The cystic fibrosis microbiome in an ecological perspective and its impact in antibiotic therapy

Detection of KI WU and Merkel cell polyomavirus in respiratory tract of cystic fibrosis patients

(2015) M. Iaria et al.   CLINICAL MICROBIOLOGY AND INFECTION

First recovery ofRasamsonia argillaceaspecies complex isolated in adolescent patient with cystic fibrosis in Slovenia - case report and review of literature

(2015) Tadeja Matos et al.   MYCOSES

Cooperative pathogenicity in cystic fibrosis: Stenotrophomonas maltophilia modulates Pseudomonas aeruginosa virulence in mixed biofilm

(2015) Arianna Pompilio et al.   Frontiers in Microbiology

Pyocycanin, a Contributory Factor in Haem Acquisition and Virulence Enhancement of Porphyromonas gingivalis in the Lung

(2015) Malgorzata Benedyk et al.   PLoS One

Reduced Bacterial Colony Count of Anaerobic Bacteria Is Associated with a Worsening in Lung Clearance Index and Inflammation in Cystic Fibrosis

(2015) Katherine O’Neill et al.   PLoS One

Species-specific viability analysis of Pseudomonas aeruginosa, Burkholderia cepacia and Staphylococcus aureus in mixed culture by flow cytometry

(2014) Marc Rüger et al.   BMC MICROBIOLOGY

Contribution of Veillonella parvula to Pseudomonas aeruginosa-Mediated Pathogenicity in a Murine Tumor Model System

(2014) Christian Pustelny et al.   INFECTION AND IMMUNITY

Breath gas metabolites and bacterial metagenomes from cystic fibrosis airways indicate active pH neutral 2,3-butanedione fermentation

(2014) Katrine L Whiteson et al.   ISME Journal

Mechanisms of reduced susceptibility and genotypic prediction of antibiotic resistance in Prevotella isolated from cystic fibrosis (CF) and non-CF patients

(2014) Laura J Sherrard et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Mechanisms of synergy in polymicrobial infections

(2014) Justine L. Murray et al.   JOURNAL OF MICROBIOLOGY

Targeting virulence: can we make evolution-proof drugs?

(2014) Richard C. Allen et al.   NATURE REVIEWS MICROBIOLOGY

Microbiota Present in Cystic Fibrosis Lungs as Revealed by Whole Genome Sequencing

(2014) Philippe M. Hauser et al.   PLoS One

Interactions in multispecies biofilms: do they actually matter?

(2014) Mette Burmølle et al.   TRENDS IN MICROBIOLOGY

Polybacterial human disease: the ills of social networking

(2014) Francesca L. Short et al.   TRENDS IN MICROBIOLOGY

Aerosolized antibiotics in cystic fibrosis: an update

(2014) Stanley B Fiel   Expert Review of Respiratory Medicine

Developments and strategies for inhaled antibiotic drugs in tuberculosis therapy: A critical evaluation

(2013) M. Hoppentocht et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Inhaled antibiotics for the treatment of chronic bronchopulmonaryPseudomonas aeruginosainfection in cystic fibrosis: systematic review of randomised controlled trials

(2013) Luis Máiz et al.   EXPERT OPINION ON PHARMACOTHERAPY

Flagellar Motility Is a Key Determinant of the Magnitude of the Inflammasome Response to Pseudomonas aeruginosa

(2013) Yash R. Patankar et al.   INFECTION AND IMMUNITY

Biofilm Matrix and Its Regulation in Pseudomonas aeruginosa

(2013) Qing Wei et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clinical Insights from Metagenomic Analysis of Sputum Samples from Patients with Cystic Fibrosis

(2013) Y. W. Lim et al.   JOURNAL OF CLINICAL MICROBIOLOGY

A novel Pseudomonas aeruginosa-derived effector cooperates with flagella to mediate the upregulation of interleukin 8 in human epithelial cells

(2013) Yong-Jae Kim et al.   MICROBIAL PATHOGENESIS

Pseudomonas aeruginosa Adaptation to Lungs of Cystic Fibrosis Patients Leads to Lowered Resistance to Phage and Protist Enemies

(2013) Ville-Petri Friman et al.   PLoS One

Resistance Development of Cystic Fibrosis Respiratory Pathogens When Exposed to Fosfomycin and Tobramycin Alone and in Combination under Aerobic and Anaerobic Conditions

(2013) Gerard McCaughey et al.   PLoS One

Community surveillance enhances Pseudomonas aeruginosa virulence during polymicrobial infection

(2013) A. Korgaonkar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interpreting infective microbiota: the importance of an ecological perspective

(2013) Geraint B. Rogers et al.   TRENDS IN MICROBIOLOGY

Unique microbial communities persist in individual cystic fibrosis patients throughout a clinical exacerbation

(2013) Katherine E Price et al.   Microbiome

Polymicrobial Interactions: Impact on Pathogenesis and Human Disease

(2012) B. M. Peters et al.   CLINICAL MICROBIOLOGY REVIEWS

Antibiotic resistance of mixed biofilms in cystic fibrosis: impact of emerging microorganisms on treatment of infection

