Review
Biochemistry & Molecular Biology
Chaoqun Yu, Peng Chen, Longyu Miao, Guohu Di
Summary: Acute liver injury (ALI) is a significant global public health issue, which can rapidly progress to acute liver failure and pose a serious threat to patient's life safety. The activation of NLRP3 inflammasome and programmed cell death (PCD) play crucial roles in various types of ALI. This review provides a comprehensive summary of the involvement of NLRP3 inflammasome activation and PCD in different types of ALI, offering a valuable reference for future studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Veterinary Sciences
Pei Gao, Shiyuan Zhang, Xinxin Zhang, Chenggang Xu, Libin Chen, Lei Fan, Jinlian Ren, Qiuyan Lin, Bin Xiang, Tao Ren
Summary: This study investigates the expression and tissue distribution of S1PR1 after NDV infection and demonstrates that S1PR1 regulates IL-1 beta expression mainly through the NLRP3/caspase-1 inflammasome. The findings reveal the molecular mechanism underlying the inflammatory response induced by NDV infection.
VETERINARY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Dong-Wook Kwak, Donghwan Park, Jae-Hong Kim
Summary: The study shows that BLT1 and BLT2 play a role in stimulating NLRP3 inflammasome and IL-1 beta synthesis, contributing significantly to neutrophil-dominant asthmatic airway inflammation.
Article
Microbiology
Dengjin Chen, Tianbei Tuo, Yongning Zhang, Lei Zhou, Xinna Ge, Jun Han, Xin Guo, Hanchun Yang
Summary: PRRSV and CSFV are common infectious pathogens in pig populations, posing significant threats to the healthy development of the pig industry. Vaccine immunization is the main method to prevent and control these two diseases. Studies have shown that PRRSV co-infection affects the immune response to CSFV vaccine. In this study, it was found that PRRSV and CSFV co-infection significantly increased the expression of NLRP3 and ASC, activated Caspase-1, and promoted IL-1 beta maturation, leading to the inhibition of CSFV proliferation. It was also determined that the activation of NLRP3 inflammasome is regulated by the TLR4-MyD88-NF-kappa B pathways.
VETERINARY MICROBIOLOGY
(2023)
Article
Cell Biology
Omar Escobar-Chavarria, Alejandro Benitez-Guzman, Itzel Jimenez-Vazquez, Jacobo Carrisoza-Urbina, Lourdes Arriaga-Pizano, Sara Huerta-Yepez, Guillermina Baay-Guzman, Jose A. Gutierrez-Pabello
Summary: The necrotic cell death induced by Mycobacterium bovis and the inflammasome activation in bovine macrophages help control bacterial growth.
Article
Immunology
Fengqing Hou, Lianci Peng, Jiali Jiang, Tingting Chen, Dongyi Xu, Qingyuan Huang, Chao Ye, Yuanyi Peng, Dong-Liang Hu, Rendong Fang
Summary: Staphylococcus aureus is an important zoonotic food-borne pathogen that can cause severe infections. A study found that the enterotoxin O of S. aureus can induce interleukin-1 beta secretion in mouse neutrophils, which is dependent on the activation of TLR4/JNK/NLRP3 inflammasome signaling pathway.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zi-Teng Zhang, Xiao-Lei Gu, Xin Zhao, Xian He, Hao-Wei Shi, Kun Zhang, Yi-Ming Zhang, Yi-Nan Su, Jiang-Bo Zhu, Zhi-Wei Li, Guo-Bao Li
Summary: Prior infection simulated by LPS/LTA injection resulted in latent inflammation with high cytokine levels, but did not affect animal survival or body temperature. Heat treatment induced heat stroke and death in animals without prior infection, showing no significant systemic or neuroinflammation. NLRP3 inflammasome-induced neuroinflammation was detected in animals with prior infection, and Nlrp3 knockout mice showed enhanced heat tolerance and reduced hypothalamus IL-1 beta production. IL-1 beta neutralizing antibody injection extended endotoxemic mice survival under heat stroke.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Chemistry, Multidisciplinary
Kai Chen, Qiuping Hu, Zhongcong Xie, Guang Yang
Summary: This study reveals that surgery leads to neuronal hypoactivity and impairs learning-dependent dendritic spine formation, resulting in deficits in multiple learning tasks. These neuronal and synaptic alterations are mediated by peripheral monocytes through NLRP3 inflammasome-dependent IL-1β production. Decreasing peripheral monocytes or inactivating NLRP3 inflammasomes can reduce IL-1β levels and improve neuronal and behavioral deficits.
