Article
Oncology
Ann-Kathrin Berg, Elisabeth M. Hahn, Fiona Speichinger-Hillenberg, Annemaria Silvana Grube, Nina A. Hering, Ani K. Stoyanova, Katharina Beyer
Summary: Peritonitis and abdominal sepsis are important factors causing sepsis, but their immunological background and molecular mechanism are still unclear, leading to limited treatment options. This study found that apoptosis of neutrophil granulocytes is inhibited in early abdominal sepsis, and TRAIL may have potential as a therapeutic drug.
Article
Social Sciences, Interdisciplinary
Lawrence B. Sacco, Stefanie Konig, Hugo Westerlund, Loretta G. Platts
Summary: Providing unpaid informal care in later life can have negative impacts on older adults' quality of life. The study found that the intensity and burden of caregiving are linked to lower levels and declines in quality of life. Starting and ceasing caregiving are associated with negative and positive changes in quality of life, respectively. Measures to reduce care burden or time spent caregiving are likely to improve the quality of life of older people.
SOCIAL INDICATORS RESEARCH
(2022)
Review
Immunology
Abhinit Nagar, Ravi Bharadwaj, Mohammad Omar Faruk Shaikh, Abhishek Roy
Summary: NLRP3-ASC specks are the hallmark of NLRP3 inflammasome activation, but there is no direct experimental evidence to support this notion.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Psychology, Multidisciplinary
Malcolm D. Murray, Christopher B. Menadue
Summary: The purpose of this study was to systematically review literature on how individuals with schizophrenia experience the recovery process. The review found that there needs to be a treatment shift focused on personal recovery processes. The theme of connection emerged as a key factor in recovery, with connecting with the self and the social world being important for recovery.
CURRENT PSYCHOLOGY
(2023)
Article
Medicine, General & Internal
Andrea Muellebner, Anna Herminghaus, Ingrid Miller, Martina Kames, Andreia Luis, Olaf Picker, Inge Bauer, Andrey V. Kozlov, Johanna Catharina Duvigneau
Summary: This study aimed to investigate the impact of abdominal surgery and peritoneal infection on ER stress/UPR and inflammatory markers in the liver. The results demonstrate that peritoneal infection predominantly triggers an inflammatory response, while conditions associated with organ damage are the main triggers of hepatic UPR.
FRONTIERS IN MEDICINE
(2022)
Article
Geriatrics & Gerontology
Rizwan Qaisar, M. Azhar Hussain, Asima Karim, Firdos Ahmad, Fabio Franzese, Abeer A. Al-Masri, Saad M. Alsaad, Shaea Ayed Alkahtani
Summary: This study aimed to investigate the association between handgrip strength (HGS) and quality of life in individuals with aging and Alzheimer's disease (AD). The results showed that AD subjects had lower HGS and quality of life scores compared to controls. While a positive relation was found between HGS and quality of life in controls, no such association was observed in AD subjects.
Article
Medicine, General & Internal
Michal Szczyrek, Radoslaw Mlak, Aneta Szudy-Szczyrek, Karolina Kedziora, Teresa Malecka-Massalska, Pawel Krawczyk, Janusz Milanowski
Summary: The study aimed to investigate the impact of CASP-8 gene polymorphisms on the prognosis of NSCLC patients, finding that the GG genotype was associated with distant metastases, smoking, and a family history of cancer, as well as a higher risk of early progression and shortened PFS.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemical Research Methods
Carlos Outeiral, Daniel A. Nissley, Charlotte M. Deane
Summary: This work compares the pathways generated by state-of-the-art protein structure prediction methods with experimental data on protein folding pathways. The results indicate that although these methods capture some information about the folding pathway, they are less predictive than a trivial classifier using sequence-agnostic features. The folding trajectories produced are also uncorrelated with experimental observables such as intermediate structures and the folding rate constant. These findings suggest that recent advances in structure prediction have not yet provided an enhanced understanding of protein folding.
Article
Mathematics, Applied
Juan Liu, Qinghai Liu, Xindong Zhang, Xing Chen
Summary: If there are specific paths between any two vertices in a digraph D, D may be weakly Hamiltonian-connected; if there are two specific paths simultaneously between two vertices, D may be strongly Hamiltonian-connected. Thomassen characterized weakly Hamiltonian-connected tournaments and proved that every 4-connected tournament is strongly Hamiltonian-connected in 1980. Additionally, the study also discussed the weakly and strongly trail-connected digraphs and their relationships in tournaments.
