The changing world of G protein-coupled receptors: from monomers to dimers and receptor mosaics with allosteric receptor–receptor interactions

A serine point mutation in the adenosine A2AR C-terminal tail reduces receptor heteromerization and allosteric modulation of the dopamine D2R

(2010) Dasiel O. Borroto-Escuela et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Understanding wiring and volume transmission

(2010) Luigi F. Agnati et al.   BRAIN RESEARCH REVIEWS

Adenosine-Dopamine Interactions in the Pathophysiology and Treatment of CNS Disorders

(2010) K. Fuxe et al.   CNS Neuroscience & Therapeutics

CRF receptor 1 regulates anxiety behavior via sensitization of 5-HT2 receptor signaling

(2010) Ana C Magalhaes et al.   NATURE NEUROSCIENCE

Lipid Rafts As a Membrane-Organizing Principle

(2010) D. Lingwood et al.   SCIENCE

Receptor heteromerization and drug discovery

(2010) Raphael Rozenfeld et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Molecular integration via allosteric interactions in receptor heteromers. A working hypothesis

(2009) Kjell Fuxe et al.   CURRENT OPINION IN PHARMACOLOGY

Calcium-mediated modulation of the quaternary structure and function of adenosine A2A–dopamine D2 receptor heteromers

(2009) Sergi Ferré et al.   CURRENT OPINION IN PHARMACOLOGY

Interactions between Calmodulin, Adenosine A2A, and Dopamine D2Receptors

(2009) Gemma Navarro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrated signaling in heterodimers and receptor mosaics of different types of GPCRs of the forebrain: relevance for schizophrenia

(2009) Kjell Fuxe et al.   JOURNAL OF NEURAL TRANSMISSION

Metabotropic glutamate type 5, dopamine D2and adenosine A2areceptors form higher-order oligomers in living cells

(2009) Nuria Cabello et al.   JOURNAL OF NEUROCHEMISTRY

Protein allostery, signal transmission and dynamics: a classification scheme of allosteric mechanisms

(2009) Chung-Jung Tsai et al.   Molecular BioSystems

Minireview: GPCR and G Proteins: Drug Efficacy and Activation in Live Cells

(2009) Jean-Pierre Vilardaga et al.   MOLECULAR ENDOCRINOLOGY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Allosteric communication between protomers of dopamine class A GPCR dimers modulates activation

(2009) Yang Han et al.   Nature Chemical Biology

Building a new conceptual framework for receptor heteromers

(2009) Sergi Ferré et al.   Nature Chemical Biology

Sustained cyclic AMP production by parathyroid hormone receptor endocytosis

(2009) Sébastien Ferrandon et al.   Nature Chemical Biology

The discovery of central monoamine neurons gave volume transmission to the wired brain

(2009) Kjell Fuxe et al.   PROGRESS IN NEUROBIOLOGY

Receptor–receptor interactions: A novel concept in brain integration

(2009) Luigi F. Agnati et al.   PROGRESS IN NEUROBIOLOGY

A G protein-coupled receptor at work: the rhodopsin model

(2009) Klaus Peter Hofmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

‘7TM Receptor Allostery: Putting Numbers to Shapeshifting Proteins

(2009) Terry P. Kenakin   TRENDS IN PHARMACOLOGICAL SCIENCES

Ligand binding and micro-switches in 7TM receptor structures

(2009) Rie Nygaard et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Akt/GSK3 Signaling in the Action of Psychotropic Drugs

(2008) Jean-Martin Beaulieu et al.   Annual Review of Pharmacology and Toxicology

Receptor–receptor interactions within receptor mosaics. Impact on neuropsychopharmacology

(2008) K. Fuxe et al.   BRAIN RESEARCH REVIEWS

Dopamine D2 receptors form higher order oligomers at physiological expression levels

(2008) Wen Guo et al.   EMBO JOURNAL

Identification of Dopamine D1–D3Receptor Heteromers

(2008) Daniel Marcellino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

How Calmodulin Interacts with the Adenosine A2Aand the Dopamine D2Receptors

(2008) Amina S. Woods et al.   JOURNAL OF PROTEOME RESEARCH

Reciprocal Regulation of Dopamine D1 and D3 Receptor Function and Trafficking by Heterodimerization

(2008) C. Fiorentini et al.   MOLECULAR PHARMACOLOGY

Seven Transmembrane Receptors as Nature's Prototype Allosteric Protein: De-emphasizing the Geography of Binding

(2008) T. P. Kenakin   MOLECULAR PHARMACOLOGY

Conformational cross-talk between α2A-adrenergic and μ-opioid receptors controls cell signaling

(2008) Jean-Pierre Vilardaga et al.   Nature Chemical Biology

Detection of heteromerization of more than two proteins by sequential BRET-FRET

(2008) Paulina Carriba et al.   NATURE METHODS

Dopamine D2 and Adenosine A2A Receptors Regulate NMDA-Mediated Excitation in Accumbens Neurons Through A2A–D2 Receptor Heteromerization

(2008) Karima Azdad et al.   NEUROPSYCHOPHARMACOLOGY

Heterodimers and Receptor Mosaics of Different Types of G-Protein-Coupled Receptors

(2008) Kjell Fuxe et al.   PHYSIOLOGY

GPCR monomers and oligomers: it takes all kinds

(2008) Vsevolod V. Gurevich et al.   TRENDS IN NEUROSCIENCES

How and why do GPCRs dimerize?

(2008) Vsevolod V. Gurevich et al.   TRENDS IN PHARMACOLOGICAL SCIENCES