Article
Immunology
Chaoqing Zhong, Ruiqing Wang, Mingqiang Hua, Chen Zhang, Fengjiao Han, Miao Xu, Xinyu Yang, Guosheng Li, Xiang Hu, Tao Sun, Chunyan Ji, Daoxin Ma
Summary: NLRP3 inflammasome is over-expressed and highly activated in AML bone marrow leukemia cells, promoting leukemia cell proliferation, inhibiting apoptosis and increasing resistance to chemotherapy. IL-1 beta plays a crucial role in this process. Targeting NLRP3 inflammasome may offer a novel therapeutic option for AML.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Allergy
Arinna Bertoni, Federica Penco, Hilaria Mollica, Paola Bocca, Ignazia Prigione, Anna Corcione, Davide Cangelosi, Francesca Schena, Genny Del Zotto, Adriana Amaro, Noemi Paladino, Emanuele Pontali, Marcello Feasi, Sara Signa, Marta Bustaffa, Roberta Caorsi, Serena Palmeri, Paola Contini, Raffaele De Palma, Ulrich Pfeffer, Paolo Uva, Anna Rubartelli, Marco Gattorno, Stefano Volpi
Summary: This study reveals the crucial role of IL-1 beta in driving inflammatory phenotypes in severe COVID-19 patients, whose maturation and secretion are regulated by inflammasomes. The findings suggest that targeting IL-1 beta could be an effective strategy for treating COVID-19 and provide a mechanistic explanation for the strong inflammatory manifestations associated with the disease.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Judith Bockstiegel, Silas L. Wurnig, Jonas Engelhardt, Jana Enns, Finn K. Hansen, Guenther Weindl
Summary: The deficiency of HDAC6 does not affect the release of IL-1β mediated by NLRP3 in human immune cells, indicating that the inhibition of HDAC6 is not necessary for the function of the NLRP3 pathway. In addition, HDAC6 inhibitors have the potential to suppress inflammatory responses and inhibit the release of IL-1β by regulating Toll-like receptor (TLR) signaling pathway.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Hye-Mi Jang, Ji-Yeon Park, Yeon-Ji Lee, Min-Jung Kang, Sung-Gang Jo, Yu-Jin Jeong, Nam-Pyo Cho, Sung-Dae Cho, Dong-Jae Kim, Jong-Hwan Park
Summary: The study found that TLR2 is crucial for IL-1β generation and NLRP3 activation in response to P. nigrescens, with NLRP3 inflammasome playing a key role in processing pro-IL-1β into mature IL-1β. Furthermore, the production of reactive oxygen species, P2X7R activity, and release of cathepsin B are also involved in IL-1β production in BMDCs in response to P. nigrescens.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Review
Immunology
Yang Li, Qianzhou Jiang
Summary: Inflammasomes are supramolecular platforms that respond to damage-associated and pathogen-associated patterns, activating caspases and leading to pyroptosis and cytokine secretion. The uncoupling preferences between pyroptosis and cytokine secretion have context-dependent effects and contribute to various pathological conditions. Precise coupling and uncoupling decisions are crucial for tissue repair and threat elimination.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Keyla S. G. de Sa, Luana A. Amaral, Tamara S. Rodrigues, Adriene Y. Ishimoto, Warrison A. C. de Andrade, Leticia de Almeida, Felipe Freitas-Castro, Sabrina S. Batah, Sergio C. Oliveira, Monica T. Pastorello, Alexandre T. Fabro, Dario S. Zamboni
Summary: In this study, it is demonstrated that Gasdermin-D (GSDMD) is activated during the early stages of Leishmania infection, promoting NLRP3 inflammasome activation without causing cell death. GSDMD is cleaved into a noncanonical fragment, indicating the subversion of host response by Leishmania. Skin biopsies from patients with leishmaniasis also show activation of NLRP3 inflammasome and GSDMD.