APPLIED MATHEMATICS AND COMPUTATION
(2021)
Review
Biochemical Research Methods
Luciano A. Abriata, Matteo Dal Peraro
Summary: Coupling residue coevolution estimations with machine learning methods is transforming protein structure prediction, particularly for proteins without clear homologous templates like in the recent CASP competition. However, making these advances accessible to non-experts and ensuring correct interpretation of predicted models still requires further development of web resources and tools.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Plant Sciences
Xianfeng Yang, Huifang Xie, Qunqing Weng, Kangjing Liang, Xiujuan Zheng, Yuchun Guo, Xinli Sun
Summary: This study examines the structure and deposition patterns of lignin and suberin in rice and Arabidopsis roots, revealing differences between the two species. The CASP1 protein in rice plays a crucial role in suberin biosynthesis and its loss leads to delayed CS formation and uneven lignin deposition.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Geriatrics & Gerontology
Stefan Sieber, Angelique Roquet, Charikleia Lampraki, Daniela S. Jopp
Summary: This study aimed to examine the mediating factors linking multimorbidity with quality of life (QoL) and the moderating effects of sociodemographic factors. The results showed that functional and emotional/mental health were crucial mediators between multimorbidity and QoL, and the mediation pathways were moderated by age, gender, education, and financial strain.
INNOVATION IN AGING
(2023)
Article
Multidisciplinary Sciences
Mor Bitton, Chen Keasar
Summary: Computationally generated models of protein structures provide a low-cost alternative to experimental determination and help biologists in experiment design and interpretation. A new method for estimating the accuracy of these models is presented and achieved high performance in relevant experiments. The remarkable achievement in protein structure prediction, particularly by the AlphaFold2 method, will have a significant impact on the field, including accuracy estimation.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Henry Oppermann, Elia Marcos-Graneda, Linnea A. Weiss, Christina A. Gurnett, Anne Marie Jelsig, Susanne H. Vineke, Bertrand Isidor, Sandra Mercier, Kari Magnussen, Pia Zacher, Mona Hashim, Alistair T. Pagnamenta, Simone Race, Siddharth Srivastava, Zoe Frazier, Robert Maiwald, Matthias Pergande, Donatella Milani, Martina Rinelli, Jonathan Levy, Ilona Krey, Paolo Fontana, Fortunato Lonardo, Stephanie Riley, Jasmine Kretzer, Julia Rankin, Linda M. Reis, Elena V. Semina, Miriam S. Reuter, Stephen W. Scherer, Maria Iascone, Denisa Weis, Christina R. Fagerberg, Charlotte Brasch-Andersen, Lars Kjaersgaard Hansen, Alma Kuechler, Nathan Noble, Alice Gardham, Jessica Tenney, Geetanjali Rathore, Stefanie Beck-Woedl, Tobias B. Haack, Despoina C. Pavlidou, Isis Atallah, Julia Vodopiutz, Andreas R. Janecke, Tzung-Chien Hsieh, Hellen Lesmann, Hannah Klinkhammer, Peter M. Krawitz, Johannes R. Lemke, Rami Abou Jamra, Marta Nieto, Zeynep Tumer, Konrad Platzer
Summary: This study describes the clinical presentation in an extended cohort and investigates the molecular mechanism in a Cux1(+/-) mouse model. Disease-causing CUX1 variants result in a non-syndromic phenotype of developmental delay and intellectual disability. In some individuals, this phenotype improves with age, resulting in a clinical catch-up and normal IQ in adulthood.
EUROPEAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Cell Biology
Oliver H. Voss, Daniel Arango, Justin C. Tossey, Miguel A. Villalona Calero, Andrea Doseff
Summary: Apigenin sensitizes primary lung cancer cells to TRAIL-induced apoptosis through reprogramming alternative splicing of key TRAIL/DISC components and directly binding heat shock protein 70 to promote cell death. These findings emphasize the synergies between diet and cancer treatments, providing new avenues for improved cancer therapies.
CELL DEATH & DISEASE
(2021)
Review
Chemistry, Multidisciplinary
Haoran Ren, Stefan A. Maier
Summary: Twisted light, a helical spatial mode carrying orbital angular momentum, has great potential in optical and quantum information applications. However, current experiments are hindered by bulky, expensive, and slow-response optical elements. Nanophotonics offers a solution by providing compact and multifunctional devices for generating and detecting twisted light modes.
