Article
Biochemistry & Molecular Biology
Naserddine Hamadi, Sumaya Beegam, Nur Elena Zaaba, Ozaz Elzaki, Mariam Abdulla Altamimi, Abderrahim Nemmar
Summary: Waterpipe smoking (WPS) is popular in Asian and Middle Eastern countries and has gained popularity worldwide, especially among youth. Chronic exposure to WPS is associated with inflammation, oxidative stress, apoptosis, microgliosis, and astrogliosis in the cerebellum. These effects involve the activation of NF-kappa B.
Article
Neurosciences
Kaiyi Zhu, Xing Zhu, Shenghui Sun, Wei Yang, Shiqi Liu, Zhen Tang, Rong Zhang, Jian Li, Tao Shen, Mingyan Hei
Summary: In this study, it was found that TLR4 activation induced neuronal ferroptosis following hypoxic-ischemic brain damage (HIBD), and inhibition of TLR4 attenuated oxidative stress-induced damage, decreased the activation of ferroptosis, and attenuated neuroinflammation following HIBD, thereby exerting neuroprotective effects. The results demonstrated that the inhibition of TLR4-p38 MAPK signaling modulates HIBD- or OGD-induced ferroptosis in neuronal cells and may play a novel role in brain homeostasis.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Cuiqin Fan, Ye Li, Tian Lan, Wenjing Wang, Xueqin Mao, Shu Yan Yu
Summary: The study demonstrates that curcumin can alleviate depressive behaviors in a rat model by suppressing oxidative stress, neural inflammation, and synaptic dysregulation, potentially through the miR-146a-5p/ERK signaling pathway. This suggests a neuroprotective and antidepressant role of curcumin as a potential therapeutic strategy for depression.
Review
Pharmacology & Pharmacy
Jie Li, Haitao Xiang, Chao Huang, Jiashu Lu
Summary: Myricetin is a natural flavonoid extracted from various plants with neuroprotective effects, showing potential in treating nervous system disorders. Its mechanisms of action include inhibiting oxidative stress, cellular apoptosis, and neuroinflammatory response, as well as promoting inhibitory neuron activation in the hypothalamus.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Hongxiang Hong, Xu Lu, Chunshuai Wu, Jiajia Chen, Chu Chen, Jinlong Zhang, Chao Huang, Zhiming Cui
Summary: Paeoniflorin, a compound extracted from Paeonia lactiflora Pall, has shown preventive and therapeutic effects in various types of nervous system disorders. However, comprehensive knowledge about the pharmacological effects of paeoniflorin on the nervous system is currently not available online. This review summarizes the pharmacological aspects of paeoniflorin and its possible mechanisms, highlighting its potential in the prevention and treatment of disorders like cerebral ischemia, subarachnoid hemorrhage, vascular dementia, Alzheimer's disease, Parkinson's disease, depression, post-traumatic syndrome disorder, and epilepsy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ramona D'Amico, Angela Trovato Salinaro, Roberta Fusco, Marika Cordaro, Daniela Impellizzeri, Maria Scuto, Maria Laura Ontario, Gianluigi Lo Dico, Salvatore Cuzzocrea, Rosanna Di Paola, Rosalba Siracusa, Vittorio Calabrese
Summary: The study investigated the development of neurodegenerative diseases following traumatic brain injury (TBI) and the potential of Coriolus versicolor and Hericium erinaceus in preventing PD-related pathology. The findings suggest that these nutritional fungi can prevent neuroinflammatory and oxidative processes typical of PD, thus playing a crucial role in preventing the progression of neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Daniela Impellizzeri, Mario Tomasello, Marika Cordaro, Ramona D'Amico, Roberta Fusco, Ali S. Abdelhameed, Uwe Wenzel, Rosalba Siracusa, Vittorio Calabrese, Salvatore Cuzzocrea, Rosanna Di Paola
Summary: In this study, the effects of Memophenol(TM), a compound rich in polyphenols, on a rat model of Alzheimer's disease (AD) were investigated. Memophenol(TM) reduced behavioral alterations, hippocampus neuronal degeneration, and molecular markers associated with AD. It also mitigated oxidative and inflammatory changes in the hippocampus caused by AD. These findings suggest that Memophenol(TM) protects against the behavioral and histopathological changes associated with AD by modulating oxidative and inflammatory pathways and cellular brain stress response mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Robin Mesnage, Scarlett Ferguson, Inger Brandsma, Nynke Moelijker, Gaonan Zhang, Francesca Mazzacuva, Anna Caldwell, John Halket, Michael N. Antoniou
Summary: The co-formulant POE-15 tallow amine (POE-15) and the active ingredient glyphosate in herbicides have been found to be cytotoxic, causing cell necrosis and oxidative stress. The study highlights the importance of comprehensive testing of both co-formulants and active ingredients of commercial pesticides to ensure better regulation and protection of public health and the environment.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Marika Lanza, Rossella Basilotta, Salvatore Cuzzocrea, Maria Bulzomi, Salvatore Oddo, Giovanna Casili, Emanuela Esposito
Summary: The prevalence of obesity worldwide is rapidly increasing and is considered a leading cause of death. Added sugar consumption is one of the main factors contributing to this, as it is associated with a higher risk of obesity, heart disease, diabetes, and brain illnesses such as Alzheimer's disease (AD). Excess sugar can worsen oxidative damage and brain inflammation, which are neuropathological signs of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Laura Maria De Plano, Giovanna Calabrese, Maria Giovanna Rizzo, Salvatore Oddo, Antonella Caccamo
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the accumulation of reactive oxygen species (ROS) and impaired antioxidant response. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) plays a crucial role in regulating the antioxidant response and autophagy function. However, in AD, the accumulation of A beta and tau reduces Nrf2 levels, impairing the antioxidant response and autophagy-mediated turnover. Activation of Nrf2 through genetic or pharmacological approaches may offer a potential strategy to mitigate AD pathology.
