Review
Immunology
Yang Xu, Huikai Zhang, Qian Sun, Rongxin Geng, Fanen Yuan, Baohui Liu, Qianxue Chen
Summary: Gliomas, the most common primary malignant tumor in adults' central nervous system, still lack breakthroughs in long-term treatment. Abnormalities in the immune regulatory mechanism in the tumor microenvironment are crucial for tumor cell survival, with alterations in amino acid metabolism impacting tumor cells and immune regulation mechanisms. Studying immune regulation of tryptophan metabolism in the tumor microenvironment of gliomas can help identify potential targets for treatment and enhance the efficacy of immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Chuanhong Zhong, Lilei Peng, Bei Tao, Senlin Yin, Liang Lyu, Hao Ding, Xiaobo Yang, Tangming Peng, Haiping He, Peizhi Zhou
Summary: This study investigated the specific role of TDO2 in glioma progression and found that high TDO2 expression was closely associated with poor prognosis in glioma patients. TDO2 promoted glioma cell proliferation by increasing the levels of tryptophan metabolite Kyn through the AhR/AKT signaling pathway and had immunosuppressive effects.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Sangwon Jang, Inah Park, Mijung Choi, Jihoon Kim, Seungeun Yeo, Sung-Oh Huh, Ji-Woong Choi, Cheil Moon, Han Kyoung Choe, Youngshik Choe, Kyungjin Kim
Summary: The circadian regulation of 5-HT levels, controlled by the nuclear receptor REV-ERBα, plays a significant role in social interaction behaviors. The genetic ablation of REV-ERBα in DR 5-HTergic neurons leads to impaired social preference, which is associated with elevated neuron activity and 5-HT levels at dusk. Furthermore, inhibiting the DR to NAc 5-HTergic circuit restores the impairment of social preference in these mice.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)
Article
Food Science & Technology
Danna Wang, Jianbin Wu, Peilin Zhu, Hanqi Xie, Lianxiao Lu, Wanting Bai, Weixi Pan, Renjie Shi, Jin Ye, Bing Xia, Zhenting Zhao, Yutang Wang, Xuebo Liu, Beita Zhao
Summary: Tryptophan can regulate depression-like behavior through modulating gut microbiota and metabolic pathways, improving neuroinflammation and energy metabolism.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Otto Muzik, Anthony F. Shields, Geoffrey R. Barger, Huailei Jiang, Parthasarathi Chamiraju, Csaba Juhasz
Summary: This first-in-human study tested the use of 18F-FETrp-PET in patients with neuroendocrine and brain tumors, showing promising results for molecular imaging of human gliomas. The tracer demonstrated early peak and washout in neuroendocrine tumors, while prolonged accumulation and heterogeneous uptake in gliomas, with moderate liver uptake and fast clearance into the urinary bladder.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Neurosciences
Wenxia Li, Ling Ling, Lei Xiang, Peng Ding, Wei Yue
Summary: This study aims to clarify the relationship between tryptophan metabolism-related genes (TRGs) and lower-grade glioma (LGG) comprehensively. Through analyzing the expression level of TRGs in LGG and normal tissues, key TRGs with prognostic value and differential expression in LGGs were identified, and a risk model was constructed. The study demonstrates the important role of tryptophan metabolism in LGG progression, and proposes that the TRGs risk model and molecular subtypes can serve as indicators to predict prognosis and are closely related to clinicopathological factors and tumor immune microenvironment (TIME).
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Shuxin Zhang, Siliang Chen, Zhihao Wang, Junhong Li, Yunbo Yuan, Wentao Feng, Wenhao Li, Mina Chen, Yanhui Liu
Summary: The study explored the relationship between the expression pattern of TrMGs and characteristics of gliomas, presented a TrMRS model for prognosis prediction, indicating the potential to guide the application of immunotherapy for gliomas.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Jed de Ruiter Swain, Evdokia Michalopoulou, Evan K. Noch, Michael J. Lukey, Linda Van Aelst
Summary: This review discusses the mechanisms of intercellular metabolite exchange in the healthy brain and how it is exploited by glioblastoma for tumor growth and modulation of the tumor microenvironment. The authors highlight the potential of targeting metabolic dependencies as a therapeutic avenue against this aggressive brain cancer.
