Review
Clinical Neurology
Jun Song Isaac Tan, Ling Jie Cheng, Ee Yuee Chan, Ying Lau, Siew Tiang Lau
Summary: The study found that light therapy has a certain effect on sleep disturbances in older adults with dementia, significantly reducing nighttime awakenings and improving sleep quality and relative amplitude. The results may vary in different regions. However, the current level of evidence is low, and more large-scale trials are needed to draw more definitive conclusions.
Review
Geriatrics & Gerontology
Xiangyang Xiong, Tianpeng Hu, Zhenyu Yin, Yaodan Zhang, Fanglian Chen, Ping Lei
Summary: While the question of why we need sleep remains unanswered, a better understanding of its function can lead to improved societal attitudes towards sleep. Sleep disorders are prevalent in neurodegenerative diseases and greatly impact the quality of life for patients and their families. Alzheimer's disease, in particular, is associated with sleep disorders and disturbances in circadian rhythms. This review explores the bidirectional relationships between circadian rhythm disturbances, sleep disorders, and Alzheimer's disease, and outlines potential treatment options.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Biology
Brittany Gerald, J. Bryce Ortiz, Tabitha R. F. Green, S. Danielle Brown, P. David Adelson, Sean M. Murphy, Rachel K. Rowe
Summary: Pediatric traumatic brain injury (TBI) is a major cause of death and disabilities in children and adolescents. Sleep problems following TBI can significantly impact recovery and outcomes. This study investigated the prevalence of sleep-wake disturbances (SWD) in children with TBI and identified several risk factors, such as age and injury severity. Untreated sleep problems after TBI can worsen symptoms, prolong hospital stays, and delay return to school. Identifying these risk factors can improve the diagnosis, management, and treatment of sleep problems in pediatric TBI survivors.
Review
Cell Biology
Md Farhad Hossain, Ni Wang, Ruijun Chen, Siwen Li, Jaydeep Roy, Md Giash Uddin, Zhong Li, Lee Wei Lim, You-Qiang Song
Summary: Melatonin plays crucial roles in Alzheimer's disease by promoting autophagy, improving sleep quality, and counteracting oxidative stress. The therapeutic potential of melatonin in AD may involve its multifunctional properties.
AGEING RESEARCH REVIEWS
(2021)
Review
Clinical Neurology
Tyler A. Steele, Erik K. St Louis, Aleksandar Videnovic, R. Robert Auger
Summary: Circadian rhythms play a crucial role in various physiological processes and daily life activities. Different circadian sleep-wake disorders require specific management strategies, such as light therapy, melatonin, and other pharmacological treatments.
Article
Neurosciences
Annie Y. Yao, Patrick J. Halloran, Yingying Ge, Neeraj Singh, John Zhou, James Galske, Wanxia He, Riqiang Yan, Xiangyou Hu
Summary: Alzheimer's disease (AD) patients have an increased risk of seizures and sleep disorders. Deletion of Bace1 in neurons increases epileptiform activity, while Bace1 inhibition can reduce epileptic activity and improve sleep disorders.
JOURNAL OF NEUROSCIENCE
(2023)
Review
Geriatrics & Gerontology
Ta-Wei Guu, Dag Aarsland, Dominic Ffytche
Summary: Inadequate environmental light may be a risk factor for BPSD and sundowning syndrome in dementia patients. It affects activity rhythm and worsens behavioral symptoms. Increasing light exposure and adjusting the environmental setting should be considered in the treatment of dementia patients with BPSD.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2022)
Article
Clinical Neurology
Claudio Liguori, Matteo Spanetta, Mariana Fernandes, Francesca Izzi, Fabio Placidi, Nicola Biagio Mercuri
Summary: This study aimed to compare the sleep-wake pattern in patients with epilepsy and controls. The results showed that patients with epilepsy had poorer sleep efficiency, longer sleep latency, lower synchronization and higher fragmentation of the rest-activity rhythm, lower daytime activity and delayed central phase measure compared with controls.
SEIZURE-EUROPEAN JOURNAL OF EPILEPSY
(2022)
Article
Biology
Marieke M. B. Hoekstra, Maxime Jan, Georgia Katsioudi, Yann Emmenegger, Paul Franken
Summary: The study demonstrated a correlation between PER2 bioluminescence and sleep-wake status in peripheral tissues, indicating integration of sleep-wake information by clock gene circuitry. Mathematical modeling revealed a dynamic description of PER2 driven by sleep-wake-dependent and SCN-independent circadian forces.
Review
Gastroenterology & Hepatology
Yi Li, Lingzhan Shao, Yang Mou, Yan Zhang, Yong Ping
Summary: Recent studies have shown alterations in gut microbiota in Alzheimer's disease patients, as well as a correlation between sleep and circadian rhythm disruption and greater beta-amyloid deposition and AD risk. These studies aim to identify commonalities and distinct characteristics of GM alterations in these conditions, and their impact on pathophysiology.