NATURE COMMUNICATIONS
(2023)
Article
Immunology
Cara Lang, Sohini Roy, Yu Wang, Diana Graves, Yaomin Xu, C. Henrique Serezani, Michael Korrer, Young J. Kim
Summary: The expression of inflammasome-associated genes, NLRP3 and IL-1β, is enriched in specific monocyte and macrophage subtypes in tumor-infiltrating myeloid cells in Head and Neck Squamous Cell Carcinoma (HNSCC). Deletion of NLRP3 gene promotes tumor progression, while caspase-1 signaling in myeloid cells increases myeloid survival and drives tumor growth through phagocyte-mediated inflammasome signaling.
FRONTIERS IN IMMUNOLOGY
(2022)
Letter
Dermatology
H. Kamido, D. Shimomiya, T. Kogame, R. Takimoto-Ito, T. R. Kataoka, M. Hirata, C. Ueshima, A. Otsuka, F. M. Ghazawi, T. Nomura, N. Kambe, K. Kabashima
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Letter
Dermatology
T. Kogame, N. Kambe, R. Takimoto-Ito, T. Nomura, K. Kabashima
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Pharmacology & Pharmacy
Xiaoliang Yang, Naotomo Kambe, Riko Takimoto-Ito, Kenji Kabashima
Summary: AD is an inflammatory skin disease influenced by genetics, immune response, and environment. Therapies like dupilumab, crisaborole, and delgocitinib provide hope for effective treatment, and offer insight into the pathophysiology of AD.
PHARMACOLOGY & THERAPEUTICS
(2021)
Article
Pediatrics
Akiko Arakawa, Naotomo Kambe, Ryuta Nishikomori, Akiyo Tanabe, Masamichi Ueda, Chikako Nishigori, Yoshiki Miyachi, Nobuo Kanazawa
Summary: In this case report, a patient developed sporadic Blau syndrome after BCG vaccination, with a functional mutation in NOD2 detected through genetic analysis. This suggests that BCG vaccination may trigger granuloma formation in Blau syndrome patients with such genetic background.
Article
Pediatrics
Mizuho Nishiyama, Hong-jin Li, Ikuo Okafuji, Akihiko Fujisawa, Mizue Ehara, Naotomo Kambe, Fukumi Furukawa, Nobuo Kanazawa
Summary: In Blau syndrome patients, ICAM-1 and PDGF-B were positively immunostained in NOD2-expressing giant cells in the granulomatous skin lesion, suggesting that newly differentiating macrophages harboring mutant NOD2 may play a role in granuloma formation in Blau syndrome, possibly related to sustained surface ICAM-1 expression and transient PDGF-B production.
