Targeting surface-layer proteins with single-domain antibodies: a potential therapeutic approach against Clostridium difficile-associated disease

Mutational approaches to improve the biophysical properties of human single-domain antibodies

(2014) Dae Young Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Inhibition of biofilm formation by Camelid single-domain antibodies against the flagellum of Pseudomonas aeruginosa

(2014) Hendrik Adams et al.   JOURNAL OF BIOTECHNOLOGY

A Novel Multivalent, Single-Domain Antibody Targeting TcdA and TcdB Prevents Fulminant Clostridium difficile Infection in Mice

(2014) Zhiyong Yang et al.   JOURNAL OF INFECTIOUS DISEASES

Surface layer proteins isolated from Clostridium difficile induce clearance responses in macrophages

(2014) Laura E. Collins et al.   MICROBES AND INFECTION

Biogenesis and functions of bacterial S-layers

(2014) Robert P. Fagan et al.   NATURE REVIEWS MICROBIOLOGY

Pentavalent Single-Domain Antibodies Reduce Campylobacter jejuni Motility and Colonization in Chickens

(2014) Ali Riazi et al.   PLoS One

Evaluation of Disulfide Bond Position to Enhance the Thermal Stability of a Highly Stable Single Domain Antibody

(2014) Dan Zabetakis et al.   PLoS One

Protease-resistant single-domain antibodies inhibit Campylobacter jejuni motility

(2014) G. Hussack et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Variations in Virulence and Molecular Biology among Emerging Strains of Clostridium difficile

(2013) J. J. Hunt et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Surface-Layer Protein A (SlpA) Is a Major Contributor to Host-Cell Adherence of Clostridium difficile

(2013) Michelle M. Merrigan et al.   PLoS One

Orally fed seeds producing designer IgAs protect weaned piglets against enterotoxigenic Escherichia coli infection

(2013) V. Virdi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clostridium difficile infection in the twenty-first century

(2013) Chandrabali Ghose   Emerging Microbes & Infections

Burden of Clostridium difficile on the Healthcare System

(2012) Erik R. Dubberke et al.   CLINICAL INFECTIOUS DISEASES

Disulfide linkage engineering for improving biophysical properties of human VH domains

(2012) D. Y. Kim et al.   PROTEIN ENGINEERING DESIGN & SELECTION

Dual Beneficial Effect of Interloop Disulfide Bond for Single Domain Antibody Fragments

(2011) Jochen Govaert et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutralization ofClostridium difficileToxin A with Single-domain Antibodies Targeting the Cell Receptor Binding Domain

(2011) Greg Hussack et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fourteen-Genome Comparison Identifies DNA Markers for Severe-Disease-Associated Strains of Clostridium difficile

(2011) Vincenzo Forgetta et al.   JOURNAL OF CLINICAL MICROBIOLOGY

The LMW surface-layer proteins of Clostridium difficile PCR ribotypes 027 and 001 share common immunogenic properties

(2011) P. Spigaglia et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Reannotation of the genome sequence of Clostridium difficile strain 630

(2011) M. Monot et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Immunomodulatory activities of surface-layer proteins obtained from epidemic and hypervirulent Clostridium difficile strains

(2011) M. Bianco et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Engineered Single-Domain Antibodies with High Protease Resistance and Thermal Stability

(2011) Greg Hussack et al.   PLoS One

A Role for TLR4 in Clostridium difficile Infection and the Recognition of Surface Layer Proteins

(2011) Anthony Ryan et al.   PLoS Pathogens

Epidemiological Patterns and Hospital Characteristics Associated with Increased Incidence of Clostridium difficile Infection in Quebec, Canada, 1998–2006

(2010) Rodica Gilca et al.   INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY

Economic healthcare costs of Clostridium difficile infection: a systematic review

(2010) S.S. Ghantoji et al.   JOURNAL OF HOSPITAL INFECTION

A review of mortality due to Clostridium difficile infection

(2010) J.A. Karas et al.   JOURNAL OF INFECTION

Orally Administered P22 Phage Tailspike Protein Reduces Salmonella Colonization in Chickens: Prospects of a Novel Therapy against Bacterial Infections

(2010) Shakeeba Waseh et al.   PLoS One

Toxin-Specific Antibodies for the Treatment of Clostridium difficile: Current Status and Future Perspectives

(2010) Greg Hussack et al.   Toxins

Distribution of Clostridium difficile strains from a North American, European and Australian trial of treatment for C. difficile infections: 2005–2007

(2009) Adam K. Cheknis et al.   ANAEROBE

Motility and Flagellar Glycosylation in Clostridium difficile

(2009) S. M. Twine et al.   JOURNAL OF BACTERIOLOGY

Microarray Identification of Clostridium difficile Core Components and Divergent Regions Associated with Host Origin

(2009) T. Janvilisri et al.   JOURNAL OF BACTERIOLOGY

Single domain antibodies: promising experimental and therapeutic tools in infection and immunity

(2009) Janusz Wesolowski et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

Structural insights into the molecular organization of the S-layer fromClostridium difficile

(2009) Robert P. Fagan et al.   MOLECULAR MICROBIOLOGY

Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium

(2009) Richard A Stabler et al.   GENOME BIOLOGY

Novel strategies to combat bacterial virulence

(2008) Susan V Lynch et al.   Current Opinion in Critical Care

Active immunization of hamsters againstClostridium difficileinfection using surface-layer protein

(2008) Déirdre B. Ní Eidhin et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Inhibition of Salmonella enterica Serovar Typhimurium Motility and Entry into Epithelial Cells by a Protective Antilipopolysaccharide Monoclonal Immunoglobulin A Antibody

(2008) S. J. Forbes et al.   INFECTION AND IMMUNITY

Increased Sporulation Rate of Epidemic Clostridium difficile Type 027/NAP1

(2008) T. Akerlund et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Clostridium difficile toxin synthesis is negatively regulated by TcdC

(2008) B. Dupuy et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Disulfide Bond Introduction for General Stabilization of Immunoglobulin Heavy-Chain Variable Domains

(2008) Dirk Saerens et al.   JOURNAL OF MOLECULAR BIOLOGY

Structure and mode of action of clostridial glucosylating toxins: the ABCD model

(2008) Thomas Jank et al.   TRENDS IN MICROBIOLOGY

The biology and future prospects of antivirulence therapies

(2007) Lynette Cegelski et al.   NATURE REVIEWS MICROBIOLOGY