Article
Clinical Neurology
Long Niu, Feng Zhang, Xiaojiao Xu, Yuting Yang, Song Li, Hui Liu, Weidong Le
Summary: Chronic sleep deprivation impaired learning and memory, exacerbating disease progression in Alzheimer's disease (AD) mice. Abnormal expression of clock genes in the circadian rhythm-related nuclei, especially in AD mice, was found after chronic sleep deprivation. Moreover, abnormal tau phosphorylation was accompanied by alterations in BMAL1 protein levels in the retrosplenial cortex.
Review
Neurosciences
Shi-Yu Sun, Gui-Hai Chen
Summary: Circadian rhythm sleep-wake disorders are a distinct class of sleep disorders caused by alterations to the circadian time-keeping system or a mismatch between internal and external circadian rhythms. Insomnia and excessive daytime sleepiness are the main clinical manifestations. Diagnostic evaluation should focus on sleep diaries, circadian phase markers, and environmental factors for accurate diagnosis and treatment.
CURRENT NEUROPHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yu-Ying Sun, Zhun Wang, He-Yan Zhou, Han-Chang Huang
Summary: This article discusses the relationship between Alzheimer's disease (AD) and sleep-wake disorders. Sleep-wake disorders may contribute to the development of AD and are related to its pathological features and genetic factors. Various neurotransmitters are suggested to be involved in the development of AD and sleep-wake disorders.
ACS CHEMICAL NEUROSCIENCE
(2022)
Article
Anesthesiology
M. L. van Zuylen, A. J. G. Meewisse, W. Ten Hoope, W. J. Eshuis, M. W. Hollmann, B. Preckel, S. E. Siegelaar, D. J. Stenvers, J. Hermanides
Summary: This study found peri-operative changes in diurnal sleep-wake patterns in patients undergoing surgery and general anaesthesia, leading to decreased sleep quality and increased daytime fatigue.
Review
Biochemistry & Molecular Biology
Bibiana Torok, Janos Varga, Dora Zelena
Summary: Normal biological rhythms, including sleep, are important for a healthy life. Disturbed rhythms can lead to memory impairment, a key issue in many psychiatric pathologies. Vasopressin plays a key role in the connection between sleep and memory, with V1a receptors being implicated in the interaction. The study of AVP-deficient rats provides further evidence for the importance of AVP in sleep and memory.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Terri L. Blackwell, Mariana G. Figueiro, Gregory J. Tranah, Jamie M. Zeitzer, Kristine Yaffe, Sonia Ancoli-Israel, Deborah M. Kado, Kristine E. Ensrud, Nancy E. Lane, Yue Leng, Katie L. Stone
Summary: This study found that older men with worse alignment of activity and light had lower levels of cognition and increased rates of cognitive decline. However, there was no association between phasor angle and cognition. Interventions that improve the alignment of light and activity may help slow cognitive decline in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Engineering, Biomedical
Mads Olsen, Jamie M. Zeitzer, Risa N. Richardson, Polina Davidenko, Poul J. Jennum, Helge B. D. Sorensen, Emmanuel Mignot
Summary: Wrist-worn consumer sleep technologies with accelerometers and photoplethysmography have potential to be sleep monitoring systems. A deep neural network with a strong temporal core was developed to predict sleep stages using ACC and PPG signals. The network achieved high accuracy and kappa values on both internal and external datasets.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Cell Biology
Melis Yilmaz Balban, Eric Neri, Manuela M. Kogon, Lara Weed, Bita Nouriani, Booil Jo, Gary Holl, Jamie M. Zeitzer, David Spiegel, Andrew D. Huberman
Summary: Controlled breathwork practices have emerged as potential tools for stress management and well-being. In a remote, randomized, controlled study, three different daily 5-min breathwork exercises were compared with mindfulness meditation. The study showed that exhale-focused cyclic sighing breathwork produced greater improvement in mood and reduction in respiratory rate compared to mindfulness meditation. Daily 5-min cyclic sighing has promise as an effective stress management exercise.
CELL REPORTS MEDICINE
(2023)
Meeting Abstract
Psychology, Biological
D. Mathersul, J. Schulz-Heik, T. Avery, J. Zeitzer, P. Bayley
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
(2023)
Article
Psychology, Clinical
Danielle C. Mathersul, R. Jay Schulz-Heik, Timothy J. Avery, Santiago Allende, Jamie M. Zeitzer, Peter J. Bayley
Summary: This study investigated the effects of two treatments (breathing-based yoga and cognitive processing therapy) on sleep in individuals with posttraumatic stress disorder (PTSD). The results showed that both treatments improved sleep quality, with cognitive processing therapy being more effective for reducing nightmares and breathing-based yoga being more effective for reducing insomnia. These findings support the effectiveness of trauma-focused psychotherapy for improving sleep and suggest the potential benefits of yoga-based interventions for individuals with emotional or mental health disorders like PTSD.
