Article
Biochemistry & Molecular Biology
Melania Iara Funk, Melisa Ailen Conde, Graciela Piwien-Pilipuk, Romina Maria Uranga
Summary: Inhibition of adipocyte differentiation by menadione, a synthetic form of vitamin K, is mediated, at least in part, by increased ROS and lipid peroxidation, leading to decreased intracellular lipid accumulation and triglyceride content by inhibiting the PI3K/Akt pathway.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Tomonori Hayashi, Kyoji Furukawa, Yukari Morishita, Ikue Hayashi, Naohiro Kato, Kengo Yoshida, Yoichiro Kusunoki, Seishi Kyoizumi, Waka Ohishi
Summary: This study showed that high levels of specific ROS within blood cells can be linked to enhanced inflammatory status and aging, especially after high-dose radiation exposure.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Chemistry, Physical
Jun Luo, Yani Liu, Changzheng Fan, Lin Tang, Shuaijun Yang, Milan Liu, Mier Wang, Chengyang Feng, Xilian Ouyang, Lingling Wang, Liang Xu, Jiajia Wang, Ming Yan
Summary: This study uses nitrogen deficiency carbon nitride as a model catalyst and proposes multiple reaction mechanisms for photocatalytic H2O2 production based on experiment and simulation results. It demonstrates that H2O2 can be generated through multiple pathways.
Article
Biochemistry & Molecular Biology
Ming-Jie Hou, Pan Wang, Bao Ting Zhu
Summary: In this study, it was found that protein disulfide isomerase (PDI)-mediated neuronal nitric oxide synthase (nNOS) activation plays a critical role in chemically-induced ferroptosis, which is characterized by the accumulation of nitric oxide (NO), reactive oxygen species (ROS), and lipid-ROS. Inhibition or knockdown of PDI can effectively prevent ferroptotic cell death.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Engineering, Chemical
Jing Zhang, Miaoqi Liu, Bo Pang, Chun Liu, Junjun Ma, Jianrui Niu, Ruina Zhang
Summary: Microbubble ozonation combined with electro-generated H2O2 process (EH2O2-MB-O-3) was used to degrade ciprofloxacin (CIP) in wastewater. The results showed that EH2O2-MB-O-3 process was more efficient in CIP degradation compared to other processes. The synergy between microbubble ozonation and electro-generated H2O2 enhanced CIP removal in EH2O2-MB-O-3 process.
SEPARATION AND PURIFICATION TECHNOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Hong-Gui Xu, Margot Schikora, Miroslav Sisa, Steffen Daum, Insa Klemt, Christina Janko, Christoph Alexiou, Galyna Bila, Rostyslav Bilyy, Wenjie Gong, Michael Schmitt, Leopold Sellner, Andriy Mokhir
Summary: Novel ER-targeted prodrugs have been developed with activation only in cancer cells, demonstrating anticancer efficacy and cancer cell specificity. These prodrugs induce ER stress, attenuate mitochondrial membrane potential, and generate mitochondrial ROS leading to cell death via necrosis. Activation of the new prodrugs has also been demonstrated in the Nemeth-Kellner lymphoma murine model.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Oncology
Luca Savino, Maria Carmela Di Marcantonio, Carmelo Moscatello, Roberto Cotellese, Lucia Centurione, Raffaella Muraro, Gitana Maria Aceto, Gabriella Mincione
Summary: Gastric cancer is a significant health concern worldwide. The stomach is constantly exposed to oxidative stress, and the BER system plays a crucial role in defending against oxidative DNA damage. ErbB receptors are also involved in the pathogenesis of gastric cancer. Experimental findings suggest that oxidative stress can modulate the PI3K and MAPKs pathways, leading to a reduction in gastric cancer cell growth and migration.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fangfang Tie, Yangyang Fu, Na Hu, Honglun Wang
Summary: The present study demonstrated that silibinin attenuated H2O2-induced oxidative stress by regulating Nrf2 signaling and improving mitochondrial function in human neuroblastoma cells. This suggests that silibinin could be a potential candidate for preventing neurodegenerative diseases.
