Possible new targets for GPCR modulation: allosteric interactions, plasma membrane domains, intercellular transfer and epigenetic mechanisms

Exosome target cell selection and the importance of exosomal tetraspanins: a hypothesis

(2011) Sanyukta Rana et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Angiotensin II-induced upregulation of AT1 receptor expression: sequential activation of NF-κB and Elk-1 in neurons

(2010) Amit K. Mitra et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Current perspectives on the selective regulation of dopamine D2 and D3 receptors

(2010) Dong Im Cho et al.   ARCHIVES OF PHARMACAL RESEARCH

Exploring a role for heteromerization in GPCR signalling specificity

(2010) Raphael Rozenfeld et al.   BIOCHEMICAL JOURNAL

Understanding wiring and volume transmission

(2010) Luigi F. Agnati et al.   BRAIN RESEARCH REVIEWS

Molecular basis of lysophosphatidic acid-induced NF-κB activation

(2010) Wenjing Sun et al.   CELLULAR SIGNALLING

Spatial organization of transmembrane receptor signalling

(2010) Ioanna Bethani et al.   EMBO JOURNAL

Serotonin triggers a transient epigenetic mechanism that reinstates adult visual cortex plasticity in rats

(2010) José Fernando Maya Vetencourt et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

C2C12 myoblasts release micro-vesicles containing mtDNA and proteins involved in signal transduction

(2010) M. Guescini et al.   EXPERIMENTAL CELL RESEARCH

Determinants of specificity at the protein-lipid interface in membranes

(2010) Andreas M. Ernst et al.   FEBS LETTERS

Wann sollten wir mit der medikamentösen Therapie beim Morbus Parkinson beginnen?

(2010) C. Buhmann et al.   FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE

Plasma membrane microdomains in aging and disease

(2010) Yoshiko Ohno-Iwashita et al.   Geriatrics & Gerontology International

Voltage-dependent anion channel as a resident protein of lipid rafts: post-transductional regulation by estrogens and involvement in neuronal preservation against Alzheimer’s disease

(2010) Jose Luis Herrera et al.   JOURNAL OF NEUROCHEMISTRY

Exosomes: Extracellular organelles important in intercellular communication

(2010) Suresh Mathivanan et al.   Journal of Proteomics

Enhanced hippocampal BDNF/TrkB signaling in response to fear conditioning in an animal model of posttraumatic stress disorder

(2010) Shiro Takei et al.   JOURNAL OF PSYCHIATRIC RESEARCH

G protein coupled receptors as allosteric proteins and the role of allosteric modulators

(2010) Terry Kenakin   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

On the expanding terminology in the GPCR field: The meaning of receptor mosaics and receptor heteromers

(2010) Luigi F. Agnati et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor–receptor interactions

(2010) Kjell Fuxe et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Exosomes/microvesicles as a mechanism of cell-to-cell communication

(2010) Giovanni Camussi et al.   KIDNEY INTERNATIONAL

The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury

(2010) A Lanzillotta et al.   Cell Death & Disease

Deconstructing the Dogma

(2009) John S. Mattick   Annals of the New York Academy of Sciences

Lateral organization of membrane proteins: tetraspanins spin their web

(2009) Stéphanie Charrin et al.   BIOCHEMICAL JOURNAL

Exosomes – vesicular carriers for intercellular communication

(2009) Mikael Simons et al.   CURRENT OPINION IN CELL BIOLOGY

Epigenetic influences on brain development and plasticity

(2009) Michela Fagiolini et al.   CURRENT OPINION IN NEUROBIOLOGY

Lipid membrane interactions of indacaterol and salmeterol: Do they influence their pharmacological properties?

(2009) Dario Lombardi et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Domains in biological membranes

(2009) Robert Lindner et al.   EXPERIMENTAL CELL RESEARCH

Real-Time Monitoring of Membrane Cholesterol Reveals New Insights into Epidermal Differentiation

(2009) Florian Spörl et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Astrocytes and Glioblastoma cells release exosomes carrying mtDNA

(2009) Michele Guescini et al.   JOURNAL OF NEURAL TRANSMISSION

Docosahexaenoic Acid Modifies the Clustering and Size of Lipid Rafts and the Lateral Organization and Surface Expression of MHC Class I of EL4 Cells