DEPRESSION AND ANXIETY
(2023)
Article
Multidisciplinary Sciences
Renske Lok, Marisol Duran, Jamie M. Zeitzer
Summary: This study examines the effectiveness of flash therapy, a sequence of light flashes applied during sleep, in shifting the circadian clock. The results show that flash therapy can cause significant delays in the circadian timing, up to 6 hours, with minimal impact on sleep. This finding may have practical implications for shift workers and jet travelers.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Craig Gouldthorpe, Sonia Ancoli-Israel, Elizabeth Cash, Pasquale Innominato, Gunnhild Jakobsen, Francis Levi, Christine Miaskowski, Arti Parganiha, Atanu Kumar Pati, Deidre Pereira, Victoria Revell, Jamie M. Zeitzer, Andrew Davies
Summary: In cancer patients, disrupted circadian rhythms can lead to more symptoms, poorer quality of life, and shorter survival. Currently, there are no formal criteria for diagnosing the condition, so this study aimed to provide recommendations on how to assess and diagnose circadian rhythm disorders in cancer patients.
Article
Materials Science, Biomaterials
Inga M. M. Antonsdottir, Dominique V. V. Low, Diefei Chen, Jill A. A. Rabinowitz, Yiwei Yue, Jacek Urbanek, Mark N. N. Wu, Jamie M. M. Zeitzer, Paul B. B. Rosenberg, Leah F. F. Friedman, Javaid I. I. Sheikh, Jerome A. A. Yesavage, Vadim Zipunnikov, Adam P. P. Spira
Summary: Little is known about the relationship between circadian rhythm alterations, neuropsychiatric symptoms, and cognition in memory impaired older adults. This study examined the associations of actigraphic rest/activity rhythms with depressive symptoms and cognition in this population. The findings suggest that depressive symptoms are associated with increased activity in the afternoon, evening, and overnight into midday, while better cognitive performance is associated with increased activity in the morning and afternoon.
Meeting Abstract
Neurosciences
Maryam Ahmadi, Adam J. Krause, Kathleen P. O'Hora, Beatriz Hernandez, Laura Lazzeroni, Jamie M. Zeitzer, Leah F. Friedman, Donn Posner, Clete A. Kushida, Jerome A. Yesavage, Jared Saletin, Andrea Goldstein-Piekarski
BIOLOGICAL PSYCHIATRY
(2023)
Meeting Abstract
Clinical Neurology
Renske Lok, Jamie Zeitzer
Meeting Abstract
Clinical Neurology
Allison Morehouse, Kathleen O'Hora, Beatriz Hernandez, Laura Lazzeroni, Jamie Zeitzer, Leah Friedman, Donn Posner, Clete Kushida, Jerome Yesavage, Andrea Goldstein-Piekarski
Meeting Abstract
Clinical Neurology
Jamie Zeitzer, Renske Lok, Lara Weed, Joseph Winer
Letter
Clinical Neurology
Renske Lok, Dwijen Chawra, Jamie M. Zeitzer
Article
Biology
H. Craig Heller, Erik Herzog, Allison Brager, Gina Poe, Ravi Allada, Frank Scheer, Mary Carskadon, Horacio O. de la Iglesia, Rockelle Jang, Ashley Montero, Kenneth Wright, Philippe Mouraine, Matthew P. Walker, Namni Goel, John Hogenesch, Russell N. Van Gelder, Lance Kriegsfeld, Cheri Mah, Christopher Colwell, Jamie Zeitzer, Michael Grandner, Chandra L. Jackson, J. Roxanne Prichard, Steve A. Kay, Ketema Paul
Summary: Collegiate athletes face various pressures, including academic obligations, performance impact, health issues, and extensive travel. East-west travel disrupts circadian rhythms and affects sleep quality and health. To address these concerns, we provide suggestions and steps such as bedtime protocols, afternoon naps, and adherence to lighting exposure protocols, and encourage collaboration between athletic departments and experts to promote the health and wellbeing of athletes and staff.
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)
Article
Clinical Neurology
Lara Weed, Renske Lok, Dwijen Chawra, Jamie Zeitzer
Summary: This study aims to investigate the impact of the timing and duration of missing actigraphy data on interdaily stability (IS) and intradaily variability (IV) calculations, as well as testing the performance of three missing data imputation methods. The results suggest that median ToD imputation method produces the least deviation and is recommended for recapitulating IV and IS under missing data conditions for less than 24 h.