Review
Biochemistry & Molecular Biology
Iwona Bukowska-Osko, Dorota Sulejczak, Katarzyna Kaczynska, Patrycja Kleczkowska, Karol Kramkowski, Marta Popiel, Ewa Wietrak, Pawel Kowalczyk
Summary: Structural abnormalities can cause DNA modifications, leading to various diseases including cancer. Cells defend and repair damaged genetic material through lactoferrin, an endogenous protein with antibacterial, antiviral, antifungal, and anticancer properties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Amanda Della Giustina, Judite Filgueiras Rodrigues, Erick Bagio, Sandra Bonfante, Larissa Joaquim, Graciela Zarbato, Solange Stork, Richard Simon Machado, Mariana Pereira de Souza Goldim, Lucineia Gainski Danielski, Khiany Mathias, Carlos Dacoregio, Taise Cardoso, Giulia S. Predroso, Ligia Milanez Venturini, Rubya Pereira Zaccaron, Paulo Cesar Lock Silveira, Ricardo Aurino Pinho, Fabricia Petronilho
Summary: Sepsis is a life-threatening condition caused by a dysregulated response to infection, which leads to organ dysfunction. Inflammation and oxidative stress play major roles in the damage to the lungs and brain in sepsis. A physical exercise program has protective effects against inflammation and oxidative stress in the lungs and brain of septic rats.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Neurosciences
Xiaojin Liu, Luodan Yang, Guoying Zhang, Jianya Ling
Summary: Human life and health are at serious risk from brain diseases, which are influenced by various factors. Neuroinflammation and oxidative stress play a significant role in the development of brain diseases by inducing inflammation and apoptosis. Oxidative stress-related changes are inseparable factors in the etiology of several brain diseases.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Environmental Sciences
Carolina Calderon, Gemma Castano-Vinyals, Myron Maslanyj, Joe Wiart, Ae-Kyoung Lee, Masao Taki, Kanako Wake, Alex Abert, Francesc Badia, Abdelhamid Hadjem, Hans Kromhout, Patricia de Llobet, Nadege Varsier, Emmanuelle Conil, Hyung-Do Choi, Malcolm R. Sim, Elisabeth Cardis
Summary: This study developed a unique algorithm to estimate the cumulative specific energy and induced current density in the brain from wireless phones for individuals aged 10-24 years old, finding that these doses are strongly dependent on location and communication system.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Neil B. Metcalfe, Mats Olsson
Summary: This review highlights the dynamic processes of ROS production, telomeric DNA damage, and DNA repair, emphasizing the trade-off between energetic efficiency and telomere protection. Mitochondrial features and ATP production efficiency play crucial roles in maintaining DNA integrity and telomere dynamics, with implications for individual variation and adaptation to changing environmental contexts.
