Article
Multidisciplinary Sciences
Simone Nardin Weis, Jaques Miranda F. Souza, Juliana Bender Hoppe, Marina Firmino, Manfred Auer, Nassim N. Ataii, Leonardo Assis da Silva, Mariana Maier Gaelzer, Caroline Peres Klein, Alan R. Mol, Consuelo M. R. de Lima, Diogo Onofre Souza, Christianne G. Salbego, Carlos Andre O. Ricart, Wagner Fontes, Marcelo Valle de Sousa
Summary: Research has shown that there are fundamental sex-related differences in the proteome of organotypic hippocampal slice culture, with females exhibiting a greater prevalence of astrocytic metabolism and males showing significant neuronal metabolism. These differences manifest in preferences for glucose use, mitochondrial respiration subunits, and lipid metabolism between the sexes.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Eugenia Vivi, Lea R. Seeholzer, Anastasiia Nagumanova, Barbara Di Benedetto
Summary: Clinical and pre-clinical studies have shown that neuropsychiatric disorders are associated with changes in astrocyte properties and synaptic networks. Understanding early brain development is crucial for understanding these disorders. However, animal experiments are time-consuming and resource-intensive, so alternative methods are needed. This study used an organotypic brain slice culture system to investigate the role of MEGF10 in the prefrontal cortex during early postnatal developmental stages. The results suggest that this system can be used to study age-dependent astrocyte-mediated changes in synaptic remodeling, but further optimization is needed to explore sex differences.
Article
Medicine, Research & Experimental
Enkhtuya Radnaa, Lauren Richardson, Brett Goldman, Jared K. Burks, Tuvshintugs Baljinnyam, Natasha Vora, Hui-Juan Zhang, Elizabeth A. Bonney, Arum Han, Ramkumar Menon
Summary: This study investigated the impact of oxidative stress on p38 MAPK signaling and cell fate, using amnion epithelial cells. The results showed that excessive activation of p38 can have adverse effects on cell behavior and tissue homeostasis.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucas Rischka, Chrysoula Vraka, Verena Pichler, Sazan Rasul, Lukas Nics, Gregor Gryglewski, Patricia Handschuh, Matej Murgas, Godber M. Godbersen, Leo R. Silberbauer, Jakob Unterholzner, Christoph Wotawa, Ahmed Haider, Hazem Ahmed, Roger Schibli, Thomas Mindt, Markus Mitterhauser, Wolfgang Wadsak, Andreas Hahn, Rupert Lanzenberger, Marcus Hacker, Simon M. Ametamey
Summary: This study reports on the performance characteristics of (R)-C-11-Me-NB1, a radioligand used to map GluN2B-enriched NMDARs in the human brain. The radioligand demonstrated high and heterogeneous uptake and a high test-retest reliability. It shows promise in deepening our understanding of the role of GluN2B-containing NMDARs in neurodegenerative and neuropsychiatric diseases such Alzheimer's disease and major depression.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Maria S. Hadjiagapiou, George Krashias, Christina Christodoulou, Marios Pantzaris, Anastasia Lambrianides
Summary: Synaptic dysfunction and disrupted communication between neuronal and glial cells are essential in the mechanisms of multiple sclerosis. Antibodies to the NR2 subunit of NMDAR were detected in MS patients and were correlated with clinical outcome. Furthermore, there may be a link between NR2 reactivity and anti-coagulant antibody levels in MS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Eui-Ho Park, Nam-Soo Kim, Yeon-Kyung Lee, June-Seek Choi
Summary: Accumulating evidence suggests that the medial prefrontal cortex (mPFC) plays a crucial role in the acquisition of fear memory during trace fear conditioning. Specifically, the prelimbic (PL) subregion within the mPFC is involved in short- and long-term trace fear memory formation. Furthermore, NMDA receptor-mediated neurotransmission in PL is required for the acquisition of trace fear memory.
Article
Clinical Neurology
Jilun Feng, Mu Yang, Dingge Cui, Zhi Huang, Tuo Ji, Yajun Lian
Summary: This study aimed to investigate the factors influencing or predicting the probability of recurrence of anti-NMDAR encephalitis in central China. The results showed that brainstem lesions and ≥3 abnormal sites on brain MRI were significantly associated with an increased risk of recurrence.
