Histone Deacetylases in Bone Development and Skeletal Disorders

Resveratrol supplementation affects bone acquisition and osteoporosis: Pre-clinical evidence toward translational diet therapy

(2015) Janet C. Tou   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

HDAC5 Controls MEF2C-Driven Sclerostin Expression in Osteocytes

(2015) Marc N Wein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Conditional deletion of Hdac3 in osteoprogenitor cells attenuates diet-induced systemic metabolic dysfunction

(2015) Meghan E. McGee-Lawrence et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

HDAC9 Inhibits Osteoclastogenesis via Mutual Suppression of PPARγ/RANKL Signaling

(2015) Zixue Jin et al.   MOLECULAR ENDOCRINOLOGY

Histone deacetylase 11: A novel epigenetic regulator of myeloid derived suppressor cell expansion and function

(2015) Eva Sahakian et al.   MOLECULAR IMMUNOLOGY

Clinical and molecular characterization of a patient with interstitial 6q21q22.1 deletion

(2015) Elisa Tassano et al.   Molecular Cytogenetics

The class II histone deacetylase HDAC4 regulates cognitive, metabolic and endocrine functions through its expression in osteoblasts

(2015) Munevver Parla Makinistoglu et al.   Molecular Metabolism

Deletion of Histone Deacetylase 7 in Osteoclasts Decreases Bone Mass in Mice by Interactions with MITF

(2015) Melissa Stemig et al.   PLoS One

Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders

(2014) Christophe Decroos et al.   ACS Chemical Biology

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

(2014) Evi M. Mercken et al.   AGING CELL

Outcome of patients with sarcoma and other mesenchymal tumours participating in phase I trials: a subset analysis of a European Phase I database

(2014) P. A. Cassier et al.   ANNALS OF ONCOLOGY

Circadian clock: linking epigenetics to aging

(2014) Ricardo Orozco-Solis et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Sirtuins, metabolism, and DNA repair

(2014) Jee-Eun Choi et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Teratogenic Activity of HDAC Inhibitors

(2014) Erminio Giavini et al.   CURRENT PHARMACEUTICAL DESIGN

The Sirtuin1 Activator SRT3025 Down-Regulates Sclerostin and Rescues Ovariectomy-Induced Bone Loss and Biomechanical Deterioration in Female Mice

(2014) Hanna Artsi et al.   ENDOCRINOLOGY

Loss-of-function HDAC8 mutations cause a phenotypic spectrum of Cornelia de Lange syndrome-like features, ocular hypertelorism, large fontanelle and X-linked inheritance

(2014) Frank J. Kaiser et al.   HUMAN MOLECULAR GENETICS

Histone Deacetylase 7 (Hdac7) Suppresses Chondrocyte Proliferation and β-Catenin Activity during Endochondral Ossification

(2014) Elizabeth W. Bradley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parathyroid Hormone Regulates Histone Deacetylase (HDAC) 4 through Protein Kinase A-mediated Phosphorylation and Dephosphorylation in Osteoblastic Cells

(2014) Emi Shimizu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sirtuin1 (Sirt1) Promotes Cortical Bone Formation by Preventing β-Catenin Sequestration by FoxO Transcription Factors in Osteoblast Progenitors

(2014) Srividhya Iyer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC4 integrates PTH and sympathetic signaling in osteoblasts

(2014) Arnaud Obri et al.   JOURNAL OF CELL BIOLOGY

Histone Deacetylase Inhibition Destabilizes the Multi-Potent State of Uncommitted Adipose-Derived Mesenchymal Stromal Cells

(2014) Amel Dudakovic et al.   JOURNAL OF CELLULAR PHYSIOLOGY

New and emerging HDAC inhibitors for cancer treatment

(2014) Alison C. West et al.   JOURNAL OF CLINICAL INVESTIGATION

Exome sequencing identifies a de novo mutation in HDAC8 associated with Cornelia de Lange syndrome

(2014) Lei Feng et al.   JOURNAL OF HUMAN GENETICS

Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis

(2014) Reiji Higashiyama et al.   Modern Rheumatology

Histone deacetylases and their inhibitors in cancer, neurological diseases and immune disorders

(2014) Katrina J. Falkenberg et al.   NATURE REVIEWS DRUG DISCOVERY

Separate and Combined Effects of DNMT and HDAC Inhibitors in Treating Human Multi-Drug Resistant Osteosarcoma HosDXR150 Cell Line

