Recognition in the Face of Diversity: Interactions of Heterotrimeric G proteins and G Protein-coupled Receptor (GPCR) Kinases with Activated GPCRs

Ligand-Based Peptide Design and Combinatorial Peptide Libraries to Target G Protein-Coupled Receptors

(2010) Christian W. Gruber et al.   CURRENT PHARMACEUTICAL DESIGN

Molecular basis for activation of G protein-coupled receptor kinases

(2010) Cassandra A Boguth et al.   EMBO JOURNAL

Differential Signaling of the Endogenous Agonists at the β2-Adrenergic Receptor

(2010) Susanne Reiner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomeric Rhodopsin Is Sufficient for Normal Rhodopsin Kinase (GRK1) Phosphorylation and Arrestin-1 Binding

(2010) Timothy H. Bayburt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Monomeric Rhodopsin Is the Minimal Functional Unit Required for Arrestin Binding

(2010) Hisao Tsukamoto et al.   JOURNAL OF MOLECULAR BIOLOGY

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

(2010) B. Wu et al.   SCIENCE

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

(2010) E. Y. T. Chien et al.   SCIENCE

Role of the Amino Terminus of G Protein-Coupled Receptor Kinase 2 in Receptor Phosphorylation

(2009) Christina S. Pao et al.   BIOCHEMISTRY

GRK2 Activation by Receptors: Role of the Kinase Large Lobe and Carboxyl-Terminal Tail

(2009) Rachel Sterne-Marr et al.   BIOCHEMISTRY

A Surface of the Kinase Domain Critical for the Allosteric Activation of G Protein-coupled Receptor Kinases

(2009) Chih-chin Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The structure and function of G-protein-coupled receptors

(2009) Daniel M. Rosenbaum et al.   NATURE

Structural and kinetic modeling of an activating helix switch in the rhodopsin-transducin interface

(2009) P. Scheerer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A G protein-coupled receptor at work: the rhodopsin model

(2009) Klaus Peter Hofmann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Structures of Rhodopsin Kinase in Different Ligand States Reveal Key Elements Involved in G Protein-coupled Receptor Kinase Activation

(2008) Puja Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a β1-adrenergic G-protein-coupled receptor

(2008) Tony Warne et al.   NATURE

Crystal structure of opsin in its G-protein-interacting conformation

(2008) Patrick Scheerer et al.   NATURE

Crystal structure of squid rhodopsin

(2008) Midori Murakami et al.   NATURE

Crystal structure of the ligand-free G-protein-coupled receptor opsin

(2008) Jung Hee Park et al.   NATURE

The 2.6 Angstrom Crystal Structure of a Human A2A Adenosine Receptor Bound to an Antagonist

(2008) V.-P. Jaakola et al.   SCIENCE

A day in the life of a G protein-coupled receptor: the contribution to function of G protein-coupled receptor dimerization

(2007) G Milligan   BRITISH JOURNAL OF PHARMACOLOGY