(2012) Susana Patrícia Lopes et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Treatment of lung infection in patients with cystic fibrosis: Current and future strategies

(2012) Gerd Döring et al.   Journal of Cystic Fibrosis

Metagenomics and metatranscriptomics: Windows on CF-associated viral and microbial communities

(2012) Yan Wei Lim et al.   Journal of Cystic Fibrosis

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

(2012) Anders Folkesson et al.   NATURE REVIEWS MICROBIOLOGY

The Airway Microbiota in Cystic Fibrosis: A Complex Fungal and Bacterial Community—Implications for Therapeutic Management

(2012) Laurence Delhaes et al.   PLoS One

Cystic Fibrosis-Niche Adaptation of Pseudomonas aeruginosa Reduces Virulence in Multiple Infection Hosts

(2012) Nicola Ivan Lorè et al.   PLoS One

Interkingdom metabolic transformations captured by microbial imaging mass spectrometry

(2012) W. J. Moree et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CombinedHaemophilus influenzaerespiratory infection and allergic airways disease drives chronic infection and features of neutrophilic asthma

(2012) Ama-Tawiah Essilfie et al.   THORAX

Long-term cultivation-independent microbial diversity analysis demonstrates that bacterial communities infecting the adult cystic fibrosis lung show stability and resilience

(2012) Franziska Anne Stressmann et al.   THORAX

Microbial Co-occurrence Relationships in the Human Microbiome

(2012) Karoline Faust et al.   PLoS Computational Biology

Eradication ofPseudomonas aeruginosabiofilms on cultured airway cells by a fosfomycin/tobramycin antibiotic combination

(2012) Gregory G. Anderson et al.   Pathogens and Disease

Activation of MMP-9 by human lung epithelial cells in response to the cystic fibrosis-associated pathogen Burkholderia cenocepacia reduced wound healing in vitro

(2011) Ciara Wright et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Managing Cystic Fibrosis

(2011) Malena Cohen-Cymberknoh et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Clinical Significance of Microbial Infection and Adaptation in Cystic Fibrosis

(2011) A. R. Hauser et al.   CLINICAL MICROBIOLOGY REVIEWS

Bacterial host interactions in cystic fibrosis

(2011) Máire Callaghan et al.   CURRENT OPINION IN MICROBIOLOGY

Microbial ecology and adaptation in cystic fibrosis airways

(2011) Lei Yang et al.   ENVIRONMENTAL MICROBIOLOGY

Pattern differentiation in co-culture biofilms formed byStaphylococcus aureusandPseudomonas aeruginosa

(2011) Liang Yang et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Bacterial cis-2-unsaturated fatty acids found in the cystic fibrosis airway modulate virulence and persistence of Pseudomonas aeruginosa

(2011) Kate B Twomey et al.   ISME Journal

Antimicrobial activity of fosfomycin and tobramycin in combination against cystic fibrosis pathogens under aerobic and anaerobic conditions

(2011) Gerard McCaughey et al.   Journal of Cystic Fibrosis

General Principles of Antimicrobial Therapy

(2011) Surbhi Leekha et al.   MAYO CLINIC PROCEEDINGS

A CFTR Potentiator in Patients with Cystic Fibrosis and theG551DMutation

(2011) Bonnie W. Ramsey et al.   NEW ENGLAND JOURNAL OF MEDICINE

An In Vivo Polymicrobial Biofilm Wound Infection Model to Study Interspecies Interactions

(2011) Trevor Dalton et al.   PLoS One

Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis

(2011) M. M. Tunney et al.   THORAX

The clinical impact of bacterial biofilms

(2011) Niels Høiby et al.   International Journal of Oral Science

The emerging relationship between the airway microbiota and chronic respiratory disease: clinical implications

(2011) Yvonne J Huang et al.   Expert Review of Respiratory Medicine

Detection and accurate identification of new or emerging bacteria in cystic fibrosis patients

(2010) F. Bittar et al.   CLINICAL MICROBIOLOGY AND INFECTION

Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence

(2010) P. Drevinek et al.   CLINICAL MICROBIOLOGY AND INFECTION

Pseudomonas aeruginosabiofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies

(2010) Daniel J Hassett et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Biofilms in chronic infections – a matter of opportunity – monospecies biofilms in multispecies infections

(2010) Mette Burmølle et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Pseudomonas aeruginosa and their small diffusible extracellular molecules inhibit Aspergillus fumigatus biofilm formation

(2010) Eilidh Mowat et al.   FEMS MICROBIOLOGY LETTERS

Pseudomonas aeruginosabiofilms in cystic fibrosis

(2010) Niels Høiby et al.   Future Microbiology

Pseudomonas aeruginosa Alginate Promotes Burkholderia cenocepacia Persistence in Cystic Fibrosis Transmembrane Conductance Regulator Knockout Mice

