry Kryndushkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress granules as crucibles of ALS pathogenesis

(2013) Yun R. Li et al.   JOURNAL OF CELL BIOLOGY

The Unstable Repeats—Three Evolving Faces of Neurological Disease

(2013) David L. Nelson et al.   NEURON

Amyloid cannot resist identification

(2013) Dmitry Kryndushkin et al.   Prion

SUMO-2 and PIAS1 Modulate Insoluble Mutant Huntingtin Protein Accumulation

(2013) Jacqueline Gire O’Rourke et al.   Cell Reports

The TRK-Fused Gene Is Mutated in Hereditary Motor and Sensory Neuropathy with Proximal Dominant Involvement

(2012) Hiroyuki Ishiura et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease

(2012) Oliver D. King et al.   BRAIN RESEARCH

Insights into RNA Biology from an Atlas of Mammalian mRNA-Binding Proteins

(2012) Alfredo Castello et al.   CELL

Huntingtin protein interactions altered by polyglutamine expansion as determined by quantitative proteomic analysis

(2012) Tamara Ratovitski et al.   CELL CYCLE

RNA-binding ability of FUS regulates neurodegeneration, cytoplasmic mislocalization and incorporation into stress granules associated with FUS carrying ALS-linked mutations

(2012) J. G. Daigle et al.   HUMAN MOLECULAR GENETICS

Regulation of Chaperone Effects on a Yeast Prion by Cochaperone Sgt2

(2012) D. A. Kiktev et al.   MOLECULAR AND CELLULAR BIOLOGY

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

Solid-State NMR Studies of Amyloid Fibril Structure

(2011) Robert Tycko   Annual Review of Physical Chemistry

Understanding the role of TDP-43 and FUS/TLS in ALS and beyond

(2011) Sandrine Da Cruz et al.   CURRENT OPINION IN NEUROBIOLOGY

HD CAG-correlated gene expression changes support a simple dominant gain of function

(2011) Jessie C. Jacobsen et al.   HUMAN MOLECULAR GENETICS

Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions

(2011) Aurélien Davranche et al.   HUMAN MOLECULAR GENETICS

Structural Insights into Functional and Pathological Amyloid

(2011) Frank Shewmaker et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia

(2011) Han-Xiang Deng et al.   NATURE

Saccharomyces Genome Database: the genomics resource of budding yeast

(2011) J. M. Cherry et al.   NUCLEIC ACIDS RESEARCH

A yeast functional screen predicts new candidate ALS disease genes

(2011) J. Couthouis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Yeast Model of FUS/TLS-Dependent Cytotoxicity

(2011) Shulin Ju et al.   PLOS BIOLOGY

Molecular Determinants and Genetic Modifiers of Aggregation and Toxicity for the ALS Disease Protein FUS/TLS

(2011) Zhihui Sun et al.   PLOS BIOLOGY

FUS/TLS forms cytoplasmic aggregates, inhibits cell growth and interacts with TDP-43 in a yeast model of amyotrophic lateral sclerosis

(2011) Dmitry Kryndushkin et al.   Protein & Cell

Expression of human FUS/TLS in yeast leads to protein aggregation and cytotoxicity, recapitulating key features of FUS proteinopathy

(2011) Kazuo Fushimi et al.   Protein & Cell

Neurotoxic protein oligomerisation associated with polyglutamine diseases

(2010) Sarah L. Hands et al.   ACTA NEUROPATHOLOGICA

The Mitochondrial Proteome and Human Disease

(2010) Sarah E. Calvo et al.   Annual Review of Genomics and Human Genetics

Interaction with Polyglutamine Aggregates Reveals a Q/N-rich Domain in TDP-43

(2010) Rodrigo A. Fuentealba et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia

(2010) Ian RA Mackenzie et al.   LANCET NEUROLOGY

TAR DNA-binding protein 43 in neurodegenerative disease

(2010) Alice S. Chen-Plotkin et al.   Nature Reviews Neurology

Optical trapping with high forces reveals unexpected behaviors of prion fibrils

(2010) Jijun Dong et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Two Prion Variants of Sup35p Have In-Register Parallel β-Sheet Structures, Independent of Hydration

(2009) Frank Shewmaker et al.   BIOCHEMISTRY

Close encounters of the third kind: disordered domains and the interactions of proteins

(2009) Peter Tompa et al.   BIOESSAYS

Selective neuronal requirement for huntingtin in the developing zebrafish

(2009) T. L. Henshall et al.   HUMAN MOLECULAR GENETICS

Cross-Seeding Fibrillation of Q/N-Rich Proteins Offers New Pathomechanism of Polyglutamine Diseases

(2009) Y. Furukawa et al.   JOURNAL OF NEUROSCIENCE

Proteomics of Saccharomyces cerevisiae Organelles

(2009) Elena Wiederhold et al.   MOLECULAR & CELLULAR PROTEOMICS

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

The Role of Intrinsically Unstructured Proteins in Neurodegenerative Diseases

(2009) Swasti Raychaudhuri et al.   PLoS One

Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6

(2009) C. Vance et al.   SCIENCE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Structural Basis of Infectious and Non-Infectious Amyloids

(2008) Ulrich Baxa   Current Alzheimer Research

Abnormal proteins can form aggresome in yeast: aggresome-targeting signals and components of the machinery

(2008) Yan Wang et al.   FASEB JOURNAL

TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis

(2008) Edor Kabashi et al.   NATURE GENETICS

Fibrils with parallel in-register structure constitute a major class of amyloid fibrils: molecular insights from electron paramagnetic resonance spectroscopy

(2008) Martin Margittai et al.   QUARTERLY REVIEWS OF BIOPHYSICS

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE