Article
Cell Biology
Jinying Liu, Hongjian Lian, Jiang Yu, Jie Wu, Xiangyang Chen, Peng Wang, Lei Tian, Yunfei Yang, Jiaqi Yang, Dong Li, Shuzhen Guo
Summary: Heart failure is characterized by significant disturbance of protein turnover. This study analyzed the proteome in a heart failure model at different time points and identified critical pathways associated with the transition from cardiac hypertrophy to heart failure.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Nikolaus Berndt, Johannes Eckstein, Iwona Wallach, Sarah Nordmeyer, Marcus Kelm, Marieluise Kirchner, Leonid Goubergrits, Marie Schafstedde, Anja Hennemuth, Milena Kraus, Tilman Grune, Philipp Mertins, Titus Kuehne, Hermann-Georg Holzhuetter
Summary: The study utilized a comprehensive kinetic model of cardiac energy metabolism to assess the energy status of the left ventricles in healthy participants and patients with aortic stenosis and mitral valve insufficiency. The results indicated that patients had increased MVATP[rest] and decreased MVATP[max], leading to a decreased myocardial ATP production reserve, despite having preserved ejection fraction. The energy status was closely associated with mechanical energy demand.
Article
Clinical Neurology
Xiaopeng Chen, Yiyun Liu, Juncai Pu, Siwen Gui, Dongfang Wang, Xiaogang Zhong, Weiyi Chen, Wei Tao, Yue Chen, Xiang Chen, Peng Xie
Summary: This study identified differential expression of proteins in the intestines of macaques with depression-like behaviors. The downregulation of multiple proteins and alterations in metabolism and gut microbiota were observed. Key proteins involved in mitochondrial function and energy metabolism were inhibited, potentially leading to disruptions in energy metabolism.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Neurosciences
Lu Liu, Weizheng Li, Linpeng Wang, Pengyun Gong, Tianli Lyu, Dapeng Liu, Yajie Zhang, Yijie Guo, Xiang Liu, Min Tang, Hongke Hu, Chao Liu, Bin Li
Summary: This study utilized proteomic and metabolomic profiling to reveal that acupuncture treatment can significantly alter metabolic pathways related to migraine, involving energy metabolism and amino acid metabolism. These findings contribute to understanding the pathophysiological changes in migraine and the mechanism of acupuncture treatment.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Mariana Mescouto Lopes, Thais Ribeiro Brito, Josiane Fonseca Lage, Thais Correia Costa, Marta Maria dos Santos Fontes, Nick Vergara Lopes Serao, Tiago Antonio de Oliveira Mendes, Ricardo Andrade Reis, Renata Veroneze, Fabyano Fonseca e Silva, Marcio de Souza Duarte
Summary: This study investigated the effects of supplementing rumen-protected B-vitamin blend and hydroxy trace minerals on the hepatic proteome of finishing steers. The results indicated that the supplementation altered the abundance of proteins associated with the electron transport chain and other oxidation-reduction pathways, leading to the production of reactive oxygen species and modulation of proteins linked to oxidative-damage responses for maintaining cellular homeostasis.
Review
Biochemistry & Molecular Biology
Iveta Fizikova, Jozef Dragasek, Peter Racay
Summary: The complexity of the brain can lead to the development of serious neuropsychiatric disorders, such as schizophrenia. The etiopathogenesis of schizophrenia involves multiple mechanisms, highlighting its complexity and providing a new perspective for studying this disorder. This review focuses on the contribution of mitochondria, particularly oxidative damage, ROS, and energy metabolism. It also discusses the role of redox imbalance and lactate in oxidative stress, lipid peroxidation, and cognitive functions in schizophrenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Health Care Sciences & Services
Marta Barrera-Conde, Karina Ausin, Mercedes Lachen-Montes, Joaquin Fernandez-Irigoyen, Liliana Galindo, Aida Cuenca-Royo, Cristina Fernandez-Aviles, Victor Perez, Rafael de la Torre, Enrique Santamaria, Patricia Robledo
Summary: The study found that cannabis use causes specific alterations in RNA-related proteins in olfactory neuroepithelium cells of schizophrenia patients, which are correlated with cognitive performance and clinical signs.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Nutrition & Dietetics
Shoko Takahashi, Kenji Saito, Xuguang Li, Huijuan Jia, Hisanori Kato
Summary: This study found that chlorogenic acid enhances energy metabolism, including the TCA cycle, the glycolytic system, electron transport, and ATP synthesis. These findings contribute to our understanding of the beneficial effects of coffee consumption.
Article
Psychiatry
Jinling Zhang, Shu Chen, Jia Chen, Handi Zhang, Wen-Wang Rao
Summary: This study aimed to investigate the differences in the efficacy of topiramate (TPM) and vitamin C (VC) in reducing olanzapine (OLZ)-induced weight gain and metabolic abnormalities. The results showed that TPM was more effective in reducing OLZ-induced increase in triglyceride levels, and there were also differences in the trajectories of change in metabolic indexes between the two groups.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Microbiology
Shanshan Zhang, Baohua Zhao, Jing Li, Xiaofei Song, Yigang Tong, Wenlin An
Summary: This study investigated the protein profile changes during the invasion and killing of host cyanobacteria by the novel cyanophage YongM. The results showed significant alterations in metabolic pathways and identified key proteins involved in the YongM-host interaction. The findings provide insights for the future design and manipulation of artificial cyanophages against water blooms.
Article
Biochemistry & Molecular Biology
Rattiyaporn Kanlaya, Chonnicha Subkod, Supanan Nanthawuttiphan, Visith Thongboonkerd
Summary: Habitual coffee drinking is associated with lower risks for chronic kidney disease (CKD) and nephrolithiasis. This study investigated the cellular adaptive response of renal tubular cells to caffeine and identified protein-level changes in pathways related to proteasome, ribosome, TCA cycle, DNA replication, spliceosome, amino acid biosynthesis, carbon metabolism, nucleocytoplasmic transport, cell cycle, cytoplasmic translation, translation initiation, and mRNA metabolic process. Functional validation experiments confirmed that caffeine affects cell cycle, cellular energy, and mitochondrial function.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Review
Psychiatry
David Kolar, Branislav Krajcovic, Lenka Kleteckova, Daniela Kuncicka, Karel Vales, Hana Brozka
Summary: This study investigates the impact of the haploinsufficiency of genes involved in mitochondrial function on the development of schizophrenia in individuals with 22q11.2 deletion syndrome. The results suggest that the haploinsufficiency of these genes is associated with oxidative stress, altered energy metabolism, and calcium homeostasis, which may contribute to the emergence of schizophrenia. The findings from both in vivo and in vitro studies support the causal role of impaired mitochondrial function in the development of schizophrenia in 22q11.2 deletion syndrome.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Nutrition & Dietetics
Shuai Liu, Huizhen Lu, Shengyong Mao, Zijun Zhang, Wen Zhu, Jianbo Cheng, Yanfeng Xue
Summary: This study comprehensively analyzes the effect of undernutrition on the pituitary gland in a pregnant sheep model, which provides a foundation for further research into the mechanisms of undernutrition-caused hormone secretion and metabolic disorders.
FRONTIERS IN NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Rupu He, Ruyun Ma, Zheng Jin, Yanning Zhu, Fude Yang, Fangdi Hu, Jianye Dai
Summary: This study aimed to evaluate the efficacy of Codonopsis pilosula in suppressing Gastric Precancerous Lesions and reveal its mechanism. The results showed that Codonopsis pilosula could control inflammation, ameliorate gastritis injury, and selectively inhibit the proliferation of gastric cancer cells. The effects were closely related to its regulation of the energy-metabolism pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
J. Michael Henderson, Nina Ljubojevic, Sevan Belian, Thibault Chaze, Daryl Castaneda, Aude Battistella, Quentin Giai Gianetto, Mariette Matondo, Stephanie Descroix, Patricia Bassereau, Chiara Zurzolo
Summary: Tunnelling nanotubes (TNTs) are specialized actin-based protrusions that bridge distant cells to facilitate direct intercellular communication and cargo transfer in both physiological and pathological contexts. Linear actin filament elongation induced by Eps8 and IRSp53 is shown to promote functional and stable TNT formation. A micropatterning approach shows that TNTs originate via actin polymerization rather than cell dislodgement and exceed the length of conventional filopodia. Inhibition of Arp2/3 activity promotes functional TNT formation due to enhanced actin filament polymerization and elongation, suggesting a shift from branched to linear actin. An interaction between Eps8 and the I-BAR domain protein IRSp53 promotes formation of functional TNTs with an increased lifetime. Arp2/3 inhibition leads to reduction of Eps8 interactions with proteins facilitating actin filament depolymerization and turnover. Inhibition of branched actin networks reveals the role of linear actin filament polymerization in the formation of functional tunnelling nanotubes.
Article
Materials Science, Multidisciplinary
Shi-Pai Song, Cheng Yang, Chun-Zhi Jiang, Yong-Min Wu, Rui Guo, He Sun, Jing-Lei Yang, Yong Xiang, Xiao-Kun Zhang
Summary: The study demonstrates the importance of balancing oxygen partial pressure to improve ionic conductivity in amorphous LLTO thin films, as well as the role of proper annealing temperature in reducing oxygen defects and maintaining an amorphous state. Additionally, annealing in air without a gas stream is shown to be beneficial for reducing lithium loss and oxygen defects, leading to higher ionic conductivity. These findings provide insights into optimizing LLTO thin-film solid electrolytes for application in thin-film lithium batteries.
Article
Chemistry, Multidisciplinary
Haomin Chen, Donghwi Cho, Kwonhwan Ko, Caiyan Qin, Minsoo P. Kim, Heng Zhang, Jeng-Hun Lee, Eunyoung Kim, Dawon Park, Xi Shen, Jinglei Yang, Hyunhyub Ko, Jung-Wuk Hong, Jang-Kyo Kim, Seokwoo Jeon
Summary: This study presents a strategy for designing mechanochromic scattering membranes with high-contrast optical modulation based on Young's modulus mismatch. The 3D heterogeneity of the membrane enables incident light scattering under tension, resulting in a high transmittance contrast and maximum contrast. The membrane can be used as a smart window for effective diffusion of sunlight and enhanced coloration sensitivity.
Article
Chemistry, Multidisciplinary
Jeng-Hun Lee, Eunyoung Kim, Heng Zhang, Haomin Chen, Harun Venkatesan, Kit-Ying Chan, Jie Yang, Xi Shen, Jinglei Yang, Seokwoo Jeon, Jang-Kyo Kim
Summary: A rational approach has been proposed to design soft multifunctional sensors capable of detecting and discriminating different physical stimuli using electrospun carbon nanofiber films. The flexible sensor can detect and distinguish minute temperature and pressure stimuli in real time, with outstanding sensitivity and discriminability coordinated by tailoring the structures of the CNF films. This sensor has distinct advantages in its simple fabrication process and reliable output signal.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Chemistry, Physical
He Zhang, Kaipeng Chen, Jinglei Yang
Summary: A novel microencapsulation technique based on inverse emulsion was successfully established to encapsulate aqueous phases with different functions. The quality of microcapsules was adjusted by using different cross-linkers, with higher functionality leading to better impermeability of the microcapsule shell. This technique demonstrated versatility in encapsulating a wide variety of water-soluble/dispersible substances, except for strong inorganic acids.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2022)
Article
Mechanics
Cheng Qiu, Yuzi Han, Logesh Shanmugam, Fengyang Jiang, Zhidong Guan, Shanyi Du, Jinglei Yang
Summary: Our machine learning-based framework aims to reduce uneven load distribution in composite components with carbon fiber reinforced plastic laminates, by providing optimal parameters for bolt-hole clearances and tightening torques. This approach shows effectiveness in achieving even load distribution in mechanical joints and potential in increasing computational efficiency for the optimization problem.
COMPOSITE STRUCTURES
(2022)
Article
Materials Science, Composites
Cheng Qiu, Yuzi Han, Logesh Shanmugam, Ying Zhao, Shaotong Dong, Shanyi Du, Jinglei Yang
Summary: In this paper, a machine learning-assisted composite design framework is proposed, which utilizes a CGAN model to find feasible or optimal selections of fiber materials and layup stacking orientations that meet mechanical and non-mechanical requirements.
COMPOSITES SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Ting Han, Shusheng Chen, Xinnan Wang, Xinyao Fu, Haifei Wen, Zaiyu Wang, Dong Wang, Anjun Qin, Jinglei Yang, Ben Zhong Tang
Summary: The development of autonomous materials with built-in visualizable sensing units is important in academia and industry. However, the mechanism of turn-on sensing based on microcapsules and chemical reactions is limited. This study demonstrates a metal-free polymerization route with a reaction-induced coloration effect for damage visualization.
Article
Oncology
Haowen Jiang, Rachel L. Greathouse, Sarah Jane Tiche, Man Zhao, Bo He, Yang Li, Albert M. Li, Balint Forgo, Michaela Yip, Allison Li, Moriah Shih, Selene Banuelos, Meng-Ning Zhou, Joshua J. Gruber, Erinn B. Rankin, Zhen Hu, Hiroyuki Shimada, Bill Chiu, Jiangbin Ye
Summary: The Warburg effect is the major metabolic hallmark of cancer. In this study, researchers found that treating neuroblastoma cells with the mitochondrial uncoupler NEN can induce neural differentiation by altering metabolic and epigenetic pathways.
Article
Chemistry, Multidisciplinary
Heng Zhang, Haomin Chen, Jeng-Hun Lee, Eunyoung Kim, Kit-Ying Chan, Harun Venkatesan, Xi Shen, Jinglei Yang, Jang-Kyo Kim
Summary: This research aims to design a flexible optical/electrical skin capable of responding to complex stimuli with interactive feedback of human-readable structural colors. The OE-skin consists of various layers including an ionic electrode, elastomer dielectric layer, chromotropic layer, and a conductive carbon nanotube/MXene layer. It delivers an ultrafast, accurate response for capacitive pressure sensing and visualizes complex deformations in high-resolution spatial colors.
Article
Chemistry, Multidisciplinary
Xueqin Yang, Changhuo Xu, Xun Zhang, Pei Li, Feiyi Sun, Xinyue Liu, Xinyuan Wang, Ryan T. K. Kwok, Jinglei Yang, Jacky W. Y. Lam, Yongye Liang, Ben Zhong Tang
Summary: A facile molecular engineering strategy was developed to design photosensitizers (PSs) with aggregation induced emission (AIE) characteristics and responsive properties to the acidic tumor microenvironment (TME). Two near-infrared AIE luminogens called DBP-SPy and DBP-SPh were synthesized, which can form nanoaggregates and show different surface charge conversion properties in response to the pH of the TME. The DBP-SPy nanoaggregates demonstrated efficient photodynamic therapy on cancer cells in vitro and excellent tumor growth inhibition in vivo.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Engineering, Electrical & Electronic
Nan Nathan Xu, Yiqi An, Hongyu Yu, Jinglei Yang
Summary: This letter examines the performance of on-silicon inductor coils with integrated buck dc-dc converters made using a 180 nm CMOS process. A parallel shunting structure with different metal layers was chosen for its lower resistance and higher inductance in low-power IoT scenarios. Simulation results demonstrate stable values of more than 230 nH for the fabricated inductors within the expected frequency range. The proposed dc-dc converter achieves an efficiency of 69.1% at 30 MHz for a 12.9 mA load, operating at voltage levels of 2.4 to 1.2 V. Our approach enables high-inductance integration without the need for costly postprocessing techniques, expanding the application of power inductor and dc-dc converter integration.
IEEE SENSORS LETTERS
(2023)
Article
Physics, Applied
Biyuan Liu, Le Zhou, Yixiang Wang, Shaobin Zhuo, Yanguang Zhou, Jinglei Yang, Zhigang Li
Summary: In this study, the diffusion of LiCl electrolytes in 3D-nanoporous graphene structures (3D-NGSs) was investigated using molecular dynamics simulations. The diffusion coefficients of water, Li+, and Cl- were calculated in 3D-NGSs with different LiCl concentrations, porosities, and surface charge densities. The results showed that the diffusion coefficients followed the Arrhenius Equation and power laws for the dependence on temperature and porosity, respectively. They decreased with increasing salt concentration.
JOURNAL OF APPLIED PHYSICS
(2023)
Article
Oncology
Haowen Jiang, Clifford Jiajun He, Albert Li, Bo He, Yang Li, Meng-Ning Zhou, Jiangbin Ye
Summary: This study demonstrates that mitochondrial uncoupling effectively inhibits the reductive carboxylation in cancer cells. By activating the electron transport chain and increasing the NAD(+)/NADH ratio, mitochondrial uncoupling accelerates the oxidative tricarboxylic acid cycle and blocks reductive carboxylation. Inhibiting reductive carboxylation could be a key mechanism by which mitochondrial uncouplers inhibit tumor growth.
MOLECULAR CANCER RESEARCH
(2023)
Article
Nanoscience & Nanotechnology
Man Kwan Law, Ying Zhao, Weibin Zhang, Rui Wang, Mingcheng Shi, Yunxiao Zhang, Shusheng Chen, Jinglei Yang
Summary: Highly transparent and super-wettable nanocoatings with outstanding physical properties are in high demand. In this study, a physically durable coating based on inorganic nanoparticles and an organic segment was synthesized. The coating exhibited long-lasting wetting properties, resistance to water invasion, and improved durability through the bonding between the hydrophilic surfactant and the inorganic nanoparticles. The nanocoating demonstrated high transparency, superwetting property, effective de-frosting performance, and remained self-cleaning even after exposure to water invasion or UV weathering tests.
NANO MATERIALS SCIENCE
(2022)
Article
Chemistry, Physical
Shusheng Chen, Ting Han, Junkai Liu, Xinting Liang, Jinglei Yang, Ben Zhong Tang
Summary: This study demonstrates a facile design strategy for multifunctional polymer coatings that can sensitively show their damaging-healing processes in an on-site, real-time, and full-field manner. By embedding UV-blocking microcapsules containing an aggregation-induced emission luminogen (AIEgen) into a polymer matrix, immediate turn-on fluorescence is observed upon damage, and dual-signal variations in both the fluorescence intensity and color can be clearly visualized during the dynamic healing process. The high-contrast fluorescence change is achieved due to the collective effects of AIE and twisted intramolecular charge transfer of the luminogen. The composite polymeric coatings also exhibit excellent photo-protective and water-proof performances in addition to the autonomous damaging-healing visualization capability, making them appealing for various practical applications.
JOURNAL OF MATERIALS CHEMISTRY A
(2022)
Article
Biochemistry & Molecular Biology
Xinyu Wang, Jun Huang, Huan Li, Yanlong Li, Shuang Cai, Bangxin Xue, Zhekun Zhu, Xiangzhou Zeng, Xiangfang Zeng
Summary: Embryo development plays a crucial role in pregnancy outcome and lifelong health. A high throughput screening cell model was established to select nutrients that can enhance embryonic development. Resveratrol was identified as a potential candidate for promoting embryo development.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ren Yoshitomi, Motofumi Kumazoe, Kwan-Woo Lee, Yuki Marugame, Yoshinori Fujimura, Hirofumi Tachibana
Summary: This study investigated the connection between food components and circular RNA (circRNA), as well as the regulatory effect of (-)-Epigallocatechin-3-O-gallate (EGCG) on circRNA expression in the liver. The results showed that EGCG treatment altered the expression of circRNAs in mice livers, and one upregulated circRNA (mmu_circRNA_011775) affected the expression of genes related to liver fibrosis and the cardiovascular system.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
ViVi Tang Kang Wee, Hitoshi Shirakawa, Sung-Ling Yeh, Chiu-Li Yeh
Summary: This study investigated the effects of fermented rice bran (FRB) on modulating intestinal aryl hydrocarbon receptor (AhR) expression, innate lymphoid cell (ILC)3 populations, the fecal microbiota distribution, and their associations with dextran sodium sulfate (DSS)-induced acute colitis. The results showed that FRB supplementation can improve gut health, alleviate colitis symptoms, and have anti-colitis effects by enhancing ILC3 and AhR functions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Xinzhuang Ma, Xijuan Ren, Xuemin Zhang, Guangyin Wang, Hui Liu, Li Wang
Summary: The study demonstrates that rutin can ameliorate kidney damage caused by PFOA exposure by improving oxidative stress and regulating lipid metabolism.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Ya-Jie Ding, Xue-Ning Li, Zhe Xiao, Chen-Yang Li, Li-Hong Jia
Summary: This study investigates the impact of maternal vitamin D levels during pregnancy on infantile eczema. The findings suggest that lower prenatal maternal vitamin D levels increase the risk of eczema in infants aged 0-1 year. Furthermore, the study indicates that infants with eczema have lower expression of the Foxp3 gene in cord blood and decreased placental FOXP3 protein expression. These results suggest that vitamin D may affect the development of infantile eczema through the regulation of gene and protein expression in cord blood and placenta.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shujing Liu, Shiyu Song, Shuan Wang, Tonghui Cai, Lian Qin, Xinzhuang Wang, Guangming Zhu, Haibo Wang, Wenqi Yang, Chunlu Fang, Yuan Wei, Fu Zhou, Yang Yu, Shaozhang Lin, Shuang Peng, Liangming Li
Summary: Long-term consumption of a high-fat diet disrupts energy balance and leads to weight gain. The fat mass and obesity-associated (FTO) gene is involved in high-fat diet-induced obesity. The hypothalamus plays a crucial role in regulating energy balance, and high-fat diet-induced hypothalamic leptin resistance contributes to obesity. The study reveals that FTO is associated with hypothalamic leptin resistance and provides new insight into its role in obesity.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Xiaoling Chen, Jun He, Yuheng Luo, Ping Zheng, Bing Yu, Daiwen Chen, Zhiqing Huang
Summary: This study found that oleanolic acid promotes the transformation of fast muscle fibers to slow muscle fibers through the TGR5-mediated CaN/NFATc1 signaling pathway.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Huijuan Hu, Fan Li, Shaoli Cheng, Tingting Qu, Fanqi Shen, Jie Cheng, Lina Chen, Zhenghang Zhao, Hao Hu
Summary: Long-term alternate-day fasting can ameliorate obesity-induced anxiety-like behavior and hippocampal damage, but it can cause anxiety in normal-weight mice. Short-term alternate-day fasting does not produce adverse emotional reactions in normal-weight mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Jannis Ulke, Christian Schwedler, Janine Krueger, Vanessa Stein, Peter Geserick, Andre Kleinridders, Kai Kappert
Summary: This study characterized the glycosylation pattern of PTPRJ in the liver and found that high-fat diet-induced obesity altered the glycosylation pattern of PTPRJ. These findings provide new insights into the role of glycosylation in metabolic disorders.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Shuang Liu, Marii Mochizuki, Yasuyuki Suzuki, Erika Takemasa, Akiko Yano, Matome Imai, Masaki Mogi
Summary: This study evaluated the feasibility and efficacy of leucine supplementation in offsetting immune dysfunction in sarcopenia. The results showed that leucine supplementation not only improved muscle mass and restored mitochondrial respiratory function, but also reduced inflammation levels. These findings are important for the rational design and optimization of leucine supplementation in patients with sarcopenia and autoimmune diseases.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Zhan Su, Jun Fang, Bin Yao, Gang Liu
Summary: Osteoporosis is a serious skeletal disorder that can be prevented and treated by polyphenols, which have antioxidant and anti-allergy properties. Polyphenols affect bone metabolism and density by inhibiting oxidative stress and exhibiting antibacterial effects. This article provides an overview of the preventive and therapeutic effects of polyphenols on osteoporosis and discusses the mechanisms involved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qian Zhang, Xinhua Xiao, Jia Zheng, Ming Li, Miao Yu, Fan Ping, Tong Wang, Xiaojing Wang
Summary: Maternal high-fat diet can affect the structure and function of offspring's pancreas, leading to weight gain, glucose metabolism disorders, and insulin secretion defects. The study found that this may be related to DNA methylation of specific genes in the pancreas.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Hanaa Mousa, Aisha Al Saei, Rozaimi Mohamad Razali, Susu M. Zughaier
Summary: Vitamin D deficiency and dyslipidemia have significant implications for human health. This study investigates the proteomic profiles of individuals with and without these conditions, revealing decreased HDL-associated apolipoproteins and increased acute-phase proteins. Pathway analysis highlights inflammatory and cancer pathways associated with vitamin D deficiency and dyslipidemia.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Article
Biochemistry & Molecular Biology
Qi-Lan Jiang, Tao Li, Qin Xu, Yang Zeng, Wei Wang, Bo-Tao Zhang, Qing-Ping Yao, Rui Jiang, Jun Jiang
Summary: Environmental factors, especially dietary habits, play a significant role in the susceptibility and progression of cardiovascular diseases through epigenetic modification. This study found that a methyl donor diet can attenuate balloon injury-induced intimal hyperplasia in rat carotid arteries, potentially by influencing the composition and function of the extracellular matrix.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
Review
Biochemistry & Molecular Biology
Jiayi Cai, Yajie Qiao, Lingbin Chen, Youguang Lu, Dali Zheng
Summary: The Notch signaling pathway plays a regulatory role in normal biological processes such as cellular differentiation, apoptosis, and stem cell self-renewal. Dysregulation of this pathway is associated with various types of cancer. Natural products targeting the Notch pathway have shown potential as chemopreventive and anti-cancer agents, providing a feasible solution to fight against cancer by either alone or in combination with current therapeutic agents.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2024)