(2014) Enrico Capobianco et al.   PLoS One

Hypertrophic chondrocytes can become osteoblasts and osteocytes in endochondral bone formation

(2014) L. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone deacetylase (HDAC) 1 and 2 are essential for accurate cell division and the pluripotency of embryonic stem cells

(2014) Shereen Jamaladdin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chondrocytes Transdifferentiate into Osteoblasts in Endochondral Bone during Development, Postnatal Growth and Fracture Healing in Mice

(2014) Xin Zhou et al.   PLoS Genetics

Effect of the HDAC inhibitor vorinostat on the osteogenic differentiation of mesenchymal stem cells in vitro and bone formation in vivo

(2013) Song Xu et al.   ACTA PHARMACOLOGICA SINICA

Disruption of Sirt1 in chondrocytes causes accelerated progression of osteoarthritis under mechanical stress and during ageing in mice

(2013) Tokio Matsuzaki et al.   ANNALS OF THE RHEUMATIC DISEASES

Histone deacetylase inhibitors

(2013) Marije Slingerland et al.   ANTI-CANCER DRUGS

Class I Histone Deacetylase Inhibition Modulates Metalloproteinase Expression and Blocks Cytokine-Induced Cartilage Degradation

(2013) Kirsty L. Culley et al.   ARTHRITIS AND RHEUMATISM

Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity

(2013) Élie Abed et al.   BONE

The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis

(2013) Manuela Wuelling et al.   CELL CYCLE

Inhibition of Histone Deacetylases Potentiates BMP9-Induced Osteogenic Signaling in Mouse Mesenchymal Stem Cells

(2013) Ning Hu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Transcription and beyond: the role of mammalian class I lysine deacetylases

(2013) Mirjam Andrea Moser et al.   CHROMOSOMA

Histone Deacetylase Inhibitors in Multiple Myeloma: Rationale and Evidence for Their Use in Combination Therapy

(2013) Jonathan L. Kaufman et al.   Clinical Lymphoma Myeloma & Leukemia

The Histone Deacetylase Inhibitor, MS-275 (Entinostat), Downregulates c-FLIP, Sensitizes Osteosarcoma Cells to FasL, and Induces the Regression of Osteosarcoma Lung Metastases

(2013) Krithi Rao-Bindal et al.   CURRENT CANCER DRUG TARGETS

Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression

(2013) Nikhil Singh et al.   DEVELOPMENTAL BIOLOGY

Histone deacetylase inhibitor Trichostatin A induces neural tube defects and promotes neural crest specification in the chicken neural tube

(2013) Christina Murko et al.   DIFFERENTIATION

SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β-catenin

(2013) Petra Simic et al.   EMBO Molecular Medicine

Valproate reduces collagen and osteonectin in cultured bone cells

(2013) Emma L. Humphrey et al.   EPILEPSY RESEARCH

The tumor suppressor SirT2 regulates cell cycle progression and genome stability by modulating the mitotic deposition of H4K20 methylation

(2013) L. Serrano et al.   GENES & DEVELOPMENT

Vorinostat, a HDAC inhibitor, showed anti-osteoarthritic activities through inhibition of iNOS and MMP expression, p38 and ERK phosphorylation and blocking NF-κB nuclear translocation

(2013) Hui-ming Zhong et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Sirt1-deficient mice exhibit an altered cartilage phenotype

(2013) Odile Gabay et al.   JOINT BONE SPINE

Histone Deacetylase Inhibition Promotes Osteoblast Maturation by Altering the Histone H4 Epigenome and Reduces Akt Phosphorylation

(2013) Amel Dudakovic et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone Deacetylase 3 Suppression Increases PH Domain and Leucine-rich Repeat Phosphatase (Phlpp)1 Expression in Chondrocytes to Suppress Akt Signaling and Matrix Secretion

(2013) Elizabeth W. Bradley et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Class I HDACs Share a Common Mechanism of Regulation by Inositol Phosphates

