Use of biomarkers and imaging to assess pathophysiology, mechanisms of action and target engagement
Published 2013 View Full Article
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Title
Use of biomarkers and imaging to assess pathophysiology, mechanisms of action and target engagement
Authors
Keywords
Alzheimer’s disease, AD, MCI, prodromal, asymptomatic, amyloid cascade hypothesis, amyloid-beta, tau, biomarkers, theragnostic biomarkers, target engagement, mechanism of action, pathophysiological mechanisms, neurobiochemical markers, CSF, blood, early detection, disease-modifying compounds, therapy, clinical trials, prevention trials
Journal
Journal of Nutrition Health & Aging
Volume 17, Issue 1, Pages 54-63
Publisher
Springer Nature
Online
2013-01-09
DOI
10.1007/s12603-013-0003-1
References
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Note: Only part of the references are listed.- Drug Development Based on the Metals Hypothesis of Alzheimer's Disease
- (2017) Ashley I. Bush JOURNAL OF ALZHEIMERS DISEASE
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- (2012) Harald Hampel et al. Alzheimers & Dementia
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- (2012) Peder Buchhave ARCHIVES OF GENERAL PSYCHIATRY
- Non-Steroidal Anti-Inflammatory Drugs and Alzheimers Disease: The Epidemiological Evidence
- (2012) C.A. Szekely et al. CNS & Neurological Disorders-Drug Targets
- PRINT - ALZHEIMER’S
- (2012) Meredith Wadman NATURE
- Sting of Alzheimer's failures offset by upcoming prevention trials
- (2012) Asher Mullard NATURE REVIEWS DRUG DISCOVERY
- From inherited to sporadic AD—crossing the biomarker bridge
- (2012) Harald Hampel et al. Nature Reviews Neurology
- CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease
- (2012) R. Tarawneh et al. NEUROLOGY
- Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
- (2012) Randall J. Bateman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Stopping Alzheimer's Before It Starts
- (2012) G. Miller SCIENCE
- Preventing Alzheimer's Disease
- (2012) D. J. Selkoe SCIENCE
- Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
- (2011) Reisa A. Sperling et al. Alzheimers & Dementia
- The diagnosis of dementia due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
- (2011) Guy M. McKhann et al. Alzheimers & Dementia
- The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer’s Association workgroups on diagnostic guidelines for Alzheimer's disease
- (2011) Marilyn S. Albert et al. Alzheimers & Dementia
- The Alzheimer’s Disease Neuroimaging Initiative: A review of papers published since its inception
- (2011) Michael W. Weiner et al. Alzheimers & Dementia
- Evidence for Ordering of Alzheimer Disease Biomarkers
- (2011) Clifford R. Jack ARCHIVES OF NEUROLOGY
- Diagnosis and biomarkers of predementia in Alzheimer's disease
- (2011) Orestes V Forlenza et al. BMC Medicine
- A Blood-Based Algorithm for the Detection of Alzheimer’s Disease
- (2011) Sid E. O’Bryant et al. DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Elevated CSF levels of TACE activity and soluble TNF receptors in subjects with mild cognitive impairment and patients with Alzheimer's disease
- (2011) Hong Jiang et al. Molecular Neurodegeneration
- Identification and Validation of Novel Cerebrospinal Fluid Biomarkers for Staging Early Alzheimer's Disease
- (2011) Richard J. Perrin et al. PLoS One
- Multiplexed Immunoassay Panel Identifies Novel CSF Biomarkers for Alzheimer's Disease Diagnosis and Prognosis
- (2011) Rebecca Craig-Schapiro et al. PLoS One
- Prevention trials in Alzheimer's disease: An EU-US task force report
- (2011) Bruno Vellas et al. PROGRESS IN NEUROBIOLOGY
- Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia
- (2011) Michael Ewers et al. TRENDS IN NEUROSCIENCES
- Disease-modifying treatments for Alzheimer’s disease
