Journal
JOURNAL OF PERSONALIZED MEDICINE
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/jpm11030160
Keywords
cannabis; schizophrenia; proteomics; olfactory neuroepithelium; metabolism; RNA; ZNF326; MTREX
Funding
- DIUE de la Generalitat de Catalunya [2017-SGR-1497]
- Instituto de Salud Carlos III [PI18/00053]
- FIS-FEDER FUNDS
- Spanish Ministry of Science Innovation and Universities [PID2019-110356RB-I00]
- Department of Economic and Business Development from Government of Navarra [0011-1411-2020-000028]
- PE I + D + I 2013-2016 - ISCIII [PT17/0019/009]
- FEDER
- Spanish Ministry of Science and Innovation [RED2018-102662-T]
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The study found that cannabis use causes specific alterations in RNA-related proteins in olfactory neuroepithelium cells of schizophrenia patients, which are correlated with cognitive performance and clinical signs.
A close epidemiological link has been reported between cannabis use and schizophrenia (SCZ). However, biochemical markers in living humans related to the impact of cannabis in this disease are still missing. Olfactory neuroepithelium (ON) cells express neural features and offer a unique advantage to study biomarkers of psychiatric diseases. The aim of our study was to find exclusively deregulated proteins in ON cells of SCZ patients with and without a history of cannabis use. Thus, we compared the proteomic profiles of SCZ non-cannabis users (SCZ/nc) and SCZ cannabis users (SCZ/c) with control subjects non-cannabis users (C/nc) and control cannabis users (C/c). The results revealed that the main cascades affected in SCZ/nc were cell cycle, DNA replication, signal transduction and protein localization. Conversely, cannabis use in SCZ patients induced specific alterations in metabolism of RNA and metabolism of proteins. The levels of targeted proteins in each population were then correlated with cognitive performance and clinical scores. In SCZ/c, the expression levels of 2 proteins involved in the metabolism of RNA (MTREX and ZNF326) correlated with several cognitive markers and clinical signs. Moreover, use duration of cannabis negatively correlated with ZNF326 expression. These findings indicate that RNA-related proteins might be relevant to understand the influence of cannabis use on SCZ.
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