Article
Allergy
Yohko Kitagawa, Yuri Kawasaki, Yuichi Yamasaki, Naotomo Kambe, Syuji Takei, Megumu K. Saito
Summary: IFN-gamma stimulation plays a key role in driving aberrant inflammatory responses in BS-associated macrophages. However, long-term treatment with anti-TNF agents can ameliorate these abnormalities, suggesting a prerequisite role of TNF or similar cytokines in inducing proinflammatory signaling during macrophage development in BS patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Letter
Dermatology
K. Furuta, A. Horiguchi, Y. Nakagawa, N. Kambe, T. Kogame
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Article
Dermatology
Rintaro Shibuya, Riko Takimoto-Ito, Naotomo Kambe, Kenji Kabashima
Summary: Pruritus, a common dermatological condition, can significantly impact quality of life. Traditional antipruritic drugs may be ineffective, but recent advancements in molecularly targeted drugs have shown promising results in improving itching without the need for steroids. Understanding the cytokine-mediated mechanism of pruritus is crucial for guiding better therapies.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Letter
Dermatology
Toshiaki Kogame, Satoru Yonekura, Paola Lovato, Masahiro Hirata, Riko Takimoto-ito, Tomoya Takegami, Takayoshi Komatsu-Fujii, Naotomo Kambe, Takashi Nomura, Mads A. Ropke, Kenji Kabashima
Summary: Despite the limited sample size and low frequency of skin ILCs in this study, the data suggest that ICOS+ ILCs express IL-13Ra1 and that the density of ICOS+ ILCs decreases after four weeks of tralokinumab treatment.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Marina Ueda, Toshiaki Kogame, Gyohei Egawa, Naotomo Kambe, Kenji Kabashima
JOURNAL OF DERMATOLOGY
(2023)
Article
Allergy
Riko Takimoto-Ito, Naotomo Kambe, Toshiaki Kogame, Takashi Nomura, Kazushi Izawa, Tomoyasu Jo, Yasuhiro Kazuma, Hajime Yoshifuji, Yuya Tabuchi, Hiroyasu Abe, Mayuko Yamamoto, Kimiko Nakajima, Ozumi Tomita, Yosuke Yagi, Kazumoto Katagiri, Yuki Matsuzaka, Yohei Takeuchi, Miho Hatanaka, Takuro Kanekura, Sora Takeuchi, Takafumi Kadono, Yuya Fujita, Kiyoshi Migita, Takahiro Fujino, Takahiko Akagi, Tomoyuki Mukai, Tohru Nagano, Mitsuhiro Kawano, Hayato Kimura, Yukari Okubo, Akimichi Morita, Michihiro Hide, Takahiro Satoh, Akihiko Asahina, Nobuo Kanazawa, Kenji Kabashima
Summary: Schnitzler syndrome is a rare disorder characterized by chronic urticaria. A nationwide survey was conducted in Japan to determine the current status of the disease. Clinical information of 36 diagnosed cases was collected, providing insights into the clinical features and treatment of the syndrome. Continuous collection and long-term follow-up of clinical information are crucial for the appropriate management and further understanding of Schnitzler syndrome.
ALLERGOLOGY INTERNATIONAL
(2023)
Letter
Dermatology
Atsushi Naito, Toshiaki Kogame, Naotomo Kambe, Kenji Kabashima
JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Hitomi Nakaizumi, Naotomo Kambe, Hiroyuki Irie, Yo Kaku, Masakazu Fujimoto, Hajime Yoshifuji, Yasuhiro Kazuma, Kazumoto Katagiri, Takuro Kanekura, Kenji Kabashima
Summary: Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by bone pain, recurrent fever, and other symptoms. A key feature of the syndrome is the presence of a persistent urticarial-like rash. Histopathological data suggests that neutrophilic epitheliotropism, or the tendency of neutrophils to infiltrate and affect epithelial tissue, can be a useful marker for diagnosing SchS and differentiating it from conventional urticaria. Understanding this characteristic is crucial for early diagnosis and appropriate treatment.
JOURNAL OF DERMATOLOGY
(2023)
Review
Allergy
Kaori Takezawa, Ikuko Ueda-Hayakawa, Akihiro Tanaka, Yonsu Son, Fumikazu Yamazaki, Naotomo Kambe, Hiroyuki Okamoto, Manabu Fujimoto
Summary: This article describes the clinical features of two patients with DM-associated panniculitis and anti-TIF1 antibodies, and reviews 23 cases of panniculitis in DM patients with detailed information on autoantibodies. Female predominance and the presence of anti-MDA5 and anti-TIF1 antibodies were observed. Further case accumulation is needed to understand the relationship between panniculitis and autoantibodies.
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2022)
Letter
Allergy
Riko Takimoto-Ito, Naotomo Kambe, Kazushi Izawa, Takahiro Yasumi, Kenji Kabashima
Summary: Hereditary angioedema (HAE) is an autosomal dominant genetic disease characterized by recurrent cutaneous and submucosal swelling caused by mutations in the SERPING1 gene. A Japanese case of HAE with a novel mutation in the SERPING1 gene was reported, which may contribute to understanding the pathogenesis of HAE and the development of effective treatments.
JOURNAL OF CUTANEOUS IMMUNOLOGY AND ALLERGY
(2021)