FRONTIERS IN NEUROLOGY
(2022)
Article
Plant Sciences
Polina Yu. Kozyulina, Olga A. Pavlova, Elizaveta S. Kantsurova (Rudaya), Andrey D. Bovin, Svetlana A. Shirobokova, Aleksandra V. Dolgikh, Alina M. Dymo, Elena A. Dolgikh
Summary: The study investigated the transcriptional changes in pea roots treated with COs using RNA sequencing. It was found that there were 886 differentially expressed genes 24 hours after treatment with CO8-DA at low concentration. The findings suggest that calcium signaling regulators and MAPK cascade play a key role in pea plant responses to COs treatment.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Neurosciences
Yizhi Song, Zunshu Du, Xinyue Chen, Wanning Zhang, Guitao Zhang, Hui Li, Lirong Chang, Yan Wu
Summary: The study demonstrated that activation of astrocytic NMDARs can mitigate A beta-induced loss of synaptic proteins by increasing NGF release, while blockade of astrocytic NMDARs inhibits A beta-induced compensatory protective NGF increase. This highlights the important role of NMDARs in neurodegenerative diseases.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Ali K. Vibholm, Martin J. Dietz, Sandor Beniczky, Jakob Christensen, Andreas Hojlund, Jan Jacobsen, Dirk Bender, Arne Moller, David J. Brooks
Summary: Using [F-18] GE-179 PET, multiple clusters of abnormal NMDAR-IC activation were detected in 80% of patients with refractory focal epilepsy, suggesting a potential link between chronic seizure activity and enhanced neuronal excitability.
Article
Biochemistry & Molecular Biology
Shinhui Lee, Sanung Eom, Khoa V. A. Nguyen, Jiwon Lee, Youngseo Park, Hye Duck Yeom, Junho H. Lee
Summary: The study found that ergotamine effectively inhibits the NR1a/NR2A subunit of NMDAR, preventing excessive Ca2+ influx and neuronal death.
Article
Agriculture, Multidisciplinary
Canying Li, Jie Zhu, Yuan Cheng, Jiabao Hou, Lei Sun, Yonghong Ge
Summary: The study revealed that ASM treatment can promote the production of hydrogen peroxide, regulate the activities of NADPH oxidase and superoxide dismutase in pear exocarp, delay chlorophyll degradation, and inhibit carotenoid synthesis.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Review
Neurosciences
Bin Dong, Yang Yue, Han Dong, Yuehui Wang
Summary: NMDA receptors play a critical role in synaptic transmission and plasticity, and abnormalities in their expression and function can result in neurological disorders. NMDAR hypofunction is widely implicated in several disorders and is associated with disease progression and manifestation. Targeting NMDAR hypofunction could be a promising therapeutic approach.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Heeyoung Park, Chang-Wook Lee, Jieun Kang, Ali Sadra, Sung-Oh Huh
Summary: This study examined the effect of environmental glutamine on the expression of tryptophan hydroxylase 1 (TPH1) gene in mouse mastocytoma cells. The results showed that glutamine could stabilize the mRNA levels of TPH1 and enhance its expression.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Jennifer E. Klomp, Jeff A. Klomp, Channing J. Der
Summary: The RAF-MEK-ERK mitogen-activated protein kinase (MAPK) cascade is extensively studied and targeted by pharmaceutical industry. The ERK-MAPK cascade, initially thought to be a linear pathway, is now understood as a complex network with dynamic signaling inputs and outputs. Despite advances in understanding, the adaptability of cancer cells to inhibition of key nodes reveals a complexity that is not fully understood.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2021)
Article
Biochemistry & Molecular Biology
Tong Zhang, Junko Yanagida, Hironori Kamii, Shintaro Wada, Masaki Domoto, Hitoki Sasase, Satoshi Deyama, Takeshi Takarada, Eiichi Hinoi, Kenji Sakimura, Akihiro Yamanaka, Takashi Maejima, Michihiro Mieda, Takeshi Sakurai, Naoya Nishitani, Kazuki Nagayasu, Shuji Kaneko, Masabumi Minami, Katsuyuki Kaneda
Article
Neurosciences
Keiichiro Sato, Yumi Hamasaki, Kiyoshiro Fukui, Kazuki Ito, Kazunari Miyamichi, Masabumi Minami, Taiju Amano
JOURNAL OF NEUROSCIENCE
(2020)
Article
Neurosciences
Shintaro Wada, Junko Yanagida, Hitoki Sasase, Tong Zhang, Xueting Li, Hironori Kamii, Masaki Domoto, Satoshi Deyama, Eiichi Hinoi, Akihiro Yamanaka, Naoya Nishitani, Kazuki Nagayasu, Shuji Kaneko, Masabumi Minami, Katsuyuki Kaneda