(2013) Christopher J. Millard et al.   MOLECULAR CELL

The functional interactome landscape of the human histone deacetylase family

(2013) P. Joshi et al.   Molecular Systems Biology

Sirtuin on a high-fat diet

(2013) Poonam Bheda et al.   NATURE

SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine

(2013) Hong Jiang et al.   NATURE

Distinct Functional and Temporal Requirements for Zebrafish Hdac1 during Neural Crest-Derived Craniofacial and Peripheral Neuron Development

(2013) Myron S. Ignatius et al.   PLoS One

Sirt6 regulates postnatal growth plate differentiation and proliferation via Ihh signaling

(2013) Jinying Piao et al.   Scientific Reports

A Review of Targeted Therapies Evaluated by the Pediatric Preclinical Testing Program for Osteosarcoma

(2013) Valerie B. Sampson et al.   Frontiers in Oncology

Subcellular relocation of histone deacetylase 4 regulates growth plate chondrocyte differentiation through Ca2+/calmodulin-dependent kinase IV

(2012) Yingjie Guan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Sirtuin 1 enzymatic activity is required for cartilage homeostasis in vivo in a mouse model

(2012) Odile Gabay et al.   ARTHRITIS AND RHEUMATISM

Chemical and genetic blockade of HDACs enhances osteogenic differentiation of human adipose tissue-derived stem cells by oppositely affecting osteogenic and adipogenic transcription factors

(2012) Paola Maroni et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Histone deacetylase-4 is required during early cranial neural crest development for generation of the zebrafish palatal skeleton

(2012) April DeLaurier et al.   BMC DEVELOPMENTAL BIOLOGY

Histone deacetylase 3 is required for maintenance of bone mass during aging

(2012) Meghan E. McGee-Lawrence et al.   BONE

Fortifying the Link between SIRT1, Resveratrol, and Mitochondrial Function

(2012) John M. Denu   Cell Metabolism

SIK3 is essential for chondrocyte hypertrophy during skeletal development in mice

(2012) S. Sasagawa et al.   DEVELOPMENT

Phenotypic variant of Brachydactyly-mental retardation syndrome in a family with an inherited interstitial 2q37.3 microdeletion including HDAC4

(2012) Pablo Villavicencio-Lorini et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

MS-275, a benzamide histone deacetylase inhibitor, prevents osteoclastogenesis by down-regulating c-Fos expression and suppresses bone loss in mice

(2012) Ha-Neui Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Silent information regulator (Sir)T1 inhibits NF-κB signaling to maintain normal skeletal remodeling

(2012) James R Edwards et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Ski inhibits TGF-β/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes

(2012) Kyung-Ok Kim et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

X-exome sequencing identifies aHDAC8variant in a large pedigree with X-linked intellectual disability, truncal obesity, gynaecomastia, hypogonadism and unusual face

(2012) Magdalena Harakalova et al.   JOURNAL OF MEDICAL GENETICS

HDAC7 Inhibits Osteoclastogenesis by Reversing RANKL-Triggered β-Catenin Switch

(2012) Zixue Jin et al.   MOLECULAR ENDOCRINOLOGY

HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle

(2012) Matthew A. Deardorff et al.   NATURE

Structure of HDAC3 bound to co-repressor and inositol tetraphosphate

(2012) Peter J. Watson et al.   NATURE

Histone deacetylase inhibitors suppress mechanical stress-induced expression of RUNX-2 and ADAMTS-5 through the inhibition of the MAPK signaling pathway in cultured human chondrocytes

(2012) T. Saito et al.   OSTEOARTHRITIS AND CARTILAGE

Combinatorial Treatment of DNA and Chromatin-Modifying Drugs Cause Cell Death in Human and Canine Osteosarcoma Cell Lines

(2012) Venugopal Thayanithy et al.   PLoS One

Exposure to Valproic Acid Inhibits Chondrogenesis and Osteogenesis in Mid-Organogenesis Mouse Limbs

(2012) France-Hélène Paradis et al.   TOXICOLOGICAL SCIENCES

Roles of histone deacetylases in epigenetic regulation: emerging paradigms from studies with inhibitors

(2012) Geneviève P Delcuve et al.   Clinical Epigenetics

HDAC inhibitor trichostatin A suppresses osteoclastogenesis by upregulating the expression of C/EBP-β and MKP-1

(2011) Paul J. Williams et al.   Annals of the New York Academy of Sciences

Suberoylanilide hydroxamic acid (SAHA; vorinostat) causes bone loss by inhibiting immature osteoblasts