GENES & DEVELOPMENT
(2023)
Article
Biochemistry & Molecular Biology
Vessela Vassileva, Marta Braga, Chris Barnes, Justyna Przystal, Ali Ashek, Louis Allott, Diana Brickute, Joel Abrahams, Keittisak Suwan, Angel M. Carcaboso, Amin Hajitou, Eric O. Aboagye
Summary: The study demonstrates that [F-18]FPIA PET can be utilized for the detection and longitudinal monitoring of glioma growth with high tumor-to-brain contrast, showing a positive correlation with tumor proliferation.
Article
Biochemistry & Molecular Biology
Kirsten Berding, Thomaz F. S. Bastiaanssen, Gerard M. Moloney, Serena Boscaini, Conall R. Strain, Andrea Anesi, Caitriona Long-Smith, Fulvio Mattivi, Catherine Stanton, Gerard Clarke, Timothy G. Dinan, John F. Cryan
Summary: This study investigated the impact of a psychobiotic diet on the microbial profile and mental health in a healthy population. The results showed that the psychobiotic diet reduced perceived stress and improved stress levels, although it only had subtle effects on microbial composition and function. In addition, higher adherence to the diet was associated with greater decreases in perceived stress.
MOLECULAR PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Benatti Cristina, Rivi Veronica, Alboni Silvia, Grilli Andrea, Castellano Sara, Pani Luca, Brunello Nicoletta, Blom M. C. Johanna, Bicciato Silvio, Tascedda Fabio
Summary: Dysregulation of the kynurenine pathway is involved in various human diseases and disorders. Lymnaea stagnalis (LS), an invertebrate model, is a valuable tool for studying the complexity of this pathway. The researchers characterized the kynurenine pathway in LS, confirming the sequence conservation of key enzymes and identifying several compounds in the LS hemolymph.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ana Maria Garcia Vicente, Francisco Jose Pena Pardo, Mariano Amo-Salas, Maikal Villena Martin, Carlos Lopez Menendez, Angel Maria Soriano Castrejon, Julian Perez-Beteta
Summary: By assessing the correlation between postoperative F-18-fluorocholine PET/CT and MRI results in patients with high-grade glioma (HGG), it was found that postoperative PET/CT seems to be superior to MRI in predicting the prognosis of HGG patients and outperforms it in determining the most probable location of tumor recurrence.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Stefanie Quach, Adrien Holzgreve, Lena Kaiser, Marcus Unterrainer, Franziska J. Dekorsy, Debie Nelwan, Laura M. Bartos, Sabrina Kirchleitner, Jonathan Weller, Lorraine Weidner, Maximilian Niyazi, Viktoria C. Ruf, Jochen Herms, Sophia Stoecklein, Christian Wetzel, Markus J. Riemenschneider, Louisa Baumgarten, Niklas Thon, Matthias Brendel, Rainer Rupprecht, Peter Bartenstein, Joerg-Christian Tonn, Nathalie L. Albert
Summary: The study aimed to find markers associated with the survival of recurrent glioma patients. By performing TSPO PET scans on patients with glioma recurrence, it was found that the expression of TSPO was related to tumor grade and patient survival. In specific molecular subtypes, TSPO PET could predict survival time, providing a valuable biomarker for individualized patient management.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Honglin Ge, Guangfu Di, Zheng Yan, Dongming Liu, Yong Liu, Kun Song, Kun Yang, Xinhua Hu, Zijuan Jiang, Xiao Hu, Lei Tian, Chaoyong Xiao, Yuanjie Zou, Hongyi Liu, Jiu Chen
Summary: This study investigated the clinical features of glioma-associated epilepsy and explored the risk factors associated with it. The results showed that younger people were more likely to have epilepsy, and the grade of glioma was related to the incidence of epilepsy. For glioma patients with epilepsy, epilepsy did not lead to worse admission performance but was associated with a better prognosis.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Lisbeth Marner, Michael Lundemann, Astrid Sehested, Karsten Nysom, Lise Borgwardt, Rene Mathiasen, Peder S. Wehner, Otto M. Henriksen, Carsten Thomsen, Jane Skjoth-Rasmussen, Helle Broholm, Olga Ostrup, Julie L. Forman, Liselotte Hojgaard, Ian Law
Summary: The study found that adding [F-18]FET PET to MRI in pediatric CNS tumor patients significantly improved diagnostic accuracy, especially in treated lesions. This combination imaging technique helps differentiate tumor from non-tumor lesions more effectively, with a substantial impact on clinical management and decision-making.