Synthetic Oligodeoxynucleotides Containing Multiple Telemeric TTAGGG Motifs Suppress Inflammasome Activity in Macrophages Subjected to Oxygen and Glucose Deprivation and Reduce Ischemic Brain Injury in Stroke-Prone Spontaneously Hypertensive Rats

Initiation and perpetuation of NLRP3 inflammasome activation and assembly

(2015) Eric I. Elliott et al.   IMMUNOLOGICAL REVIEWS

Resveratrol inhibits NLRP3 inflammasome activation by preserving mitochondrial integrity and augmenting autophagy

(2015) Ya-Ping Chang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Therapeutic Implications of Orally Delivered Immunomodulatory Oligonucleotides

(2015) Dennis M Klinman   MOLECULAR THERAPY

AIM2 and NLRC4 inflammasomes contribute with ASC to acute brain injury independently of NLRP3

(2015) Adam Denes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondria: diversity in the regulation of the NLRP3 inflammasome

(2015) Prajwal Gurung et al.   TRENDS IN MOLECULAR MEDICINE

Metabolic Reprograming of Mononuclear Phagocytes in Progressive Multiple Sclerosis

(2015) Gillian Margaret Tannahill et al.   Frontiers in Immunology

The immune system in hypertension

(2014) Daniel W. Trott et al.   ADVANCES IN PHYSIOLOGY EDUCATION

Immune Cell Crosstalk in Obesity: A Key Role for Costimulation?

(2014) T. Seijkens et al.   DIABETES

Intermittent fasting attenuates inflammasome activity in ischemic stroke

(2014) David Yang-Wei Fann et al.   EXPERIMENTAL NEUROLOGY

Suppressive oligodeoxynucleotides promote the generation of regulatory T cells by inhibiting STAT1 phosphorylation

(2014) Christian Bode et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Suppressive Oligodeoxynucleotides Inhibit Silica-Induced Pulmonary Inflammation

(2014) T. Sato et al.   JOURNAL OF IMMUNOLOGY

Infectious causes of stroke

(2014) Jennifer E Fugate et al.   LANCET INFECTIOUS DISEASES

Chrysophanol Inhibits NALP3 Inflammasome Activation and Ameliorates Cerebral Ischemia/Reperfusion in Mice

(2014) Nan Zhang et al.   MEDIATORS OF INFLAMMATION

Dacarbazine with or without oblimersen (a Bcl-2 antisense oligonucleotide) in chemotherapy-naive patients with advanced melanoma and low–normal serum lactate dehydrogenase

(2014) Agop Y. Bedikian et al.   MELANOMA RESEARCH

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

AIM2 and NLRP3 inflammasomes activate both apoptotic and pyroptotic death pathways via ASC

(2013) V Sagulenko et al.   CELL DEATH AND DIFFERENTIATION

Recent progress concerning CpG DNA and its use as a vaccine adjuvant

(2013) Hidekazu Shirota et al.   Expert Review of Vaccines

Clinical Trials Using Antisense Oligonucleotides in Duchenne Muscular Dystrophy

(2013) Taeyoung Koo et al.   HUMAN GENE THERAPY

Protective role of synthetic oligodeoxynucleotides expressing immunosuppressive TTAGGG motifs in concanavalin A-induced hepatitis

(2013) Ning Li et al.   IMMUNOLOGY LETTERS

MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury

(2013) Nicolas Deroide et al.   JOURNAL OF CLINICAL INVESTIGATION

Synthetic Oligodeoxynucleotides Containing Suppressive TTAGGG Motifs Inhibit AIM2 Inflammasome Activation

(2013) J. J. Kaminski et al.   JOURNAL OF IMMUNOLOGY

Mitochondrial Reactive Oxygen Species Induces NLRP3-Dependent Lysosomal Damage and Inflammasome Activation

(2013) M. E. Heid et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 4 signaling in intracerebral hemorrhage-induced inflammation and injury