(2011) Meghan E. McGee-Lawrence et al.   BONE

Endocrine Regulation of Male Fertility by the Skeleton

(2011) Franck Oury et al.   CELL

Sirt1 Is a Regulator of Bone Mass and a Repressor ofSostEncoding for Sclerostin, a Bone Formation Inhibitor

(2011) Einav Cohen-Kfir et al.   ENDOCRINOLOGY

MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4

(2011) Ying-Jie Guan et al.   FASEB JOURNAL

HDAC3 and HDAC7 Have Opposite Effects on Osteoclast Differentiation

(2011) Lan Pham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Resveratrol-mediated SIRT-1 Interactions with p300 Modulate Receptor Activator of NF-κB Ligand (RANKL) Activation of NF-κB Signaling and Inhibit Osteoclastogenesis in Bone-derived Cells

(2011) Mehdi Shakibaei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Histone deacetylase inhibitor MS-275 stimulates bone formation in part by enhancing Dhx36-mediated TNAP transcription

(2011) Ha-Neui Kim et al.   JOURNAL OF BONE AND MINERAL RESEARCH

A systems biology approach to identify molecular pathways altered by HDAC inhibition in osteosarcoma

(2011) Luke A. Wittenburg et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Inhibitors of histone deacetylases in class I and class II suppress human osteoclasts in vitro

(2011) M.D. Cantley et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Valproic Acid Suppresses Interleukin-1ß-induced Microsomal Prostaglandin E2 Synthase-1 Expression in Chondrocytes Through Upregulation of NAB1

(2011) NADIA ZAYED et al.   JOURNAL OF RHEUMATOLOGY

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(2011) Leo Joosten et al.   MOLECULAR MEDICINE

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(2011) Charles Dinarello et al.   MOLECULAR MEDICINE

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

In Vitro and In Vivo Osteogenic Activity of Largazole

(2011) Su-Ui Lee et al.   ACS Medicinal Chemistry Letters

Haploinsufficiency of HDAC4 Causes Brachydactyly Mental Retardation Syndrome, with Brachydactyly Type E, Developmental Delays, and Behavioral Problems

(2010) Stephen R. Williams et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Bone and glucose metabolism: A two-way street

(2010) Katherine J. Motyl et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Histone deacetylase inhibitors: A chemical genetics approach to understanding cellular functions

(2010) Paul A. Marks   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The histone deacetylase inhibitor valproic acid sensitizes human and canine osteosarcoma to doxorubicin

(2010) Luke A. Wittenburg et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

HDAC6 a new cellular stress surveillance factor

(2010) Patrick Matthias et al.   CELL CYCLE

Regulatory signal transduction pathways for class IIa histone deacetylases

(2010) Maribel Parra et al.   CURRENT OPINION IN PHARMACOLOGY

Zfp521 Is a Target Gene and Key Effector of Parathyroid Hormone-Related Peptide Signaling in Growth Plate Chondrocytes

(2010) Diego Correa et al.   DEVELOPMENTAL CELL

Adverse effects of valproate on bone: Defining a model to investigate the pathophysiology

(2010) Susan M. Senn et al.   EPILEPSIA

Histone deacetylases in skeletal development and bone mass maintenance

(2010) Meghan E. McGee-Lawrence et al.   GENE

A mutation in the 3′-UTR of the HDAC6 gene abolishing the post-transcriptional regulation mediated by hsa-miR-433 is linked to a new form of dominant X-linked chondrodysplasia

(2010) Delphine Simon et al.   HUMAN MOLECULAR GENETICS

HDAC4 Represses Matrix Metalloproteinase-13 Transcription in Osteoblastic Cells, and Parathyroid Hormone Controls This Repression

(2010) Emi Shimizu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HDAC3 Is Negatively Regulated by the Nuclear Protein DBC1

(2010) Claudia C. S. Chini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alleviation of osteoarthritis by Trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis

(2010) Wei-Ping Chen et al.   MOLECULAR BIOLOGY REPORTS

The Histone Deacetylase Inhibitor, Vorinostat, Reduces Tumor Growth at the Metastatic Bone Site and Associated Osteolysis, but Promotes Normal Bone Loss