- (2011) Daniela Galimberti et al. Therapeutic Advances in Neurological Disorders
- Blood-brain barrier disturbance in patients with Alzheimer's disease is related to vascular factors
- (2010) K. Blennow et al. ACTA NEUROLOGICA SCANDINAVICA
- A Serum Protein–Based Algorithm for the Detection of Alzheimer Disease
- (2010) Sid E. O’Bryant ARCHIVES OF NEUROLOGY
- YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease
- (2010) Rebecca Craig-Schapiro et al. BIOLOGICAL PSYCHIATRY
- Low Incidence of Post-Lumbar Puncture Headache in 1,089 Consecutive Memory Clinic Patients
- (2010) Henrik Zetterberg et al. EUROPEAN NEUROLOGY
- High-molecular-weight β-amyloid oligomers are elevated in cerebrospinal fluid of Alzheimer patients
- (2010) Hiroaki Fukumoto et al. FASEB JOURNAL
- Prediction of Alzheimer’s Disease Using Midregional Proadrenomedullin and Midregional Proatrial Natriuretic Peptide
- (2010) Katharina Buerger et al. JOURNAL OF CLINICAL PSYCHIATRY
- Reimagining Alzheimer's Disease--An Age-Based Hypothesis
- (2010) K. Herrup JOURNAL OF NEUROSCIENCE
- Revising the definition of Alzheimer's disease: a new lexicon
- (2010) Bruno Dubois et al. LANCET NEUROLOGY
- Biomarkers in Alzheimer's disease drug development
- (2010) Kaj Blennow NATURE MEDICINE
- Biomarkers for Alzheimer's disease: academic, industry and regulatory perspectives
- (2010) Harald Hampel et al. NATURE REVIEWS DRUG DISCOVERY
- Cerebrospinal fluid and plasma biomarkers in Alzheimer disease
- (2010) Kaj Blennow et al. Nature Reviews Neurology
- Alzheimer's Disease
- (2010) Henry W. Querfurth et al. NEW ENGLAND JOURNAL OF MEDICINE
- Biomarkers for Alzheimer's disease therapeutic trials
- (2010) Harald Hampel et al. PROGRESS IN NEUROBIOLOGY
- Use of theragnostic markers to select drugs for phase II/III trials for Alzheimer disease
- (2010) Henrik Zetterberg et al. Alzheimers Research & Therapy
- A novel Aβ isoform pattern in CSF reflects γ-secretase inhibition in Alzheimer disease
- (2010) Erik Portelius et al. Alzheimers Research & Therapy
- A γ-secretase inhibitor decreases amyloid-β production in the central nervous system
- (2009) Randall J. Bateman et al. ANNALS OF NEUROLOGY
- Cerebrospinal Fluid β-Amyloid 42 and Tau Proteins as Biomarkers of Alzheimer-Type Pathologic Changes in the Brain
- (2009) Tero Tapiola et al. ARCHIVES OF NEUROLOGY
- Blood-Based Microcirculation Markers in Alzheimer's Disease–Diagnostic Value of Midregional Pro-atrial Natriuretic Peptide/C-terminal Endothelin-1 Precursor Fragment Ratio
- (2009) Katharina Buerger et al. BIOLOGICAL PSYCHIATRY
- Serial PIB and MRI in normal, mild cognitive impairment and Alzheimer's disease: implications for sequence of pathological events in Alzheimer's disease
- (2009) Clifford R. Jack et al. BRAIN
- Total and phosphorylated tau protein as biological markers of Alzheimer’s disease
- (2009) Harald Hampel et al. EXPERIMENTAL GERONTOLOGY
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- Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity
- (2009) Kajsa Sämgård et al. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
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- (2009) Henrik Zetterberg SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION
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- (2008) Ahmadul Kadir et al. ANNALS OF NEUROLOGY
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- (2008) S. Sankaranarayanan et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
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- Beta‐site amyloid precursor protein cleaving enzyme 1 (BACE1) as a biological candidate marker of Alzheimer's disease
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- Core candidate neurochemical and imaging biomarkers of Alzheimer’s disease
- (2007) Harald Hampel et al. Alzheimers & Dementia
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