(2013) Huang Fang et al.   Journal of Neuroinflammation

Global and regional burden of stroke during 1990–2010: findings from the Global Burden of Disease Study 2010

(2013) Valery L Feigin et al.   LANCET

Pivotal Roles of Monocytes/Macrophages in Stroke

(2013) Tsuyoshi Chiba et al.   MEDIATORS OF INFLAMMATION

Suppressive Oligodeoxynucleotides Promote the Development of Th17 Cells

(2013) Christian Bode et al.   PLoS One

Intravenous immunoglobulin suppresses NLRP1 and NLRP3 inflammasome-mediated neuronal death in ischemic stroke

(2013) D Yang-Wei Fann et al.   Cell Death & Disease

NLRP3 activation induces ASC-dependent programmed necrotic cell death, which leads to neutrophilic inflammation

(2013) T Satoh et al.   Cell Death & Disease

The Innate Immune System After Ischemic Injury

(2013) Gabriel Courties et al.   JAMA Neurology

Inflammatory Cytokines in Experimental and Human Stroke

(2012) Kate Lykke Lambertsen et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Inflammation in Atrial Fibrillation

(2012) Yutao Guo et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inflammasomes: far beyond inflammation

(2012) Jorge Henao-Mejia et al.   NATURE IMMUNOLOGY

Role of the Inflammasome in Myocardial Infarction

(2012) Masafumi Takahashi   TRENDS IN CARDIOVASCULAR MEDICINE

Caspase-1: is IL-1 just the tip of the ICEberg?

(2012) A Denes et al.   Cell Death & Disease

The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases

(2011) Beckley K. Davis et al.   Annual Review of Immunology

A clinical perspective of IL-1β as the gatekeeper of inflammation

(2011) Charles A. Dinarello   EUROPEAN JOURNAL OF IMMUNOLOGY

Proof of Concept: Pharmacological Preconditioning with a Toll-like Receptor Agonist Protects against Cerebrovascular Injury in a Primate Model of Stroke

(2011) Frances Rena Bahjat et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Improving reperfusion therapy for acute ischaemic stroke

(2011) J. L. SAVER   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

The immunology of stroke: from mechanisms to translation

(2011) Costantino Iadecola et al.   NATURE MEDICINE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Differential Requirement for Caspase-1 Autoproteolysis in Pathogen-Induced Cell Death and Cytokine Processing

(2010) Petr Broz et al.   Cell Host & Microbe

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Pathophysiological Impact of Cigarette Smoke Exposure on the Cerebrovascular System with a Focus on the Blood-brain Barrier: Expanding the Awareness of Smoking Toxicity in an Underappreciated Area

(2010) Peter Mazzone et al.   International Journal of Environmental Research and Public Health

Therapeutic Applications and Mechanisms Underlying the Activity of Immunosuppressive Oligonucleotides

(2009) Dennis M. Klinman et al.   Annals of the New York Academy of Sciences

A suppressive oligodeoxynucleotide inhibits ocular inflammation

(2009) C. Fujimoto et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Regulatory T cells are key cerebroprotective immunomodulators in acute experimental stroke

(2009) Arthur Liesz et al.   NATURE MEDICINE

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Necrotic cells trigger a sterile inflammatory response through the Nlrp3 inflammasome

(2009) S. S. Iyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

(2008) Denise P Abulafia et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Toll-Like Receptor 9: A New Target of Ischemic Preconditioning in the Brain

(2008) Susan L Stevens et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Suppressive oligodeoxynucleotides inhibit atherosclerosis in ApoE−/− mice through modulation of Th1/Th2 balance

(2008) Xiang Cheng et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Acute ischaemic stroke and infection: recent and emerging concepts

(2008) Hedley CA Emsley et al.   LANCET NEUROLOGY

Systemic infection, inflammation and acute ischemic stroke

(2008) B.W. McColl et al.   NEUROSCIENCE