Article
Biochemistry & Molecular Biology
SeoYoung Kim, Hee Jin, Hang-Rhan Seo, Hae June Lee, Yun-Sil Lee
CELL DEATH AND DIFFERENTIATION
(2019)
Article
Cell Biology
Na-Kyung Han, Myung Gu Jung, Ye Ji Jeong, Yeonghoon Son, Su Chul Han, Seungwoo Park, Young-Bin Lim, Yoon-Jin Lee, Sung-Ho Kim, Su Cheol Park, Hae-June Lee
Correction
Chemistry, Medicinal
Gil-Im Mun, Seoyoung Kim, Eun Choi, Cha Soon Kim, Yun-Sil Lee
ARCHIVES OF PHARMACAL RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Yeonghoon Son, Ye Ji Jeong, Na-Rae Shin, Se Jong Oh, Kyung Rok Nam, Hyung-Do Choi, Jae Yong Choi, Hae-June Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Oncology
Soo-Yeon Hwang, Seul-Ki Choi, Seung Hee Seo, Hyunji Jo, Jae-Ho Shin, Younghwa Na, Yun-Sil Lee, Youngjoo Kwon
Review
Oncology
Hee Jin, Youngjo Yoo, Younghwa Kim, Yeijin Kim, Jaeho Cho, Yun-Sil Lee
Article
Biochemistry & Molecular Biology
Yeonghoon Son, Na-Rae Shin, Sung-Ho Kim, Su-Cheol Park, Hae-June Lee
Summary: This study investigated the role of FGL1 in regulating sorafenib resistance in HCC cells, showing that high expression of FGL1 in HCC cells leads to greater sensitivity to sorafenib and knocking down FGL1 can reduce the inhibitory effects of sorafenib, possibly through modulation of ERK and autophagy signals. These findings suggest FGL1 as a potential biomarker for sorafenib resistance and a target for HCC therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hee Jin, Kyuri Kim, Ga-Young Park, Minjeong Kim, Hae-June Lee, Sangbong Jeon, Ju Hwan Kim, Hak Rim Kim, Kyung-Min Lim, Yun-Sil Lee
Summary: Research shows that the impact of EMF-LTE on DNA double-strand breaks (DSB) remains controversial, but it can reduce DNA damage and promote repair. The skin may benefit from the protective effects of EMF-LTE, but further studies are needed to understand its impact on human health.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Hawon Yoo, Seul-Ki Choi, Jaeok Lee, So Hyeon Park, You Na Park, Soo-Yeon Hwang, Jae-Ho Shin, Younghwa Na, Youngjoo Kwon, Hwa Jeong Lee, Yun-Sil Lee
Summary: Inhibition of HSP27 has been suggested as a potential strategy for cancer therapy, and the chromenone compound NA49 shows promising cancer inhibition effects in combination with anticancer drugs such as cisplatin and gefitinib in NSCLC cell lines, highlighting its potential in overcoming HSP27-mediated drug resistance.
Article
Biochemistry & Molecular Biology
Ye Ji Jeong, Yeonghoon Son, Hye-Jin Park, Se Jong Oh, Jae Yong Choi, Young-Gyu Ko, Hae-June Lee
Summary: Research has shown that aripiprazole can effectively reduce beta-amyloid accumulation, inhibit neuroinflammation, and maintain cerebral glucose metabolism in 5xFAD AD mice, demonstrating its potential in the treatment of Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Min Ji Bae, Min Kook Kang, Yong Uk Kye, Jeong-Hwa Baek, Ye-Ji Sim, Hae-June Lee, Yeong-Rok Kang, Wol Soon Jo, Joong Sun Kim, Chang Geun Lee
Summary: The study revealed that the radiation dose rate has different effects on the testes of mice. Low dose rate radiation caused more severe tissue toxicity and adverse effects on sperm production compared to high dose rate radiation. This suggests that the dose rate of radiation may have differential impacts on different organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ji-Hee Kim, Jae-Kyung Nam, A-Ram Kim, Min-Sik Park, Hae-June Lee, Joonho Park, Joon Kim, Yoon-Jin Lee
Summary: Radiation-induced skin injury (RISI) is a common side effect of radiotherapy for cancer patients. Despite its severity, there are limited treatments available. This study suggests that 2-Methoxyestradiol (2-ME) could potentially be a potent therapeutic agent for RISI by targeting HIF-1 alpha and preventing vascular damage and fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Soo-Ho Lee, Ye Ji Jeong, Jeongwoo Park, Hyun-Yong Kim, Yeonghoon Son, Kwang Seok Kim, Hae-June Lee
Summary: This study aimed to investigate the effects of low-dose radiation on vascular endothelial cells from type 2 diabetes patients and normal individuals. Through RNA sequencing, differentially expressed genes and CVD-associated signaling pathways were identified.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Won Seok Lee, Hae-June Lee, Ji Yeong Yang, Hye-Lim Shin, Sik-Won Choi, Jong-Ki Kim, Woo Duck Seo, Eun Ho Kim
Summary: Oat seedling extract (OSE) has been found to have antioxidant activity and a specific mechanism for combating Alzheimer's disease (AD), providing neuroprotective effects against neurodegeneration, synaptic dysfunction, and neuroinflammation.
Article
Computer Science, Information Systems
Jihye Park, Kyuho Kang, Yeonghoon Son, Kwang Seok Kim, Keunsoo Kang, Hae-June Lee
Summary: Low-dose radiation refers to exposure to ionizing radiation at levels considered safe but with effects not fully understood. This study used RNA-seq to analyze gene expression in human aortic endothelial cells (HAECs) and diabetic HAECs exposed to different doses of low-dose radiation. Differentially expressed genes and enriched pathways were identified. The data generated are publicly available through the GEO database. This study contributes to understanding the potential health risks of low-dose radiation exposure.