(2009) Saame Raza Shaikh et al.   JOURNAL OF NUTRITION

Allosteric Modulators of G Protein-Coupled Receptors: Future Therapeutics for Complex Physiological Disorders

(2009) L. Wang et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

(2009) Chung-Jung Tsai et al.   Molecular BioSystems

Epigenetic Modulation of mGlu2 Receptors by Histone Deacetylase Inhibitors in the Treatment of Inflammatory Pain

(2009) S. Chiechio et al.   MOLECULAR PHARMACOLOGY

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

(2009) Tomoko Wakabayashi et al.   NATURE CELL BIOLOGY

Cystatin C is released in association with exosomes: A new tool of neuronal communication which is unbalanced in Alzheimer's disease

(2009) Roberta Ghidoni et al.   NEUROBIOLOGY OF AGING

Transcription Factors in Long-Term Memory and Synaptic Plasticity

(2009) Cristina M. Alberini   PHYSIOLOGICAL REVIEWS

Receptor–receptor interactions: A novel concept in brain integration

(2009) Luigi F. Agnati et al.   PROGRESS IN NEUROBIOLOGY

The psychiatric side-effects of rimonabant

(2009) Fabrício A. Moreira et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Tetraspanin-enriched microdomains: a functional unit in cell plasma membranes

(2009) María Yáñez-Mó et al.   TRENDS IN CELL BIOLOGY

Shedding microvesicles: artefacts no more

(2009) Emanuele Cocucci et al.   TRENDS IN CELL BIOLOGY

‘7TM Receptor Allostery: Putting Numbers to Shapeshifting Proteins

(2009) Terry P. Kenakin   TRENDS IN PHARMACOLOGICAL SCIENCES

Allosteric Communication Occurs via Networks of Tertiary and Quaternary Motions in Proteins

(2009) Michael D. Daily et al.   PLoS Computational Biology

G-Protein-Coupled Receptors: From Classical Modes of Modulation to Allosteric Mechanisms

(2008) Thomas M. Bridges et al.   ACS Chemical Biology

Membrane-associated stress proteins: More than simply chaperones

(2008) Ibolya Horváth et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Inhibition of γ-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes

(2008) Robyn A. Sharples et al.   FASEB JOURNAL

Cardioprotective signaling to mitochondria

(2008) Keith D. Garlid et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

NF-κB p50/RelA and c-Rel-containing dimers: opposite regulators of neuron vulnerability to ischaemia

(2008) Ilenia Sarnico et al.   JOURNAL OF NEUROCHEMISTRY

Modeling the Binding and Function of Metabotropic Glutamate Receptors

(2008) X. Rovira et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Reviews in Molecular Biology and Biotechnology: Transmembrane Signaling by G Protein-Coupled Receptors

(2008) Louis M. Luttrell   MOLECULAR BIOTECHNOLOGY

Evolvability and hierarchy in rewired bacterial gene networks

(2008) Mark Isalan et al.   NATURE

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Cooperativity and biological complexity

(2008) Adrian Whitty   Nature Chemical Biology

Allosteric regulation and catalysis emerge via a common route

(2008) Nina M Goodey et al.   Nature Chemical Biology

Targeting of tetraspanin proteins — potential benefits and strategies

(2008) Martin E. Hemler   NATURE REVIEWS DRUG DISCOVERY

Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer

(2008) B. J. C. Quah et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epigenetic principles and mechanisms underlying nervous system functions in health and disease

(2008) M MEHLER   PROGRESS IN NEUROBIOLOGY

Allostery: an illustrated definition for the ‘second secret of life’

(2008) Aron W. Fenton   TRENDS IN BIOCHEMICAL SCIENCES

RNA editing, DNA recoding and the evolution of human cognition

(2008) John S. Mattick et al.   TRENDS IN NEUROSCIENCES

Epigenetics and Complex Disease: From Etiology to New Therapeutics

(2007) Carolyn Ptak et al.   Annual Review of Pharmacology and Toxicology

Understanding neuronal molecular networks builds on neuronal cellular network architecture

(2007) Luigi F. Agnati et al.   BRAIN RESEARCH REVIEWS

Structural plasticity in G-protein coupled receptors as demonstrated by the allosteric actions of homocysteine and computer-assisted analysis of disordered domains

(2007) L.F. Agnati et al.   BRAIN RESEARCH REVIEWS