Article
Chemistry, Physical
Jun Luo, Changzheng Fan, Lin Tang, Yani Liu, Zhixuan Gong, Tangshan Wu, Xinlan Zhen, Chengyang Feng, Haopeng Feng, Lingling Wang, Liang Xu, Ming Yan
Summary: The study found that nitrogen-deficient and boron-doped g-C3N4 can be used for photocatalytic H2O2 production, where the reaction mechanism is mainly influenced by the interaction between active species and proton donor. Among different reaction mechanisms, 1O2, center dot O2- and holes play dominant roles, while H2O2 generation may be limited by the dissociation of proton donor or desorption of H+ on the catalyst surface.
APPLIED CATALYSIS B-ENVIRONMENTAL
(2022)
Review
Biochemistry & Molecular Biology
Yuantao Tan, Yaoke Duan, Qing Chi, Rong Wang, Yue Yin, Dongjie Cui, Shuang Li, Aiying Wang, Ruonan Ma, Bing Li, Zhen Jiao, Hao Sun
Summary: Radiation is prevalent in nature and has both negative and positive effects on plants. Reactive oxygen species (ROS) play a role in the plant response to radiation and act as signaling molecules to regulate downstream reactions. Through studies using new technologies like RNA-seq, the role of ROS in plants' response to UV, ion beam, and plasma radiation has been elucidated. This review provides insights into the mechanisms of plant response to radiation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Immunology
Weiji Lin, Pan Shen, Yaqin Song, Ying Huang, Shenghao Tu
Summary: ROS plays a crucial role in preventing abnormal autoimmunity and may be necessary in some cases, such as in a mouse model of rheumatoid arthritis. It acts as a mediator between innate and adaptive immune cells, influencing T cell activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Min Hye Kang, Yun-Jeong Ji, Yu Mi Han, Gwi Yeong Jang, Dong Hwi Kim, Jeong Hoon Lee, Geum-Soog Kim, Su Ji Choi, Hyung Don Kim
Summary: The study found that Sasa borealis has high antioxidant activity, can effectively reduce ROS generation, promote the expression of a range of antioxidant enzymes, and shows potential for preventing neurodegenerative diseases.
APPLIED SCIENCES-BASEL
(2022)
Article
Biophysics
Xiaocui Zhao, Renkang Zhu, Max Anikovskiy, Qingxi Wu, Zhifeng Ding
Summary: This study utilized scanning electrochemical microscopy (SECM) to quantitatively determine the extracellular H2O2 released from single COS-7 cells with high spatial resolution. The SECM mode allowed for efficient recording of probe approach curves (PACs) and visualization of cell topography simultaneously. The H2O2 concentration at the membrane surface of intact COS-7 cells was determined to be 0.020 mM using experimental PACs and a simulated PAC with a known H2O2 release value. Additionally, confocal microscopy was used to demonstrate the intracellular H2O2 profile, showing that H2O2 generation is centered at the endoplasmic reticula.
BIOSENSORS & BIOELECTRONICS
(2023)
Article
Engineering, Environmental
Gongduan Fan, Yujian Li, Banghao Du, Lei Yao, Chenjian Cai, Hao Li, Shoubin Chen, Jianyong Zou, Zhanglin Hong, Kai-Qin Xu
Summary: As an emerging advanced oxidation technology, UV/PAA shows great potential in removing pharmaceuticals and personal care products (PPCPs) in wastewater treatment. The study investigated the degradation effects and PAA activation mechanisms by UV irradiation on ibuprofen, and found that the UV/PAA process exhibited excellent degradation efficiency and a synergistic effect between UV and PAA. The study also identified the reactive oxygen species involved in the degradation and analyzed the intermediates produced during the process.
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
(2023)
Article
Biochemistry & Molecular Biology
Mina Raileanu, Mihai Straticiuc, Decebal-Alexandru Iancu, Radu-Florin Andrei, Mihai Radu, Mihaela Bacalum
Summary: The increased use of proton therapy has led to the need for a better understanding of the cellular mechanisms involved. This study investigated the effects of accelerated proton beam on hep-atocarcinoma cells. The results showed that proton irradiation induced both morphological and functional changes in HepG2 cells, including alterations in mitochondrial levels and cell cycle regulation, as well as changes in nuclear and membrane structures.