(2010) J. Pratap et al.   MOLECULAR CANCER THERAPEUTICS

Histone Deacetylase 3 Depletion in Osteo/Chondroprogenitor Cells Decreases Bone Density and Increases Marrow Fat

(2010) David F. Razidlo et al.   PLoS One

Trichostatin A inhibits expression of cathepsins in experimental osteoarthritis

(2010) Wei-Ping Chen et al.   RHEUMATOLOGY INTERNATIONAL

Genetic Control of Bone Formation

(2009) Gerard Karsenty et al.   Annual Review of Cell and Developmental Biology

NFATc1 mediates HDAC-dependent transcriptional repression of osteocalcin expression during osteoblast differentiation

(2009) Min-Kyung Choo et al.   BONE

Histone deacetylase inhibitors decrease proliferation potential and multilineage differentiation capability of human mesenchymal stem cells

(2009) S. Lee et al.   CELL PROLIFERATION

Histone deacetylase 4 promotes TGF-β1-induced synovium-derived stem cell chondrogenesis but inhibits chondrogenically differentiated stem cell hypertrophy

(2009) Ming Pei et al.   DIFFERENTIATION

A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes

(2009) Sohee Hong et al.   FASEB JOURNAL

Epigenetic control of skull morphogenesis by histone deacetylase 8

(2009) M. Haberland et al.   GENES & DEVELOPMENT

Inhibition of histone deacetylases antagonized FGF2 and IL-1β effects on MMP expression in human articular chondrocytes

(2009) Xibin Wang et al.   GROWTH FACTORS

Histone deacetylase HDAC1/HDAC2-controlled embryonic development and cell differentiation

(2009) Reinhard Brunmeir et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans

(2009) Hui Li et al.   JOURNAL OF CLINICAL INVESTIGATION

Parathyroid Hormone-Related Peptide Represses Chondrocyte Hypertrophy through a Protein Phosphatase 2A/Histone Deacetylase 4/MEF2 Pathway

(2009) E. Kozhemyakina et al.   MOLECULAR AND CELLULAR BIOLOGY

c-Cbl and Cbl-b Act Redundantly to Protect Osteoclasts from Apoptosis and to Displace HDAC6 from β-Tubulin, Stabilizing Microtubules and Podosomes

(2009) Enkhtsetseg Purev et al.   MOLECULAR BIOLOGY OF THE CELL

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

(2009) Fernando Rivadeneira et al.   NATURE GENETICS

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

(2009) C. Choudhary et al.   SCIENCE

Conserved Metabolic Regulatory Functions of Sirtuins

(2008) Bjoern Schwer et al.   Cell Metabolism

Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

(2008) Olesya Vakhrusheva et al.   CIRCULATION RESEARCH

Regulation of Cartilage-specific Gene Expression in Human Chondrocytes by SirT1 and Nicotinamide Phosphoribosyltransferase

(2008) Mona Dvir-Ginzberg et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endocrine functions of bone in mineral metabolism regulation

(2008) L. Darryl Quarles   JOURNAL OF CLINICAL INVESTIGATION

Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice

(2008) Rusty L. Montgomery et al.   JOURNAL OF CLINICAL INVESTIGATION

Mice Lacking Histone Deacetylase 6 Have Hyperacetylated Tubulin but Are Viable and Develop Normally

(2008) Y. Zhang et al.   MOLECULAR AND CELLULAR BIOLOGY

Deletion of Histone Deacetylase 3 Reveals Critical Roles in S Phase Progression and DNA Damage Control

(2008) Srividya Bhaskara et al.   MOLECULAR CELL

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS

The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men

(2008) Xiang-Jiao Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Trichostatin A, a histone deacetylase inhibitor, suppresses synovial inflammation and subsequent cartilage destruction in a collagen antibody-induced arthritis mouse model

(2008) Y. Nasu et al.   OSTEOARTHRITIS AND CARTILAGE

Histone deacetylase inhibitors suppress interleukin-1β-induced nitric oxide and prostaglandin E2 production in human chondrocytes

(2008) N. Chabane et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of bone formation by osteoclasts involves Wnt/BMP signaling and the chemokine sphingosine-1-phosphate

(2008) L. Pederson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histone Deacetylase Inhibitors Promote Apoptosis and Senescence in Human Mesenchymal Stem Cells

(2008) Giovanni Di Bernardo et al.   STEM CELLS AND DEVELOPMENT