ADVANCED MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Florian N. N. Loch, Carsten Kamphues, Katharina Beyer, Christian Schineis, Wael Rayya, Johannes C. C. Lauscher, David Horst, Mihnea P. P. Dragomir, Simon Schallenberg
Summary: Immune checkpoint therapy has shown promise in treating solid tumors, but its role in pancreatic ductal adenocarcinoma is limited. This study aimed to create a profile of immune checkpoint expression and its prognostic relevance in PDAC. The presence of VISTA and PD-L1 significantly correlated with shorter overall survival, suggesting they may be potential targets for ICT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Ioannis Pozios, Nina A. Hering, Emily Guenzler, Marco Arndt, Sefer Elezkurtaj, Thomas Knosel, Christiane J. Bruns, Georgios A. Margonis, Katharina Beyer, Hendrik Seeliger
Summary: The study found that gp130 is expressed in the epithelium of most human PDAC, but is rarely expressed in the stroma. The small molecule gp130 inhibitor SC144 potently inhibits PDAC progression in vitro and may block IL-6 or OSM/gp130/STAT3 signaling. These results suggest gp130 as a potential new drug target for pancreatic cancer therapy.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Gastroenterology & Hepatology
Melinda Wang, Frank Ulrich Weiss, Xiaojia Guo, Thomas Kolodecik, Jan Philipp Bewersdorf, Loren Laine, Markus M. Lerch, Gary Desir, Fred S. Gorelick
Summary: Severe acute pancreatitis is associated with high morbidity and mortality rates. Plasma renalase levels decrease significantly in a murine acute pancreatitis model. This study aimed to investigate the levels of plasma renalase in hospitalized acute pancreatitis patients to determine if similar phenomenon occurs in humans.
Article
Nanoscience & Nanotechnology
Boris Kalinic, Tiziana Cesca, Ionut Gabriel Balasa, Mirko Trevisani, Andrea Jacassi, Stefan A. Maier, Riccardo Sapienza, Giovanni Mattei
Summary: In this study, we combine quasi-BIC modes with nanogaps in silicon slotted nanoantennas to enhance the electromagnetic local density of optical states (LDOS) in the optically active region. This leads to a significant boosting of photoluminescence intensity and decay rate of Er3+ emission. The nanoantenna directivity is also increased, showing strong beaming effects.
Article
Chemistry, Multidisciplinary
Luca M. Berger, Malo Duportal, Leonardo de Souza Menezes, Emiliano Cortes, Stefan A. Maier, Andreas Tittl, Katharina Krischer
Summary: Electrocatalysis is crucial for achieving a zero-carbon future and driving research in hydrogen generation and carbon dioxide reduction. Surface-enhanced infrared absorption spectroscopy (SEIRAS) is a suitable method for investigating electrocatalytic processes but has limitations in detecting short-lived intermediates. A new nanophotonic-electrochemical SEIRAS platform has been developed to overcome these limitations and provide a deeper understanding of catalytic reactions.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Physical
Allison R. Pessoa, Jefferson A. O. Galindo, Luiz F. dos Santos, Rogeria R. Goncalves, Stefan A. Maier, Leonardo de S. Menezes, Anderson M. Amaral
Summary: Lanthanide-doped single dielectric nanoparticles are used for nanoscale temperature sensing with high resolution. However, the low number of emitters in individual nanocrystals requires higher excitation power densities, which can cause overlapping emissions and affect temperature measurements. This study demonstrates a method to separate and correct these overlapping bands, resulting in improved temperature readout accuracy and corrected thermal artifacts.
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Article
Medicine, General & Internal
Johannes Lauscher, Katharina Beyer, Achim Hellinger, Roland S. Croner, Karsten Ridwelski, Christian Krautz, Christine Lim, Paul M. Coplan, Marc Kurepkat, Goran Ribaric
Summary: The study aims to evaluate the impact of a digital operative workflow on complications and mortality in patients undergoing left-sided colorectal resection with primary stapled colorectal anastomosis. The study will be conducted at five certified academic colorectal centers in Germany, with a sample size of 528 cases. The primary endpoint is the overall rate of surgical complications, including death.