JOURNAL OF STRUCTURAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
SeoYoung Kim, Hee Jin, Hang-Rhan Seo, Hae June Lee, Yun-Sil Lee
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Biochemistry & Molecular Biology
Ye Ji Jeong, Yeonghoon Son, Na-Kyung Han, Hyung-Do Choi, Jeong-Ki Pack, Nam Kim, Yun-Sil Lee, Hae-June Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Neurosciences
Yeonghoon Son, Jin Su Kim, Ye Ji Jeong, Youn Kyoung Jeong, Jong Hwa Kwon, Hyung-Do Choi, Jeong-Ki Pack, Nam Kim, Yun-Sil Lee, Hae-June Lee
NEUROSCIENCE LETTERS
(2018)
Article
Cell Biology
Jin-Mo Kim, Hyun Yoo, Jee-Youn Kim, Sang Ho Oh, Jeong Wook Kang, Byung Rok Yoo, Song Yee Han, Cha Soon Kim, Won Hoon Choi, Eun-Jung Lee, Hyeong Ju Byeon, Won Jai Lee, Yun-Sil Lee, Jaeho Cho
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
(2018)
Article
Genetics & Heredity
Hee Jin, Ga-Young Kang, Seulgi Jeon, Jin-Mo Kim, You Na Park, Jaeho Cho, Yun-Sil Lee
JOURNAL OF MOLECULAR MEDICINE-JMM
(2019)
Article
Food Science & Technology
Seoyoung Kim, Ga-Young Park, Young Jo Yoo, Ji Seong Jeong, Ki Taek Nam, Sun-Ha Jee, Kyung-Min Lim, Yun-Sil Lee
FOOD AND CHEMICAL TOXICOLOGY
(2019)
Article
Oncology
Jiwon Jung, Ji-Sun Lee, Yun-Sil Lee, Kyunglim Lee
Article
Oncology
Jee-Youn Kim, Seulgi Jeon, Young Jo Yoo, Hee Jin, Hee Yeon Won, Kyeonghee Yoon, Eun Sook Hwang, Yoon-Jin Lee, Younghwa Na, Jaeho Cho, Yun-Sil Lee
CLINICAL CANCER RESEARCH
(2019)
Correction
Chemistry, Medicinal
Gil-Im Mun, Seoyoung Kim, Eun Choi, Cha Soon Kim, Yun-Sil Lee
ARCHIVES OF PHARMACAL RESEARCH
(2019)
Article
Environmental Sciences
Bu-Yeo Kim, Minjeong Kim, Ji Seong Jeong, Sun-Ha Jee, Il-Hyun Park, Byung-Chul Lee, Sun-Ku Chung, Kyung-Min Lim, Yun-Sil Lee
ENVIRONMENTAL RESEARCH
(2019)
Review
Oncology
Seul-Ki Choi, Heejin Kam, Kye-Young Kim, Suk In Park, Yun-Sil Lee
Correction
Chemistry, Medicinal
Gil-Im Mun, Seoyoung Kim, Eun Choi, Cha Soon Kim, Yun-Sil Lee
ARCHIVES OF PHARMACAL RESEARCH
(2020)
Article
Oncology
Soo-Yeon Hwang, Seul-Ki Choi, Seung Hee Seo, Hyunji Jo, Jae-Ho Shin, Younghwa Na, Yun-Sil Lee, Youngjoo Kwon
Review
Oncology
Hee Jin, Youngjo Yoo, Younghwa Kim, Yeijin Kim, Jaeho Cho, Yun-Sil Lee
Article
Pharmacology & Pharmacy
Hawon Yoo, Seul-Ki Choi, Jaeok Lee, So Hyeon Park, You Na Park, Soo-Yeon Hwang, Jae-Ho Shin, Younghwa Na, Youngjoo Kwon, Hwa Jeong Lee, Yun-Sil Lee
Summary: Inhibition of HSP27 has been suggested as a potential strategy for cancer therapy, and the chromenone compound NA49 shows promising cancer inhibition effects in combination with anticancer drugs such as cisplatin and gefitinib in NSCLC cell lines, highlighting its potential in overcoming HSP27-mediated drug resistance.