Article
Neurosciences
Ryuto Hara, Yuta Asaoka, Daiki Takahashi, Hiroshi Nomura, Taiju Amano, Masabumi Minami
NEUROSCIENCE LETTERS
(2020)
Article
Neurosciences
Ryuto Hara, Daiki Takahashi, Tatsuhiro Takehara, Taiju Amano, Masabumi Minami
Article
Pharmacology & Pharmacy
Tomoyuki Kaneko, Ryuto Hara, Taiju Amano, Masabumi Minami
Summary: This study investigated the effects of neurotensin (NTS) on excitability of type II neurons in rat dlBNST, revealing diverse signaling pathways mediate NTS effects, including depolarizing effects through potassium conductance blocking and hyperpolarizing effects via non-selective cation conductance increase or decrease.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Satoshi Deyama, Masabumi Minami, Katsuyuki Kaneda
Summary: Ketamine and other rapid-acting antidepressants show rapid and sustained antidepressant effects, but with potential side effects. Resolvins as novel therapeutic candidates for depression are promising due to their ability to exert antidepressant effects with mTORC1 activation.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2021)
Article
Behavioral Sciences
Shun Aoki, Satoshi Deyama, Rinako Sugie, Kohei Ishimura, Hayato Fukuda, Satoshi Shuto, Masabumi Minami, Katsuyuki Kaneda
Summary: This study demonstrated that RvE1 alleviates depression-like behavior induced by repeated injections of prednisolone, suggesting its antidepressant-like effects in a mouse model of repeated PSL-induced depression.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Hiroe Suzuki, Takahisa Otsuka, Natsuko Hitora-Imamura, Kohei Ishimura, Hayato Fukuda, Koichi Fujiwara, Satoshi Shuto, Satoshi Deyama, Masabumi Minami
Summary: In a murine model of chronic pain-induced depression, the bioactive lipid RvE1 was found to have an antidepressant effect along with chemerin, possibly through the ChemR23 receptor. These results suggest that RvE1 and its receptor may be promising targets for the development of novel antidepressants.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2021)
Article
Biology
Minami Kanai, Ryota Kamiizawa, Natsuko Hitora-Imamura, Masabumi Minami
Summary: In this study, the neuronal pathways from the paraventricular thalamic nucleus (PVT) to the nucleus accumbens (NAc), bed nucleus of the stria terminalis (BNST), and central nucleus of the amygdala (CeA) were found to be activated during exposure to hot and cold environments. These pathways may be involved in avoidance behaviors from hot and cold environments for behavioral thermoregulation.
JOURNAL OF THERMAL BIOLOGY
(2022)
Article
Neurosciences
Kiyoshiro Fukui, Keiichiro Sato, Shunsaku Murakawa, Masabumi Minami, Taiju Amano
Summary: The study revealed that administration of estrogen to adult mice induces infanticidal behavior and enhances excitatory synaptic transmission in the related brain region, BSTrh. The increase in glutamate release probability and synaptic connectivity between AHi neurons and BSTrh may contribute to the expression of infanticide.
Article
Multidisciplinary Sciences
Naoki Yamauchi, Keiichiro Sato, Kenta Sato, Shunsaku Murakawa, Yumi Hamasaki, Hiroshi Nomura, Taiju Amano, Masabumi Minami
Summary: This study reveals the neuronal plasticity in the bed nucleus of the stria terminalis (BNST) induced by chronic pain, which contributes to maladaptive anxiety. The findings provide insights into the underlying mechanisms of psychiatric disorders induced by chronic pain.
Article
Neurosciences
Saya Arakaki, Masabumi Minami
Summary: The results demonstrate that enhanced noradrenergic transmission via beta-adrenoceptors in the ventral bed nucleus of the stria terminalis (vBNST) plays a crucial role in nicotine withdrawal-induced aversive behavior.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2022)
Article
Neurosciences
Hiroe Suzuki, Natsuko Hitora-Imamura, Satoshi Deyama, Masabumi Minami
Summary: Intracerebroventricular injection of resolvin D2 showed an antidepressant effect in a murine model of chronic pain-induced depression, without affecting locomotor activity. It may be a promising lead for the development of novel antidepressants.
NEUROPSYCHOPHARMACOLOGY REPORTS
(2021)
Article
Neurosciences
Fumiya Shinohara, Saya Arakaki, Taiju Amano, Masabumi Minami, Katsuyuki Kaneda
NEUROPSYCHOPHARMACOLOGY REPORTS
(2020)