Article
Oncology
Ani K. Stoyanova, Arne Sattler, Elisabeth M. Hahn, Nina A. Hering, Marco Arndt, Johannes Christian Lauscher, Fiona Speichinger-Hillenberg, Katja Kotsch, Ann-Kathrin Berg, Katharina Beyer
Summary: This study provides a comprehensive immune profile of TRAIL-deficient mice, indicating a potential role of TRAIL in immune regulation. The results show that T-lymphocytes of TRAIL(-/-) mice have lower proliferation rates, which can be increased by recombinant TRAIL administration, suggesting the importance of TRAIL in immune modulation.
Article
Oncology
Ann-Kathrin Berg, Elisabeth M. Hahn, Fiona Speichinger-Hillenberg, Annemaria Silvana Grube, Nina A. Hering, Ani K. Stoyanova, Katharina Beyer
Summary: Peritonitis and abdominal sepsis are important factors causing sepsis, but their immunological background and molecular mechanism are still unclear, leading to limited treatment options. This study found that apoptosis of neutrophil granulocytes is inhibited in early abdominal sepsis, and TRAIL may have potential as a therapeutic drug.
Article
Materials Science, Multidisciplinary
Luca M. Berger, Martin Barkey, Stefan A. Maier, Andreas Tittl
Summary: This article investigates an emerging class of metasurfaces that can control the coupling between bound states in the continuum (BICs) and the far field. It is demonstrated experimentally that these metasurfaces sustain angular-robust quasi-BICs in the mid-infrared spectral region. Compared to conventional alternatives, these metasurfaces exhibit superior performance, making them promising for applications in bio-sensing, optical devices, and photonic devices using focused light.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Materials Science, Multidisciplinary
Simone Ezendam, Lin Nan, Ianina L. Violi, Stefan A. Maier, Emiliano Cortes, Guillaume Baffou, Julian Gargiulo
Summary: Metallic nanoparticles have strong photothermal responses, but measuring their temperature accurately is challenging. Anti Stokes thermometry is a label-free technique mainly used for single particles. This study introduces the theoretical framework to apply it to the collective heating of ensembles and demonstrates temperature measurements of arrays of Au nanodisks, which are validated with wavefront microscopy, showing excellent agreement.
ADVANCED OPTICAL MATERIALS
(2023)
Article
Optics
Lucca Kuehner, Fedja J. Wendisch, Alexander A. Antonov, Johannes Buerger, Ludwig Huettenhofer, Leonardo de S. Menezes, Stefan A. Maier, Maxim V. Gorkunov, Yuri Kivshar, Andreas Tittl
Summary: This research introduces a novel nanofabrication approach to effectively control resonance features and nanophotonic functionalities in all-dielectric metasurfaces by unlocking the height of individual resonators. Using this approach, an optical all-dielectric metasurface with maximum intrinsic chirality is demonstrated, which selectively responds to light of a particular circular polarization depending on the structural handedness.
LIGHT-SCIENCE & APPLICATIONS
(2023)
Review
Immunology
Juliane Glaubitz, Saeedeh Asgarbeik, Rabea Lange, Hala Mazloum, Hager Elsheikh, Frank Ulrich Weiss, Matthias Sendler
Summary: Acute pancreatitis is a common inflammatory disease of the gastrointestinal tract and is increasingly diagnosed in hospitalized patients. It often progresses to chronic pancreatitis over time, with immune response playing a significant role in determining the severity and course of the disease. The mortality rate of acute pancreatitis is high, caused by excessive inflammation or inhibition of bacterial defense mechanisms leading to severe necrotizing pancreatitis. Targeting the immune response is the most promising therapeutic strategy, but the complexity of the immune response and the risk of chronic disease development limit treatment interventions.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Optics
Jisoo Kim, Johannes Buerger, Bumjoon Jang, Matthias Zeisberger, Julian Gargiulo, Leonardo de S. Menezes, Stefan A. Maier, Markus A. Schmidt
Summary: In this study, the properties of the on-chip hollow-core microgap waveguide in the context of optofluidics were investigated. The waveguide allows for intense light-water interaction and has fast response times. Various absorption-related experiments demonstrated the spectroscopic capabilities of the nanoprinted waveguide, and time-resolved experiments showed improved diffusion times due to the lateral access provided by the microgaps. Overall, the microgap waveguide represents a promising pathway for on-chip spectroscopy in aqueous environments.