(2010) S. S. Chattoraj et al.   INFECTION AND IMMUNITY

The continuing crisis in antibiotic resistance

(2010) G.L. French   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Antibiotic resistance of bacterial biofilms

(2010) Niels Høiby et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Mutators in cystic fibrosis chronic lung infection: Prevalence, mechanisms, and consequences for antimicrobial therapy

(2010) Antonio Oliver   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung

(2010) Max Schobert et al.   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Impact of Staphylococcus aureus on the pathogenesis of chronic cystic fibrosis lung disease

(2010) Barbara C. Kahl   INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY

Phylogenetic and metabolic diversity of bacteria associated with cystic fibrosis

(2010) Adam M Guss et al.   ISME Journal

Isolation of the Fungus Geosmithia argillacea in Sputum of People with Cystic Fibrosis

(2010) R. C. Barton et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Burkholderia cenocepacia O polysaccharide chain contributes to caspase-1-dependent IL-1β production in macrophages

(2010) Sheetal Kotrange et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Virulence of an emerging respiratory pathogen, genus Pandoraea, in vivo and its interactions with lung epithelial cells

(2010) A. Costello et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Pseudomonas aeruginosa secreted factors impair biofilm development in Candida albicans

(2010) Lucy J. Holcombe et al.   MICROBIOLOGY-SGM

Anti-virulence strategies to combat bacteria-mediated disease

(2010) David A. Rasko et al.   NATURE REVIEWS DRUG DISCOVERY

Pathogenesis of bronchiectasis

(2010) Paul King   Paediatric Respiratory Reviews

Relative contribution of Prevotella intermedia and Pseudomonas aeruginosa to lung pathology in airways of patients with cystic fibrosis

(2010) M. Ulrich et al.   THORAX

New Antimicrobial Strategies in Cystic Fibrosis

(2010) Mireille van Westreenen et al.   PEDIATRIC DRUGS

Efflux Unbalance in Pseudomonas aeruginosa Isolates from Cystic Fibrosis Patients

(2009) L. Vettoretti et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Respiratory Microbiology of Patients With Cystic Fibrosis in the United States, 1995 to 2005

(2009) Samiya Razvi et al.   CHEST

The Effect of Chronic Infection With Aspergillus fumigatus on Lung Function and Hospitalization in Patients With Cystic Fibrosis

(2009) Reshma Amin et al.   CHEST

Antibiotic-resistant obligate anaerobes during exacerbations of cystic fibrosis patients

(2009) D. Worlitzsch et al.   CLINICAL MICROBIOLOGY AND INFECTION

First report of Paenibacillus cineris from a patient with cystic fibrosis

(2009) Robson Souza Leão et al.   DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE

Delivery of antibiotics to the respiratory tract: an update

(2009) Daniela Traini et al.   Expert Opinion on Drug Delivery

Antibacterial activities of a fosfomycin/tobramycin combination: a novel inhaled antibiotic for bronchiectasis

(2009) D. L. MacLeod et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Trichosporon mycotoxinivorans, a Novel Respiratory Pathogen in Patients with Cystic Fibrosis

(2009) P. W. Hickey et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Low Rates of Pseudomonas aeruginosa Misidentification in Isolates from Cystic Fibrosis Patients

(2009) T. J. Kidd et al.   JOURNAL OF CLINICAL MICROBIOLOGY

Pseudomonas aeruginosabiofilms in the respiratory tract of cystic fibrosis patients

(2009) Thomas Bjarnsholt et al.   PEDIATRIC PULMONOLOGY

Burkholderia cepaciaComplex: Impact on the Cystic Fibrosis Lung Lesion

(2009) Joseph Lynch   SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE

Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways

(2009) Daniel J. Hassett et al.   TRENDS IN MICROBIOLOGY

Detection of Anaerobic Bacteria in High Numbers in Sputum from Patients with Cystic Fibrosis

(2008) Michael M. Tunney et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

The role of quorum sensing in chronic cystic fibrosisPseudomonas aeruginosainfections

(2008) Craig Winstanley et al.   FEMS MICROBIOLOGY LETTERS

Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice

(2008) C. Castellani et al.   Journal of Cystic Fibrosis

Guidelines for Diagnosis of Cystic Fibrosis in Newborns through Older Adults: Cystic Fibrosis Foundation Consensus Report

(2008) Philip M. Farrell et al.   JOURNAL OF PEDIATRICS

Molecular Detection of Multiple Emerging Pathogens in Sputa from Cystic Fibrosis Patients

(2008) Fadi Bittar et al.   PLoS One

Discerning the Complexity of Community Interactions Using a Drosophila Model of Polymicrobial Infections

(2008) Christopher D. Sibley et al.   PLoS Pathogens

Evaluation of in vitro virulence characteristics of the genus Pandoraea in lung epithelial cells

(2007) E. Caraher et al.   JOURNAL OF MEDICAL MICROBIOLOGY